Cong Liu¹, Zhenyu Zhang¹, Ronghua Feng¹, Mengsi Zeng¹, Hui Li¹, Mei Zhu¹, Lan Zhuang^2,*, Zongjuan Li^1,*, Tao Wu^1,*

Oncology Research, Vol.34, No.5, 2026, DOI:10.32604/or.2026.077059 - 22 April 2026

Abstract Background: Breast cancer is the leading cause of cancer-related deaths in women, primarily due to distant metastasis. Metabolic reprogramming plays a critical role in tumor growth and spread, but the metabolic mechanisms underlying metastasis in breast cancer remain unclear. The primary objective of this study is to identify molecular targets mediating breast cancer progression and to evaluate whether targeting the metabolic reprogramming represents a potential therapeutic strategy. Methods: To uncover key metabolic regulators involved in breast cancer progression, we analyzed high-throughput RNA sequencing data and identified Paired Like Homeodomain 1 (PITX1) as a frequently upregulated… More >

Edward Sutanto¹, Rinni Sutanto², Sara Velichkovikj³, Nikola Hadzi-Petrushev⁴, Mitko Mladenov⁴, Dimiter Avtanski^5,6,7, Radoslav Stojchevski^5,6,8,*

Oncology Research, Vol.34, No.5, 2026, DOI:10.32604/or.2026.076157 - 22 April 2026

Abstract The rapid growth and accessibility of artificial intelligence (AI) and machine learning (ML) have opened many avenues to revolutionize biomedical research, particularly in oncogenesis. Oncogenesis is a hallmark process in the development of cancer, involving the amplification of proto-oncogenes and the subsequent dysregulation of molecular signaling networks. These pathways—including the RAS/RAF/MEK/ERK, PI3K-AKT, JAK-STAT, TGF-β/Smad, Wnt/β-Catenin, and Notch cascades—have been studied extensively in isolation, with major strides achieved in understanding how they drive cancer. However, there are still many considerations regarding how these networks interact. Ongoing studies show that crosstalk among these pathways occurs through feedback… More >

Yan Zhu^1,#, Bin Guan^1,#, Wencai Guan¹, Jihong Zhang¹, Shiyu Wang¹, Jimin Shi¹, Wei Fan¹, Qi Lu^2,3, Lingyun Zhang^4,5,*, Guoxiong Xu^1,2,*

Oncology Research, Vol.34, No.5, 2026, DOI:10.32604/or.2026.075241 - 22 April 2026

Abstract Background: Ovarian cancer poses the greatest threat to survival among gynecologic cancers in women. Long non-coding RNAs (lncRNAs) have emerged as critical regulators in oncogenesis. The current study aimed to elucidate the function and regulatory mechanism of lncRNA KRT7-AS in ovarian cancer. Methods: The clinical significance of KRT7-AS was evaluated through bioinformatics analysis of data from public repositories. KRT7-AS expression was examined by RT-qPCR and fluorescence in situ hybridization. The function analyses were conducted using assays for cell proliferation, migration, invasion, wound healing, and colony formation. Assessment of cell cycle and apoptosis was performed using flow… More >

Aleksander Strąk¹, Ludmiła Grzybowska-Szatkowska^1,*, Paweł Cisek¹, Marta Ostrowska-Leśko², Jarosław Dudka², Joanna Kubik³, Jacek Osuchowski⁴, Paweł Szmygin⁴, Bożena Jarosz⁴, Andrzej Krajka⁵, Tomasz Krajka⁶, Kazimierz Szatkowski⁷, Brygida Ślaska⁸

Oncology Research, Vol.34, No.5, 2026, DOI:10.32604/or.2026.074078 - 22 April 2026

Abstract Objectives: Brain gliomas are among the tumors with the worst prognosis, and their incidence is increasing. Postoperative temozolomide-based chemoradiotherapy for grades 3 and 4 gliomas extended overall survival (OS) by approximately two months. An increasing number of clinical trials are investigating molecular-based therapy. Recent studies have demonstrated the involvement of Golgi apparatus proteins, including MYO18A (myosin-18A), in processes associated with abnormal proliferation, migration, apoptosis evasion, and angiogenesis promotion. The aim of this study was to investigate whether MYO18A has prognostic value in patients treated for brain gliomas. Methods: The research material in the work included… More >

Jun-Hui Chen¹, Si-Run Du¹, Chang Liu¹, Bei-Bei Liu¹, Hai-Ying Xu², Xin-Ying Ji², Bo Feng³, Chun-Zheng Ma³, Jun-Hui Guo^3,*

Oncology Research, Vol.34, No.5, 2026, DOI:10.32604/or.2026.073484 - 22 April 2026

