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  • Open Access

    ARTICLE

    NR4A1 enhances glycolysis in hypoxia-exposed pulmonary artery smooth muscle cells by upregulating HIF-1α expression

    CHENYANG CHEN1,*, JUAN WEN1, WEI HUANG1, JIANG LI2,*

    BIOCELL, Vol.47, No.11, pp. 2423-2433, 2023, DOI:10.32604/biocell.2023.044459

    Abstract Background: Pulmonary arterial hypertension (PAH) is a chronic and progressive disease that is strongly associated with dysregulation of glucose metabolism. Alterations in nuclear receptor subfamily 4 group A member 1 (NR4A1) activity alter the outcome of PAH. This study aimed to investigate the effects of NR4A1 on glycolysis in PAH and its underlying mechanisms. Methods: This study included twenty healthy volunteers and twenty-three PAH patients, and plasma samples were collected from the participants. To mimic the conditions of PAH in vitro, a hypoxia-induced model of pulmonary artery smooth muscle cell (PASMC) model was established. The proliferation of PASMCs was assessed… More > Graphic Abstract

    NR4A1 enhances glycolysis in hypoxia-exposed pulmonary artery smooth muscle cells by upregulating HIF-1α expression

  • Open Access

    ARTICLE

    Construction of a Computational Scheme for the Fuzzy HIV/AIDS Epidemic Model with a Nonlinear Saturated Incidence Rate

    Muhammad Shoaib Arif1,2,*, Kamaleldin Abodayeh1, Yasir Nawaz2

    CMES-Computer Modeling in Engineering & Sciences, Vol.138, No.2, pp. 1405-1425, 2024, DOI:10.32604/cmes.2023.028946

    Abstract This work aimed to construct an epidemic model with fuzzy parameters. Since the classical epidemic model does not elaborate on the successful interaction of susceptible and infective people, the constructed fuzzy epidemic model discusses the more detailed versions of the interactions between infective and susceptible people. The next-generation matrix approach is employed to find the reproduction number of a deterministic model. The sensitivity analysis and local stability analysis of the system are also provided. For solving the fuzzy epidemic model, a numerical scheme is constructed which consists of three time levels. The numerical scheme has an advantage over the existing… More >

  • Open Access

    ARTICLE

    Dense Spatial-Temporal Graph Convolutional Network Based on Lightweight OpenPose for Detecting Falls

    Xiaorui Zhang1,2,3,*, Qijian Xie1, Wei Sun3,4, Yongjun Ren1,2,3, Mithun Mukherjee5

    CMC-Computers, Materials & Continua, Vol.77, No.1, pp. 47-61, 2023, DOI:10.32604/cmc.2023.042561

    Abstract Fall behavior is closely related to high mortality in the elderly, so fall detection becomes an important and urgent research area. However, the existing fall detection methods are difficult to be applied in daily life due to a large amount of calculation and poor detection accuracy. To solve the above problems, this paper proposes a dense spatial-temporal graph convolutional network based on lightweight OpenPose. Lightweight OpenPose uses MobileNet as a feature extraction network, and the prediction layer uses bottleneck-asymmetric structure, thus reducing the amount of the network. The bottleneck-asymmetrical structure compresses the number of input channels of feature maps by… More >

  • Open Access

    ARTICLE

    Coping with Trauma: The Relationship between Religiosity, Spirituality, and Post-Traumatic Symptoms among Civilians Exposed to Ongoing Rocket-Fire

    Jonathan T. Wolkinson, Michael Weinberg*

    International Journal of Mental Health Promotion, Vol.25, No.10, pp. 1137-1145, 2023, DOI:10.32604/ijmhp.2023.029641

    Abstract Living under ongoing shelling and missile attacks could cause a widespread of disruption of everyday life and emotional distress. Coping with such distress could be associated with the personal resources of religion and spirituality. The present study aimed to examine the relationships between religiosity and spirituality with Post Traumatic stress Disorder (PTSD) symptoms among a civilian population frequently exposed to missile and rocket threats. One hundred and twenty-four (N = 124) civilian participants living within 10 km from shelling and missile attacks fired towards them, completed demographic, religiosity, spirituality, and PTSD questionnaires. The study findings demonstrate that religiosity is associated… More >

  • Open Access

    ARTICLE

    Full Scale-Aware Balanced High-Resolution Network for Multi-Person Pose Estimation

    Shaohua Li, Haixiang Zhang*, Hanjie Ma, Jie Feng, Mingfeng Jiang

    CMC-Computers, Materials & Continua, Vol.76, No.3, pp. 3379-3392, 2023, DOI:10.32604/cmc.2023.041538

    Abstract Scale variation is a major challenge in multi-person pose estimation. In scenes where persons are present at various distances, models tend to perform better on larger-scale persons, while the performance for smaller-scale persons often falls short of expectations. Therefore, effectively balancing the persons of different scales poses a significant challenge. So this paper proposes a new multi-person pose estimation model called FSA Net to improve the model’s performance in complex scenes. Our model utilizes High-Resolution Network (HRNet) as the backbone and feeds the outputs of the last stage’s four branches into the DCB module. The dilated convolution-based (DCB) module employs… More >

  • Open Access

    ARTICLE

    Proposer un accompagnement au sevrage tabagique aux patients atteints de cancer : le rôle des associations proposant des soins de support. Exemple de la Ligue Contre le Cancer Gironde

