Qi Lu^1,2, Longfei Jin², Cuiling Tong³, Feng Liu², Bei Huang², Dejian Zhang^1,2,*

Phyton-International Journal of Experimental Botany, Vol.93, No.4, pp. 661-679, 2024, DOI:10.32604/phyton.2024.049733

Abstract A Plant Biostimulant is any substance or microorganism applied to plants to enhance nutrition efficiency, abiotic stress tolerance, and/or crop quality traits, regardless of its nutrient content. The application of Plant biostimulants (PBs) in production can reduce the application of traditional pesticides and chemical fertilizers and improve the quality and yield of crops, which is conducive to the sustainable development of agriculture. An in-depth understanding of the mechanism and effect of various PBs is very important for how to apply PBs reasonably and effectively in the practice of crop production. This paper summarizes the main classification of PBs; The growth… More >

ANDI ZHAO^1,2,#, YUE WANG^3,#, ZIJIN WANG^1,2, QING SHAO^1,2, QI GONG^1,2, HUI ZHU^1,2, SHIYA SHEN^1,2, HU LIU^1,2,*, XUEJUAN CHEN^1,2,*

Oncology Research, Vol.32, No.5, pp. 983-998, 2024, DOI:10.32604/or.2024.045972

Abstract Numerous studies have characterized the critical role of circular RNAs (circRNAs) as regulatory factors in the progression of multiple cancers. However, the biological functions of circRNAs and their underlying molecular mechanisms in the progression of uveal melanoma (UM) remain enigmatic. In this study, we identified a novel circRNA, circ_0053943, through re-analysis of UM microarray data and quantitative RT-PCR. Circ_0053943 was found to be upregulated in UM and to promote the proliferation and metastatic ability of UM cells in both in vitro and in vivo settings. Mechanistically, circ_0053943 was observed to bind to the KH1 and KH2 domains of insulin-like growth… More > Graphic Abstract

XIAOXI WANG¹, YANFEI JIA², QIANG LI², QIANG YANG², YINGFENG LIU¹, BEIFENG WEI¹, XIANG NIU¹, YINJIE ZHANG¹, XIAODONG LUO², ZIYU ZHAO^1,*, PENG WANG^1,*

Oncology Research, Vol.32, No.5, pp. 933-941, 2024, DOI:10.32604/or.2023.042581

Abstract MicroRNA (miR)-200b-3p has been associated with many tumors, but its involvement in pituitary adenoma is unclear. This study investigated the molecular mechanism underlying miR-200b-3p regulation in pituitary adenomas to provide a theoretical basis for treatment. Bioinformatics was used to analyze pituitary adenoma-related genes and screen new targets related to RECK and miRNA. As well, the relationship between miR-200b-3p and RECK protein was verified using a double-luciferase reporter gene assay. The expression of miR-200b-3p in clinical samples was analyzed by in situ hybridization. Transfection of the miR-200b-3p inhibitor and small interfering-RECK (si-RECK) was verified by qPCR. GH3 cell viability and proliferation… More >

JINGJING TIAN^1,*, XIBAO HU², XINRONG ZHANG¹

Oncology Research, Vol.32, No.5, pp. 925-931, 2024, DOI:10.32604/or.2023.042447

Abstract To confirm the relationship between Circ_0003855 and EC, we purchased the Human esophageal carcinoma cell line Eca109 and normal human esophageal epithelial cells HEEC, and the expression levels of Circ_0003855, miR-622, and FLOT1 were detected. The results show that Circ_0003855 and FLOT1 were highly expressed in Eca109 cells, while miR-622 was lowly expressed (p < 0.05). Subsequently, Circ_0003855 small interfering RNA (si-Circ_0003855) and its negative control (si-NC) were used to detect changes in cellular biological behaviors. We found that the activity of Eca109 cells was reduced after interfering with the expression of Circ_0003855, and miR-622 expression was elevated, while FLOT1… More >

FEI KONG¹, QIYUAN TIAN², BINGLIN KUANG³, LILI SHANG⁴, XIAOXIAO ZHANG⁵, DONGYANG LI⁵, YING KONG^6,*

BIOCELL, Vol.48, No.4, pp. 665-675, 2024, DOI:10.32604/biocell.2024.046342

Abstract Introduction: Myocardial ischemia-reperfusion (IR) injury has received widespread attention due to its damaging effects. Electroacupuncture (EA) pretreatment has preventive effects on myocardial IR injury. SLC26A4 is a Na+ independent anion reverse transporter and has not been reported in myocardial IR injury. Objectives: To find potential genes that may be regulated by EA and explore the role of this gene in myocardial IR injury. Methods: RNA sequencing and bioinformatics analysis were performed to obtain the differentially expressed genes in the myocardial tissue of IR rats with EA pretreatment. Myocardial infarction size was detected by TTC staining. Serum CK, creatinine kinase-myocardial band,… More > Graphic Abstract