Abstract Esophageal cancer (EC) ranks among the most lethal gastrointestinal malignancies. Due to challenges in early diagnosis, molecular heterogeneity, and therapeutic resistance, patient prognosis remains extremely poor, necessitating the development of novel biomarkers and therapeutic targets. As a core effector of the Hippo signaling pathway, the potential significance of Yes-associated protein 1 (YAP1) has garnered increasing attention. This paper aims to systematically summarize the multi-omics research, molecular mechanisms, and preclinical/translational evidence for YAP1, covering its activation pathways, biological functions, clinical significance, and therapeutic strategies. We elucidated YAP1’s multidimensional regulatory network in EC, including Hippo-dependent and -independent mechanisms, cross-regulation… More >

Yung-Chieh Huang^1,2,3, Wen-Chien Cheng^4,5, Ya-Hsuan Chao⁶, Tzu-Ting Chen^7,*, Chi-Chen Lin^8,9,10,11,*

BIOCELL, Vol.50, No.4, 2026, DOI:10.32604/biocell.2025.072732 - 21 April 2026

Abstract Protein arginine deiminases (PADs) are key enzymes in the development of rheumatoid arthritis (RA), catalyzing the conversion of arginine to citrulline in a process called citrullination. This post-translational modification is crucial to RA pathogenesis as it creates neo-antigens that trigger the production of anti-citrullinated protein antibodies (ACPAs). These ACPAs are highly specific to RA and often appear before clinical symptoms, making them valuable biomarkers for diagnosis and prognosis. Beyond ACPA production, PADs, particularly PAD4, play a vital role in forming neutrophil extracellular traps (NETs). NETs contribute to inflammation and joint damage, further highlighting the importance… More > Graphic Abstract

Leonard G. Gomella

Canadian Journal of Urology, Vol.33, No.2, pp. 233-234, 2026, DOI:10.32604/cju.2026.083134 - 20 April 2026

Abstract This article has no abstract. More >

Kuok Ho Daniel Tang^*

Journal of Polymer Materials, Vol.43, No.1, 2026, DOI:10.32604/jpm.2025.074391 - 03 April 2026

Abstract Biobased biodegradable plastics have gained increasing attention as sustainable alternatives to petroleum-based materials in food packaging, offering biodegradability, renewability, and reduced environmental impact. This review adopts a narrative review approach, integrating studies published between 2015 and 2025 from major databases to critically evaluate the recent advances, feasibility, and limitations of biobased biodegradable plastics in food packaging. Literature was thematically analyzed by material type and functional enhancement to assess their feasibility and limitations for sustainable packaging applications. Recent advances have focused on enhancing their mechanical, barrier, and functional properties through polymer blending, nanoparticle reinforcement, and incorporation… More >

Mete Han Kizilkaya¹, Boran Cakan^2,3,*, Mehmet Bicer⁴, Ender Odemis^1,5

Structural and Congenital Heart Disease, Vol.21, No.1, 2026, DOI:10.32604/schd.2026.074189 - 31 March 2026

Abstract Background: Transcatheter closure of perimembranous ventricular septal defects (pmVSDs) with Lifetech™ Konar-Multifunctional Occluder (MFO) has demonstrated high procedural success and safety. However, long-term complications due to valve–device interaction are rarely reported. We describe a pediatric patient who developed progressive right ventricular outflow tract (RVOT) obstruction and severe tricuspid regurgitation 20 months after MFO closure, highlighting mechanisms, management, and outcomes. Case Description: A 13-year-old girl underwent successful MFO closure of a 6-mm pmVSD. Early follow-up showed trivial tricuspid regurgitation and mild subpulmonic stenosis. Pre-procedural imaging revealed right ventricular hypertrophy caused by long-standing jet-related turbulence from the pmVSD, with… More >

Yen-Pin Chen^1,2,3, Rathinasamy Baskaran⁴, Hema Sri Devi⁴, Chaouhan Hitesh Singh⁴, Yu-Jung Lin^4,5, Marthandam Asokan Shibu⁶, Wei-Wen Kuo⁷, Shih-Chieh Liao⁸, Ming-Cheng Chen⁹, Tso-Fu Wang¹⁰, Chi-Cheng Li¹¹, Tsung-Jung Ho¹², Tzu-Ching Shih¹³, Shinn-Zong Lin^14,15,16,*, Chih-Yang Huang^4,17,18,19,*

Oncology Research, Vol.34, No.4, 2026, DOI:10.32604/or.2026.073080 - 23 March 2026

Abstract Objective: MicroRNAs (miRNAs) are small, non-coding RNAs that play a key role in the development of chemoresistance in various cancer types, including colorectal cancer (CRC). In this study, we aimed to study the underlying mechanisms of miRNA in chemotherapy-resistant CRC. Methods: LoVo CRC cell line was exposed to oxaliplatin at an increased dose, and cells were cultured in the presence of oxaliplatin to develop LoVoOXR cells. Microarray and Quantitative Reverse Transcription Polymerase Chain Reaction (qRT-PCR), western blot, and transwell assay were used to evaluate the chemoresistance in LoVo^OXR CRC cells. Results: Microarray and qRT-PCR analysis showed… More >