    Océane Phanatzis1,2,*, Rébecca Ratel1,2, Isabelle Barcos1,2, Marie Daspas3, Emmanuelle Clairembault3, François Alla1,2

    Psycho-Oncologie, Vol.17, No.3, pp. 133-145, 2023, DOI:10.32604/po.2023.044916

    Abstract Objectif : L’objectif de cet article est d’exposer les composantes interventionnelles et contextuelles d’un accompagnement au sevrage tabagique dans le cadre des soins oncologiques de support (SOS) délivrés par une association, qui soit viable en contexte français et efficace, et de décrire le processus de recherche partenariale dans lequel elles ont été élaborées. Méthodes : L’intervention a été développée à partir d’un ensemble de données recueillies lors d’une étude de viabilité à la mise en place d’une offre de sevrage tabagique au sein de la Ligue Contre le Cancer Gironde, une revue de la portée sur les interventions probantes et… More >

  • Open Access

    ARTICLE

    Advanced Guided Whale Optimization Algorithm for Feature Selection in BlazePose Action Recognition

    Motasem S. Alsawadi1,*, El-Sayed M. El-kenawy2, Miguel Rio1

    Intelligent Automation & Soft Computing, Vol.37, No.3, pp. 2767-2782, 2023, DOI:10.32604/iasc.2023.039440

    Abstract The BlazePose, which models human body skeletons as spatiotemporal graphs, has achieved fantastic performance in skeleton-based action identification. Skeleton extraction from photos for mobile devices has been made possible by the BlazePose system. A Spatial-Temporal Graph Convolutional Network (STGCN) can then forecast the actions. The Spatial-Temporal Graph Convolutional Network (STGCN) can be improved by simply replacing the skeleton input data with a different set of joints that provide more information about the activity of interest. On the other hand, existing approaches require the user to manually set the graph’s topology and then fix it across all input layers and samples.… More >

  • Open Access

    ARTICLE

    CNN Accelerator Using Proposed Diagonal Cyclic Array for Minimizing Memory Accesses

    Hyun-Wook Son1, Ali A. Al-Hamid1,2, Yong-Seok Na1, Dong-Yeong Lee1, Hyung-Won Kim1,*

    CMC-Computers, Materials & Continua, Vol.76, No.2, pp. 1665-1687, 2023, DOI:10.32604/cmc.2023.038760

    Abstract This paper presents the architecture of a Convolution Neural Network (CNN) accelerator based on a new processing element (PE) array called a diagonal cyclic array (DCA). As demonstrated, it can significantly reduce the burden of repeated memory accesses for feature data and weight parameters of the CNN models, which maximizes the data reuse rate and improve the computation speed. Furthermore, an integrated computation architecture has been implemented for the activation function, max-pooling, and activation function after convolution calculation, reducing the hardware resource. To evaluate the effectiveness of the proposed architecture, a CNN accelerator has been implemented for You Only Look… More >

  • Open Access

    ARTICLE

    A Survey on Deep Learning-Based 2D Human Pose Estimation Models

    Sani Salisu1,2, A. S. A. Mohamed1,*, M. H. Jaafar3, Ainun S. B. Pauzi1, Hussain A. Younis1,4

    CMC-Computers, Materials & Continua, Vol.76, No.2, pp. 2385-2400, 2023, DOI:10.32604/cmc.2023.035904

    Abstract In this article, a comprehensive survey of deep learning-based (DL-based) human pose estimation (HPE) that can help researchers in the domain of computer vision is presented. HPE is among the fastest-growing research domains of computer vision and is used in solving several problems for human endeavours. After the detailed introduction, three different human body modes followed by the main stages of HPE and two pipelines of two-dimensional (2D) HPE are presented. The details of the four components of HPE are also presented. The keypoints output format of two popular 2D HPE datasets and the most cited DL-based HPE articles from… More >

  • Open Access

    ARTICLE

    The potency of N, N'-diphenyl-1,4-phenylenediamine and adipose-derived stem cell co-administration in alleviating hepatorenal dysfunction complications associated with type 1 diabetes mellitus in rats

    HANY M. ABD EL-LATEEF1,2,*, SAFA H. QAHL3, EMAN FAYAD4, SARAH A. ALTALHI4, IBRAHIM JAFRI4, EL SHAIMAA SHABANA5, MARWA K. DARWISH6,7, REHAB MAHER8, SAAD SHAABAN1,9, SHADY G. EL-SAWAH10,*

    BIOCELL, Vol.47, No.8, pp. 1885-1895, 2023, DOI:10.32604/biocell.2023.030680

    Abstract Background: The increasing occurrence of diabetes mellitus (DM) noted worldwide has considerably elicited concern in the recent past. DM is associated with elevated vascular complications, morbidity, mortality, and poor quality of life. In this context, mesenchymal stem cells (MSCs) have shown significant therapeutic potentialities in managing and curing type 1 DM owing to their self-renewable, immunosuppressive, and differentiation capacities. We investigated the potential action of N, N′-diphenyl-1,4-phenylenediamine (DPPD), a well-known synthetic antioxidant to enhance the therapeutic ability of the adipose-derived stem cells (AD-MSCs) in alleviating kidney and liver complications in diabetic rats. Methods: Over the four weeks of experiments, albino… More > Graphic Abstract

    The potency of <i>N</i>, <i>N'</i>-diphenyl-1,4-phenylenediamine and adipose-derived stem cell co-administration in alleviating hepatorenal dysfunction complications associated with type 1 diabetes mellitus in rats

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