Lei Liang, Xiangyang Hu^*

Phyton-International Journal of Experimental Botany, Vol.93, No.3, pp. 517-531, 2024, DOI:10.32604/phyton.2024.049277

Abstract With the rapid development of modern molecular biology and bioinformatics, many studies have proved that transcription factors play an important role in regulating the growth and development of plants. SPATULA (SPT) belongs to the bHLH transcription family and participates in many processes of regulating plant growth and development. This review systemically summarizes the multiple roles of SPT in plant growth, development, and stress response, including seed germination, flowering, leaf size, carpel development, and root elongation, which is helpful for us to better understand the functions of SPT. More >

XIAOFENG GAO^1,2,3,4, JUANJUAN GE³, XUZHENG GAO^1,3, NA MEI^1,3, YANTING SU³, SHIGANG SHAN³, WENBIN QIAN³, JIANGHENG GUAN⁵, ZHENWANG ZHANG^1,3,*, LONG WANG^2,3,4,*

Oncology Research, Vol.32, No.4, pp. 659-678, 2024, DOI:10.32604/or.2023.046712

Abstract Background: IQGAP3 plays a crucial role in regulating cell proliferation, division, and cytoskeletal organization. Abnormal expression of IQGAP3 has been linked to various tumors, but its function in glioma is not well understood. Methods: Various methods, including genetic differential analysis, single-cell analysis, ROC curve analysis, Cox regression, Kaplan-Meier analysis, and enrichment analysis, were employed to analyze the expression patterns, diagnostic potential, prognostic implications, and biological processes involving IQGAP3 in normal and tumor tissues. The impact of IQGAP3 on immune infiltration and the immune microenvironment in gliomas was evaluated using immunofluorescence. Additionally, the cBioPortal database was used to analyze copy number… More > Graphic Abstract

J.N. Chung^a,†, Tailian Chen^b, Shalabh C. Maroo^c

Frontiers in Heat and Mass Transfer, Vol.2, No.2, pp. 1-19, 2011, DOI:10.5098/hmt.v2.2.3004

Abstract Recent research progress in the area of nano/micro scale nucleate boiling is reviewed and an up-to-date summary is provided with a focus on the advances of fundamental boiling physics. This review examines nano/micro scale pool boiling experimental and theoretical/numerical work reported in the open literature. On the experimental side, the topics covered are moving contact line, critical heat flux, boiling curve, nucleation, single bubble boiling cycle, bubble coalescence boiling cycle, heater size effect, nanofluid, and nanoscale-structured heater surface. For the theoretical/numerical work, continuum mechanics modeling of the micro-region and molecular dynamics modeling of the nano-region are included. More >

Zhenhua Yu¹, Zhengqi Liu¹, Xuya Cong^1,*, Xiaobo Li², Li Yin³

CMC-Computers, Materials & Continua, Vol.78, No.1, pp. 1-29, 2024, DOI:10.32604/cmc.2023.042361

Abstract As one of the most effective techniques for finding software vulnerabilities, fuzzing has become a hot topic in software security. It feeds potentially syntactically or semantically malformed test data to a target program to mine vulnerabilities and crash the system. In recent years, considerable efforts have been dedicated by researchers and practitioners towards improving fuzzing, so there are more and more methods and forms, which make it difficult to have a comprehensive understanding of the technique. This paper conducts a thorough survey of fuzzing, focusing on its general process, classification, common application scenarios, and some state-of-the-art techniques that have been… More >

Refah Alotaibi¹, Mazen Nassar^2,3, Ahmed Elshahhat^4,*

CMES-Computer Modeling in Engineering & Sciences, Vol.138, No.3, pp. 2571-2596, 2024, DOI:10.32604/cmes.2023.030582

Abstract A novel extended Lindley lifetime model that exhibits unimodal or decreasing density shapes as well as increasing, bathtub or unimodal-then-bathtub failure rates, named the Marshall-Olkin-Lindley (MOL) model is studied. In this research, using a progressive Type-II censored, various inferences of the MOL model parameters of life are introduced. Utilizing the maximum likelihood method as a classical approach, the estimators of the model parameters and various reliability measures are investigated. Against both symmetric and asymmetric loss functions, the Bayesian estimates are obtained using the Markov Chain Monte Carlo (MCMC) technique with the assumption of independent gamma priors. From the Fisher information… More >