J.N. Chung^a,†, Tailian Chen^b, Shalabh C. Maroo^c

Frontiers in Heat and Mass Transfer, Vol.2, No.2, pp. 1-19, 2011, DOI:10.5098/hmt.v2.2.3004

Abstract Recent research progress in the area of nano/micro scale nucleate boiling is reviewed and an up-to-date summary is provided with a focus on the advances of fundamental boiling physics. This review examines nano/micro scale pool boiling experimental and theoretical/numerical work reported in the open literature. On the experimental side, the topics covered are moving contact line, critical heat flux, boiling curve, nucleation, single bubble boiling cycle, bubble coalescence boiling cycle, heater size effect, nanofluid, and nanoscale-structured heater surface. For the theoretical/numerical work, continuum mechanics modeling of the micro-region and molecular dynamics modeling of the nano-region are included. More >

Zhenhua Yu¹, Zhengqi Liu¹, Xuya Cong^1,*, Xiaobo Li², Li Yin³

CMC-Computers, Materials & Continua, Vol.78, No.1, pp. 1-29, 2024, DOI:10.32604/cmc.2023.042361

Abstract As one of the most effective techniques for finding software vulnerabilities, fuzzing has become a hot topic in software security. It feeds potentially syntactically or semantically malformed test data to a target program to mine vulnerabilities and crash the system. In recent years, considerable efforts have been dedicated by researchers and practitioners towards improving fuzzing, so there are more and more methods and forms, which make it difficult to have a comprehensive understanding of the technique. This paper conducts a thorough survey of fuzzing, focusing on its general process, classification, common application scenarios, and some state-of-the-art techniques that have been… More >

Refah Alotaibi¹, Mazen Nassar^2,3, Ahmed Elshahhat^4,*

CMES-Computer Modeling in Engineering & Sciences, Vol.138, No.3, pp. 2571-2596, 2024, DOI:10.32604/cmes.2023.030582

Abstract A novel extended Lindley lifetime model that exhibits unimodal or decreasing density shapes as well as increasing, bathtub or unimodal-then-bathtub failure rates, named the Marshall-Olkin-Lindley (MOL) model is studied. In this research, using a progressive Type-II censored, various inferences of the MOL model parameters of life are introduced. Utilizing the maximum likelihood method as a classical approach, the estimators of the model parameters and various reliability measures are investigated. Against both symmetric and asymmetric loss functions, the Bayesian estimates are obtained using the Markov Chain Monte Carlo (MCMC) technique with the assumption of independent gamma priors. From the Fisher information… More >

SHUHUI WU^1,2,#, PING XU^3,#, XIANGBIN XU², SONG-BAI LIU^1,2,*

BIOCELL, Vol.47, No.11, pp. 2385-2395, 2023, DOI:10.32604/biocell.2023.029687

Abstract Nucleic acid (DNA and RNA) detection and quantification methods play vital roles in molecular biology. With the development of molecular biology, isothermal amplification of DNA/RNA, as a new molecular biology technology, can be amplified under isothermal condition, it has the advantages of high sensitivity, high specificity, and high efficiency, and has been applied in various fields of biotechnology, including disease diagnosis, pathogen detection, food hygiene and safety detection and so on. This paper introduces the progress of isothermal amplification technology, including rolling circle amplification (RCA), nucleic acid sequence-dependent amplification (NASBA), strand displacement amplification (SDA), loop-mediated isothermal amplification (LAMP), helicase-dependent amplification… More >

J. N. Chung^*, Kun Yuan

Frontiers in Heat and Mass Transfer, Vol.6, pp. 1-7, 2015, DOI:10.5098/hmt.6.1

Abstract Chilldown or quenching is a complicated process that initiates the cryogenic fluid line transport, and it involves unsteady two-phase heat and mass transfer. To advance our understanding of this process, we have reviewed recent experimental investigations. The chilldown process can be generally divided into three regimes: film boiling, transition boiling and nucleate boiling, and each regime is associated with a different flow pattern and heat transfer mechanism. Under low flow rate conditions, it is concluded that the two-phase flow regime is dispersed flow in the film boiling regime. The dispersed liquid phase is in the form of long filaments as… More >

