Rohan Suresh Daniel^1,2, Georgia K. Schmidt^1,2, Hayato Nakanishi^1,2, Karen Smayra^1,2, Mariah N. Mascara^1,2, Dilip K. Vankayalapati^1,2, Reem H. Matar^1,2,3, Christian A. Than^1,2,4, George Shiakos⁵, Ioannis Tzanavaros^2,5,*

Congenital Heart Disease, Vol.18, No.2, pp. 245-265, 2023, DOI:10.32604/chd.2023.027596

Abstract Background: Persistent patent ductus arteriosus (pPDA) is a common condition in preterm infants. This meta-analysis aimed to assess the safety and efficacy of transcatheter closure (TC) when compared to surgical ligation (SL) in preterm infants with pPDA. Methods: A literature search of Ovid Cochrane Library, Medline, Embase, Epub, Scopus, PMC Preprints, and was conducted from inception to May 06, 2022. Eligible studies reported infants diagnosed with pPDA born at ≤2000 g birth weight or at ≤37 weeks’ who underwent TC or SL as treatment. This review was registered in PROSPERO (CRD42022325944). Results: From 97 studies screened, 8 studies met the… More >

Anna Szabina Szele^1,*, Beáta Erika Nagy²

International Journal of Mental Health Promotion, Vol.24, No.5, pp. 699-709, 2022, DOI:10.32604/ijmhp.2022.021809

Abstract Preterm and low birth weight infants are at higher risk of neurodevelopmental outcomes; breastfeeding offers several beneficial aspects for them. This study aimed to describe the average neurodevelopmental outcomes of preterm infants and examine the associations between neurodevelopment and breastfeeding among Hungarian preterm infants at 12 months of corrected age. 154 preterm infants with low birth weight (<2500 g) and their mothers were participated in this study. Bayley-III Screening Test (Bayley Scales of Infant and Toddler Development Screening Test, Third Edition) was administered to measure the cognitive, language and motor skills of infants; breastfeeding data was obtained through parental anamnesis. To… More >

Gustaf Tanghöj^1,*, Anna Lindam², Petru Liuba^3,4, Gunnar Sjöberg⁵, Estelle Naumburg¹

Congenital Heart Disease, Vol.15, No.5, pp. 287-299, 2020, DOI:10.32604/CHD.2020.011977

Abstract Objective: Secundum atrial septal defect (ASD II) is a common congenital heart defect, and interatrial communications among preterm children is even more common. The objective of this study was to calculate the incidence of ASD II in children, with assessment to gestational age at birth. Further, to assess maternal, prenatal and postnatal risk factors associated with ASD II among children of different gestational age at birth. Design: This national registry based retrospective incidence study was supplemented with a national case-control study, using the Swedish Register of Congenial Heart Disease, Swedish Medical Birth Register and Statistics Sweden. All children, 0–18 years… More >

Koert de Waal¹, Nilkant Phad¹, Nick Collins², Andrew Boyle²

Congenital Heart Disease, Vol.12, No.3, pp. 364-372, 2017, DOI:10.1111/chd.12454

Abstract Background: Sustained volume load due to a patent ductus arteriosus (PDA) leads to cardiac remodeling. Remodeling changes can become pathological and are associated with cardiovascular disease progression. Data on remodeling changes in preterm infants is not available.
Methods: Clinical and echocardiography data were collected in preterm infants <30 weeks gestation on postnatal day 3 and then every 7–14 days until closure of the ductus arteriosus. Images were analyzed using conventional techniques and speckle tracking. Remodeling changes of infants with prolonged (>14 days) exposure to a PDA were compared to control infants without a PDA.
Results: Thirty out of 189 infants… More >

Jennifer L. Shepherd, Shahab Noori

Congenital Heart Disease, Vol.14, No.1, pp. 21-26, 2019, DOI:10.1111/chd.12727

Abstract Objective: There is no consensus on the definition of a hemodynamically significant patent ductus arteriosus (hsPDA). In this review article, our objective is to discuss the main variables that one should consider when determining the hemodynamic signifi‐ cance of a PDA.
Results: We describe the various approaches that have been utilized over time to define an hsPDA and discuss the strengths and weaknesses of each echocardio‐ graphic index. Finally, we propose a comprehensive and individualized approach in determining the hemodynamic significance of the PDA.
Conclusion: There are several PDA‐related clinical, echocardiographic, and other ob‐ jective variables to take into consideration… More >

Myriam Almeida‐Jones^1,2, Nai Yu Tang^1,2, Aneela Reddy³, Evan Zahn^1,2

Congenital Heart Disease, Vol.14, No.1, pp. 60-64, 2019, DOI:10.1111/chd.12712

Abstract Clinically significant patent ductus arteriosus (PDA) has been associated with signifi‐ cant morbidity in extremely low birth weight (ELBW) infants. Current management of ELBW infants with hemodynamically significant PDA includes supportive treatment, pharmacological therapy, and surgical ligation. All of these therapeutic options have their advantages and limitations. More recently, transcatheter PDA closure has been described as a viable option in this population. In this paper, we provide a compre‐ hensive review of this emerging procedure. More >

Leah Apalodimas, Benjamin Rush Waller III, Ranjit Philip, Judy Crawford, Jorden Cunningham, Shyam Sathanandam

Congenital Heart Disease, Vol.14, No.1, pp. 90-94, 2019, DOI:10.1111/chd.12705

Abstract Objectives: Patent ductus arteriosus (PDA) is a common finding in preterm infants. A hemodynamically significant PDA may require intervention for closure. This article aims to describe a transcatheter PDA closure (TCPC) program for preterm infants and the components of a comprehensive outpatient follow-up strategy.
Setting: A multidisciplinary team approach including neonatology, cardiology, anesthesiology, medical transport team, pulmonology, cardiac surgery, neurodevelopmental specialist, nutrition, speech therapy, social work, research collaborators, and other health care specialists is integral to the dedicated care and promotion of wellness of extremely low birth weight (ELBW) infants.
Patients: To date, we have performed TCPC on 134 ELBW… More >

Ranjit Philip¹, Jeffrey A. Towbin¹, Shyam Sathanandam ¹, Jason Goldberg¹, Thomas Yohannan¹, Nithya Swaminathan¹, Jason Nathaniel Johnson^1,2

Congenital Heart Disease, Vol.14, No.1, pp. 33-36, 2019, DOI:10.1111/chd.12701

Abstract There continues to be controversy on the long‐term effects of a patent ductus arte‐ riosus (PDA) and its management. However, the hemodynamic effects of a large PDA in a preterm infant are well known. This article aims to provide insight into the adap‐ tive changes and remodeling effects of a PDA on the myocardium in preterm infants. More >