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  • Open Access


    Association of Congenital Heart Defects (CHD) with Factors Related to Maternal Health and Pregnancy in Newborns in Puerto Rico

    Yamixa Delgado1,*, Caliani Gaytan1, Naydi Perez2, Eric Miranda3, Bryan Colón Morales1, Mónica Santos1

    Congenital Heart Disease, Vol.19, No.1, pp. 19-31, 2024, DOI:10.32604/chd.2024.046339

    Abstract Background: Given the pervasive issues of obesity and diabetes both in Puerto Rico and the broader United States, there is a compelling need to investigate the intricate interplay among body mass index (BMI), pregestational, and gestational maternal diabetes, and their potential impact on the occurrence of congenital heart defects (CHD) during neonatal development. Methods: Using the comprehensive System of Vigilance and Surveillance of Congenital Defects in Puerto Rico, we conducted a focused analysis on neonates diagnosed with CHD between 2016 and 2020. Our assessment encompassed a range of variables, including maternal age, gestational age, BMI, pregestational diabetes, gestational diabetes, hypertension,… More >

  • Open Access


    Maternal Vascular Dysfunction in Congenital Heart Defects

    Yanli Liu1,2, Fengzhen Han2, Jian Zhuang4, Yanqiu Ou4, Yanji Qu5, Yanyan Lin2, Weina Zhang2, Haiping Wang3,*, Liping Huang1,*

    Congenital Heart Disease, Vol.18, No.5, pp. 561-570, 2023, DOI:10.32604/chd.2023.030511

    Abstract Background: Research on fetal congenital heart defect (CHD) mostly focuses on etiology and mechanisms. However, studies on maternal complications or pathophysiology are limited. Our objective was to determine whether vascular dysfunction exists in pregnant women carrying a fetus with congenital heart defects. Methods: We conducted a case-control study. 27 cases of pregnant women carrying a fetus with major CHD admitted to our hospital for delivery between April 2021 and August 2022 were selected. Every case was matched with about 2 pregnant complication-free controls without fetal abnormalities. The proangiogenic and anti-angiogenic factors and pregnancy outcomes were compared. Results: The proangiogenic factors… More > Graphic Abstract

    Maternal Vascular Dysfunction in Congenital Heart Defects

  • Open Access


    Delivery Outcomes in Non-Tertiary Referral Centers for Women with Congenital Heart Disease

    Daniel Sweeney1, Scott Cohen2,3, Salil Ginde2,3, Jennifer Gerardin2,3, Peter Bartz2,3, Matthew Buelow2,3,*

    Congenital Heart Disease, Vol.18, No.3, pp. 315-323, 2023, DOI:10.32604/chd.2023.027349

    Abstract Background: Women with congenital heart disease (CHD) have increased risk for adverse events during pregnancy and delivery. Prior studies have assessed pregnancy and delivery outcomes at tertiary referral centers (TRC). The aim of our study was to assess pregnancy outcomes in women with CHD who deliver in a non-tertiary referral center (non-TRC). Methods: Clinical demographics were collected, including anatomic complexity, physiologic state and pre-pregnancy risk assessment. Patients were stratified by delivery location, either TRC or non-TRC. Maternal and neonatal complications of pregnancy were reported. Results: Women with CHD who delivered in a TRC had a higher pre-pregnancy risk when assessed… More > Graphic Abstract

    Delivery Outcomes in Non-Tertiary Referral Centers for Women with Congenital Heart Disease

  • Open Access


    Data Analytics on Unpredictable Pregnancy Data Records Using Ensemble Neuro-Fuzzy Techniques

    C. Vairavel1,*, N. S. Nithya2

    Computer Systems Science and Engineering, Vol.46, No.2, pp. 2159-2175, 2023, DOI:10.32604/csse.2023.036598

    Abstract The immune system goes through a profound transformation during pregnancy, and certain unexpected maternal complications have been correlated to this transition. The ability to correctly examine, diagnoses, and predict pregnancy-hastened diseases via the available big data is a delicate problem since the range of information continuously increases and is scalable. Many approaches for disease diagnosis/classification have been established with the use of data mining concepts. However, such methods do not provide an appropriate classification/diagnosis model. Furthermore, single learning approaches are used to create the bulk of these systems. Classification issues may be made more accurate by combining predictions from many… More >

  • Open Access


    An Automated System for Early Prediction of Miscarriage in the First Trimester Using Machine Learning

    Sumayh S. Aljameel1, Malak Aljabri1,2, Nida Aslam1, Dorieh M. Alomari3,*, Arwa Alyahya1, Shaykhah Alfaris1, Maha Balharith1, Hiessa Abahussain1, Dana Boujlea1, Eman S. Alsulmi4

    CMC-Computers, Materials & Continua, Vol.75, No.1, pp. 1291-1304, 2023, DOI:10.32604/cmc.2023.035710

