Thomas Kidu¹, Harini Kethar², Haben Gebrekidan³, Haleem Farman⁴, Ahmed Sedik^4,5, Walid El-Shafai^6,7, Jawad Khan^8,*

CMES-Computer Modeling in Engineering & Sciences, Vol.146, No.2, 2026, DOI:10.32604/cmes.2026.076798 - 26 February 2026

Abstract Colorectal cancer is the third most diagnosed cancer worldwide, and immune checkpoint inhibitors have shown promising therapeutic outcomes in selected patient groups. This study performed a comprehensive analysis of multi-omics data from The Cancer Genome Atlas colorectal adenocarcinoma cohort (TCGA-COADREAD), accessed through cBioPortal, to develop machine learning models for predicting progression-free survival (PFS) following immunotherapy. The dataset included clinical variables, genomic alterations in Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS), B-Raf Proto-Oncogene (BRAF), and Neuroblastoma RAS Viral Oncogene Homolog (NRAS), microsatellite instability (MSI) status, tumor mutation burden (TMB), and expression of immune checkpoint genes. Kaplan–Meier… More >

Oncology Research Editorial Office

Oncology Research, Vol.34, No.3, 2026, DOI:10.32604/or.2026.080055 - 24 February 2026

Abstract This article has no abstract. More >

Pauline Gousseau^#, Laurie Genest, Guillaume Froget, Tristan Rupp^§,*

Oncology Research, Vol.34, No.3, 2026, DOI:10.32604/or.2025.072141 - 24 February 2026

Abstract Objectives: The five-year survival rate for pancreatic cancer is notably low, posing a significant challenge to patient health. The primary treatments are radiotherapy and chemotherapy, sometimes combined with targeted therapy; however, their clinical benefits are limited. Therefore, developing new models to evaluate the therapeutic potential of novel molecules is essential. Fingolimod and Dimethyl Fumarate (DMF), currently used to treat multiple sclerosis, have recently been shown to have anti-cancer effects in several preclinical tumor models. This study aims to evaluate the therapeutic potential of Fingolimod and DMF in pancreatic cancer by investigating their respective in vitro cytotoxicity… More > Graphic Abstract

Gwan Hee Han^1,2,#, Hee Yun^3,#, Joon-Yong Chung⁴, Jae-Hoon Kim^3,5,6, Hanbyoul Cho^3,5,6,*

Oncology Research, Vol.34, No.3, 2026, DOI:10.32604/or.2025.072105 - 24 February 2026

Abstract Objectives: Phosphodiesterase 1A (PDE1A) regulates intracellular cyclic nucleotide signaling and has been implicated in tumor progression, but its clinical relevance and functional role in epithelial ovarian cancer (EOC), particularly in relation to the response to platinum remain unclear. This study aimed to evaluate the clinical significance of PDE1A in EOG and to clarify its functional role in tumor progression and response to platinum-based chemotherapy. Methods: PDE1A mRNA and protein levels were analyzed using public databases, RNA sequencing, and immunohistochemistry. Correlations between PDE1A expression, clinicopathological features, and prognosis were assessed. Functional roles were investigated in ovarian… More >

Guojian Zhou^1,2,#, Rui Zhang^1,#, Lei Nie^1,#, Yi Si¹, Ting Liu¹, Jing Wang¹, Shuangshuang Han¹, Mingda Xuan¹, Jia Wang^3,*, Weifang Yu^1,*

Oncology Research, Vol.34, No.3, 2026, DOI:10.32604/or.2025.070333 - 24 February 2026

Abstract Objectives: Gastric cancer (GC) is among the most prevalent malignancies worldwide, ranking as the fifth most common cancer and the fifth leading cause of cancer-related mortality. This study intends to investigate how Inhibin subunit beta A (INHBA) promotes the progression of GC by activating the mitogen-activated protein kinase (MAPK) signaling pathway via targeting Integrin alpha-6 (ITGA6). Methods: Quantitative reverse transcription-Polymerase Chain Reaction (qRT-PCR) and Immunohistochemistry (IHC) were utilised to validate the expression levels of INHBA in GC, which were subsequently correlated with the clinicopathological factors and outcomes. Cellular and animal studies were conducted to ascertain… More >

Pingping Hu^1,2,#, Zhenhao Fei^1,2,#, Jianhua Bai^1,2, Zhiwen Wang^1,2, Yun Jin^1,2,*

Oncology Research, Vol.34, No.3, 2026, DOI:10.32604/or.2025.070207 - 24 February 2026

