Xin Yin^1,#, Shuai Wang^1,#, Chunguang Wang¹, Haichao Wang², Zheying Zong^1,3,*, Zeyu Ban¹

Phyton-International Journal of Experimental Botany, Vol.93, No.5, pp. 843-858, 2024, DOI:10.32604/phyton.2024.049114 - 28 May 2024

Abstract This study employed the bibliometric software CiteSpace 6.1.R6 to analyze the correlation between thermal infrared, spectral remote sensing technology, and the estimation of economic forest water stress. It aimed to review the development and current status of this field, as well as to identify future research trends. A search was conducted on the China National Knowledge Infrastructure (CNKI) database using the keyword “water stress” for relevant studies from 2003 to 2023. The visual analysis function of CNKI was used to generate the distribution of annual publication volume, and CiteSpace 6.1.R6 was utilized to create network More >

MAHER KURDI^1,*, ALAA ALKHOTANI², ABDULRAHMAN SABBAGH³, EYAD FAIZO⁴, AHMED I. LARY⁵, AHMED K. BAMAGA⁶, MAJID ALMANSOURI⁷, BADR HAFIZ⁸, THAMER ALSHARIF⁹, SALEH BAEESA⁸

Oncology Research, Vol.32, No.6, pp. 1037-1045, 2024, DOI:10.32604/or.2024.051112 - 23 May 2024

Abstract Background: The dysregulation of Isocitrate dehydrogenase (IDH) and the subsequent production of 2-Hydroxyglutrate (2HG) may alter the expression of epigenetic proteins in Grade 4 astrocytoma. The interplay mechanism between IDH, O-6-methylguanine-DNA methyltransferase (MGMT)-promoter methylation, and protein methyltransferase proteins-5 (PRMT5) activity, with tumor progression has never been described. Methods: A retrospective cohort of 34 patients with G4 astrocytoma is classified into IDH-mutant and IDH-wildtype tumors. Both groups were tested for MGMT-promoter methylation and PRMT5 through methylation-specific and gene expression PCR analysis. Inter-cohort statistical significance was evaluated. Results: Both IDH-mutant WHO grade 4 astrocytomas (n = 22, 64.7%) and IDH-wildtype… More > Graphic Abstract

JUNZHE YI^1,#, BINBIN LI^2,#, XIAOMIN YIN³, LINGRUI LIU¹, CAILU SONG¹, YING ZHAO⁴, MANBO CAI³, HAILIN TANG¹, DONG CHEN^4,*, NING LYU^1,*

Oncology Research, Vol.32, No.6, pp. 1129-1139, 2024, DOI:10.32604/or.2024.047524 - 23 May 2024

Abstract Circular RNAs (circRNAs) have been recognized as pivotal regulators in tumorigenesis, yet the biological functions as well as molecular mechanisms of the majority of circRNAs in hepatocellular carcinoma (HCC) remain elusive. We sought to unveil the expression profile and biological role of circMYBL2 in HCC. Initial microarray analyses were conducted to probe the expression profile of circMYBL2 in HCC cells, and qRT‒PCR analysis was then performed in HCC cell lines and tissues, revealing significant upregulation of circMYBL2. Subsequent experiments were conducted to evaluate the biological function of circMYBL2 in HCC progression. Furthermore, bioinformatics analysis, qRT‒PCR… More >

Xiaoli You^1,2,3,, Ruiyu Bai^1,2,3,4,, Kai Xue^1,2,3, Zimo Zhang^1,2,3, Minghao Wang⁵, Xuanqi Wang^1,2,3, Jiahao Wang^1,2,3, Jinku Guo^1,2, Qiang Shen³, Honglong Chang³, Xu Long^6,*, Bowen Ji^1,2,3,*

CMES-Computer Modeling in Engineering & Sciences, Vol.140, No.2, pp. 1205-1231, 2024, DOI:10.32604/cmes.2024.049047 - 20 May 2024

Abstract Implanted neural probes can detect weak discharges of neurons in the brain by piercing soft brain tissue, thus as important tools for brain science research, as well as diagnosis and treatment of brain diseases. However, the rigid neural probes, such as Utah arrays, Michigan probes, and metal microfilament electrodes, are mechanically unmatched with brain tissue and are prone to rejection and glial scarring after implantation, which leads to a significant degradation in the signal quality with the implantation time. In recent years, flexible neural electrodes are rapidly developed with less damage to biological tissues, excellent… More >

Haixia Kou^1,*, Bowen Yang¹, Xuyao Zhang², Xiaobo Yang¹, Haibo Zhao¹

Structural Durability & Health Monitoring, Vol.18, No.3, pp. 277-297, 2024, DOI:10.32604/sdhm.2024.045023 - 15 May 2024

Abstract Given the difficulty in accurately evaluating the fatigue performance of large composite wind turbine blades (referred to as blades), this paper takes the main beam structure of the blade with a rectangular cross-section as the simulation object and establishes a composite laminate rectangular beam structure that simultaneously includes the flange, web, and adhesive layer, referred to as the blade main beam sub-structure specimen, through the definition of blade sub-structures. This paper examines the progressive damage evolution law of the composite laminate rectangular beam utilizing an improved 3D Hashin failure criterion, cohesive zone model, B-K failure More > Graphic Abstract

