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  • Open Access

    ARTICLE

    Tmem39b promotes tumor progression and sorafenib resistance by inhibiting ferroptosis in hepatocellular carcinoma

    MING ZHUANG, XUE ZHANG, LU LI, LIMING WEN, JIAMIN QIN*

    Oncology Research, Vol.32, No.8, pp. 1347-1357, 2024, DOI:10.32604/or.2024.046170 - 17 July 2024

    Abstract Hepatocellular carcinoma (HCC) poses a significant threat to human health. Resistance to sorafenib in the chemotherapy of HCC is a common and significant issue that profoundly impacts clinical treatment. While several members of the transmembrane (TMEM) protein family have been implicated in the occurrence and progression of HCC, the association between TMEM39b and HCC remains unexplored. This study revealed a significant overexpression of TMEM39b in HCC, which correlated with a poor prognosis. Subsequent investigation revealed that RAS-selective lethal 3 (RSL3) induced pronounced ferroptosis in HCC, and knocking down the expression of TMEM39b significantly decreased its More >

  • Open Access

    ARTICLE

    Evaluations of Chris-Jerry Data Using Generalized Progressive Hybrid Strategy and Its Engineering Applications

    Refah Alotaibi1, Hoda Rezk2, Ahmed Elshahhat3,*

    CMES-Computer Modeling in Engineering & Sciences, Vol.140, No.3, pp. 3073-3103, 2024, DOI:10.32604/cmes.2024.050606 - 08 July 2024

    Abstract A new one-parameter Chris-Jerry distribution, created by mixing exponential and gamma distributions, is discussed in this article in the presence of incomplete lifetime data. We examine a novel generalized progressively hybrid censoring technique that ensures the experiment ends at a predefined period when the model of the test participants has a Chris-Jerry (CJ) distribution. When the indicated censored data is present, Bayes and likelihood estimations are used to explore the CJ parameter and reliability indices, including the hazard rate and reliability functions. We acquire the estimated asymptotic and credible confidence intervals of each unknown quantity. More >

  • Open Access

    ARTICLE

    Bayesian and Non-Bayesian Analysis for the Sine Generalized Linear Exponential Model under Progressively Censored Data

    Naif Alotaibi1, A. S. Al-Moisheer2, Ibrahim Elbatal1, Mohammed Elgarhy3,4, Ehab M. Almetwally1,5,*

    CMES-Computer Modeling in Engineering & Sciences, Vol.140, No.3, pp. 2795-2823, 2024, DOI:10.32604/cmes.2024.049188 - 08 July 2024

    Abstract This article introduces a novel variant of the generalized linear exponential (GLE) distribution, known as the sine generalized linear exponential (SGLE) distribution. The SGLE distribution utilizes the sine transformation to enhance its capabilities. The updated distribution is very adaptable and may be efficiently used in the modeling of survival data and dependability issues. The suggested model incorporates a hazard rate function (HRF) that may display a rising, J-shaped, or bathtub form, depending on its unique characteristics. This model includes many well-known lifespan distributions as separate sub-models. The suggested model is accompanied with a range of More >

  • Open Access

    ARTICLE

    Silvestrol alleviates glioblastoma progression through ERK pathway modulation and MANBA and NRG-1 expression

    LAN ZHOU1,#, QI ZHANG2,#, BO TIAN1,*, FENG YANG1,*

    BIOCELL, Vol.48, No.7, pp. 1081-1093, 2024, DOI:10.32604/biocell.2024.049878 - 03 July 2024

    Abstract Background: Glioblastoma, a notably malignant tumor within the central nervous system, is distinguished by its aggressive behavior. Silvestrol, a robust inhibitor of the RNA helicase eukaryotic initiation factor 4A (eIF4A), has shown significant potential as an anticancer compound. Yet, the impact of silvestrol on glioblastoma, especially its molecular mechanisms, has not been fully elucidated. Methods: This investigation employed a variety of in vitro assays, such as cell counting kit-8 (CCK-8), clonogenic, 5-ethynyl-2′-deoxyuridine (EDU), wound healing, and flow cytometry, to evaluate cell cycle progression, apoptosis, cell viability, and migration. Western blot analysis was also performed to study… More >

  • Open Access

    REVIEW

    Research Progress on Plant Anti-Freeze Proteins

    Zhengyang Zhang#, Weixue Liu#, Yinran Huang*, Ping Li*

    Phyton-International Journal of Experimental Botany, Vol.93, No.6, pp. 1263-1274, 2024, DOI:10.32604/phyton.2024.050755 - 27 June 2024

    Abstract Plant antifreeze proteins (AFPs) are special proteins that can protect plant cells from ice crystal damage in low-temperature environments, and they play a crucial role in the process of plants adapting to cold environments. Proteins with these characteristics have been found in fish living in cold regions, as well as many plants and insects. Although research on plant AFPs started relatively late, their application prospects are broad, leading to the attention of many researchers to the isolation, cloning, and genetic improvement of plant AFP genes. Studies have found that the distribution of AFPs in different species… More >