    Abstract Currently, the risk factors of pregnancy loss are increasing and are considered a major challenge because they vary between cases. The early prediction of miscarriage can help pregnant ladies to take the needed care and avoid any danger. Therefore, an intelligent automated solution must be developed to predict the risk factors for pregnancy loss at an early stage to assist with accurate and effective diagnosis. Machine learning (ML)-based decision support systems are increasingly used in the healthcare sector and have achieved notable performance and objectiveness in disease prediction and prognosis. Thus, we developed a model to help obstetricians predict the… More >

  • Open Access


    Evaluation of Perinatal and Developmental Outcomes in Neonates with Abstinence Syndrome Admitted to NICU

    Ali Kheradmand1, Sahar Ashrafzadeh2, Farzane Rouzegari3, Samin Aliakbarian1, Ali Naseh4,*

    International Journal of Mental Health Promotion, Vol.25, No.2, pp. 265-274, 2023, DOI:10.32604/ijmhp.2023.024773

    Abstract Drug abuse by pregnant women is one of the significant problems for mothers and their neonates. This study aimed to investigate the effects of maternal substance use disorder during pregnancy on neonatal developmental criteria. In a case-control study, clinical records of 90 neonates diagnosed with neonatal abstinence syndrome who were admitted to NICU in one of four hospitals affiliated with Shahid-Beheshti University of Medical Sciences in Tehran, Iran between 2017 and 2020 were compared to 90 neonates without neonatal abstinence syndrome (control group). Demographic information and data for neonatal developmental characteristics and complications were extracted from the clinical records of… More >

  • Open Access


    Impact of SARS-CoV-2 infection during pregnancy on postnatal brain development: The potential role of glial cells


    BIOCELL, Vol.46, No.12, pp. 2517-2523, 2022, DOI:10.32604/biocell.2022.021566

    Abstract Glial cells are crucial for maintaining central nervous system (CNS) homeostasis. They actively participate in immune responses, as well as form functional barriers, such as blood-brain barrier (BBB), which restrict the entry of pathogens and inflammatory mediators into the CNS. In general, viral infections during the gestational period can alter the embryonic and fetal environment, and the related inflammatory response may affect neurodevelopment and lead to behavioral dysfunction during later stage of life, as highlighted by our group for Zika virus infection. Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) induces a cytokine storm and, during pregnancy, may be related to a… More >

  • Open Access


    Analysis of specific lipid metabolites in cord blood of patients with gestational diabetes mellitus


    BIOCELL, Vol.46, No.6, pp. 1565-1573, 2022, DOI:10.32604/biocell.2022.018347

    Abstract This work aimed to clarify the interaction between the fetus and pregnant patients with gestational diabetes mellitus (GDM), the lipid metabolomics analysis of the fetal umbilical cord blood of GDM patients and normal pregnant women were performed to screen out the specific lipid metabolites for pathogenesis of GDM. From 2019–2020, 21 patients with GDM and 22 normal pregnant women were enrolled in Hexian Memorial Hospital, Panyu District, Guangzhou. The general information such as weight, height, age, body mass index (BMI) before pregnancy were analyzed. Non-targeted metabonomic detection and analysis were performed in umbilical cord plasma using LC-MS method. The age,… More >

  • Open Access


    Pregnancy in Patients with Shone Complex: A Single-Center Case Series

    Rachel Gardner1, Emily Durbak1, Rachael Baird2, Katherine Singh2, Jeff Chapa2, David Majdalany3,*

    Congenital Heart Disease, Vol.17, No.2, pp. 147-160, 2022, DOI:10.32604/chd.2022.017366

    Abstract Background: There is limited literature written on the course and outcomes for pregnant mothers with Shone complex. Methods: We describe a case series of five pregnancies in four women with Shone complex within a multidisciplinary cardio-obstetrics clinic from 2016–2018. Results: Maternal age ranged from 21–39 years. Three patients had preserved left ventricular function while one had moderately decreased function. Gestational age at presentation ranged from 6–15 weeks. There were three successful pregnancies (mean gestational age = 37 weeks, range 35–39 weeks) with one patient accounting for two unsuccessful pregnancies. All infants were delivered via Cesarean section. One infant required a… More >

  • Open Access


    Small RNA sequencing revealed aberrant piRNA expression profiles in deciduas of recurrent spontaneous abortion patients


    BIOCELL, Vol.46, No.4, pp. 1013-1023, 2022, DOI:10.32604/biocell.2022.016744

    Abstract Piwi-interacting RNAs (piRNAs) is a novel class of non-coding RNAs. However, changes in piRNA expression profiles in recurrent spontaneous abortion (RSA) have not yet been investigated. The aim of this study was to identify differentially expressed piRNAs in deciduas of RSA patients. Decidua tissues were collected by curettage from recruited RSA patients and normal early pregnant (NEP) women with their informed consent. Small RNA sequencing was used to evaluate the differences in piRNA expression profiles between RSA and NEP. The present results demonstrated that the counts of total piRNA reads in RSA samples were increased compared with those in NEP… More >

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