CHENG-GONG LUO^1,2,#, JIAO ZHANG^1,#, YUN-ZHAO AN¹, XUAN LIU¹, SHUAI-JIE LI¹, WEI ZHANG¹, KAI LI¹, XU ZHAO¹, DONG-BO YUAN¹, LING-YUE AN¹, WEI CHEN², YE TIAN^1,*, BIN XU^1,*

BIOCELL, Vol.48, No.5, pp. 771-792, 2024, DOI:10.32604/biocell.2024.048878 - 06 May 2024

Abstract Background: Ferroptosis, a lipid peroxidation-mediated programmed cell death, is closely linked to tumor development, including prostate cancer (PCa). Despite established connections between ferroptosis and PCa, a comprehensive investigation is essential for understanding its impact on patient prognosis. Methods: A risk model incorporating four ferroptosis-related genes was developed and validated. Elevated risk scores correlated with an increased likelihood of biochemical recurrence (BCR), diminished immune infiltration, and adverse clinicopathological characteristics. To corroborate these results, we performed validation analyses utilizing datasets from both the Cancer Genome Atlas Cohort (TCGA) and the Gene Expression Synthesis Cohort (GEO). Moreover, we conducted… More >

XINRU FENG¹, LI XIAO^2,*

BIOCELL, Vol.48, No.5, pp. 793-801, 2024, DOI:10.32604/biocell.2024.048395 - 06 May 2024

Abstract Background: Galectin 2 (LGALS2) is a protein previously reported to serve as a mediator of disease progression in a range of cancers. The function of LGALS2 in oral squamous cell carcinoma (OSCC), however, has yet to be explored, prompting the present study to address this literature gap. Methods: Overall, 144 paired malignant tumor tissues and paracancerous OSCC patient samples were harvested and the LGALS2 expression levels were examined through qPCR and western immunoblotting. The LGALS2 coding sequence was introduced into the pcDNA3.0 vector, to enable the overexpression of this gene, while an LGALS2-specific shRNA and… More >

JING HUI^1,2, NANA SUN³, YONG LIU⁴, CHUNBO YU^1,2, YONG KE⁴, YONG CAO⁴, ANXIAO YU⁴, QINGHONG KONG^1,2,*, YUN LIU^1,2,4,*

BIOCELL, Vol.48, No.5, pp. 803-815, 2024, DOI:10.32604/biocell.2024.047122 - 06 May 2024

Abstract Background: Although it has been established that the human Solute Carrier Family 22 (SLC22) functions as a cationic transporter, influencing cellular biological metabolism by modulating the uptake of various cations, its impact on cancer prognosis remains unclear. Methods: We conducted a comprehensive analysis utilizing data from The Cancer Genome Atlas (TCGA) and other databases to assess the prognostic value and functional implications across various tumors. Silence of SLC22A1 RNA in glioma U251 cells was performed to access the impact of SLC22A1 on lower-grade glioma (LGG) progression. Results: Our findings demonstrated a significant correlation between SLC22A1 expression… More >

Qi Lu^1,2, Longfei Jin², Cuiling Tong³, Feng Liu², Bei Huang², Dejian Zhang^1,2,*

Phyton-International Journal of Experimental Botany, Vol.93, No.4, pp. 661-679, 2024, DOI:10.32604/phyton.2024.049733 - 29 April 2024

Abstract A Plant Biostimulant is any substance or microorganism applied to plants to enhance nutrition efficiency, abiotic stress tolerance, and/or crop quality traits, regardless of its nutrient content. The application of Plant biostimulants (PBs) in production can reduce the application of traditional pesticides and chemical fertilizers and improve the quality and yield of crops, which is conducive to the sustainable development of agriculture. An in-depth understanding of the mechanism and effect of various PBs is very important for how to apply PBs reasonably and effectively in the practice of crop production. This paper summarizes the main More >

ANDI ZHAO^1,2,#, YUE WANG^3,#, ZIJIN WANG^1,2, QING SHAO^1,2, QI GONG^1,2, HUI ZHU^1,2, SHIYA SHEN^1,2, HU LIU^1,2,*, XUEJUAN CHEN^1,2,*

Oncology Research, Vol.32, No.5, pp. 983-998, 2024, DOI:10.32604/or.2024.045972 - 23 April 2024

Abstract Numerous studies have characterized the critical role of circular RNAs (circRNAs) as regulatory factors in the progression of multiple cancers. However, the biological functions of circRNAs and their underlying molecular mechanisms in the progression of uveal melanoma (UM) remain enigmatic. In this study, we identified a novel circRNA, circ_0053943, through re-analysis of UM microarray data and quantitative RT-PCR. Circ_0053943 was found to be upregulated in UM and to promote the proliferation and metastatic ability of UM cells in both in vitro and in vivo settings. Mechanistically, circ_0053943 was observed to bind to the KH1 and KH2 domains of insulin-like… More > Graphic Abstract