  • Open Access

    ARTICLE

    LncRNA PCGEM1 facilitates cervical cancer progression via miR-642a-5p/KIF5B axis

    YUANLIN LIU1,3,#, YAN LIU2,#, YAN WANG2, QIANG WANG2, YAN YAN1, DANDAN ZHANG2,*, HUIQIN LIU2,*

    Oncology Research, Vol.32, No.7, pp. 1221-1229, 2024, DOI:10.32604/or.2024.047454 - 20 June 2024

    Abstract At present, the role of many long non-coding RNAs (lncRNAs) as tumor suppressors in the formation and development of cervical cancer (CC) has been studied. However, lncRNA prostate cancer gene expression marker 1 (PCGEM1), whose high expression not only aggravates ovarian cancer but also can induce tumorigenesis and endometrial cancer progression, has not been studied in CC. The objective of this study was to investigate the expression and the underlying role of PCGEM1 in CC. The relative expression of PCGEM1 in CC cells was detected by real-time PCR. After the suppression of PCGEM1 expression by… More > Graphic Abstract

    LncRNA PCGEM1 facilitates cervical cancer progression via miR-642a-5p/KIF5B axis

  • Open Access

    ARTICLE

    Silencing of the long non-coding RNA LINC00265 triggers autophagy and apoptosis in lung cancer by reducing protein stability of SIN3A oncogene

    XIAOBI HUANG1,#, CHUNYUAN CHEN2, YONGYANG CHEN1,#, HONGLIAN ZHOU1, YONGHUA CHEN1, ZHONG HUANG1, YULIU XIE1, BAIYANG LIU1, YUDONG GUO1, ZHIXIONG YANG1, GUANGHUA CHEN3,*, WENMEI SU1,4,*

    Oncology Research, Vol.32, No.7, pp. 1185-1195, 2024, DOI:10.32604/or.2023.030771 - 20 June 2024

    Abstract Background: Long non-coding RNAs are important regulators in cancer biology and function either as tumor suppressors or as oncogenes. Their dysregulation has been closely associated with tumorigenesis. LINC00265 is upregulated in lung adenocarcinoma and is a prognostic biomarker of this cancer. However, the mechanism underlying its function in cancer progression remains poorly understood. Methods: Here, the regulatory role of LINC00265 in lung adenocarcinoma was examined using lung cancer cell lines, clinical samples, and xenografts. Results: We found that high levels of LINC00265 expression were associated with shorter overall survival rate of patients, whereas knockdown of LINC00265 inhibited proliferation… More >

  • Open Access

    REVIEW

    A Research Progress of CO2-Responsive Plugging Channeling Gels

    Yang Xiong1,2, Jianxin Liu1,2,*, Xianhao Yi2, Bangyan Xiao2, Dan Wu2, Biao Wu2, Chunyu Gao2

    Energy Engineering, Vol.121, No.7, pp. 1759-1780, 2024, DOI:10.32604/ee.2024.048536 - 11 June 2024

    Abstract In the heterogeneous reservoirs, CO2 flooding easily leads to CO2 gas channeling, which can seriously affect sweeping efficiency and reduce oil recovery. After thoroughly investigating the advantages and shortcomings of various CO2 plugging technologies, this paper focuses on the feasibility of improving conventional water-alternating gas (WAG) through CO2-responsive gel materials. Based on the different chemical reaction mechanisms between the unique chemical structure and CO2, changes in the material’s physical and chemical properties can respond to CO2. The feasibility of utilizing these property changes for CO2-responsive plugging is explored. Various CO2-responsive gels and gel nanoparticles have been extensively researched in More >

  • Open Access

    REVIEW

    Research progress on natural products against hepatocellular carcinoma

    LINGLI ZHANG1,2,#, YAN LI1,#, JINGXIN MAO1,*

    BIOCELL, Vol.48, No.6, pp. 905-922, 2024, DOI:10.32604/biocell.2024.050396 - 10 June 2024

    Abstract Hepatocellular carcinoma (HCC) remains a prevalent and challenging malignancy globally, characterized by its numerous causal factors and generally unfavorable prognosis. In the relentless pursuit of effective treatment modalities, natural products have emerged as a promising and relatively non-toxic alternative, garnering significant interest. The integration of natural products with contemporary medical research has yielded encouraging therapeutic outcomes in the management of HCC. This review offers a comprehensive overview of the causal factors underlying HCC, and the diverse treatment options available, and highlights the advancements made by natural products in anti-HCC research. Particularly, we provide an outline More >

  • Open Access

    RETRACTION

    Retraction: KIF18A is a potential prognostic factor and promotes tumor progression in oral tongue squamous cell carcinoma

    BIOCELL Editorial Office

    BIOCELL, Vol.48, No.6, pp. 1009-1009, 2024, DOI:10.32604/biocell.2024.054510 - 05 June 2024

    Abstract This article has no abstract. More >

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