GERWIN HELLER^1,*, THORSTEN FUEREDER¹, ALEXANDER MICHAEL GRANDITS¹, ROTRAUD WIESER^1,2,*

Oncology Research, Vol.32, No.1, pp. 1-17, 2024, DOI:10.32604/or.2023.044774

Abstract Head and neck squamous cell carcinoma (HNSCC) is one of the most frequent cancers worldwide. The main risk factors are consumption of tobacco products and alcohol, as well as infection with human papilloma virus. Approved therapeutic options comprise surgery, radiation, chemotherapy, targeted therapy through epidermal growth factor receptor inhibition, and immunotherapy, but outcome has remained unsatisfactory due to recurrence rates of ~50% and the frequent occurrence of second primaries. The availability of the human genome sequence at the beginning of the millennium heralded the omics era, in which rapid technological progress has advanced our knowledge of the molecular biology of… More >

YUN ZHANG^1,2,#, SHALING TANG^1,2,#, YUBO GAO^1,2, ZHONGTING LU^1,2, YUAN YANG^1,2, JING CHEN³, TAO LI^4,*

Oncology Research, Vol.32, No.1, pp. 61-71, 2024, DOI:10.32604/or.2023.043481

Abstract Colorectal cancer (CRC) is a major global health problem with high morbidity and mortality rates. Surgical resection is the main treatment for early-stage CRC, but detecting it early is challenging. Therefore, effective therapeutic targets for advanced patients are still lacking. Exosomes, tiny vesicles in body fluids, play a crucial role in tumor metastasis, immune regulation, and drug resistance. Interestingly, they can even serve as a biomarker for cancer diagnosis and prognosis. Studies have shown that exosomes can carry miRNA, mediate the polarization of M1/M2 macrophages, promote the proliferation and metastasis of cancer cells, and affect the prognosis of CRC. Since… More > Graphic Abstract

JIAZHUANG LI^*, WEI ZHANG, SHOUBAO GAO, LI SUN, QINGYANG TAI, YING LIU

BIOCELL, Vol.47, No.10, pp. 2313-2320, 2023, DOI:10.32604/biocell.2023.029860

Abstract Background: Trastuzumab resistance accounts for chemotherapy failure in gastric cancer patients in clinical practice. The significance of long non-coding RNAs (lncRNAs) in the maintenance of drug resistance in gastric cancer has been already underlined. Method: This study aimed to identify the specific role of lncRNA-ATB in gastric cancer progression and trastuzumab resistance. The downstream miRs of lncRNA-ATB and target genes of miRs were predicted by bioinformatics analysis and verified using dual luciferase reporter assay. Loss- and gain-function assays were performed to explore the roles of lncRNA-ATB, miR-200c, and zinc-finger protein 217 (ZNF217) in the cell functions and trastuzumab resistance of… More >

LINGYAN LV^1,2,#, JING ZHAO^1,2,#, XUAN WANG^1,2, LIUYAN XU^1,2, YINGYI FAN², CHUNHUI WANG³, HONGQIAO FAN^4,5,*, XIAOHUA PEI^5,*

BIOCELL, Vol.47, No.9, pp. 1977-1994, 2023, DOI:10.32604/biocell.2023.030742

Abstract Background: The development and prognosis of breast cancer are intricately linked to psychological stress. In addition, depression is the most common psychological comorbidity among breast cancer survivors, and reportedly, Fang-Xia-Dihuang decoction (FXDH) can effectively manage depression in such patients. However, its pharmacological and molecular mechanisms remain obscure. Methods: Public databases were used for obtaining active components and related targets. Main active components were further verified by ultra-high-performance liquid chromatography-high-resolution mass spectrometry (UPLC-HRMS). Protein–protein interaction and enrichment analyses were taken to predict potential hub targets and related pathways. Molecule docking was used to understand the interactions between main compounds and hub… More >

WEI DU¹, FANG YIN¹, YATING ZHONG¹, MINJIE LUO¹, ZHEN WANG², PENG LIN², QING LIU^2,*, HAN YANG^2,*

Oncology Research, Vol.31, No.6, pp. 929-936, 2023, DOI:10.32604/or.2023.030611

Abstract Non-small cell lung cancer (NSCLC) is a highly lethal cancer, and better treatments are urgently needed. Many studies have implicated circular RNAs (circRNAs) in the progression of multiple malignant tumors. Nonetheless, the functions of circRNAs in NSCLC remain unclear. To study new targets for the treatment of NSCLC, circRNA expression profiling was performed on NSCLC tissues and para-carcinoma nonmalignant tissues. RNA was isolated and used for circRNA sequencing. Biological studies were performed in vitro and in vivo to determine the functions of circRNAs in NSCLC, including their functions in cell proliferation and migration. How circRNAs function in NSCLC was explored… More > Graphic Abstract