Abstract Objectives: Pancreatic cancer (PC) is characterized by poor prognosis due to its limited treatment choices and delayed detection. S100A14 has been implicated in tumor progression, yet its regulatory hierarchy and functional interplay in PC remain unclear. This study aimed to define the role of S100A14 in PC progression. Methods: Integrated bioinformatic analyses of TCGA-PAAD and GSE22780 datasets identified candidate hub genes. Prognostic relevance was assessed via Kaplan-Meier and ROC analyses. Functional experiments were performed in PANC-1 and BxPC-3 cells, including qRT-PCR, CCK-8 assay, Western blotting, Transwell assay, and apoptosis assay. Co-immunoprecipitation (Co-IP) was used to verify… More >

Przemysław Piwowarczyk¹, Justyna Woś¹, Agata Szymańska¹, Sylwia Chocholska², Waldemar Tomczak², Jacek Roliński¹, Agnieszka Bojarska-Junak^1,*

BIOCELL, Vol.50, No.2, 2026, DOI:10.32604/biocell.2025.074128 - 14 February 2026

Abstract Objectives: Chronic lymphocytic leukemia (CLL) is characterized by progressive immune dysregulation. Invariant natural killer T (iNKT) cells support immune surveillance, but the clinical relevance of their regulatory subsets remains unclear. FoxP3⁺ regulatory iNKT cells (iNKTreg) and E4BP4⁺IL-10⁺ (iNKT10) cells may reflect immunoregulatory changes associated with disease progression. The study aimed to quantify circulating iNKTreg and iNKT10 subsets and monocytic myeloid-derived suppressor cells (M-MDSCs) in treatment-naïve CLL patients and evaluate their associations with disease characteristics and time to first treatment (TTFT). Methods: Peripheral blood samples from 60 untreated CLL patients and 20 healthy donors were analyzed by… More >

Zia Ur Rahman¹, Nigar Ali^1,2, Dragan Pamucar³, Imtiaz Ahmad^1,2, Haci Mehmet Baskonus^2,*, Naseer Ul Haq¹, Zeeshan Ali⁴

CMES-Computer Modeling in Engineering & Sciences, Vol.146, No.1, 2026, DOI:10.32604/cmes.2025.070268 - 29 January 2026

Abstract Hepatitis B Virus (HBV) infection and heavy alcohol consumption are the two primary pathogenic causes of liver cirrhosis. In this paper, we proposed a deterministic mathematical model and a logistic equation to investigate the dynamics of liver cirrhosis progression as well as to explain the implications of variations in alcohol consumption on chronic hepatitis B patients, respectively. The intricate interactions between liver cirrhosis, recovery, and treatment dynamics are captured by the model. This study aims to show that alcohol consumption by Hepatitis B-infected individuals accelerates liver cirrhosis progression while treatment of acutely infected individuals reduces… More >

Xinyang Li^1,2,3,#, Luyuan Ma^1,2,3,#, Chuan Shen^1,2,3, Ruolan Gu^1,2,3, Shilong Dong^1,2,3, Mingjie Liu^1,2,3, Ying Xiao^1,2,3, Wenpeng Liu^1,2,3, Yuexia Liu^1,2,3, Caiyan Zhao^1,2,3,*

Oncology Research, Vol.34, No.2, 2026, DOI:10.32604/or.2025.073179 - 19 January 2026

Abstract Background: Hepatocellular carcinoma (HCC) is an aggressive and lethal malignancy. Metabolic reprogramming dynamically remodels the tumor microenvironment (TME) and drives HCC progression. This study investigated the mechanism through which metabolic reprogramming remodels the TME in HCC. Methods: HCC patient transcriptome data were subjected to bioinformatics analysis to identify differentially expressed genes and immune infiltration status. Immunohistochemical analysis was performed to determine the correlation between succinate dehydrogenase complex subunit A (SDHA) expression and M2 macrophage infiltration. SDHA-knockdown or SDHA-overexpressing HCC cells were used for in vitro experiments, including co-culturing, flow cytometry, and enzyme-linked immunosorbent assay. Western blotting… More >

Jiayu Zou^1,2,3, Yajie Lu³, Jiaqi Li³, Zhaokai Zhou^4,5, Fu Peng³, Pu Qiu^2,*, Hailin Tang⁶, Cheng Peng^1,*

Oncology Research, Vol.34, No.2, 2026, DOI:10.32604/or.2025.071940 - 19 January 2026

Abstract Lung cancer is the most common but fatal malignant tumor worldwide. Patients with lung cancer experienced a relatively low 5-year overall survival rate, and issues such as metastasis and drug resistance remain prominent challenges in its clinical management. Neddylation, a novel type of post-translational modification, was overactivated in lung cancer and was closely associated with its occurrence, development, metastasis, and drug resistance. This review systematically summarizes the biological process of neddylation and deeply explores the latest research progress on how neddylation affects lung cancer cell proliferation, metastasis, and drug resistance mechanisms, with a focus on More >