Wei Zhu, Yan Song, Di Chen, Huimin Chen, Dingding Zhang, Lu Chen^*

International Journal of Mental Health Promotion, Vol.27, No.11, pp. 1681-1694, 2025, DOI:10.32604/ijmhp.2025.070461 - 28 November 2025

Abstract Objectives: Fear of recurrence (FoR) is a common psychological burden in cerebral glioma patients. Spousal emotional support and self-disclosure may help mitigate FoR, yet their roles in this population are unclear. This study aimed to explore the association between FoR, spousal emotional support, and self-disclosure in patients with cerebral glioma. Methods: Patients with cerebral glioma were assessed using the Fear of Progression Questionnaire-Short Form (FoP-Q-SF), Perceived Social Support Scale (PSSS), Distress Disclosure Index (DDI), and Acceptance and Action Questionnaire (AAQ). Pearson correlation analysis was conducted to examine the relationships among the scale scores, while multiple linear… More >

Jiunn-Wei Wang^1,2,3, Wen-Hung Hsu^2,3,4, Fang-Jung Yu^2,3, Fu-Chen Kuo⁵, Chung-Jung Liu^3,6, Chao-Hung Kuo^1,2,3, Jaw-Yuan Wang^7,8, Ming-Hong Lin^9,*, Deng-Chyang Wu^1,2,3,*

Oncology Research, Vol.33, No.12, pp. 3907-3922, 2025, DOI:10.32604/or.2025.070432 - 27 November 2025

Abstract Objectives: Colorectal adenomatous polyps frequently recur after removal and are precursors to colorectal cancer, highlighting the need for effective preventive strategies. This study evaluated the efficacy of probiotic Clostridium butyricum MIYAIRI 588 (CBM588) in preventing colorectal adenoma recurrence in high-risk patients. Methods: We conducted a randomized, single-blind, two-year crossover trial in patients with a history of adenomatous polyps. Participants received CBM588 in either the first or second year, with the alternate year as observation, and underwent annual surveillance colonoscopies. Outcomes (adenoma recurrence and polyp counts) were analyzed by intention-to-treat (ITT) and per-protocol (PP) approaches. Results: A total… More >

Szymon Piątek¹, Anna Dańska-Bidzińska^2,*, Paweł Derlatka², Bartosz Szymanowski³, Renata Duchnowska³, Aleksandra Zielińska⁴, Natalia Sawicka⁴, Aleksander Gorzeń⁵, Wojciech Michalski⁶, Mariusz Bidziński¹

Oncology Research, Vol.33, No.11, pp. 3405-3416, 2025, DOI:10.32604/or.2025.068609 - 22 October 2025

Abstract Objectives: Monitoring of Cancer Antigen 125 (CA125) during ovarian cancer (OC) maintenance treatment with poly(ADP-ribose) polymerase inhibitors (PARPis) may be insufficient when using Gynecologic Cancer Intergroup (GCIG) biochemical progression criteria. This study aimed to evaluate the usefulness of CA125 monitoring in detecting OC recurrence during PARPis maintenance treatment. Methods: This multicenter retrospective cohort study included patients with primary OC who achieved complete or partial response after first-line platinum-based chemotherapy followed by PARPis maintenance treatment. Progression was defined using Response Evaluation Criteria in Solid Tumors (RECIST) and GCIG biochemical criteria. New biochemical progression definitions, based on… More >

Marie Chaumel¹, Nicolas Brichart², Franck Bruyère¹, Ali Bourgi^1,*

Canadian Journal of Urology, Vol.32, No.4, pp. 359-366, 2025, DOI:10.32604/cju.2025.066470 - 29 August 2025

Abstract Background: The COVID-19 pandemic disrupted healthcare systems globally, raising concerns about delayed cancer diagnosis and treatment. In France, transurethral resection of bladder tumors (TURBT) was prioritized in national urology guidelines to ensure the timely management of urothelial carcinoma. This study aimed to assess the impact of care reorganization on tumor staging, recurrence, palliative care, and mortality in bladder cancer patients from the pre-pandemic through late-pandemic periods. Methods: We conducted a retrospective multicenter study including all patients who underwent TURBT with histologically confirmed urothelial carcinoma between April and December of 2019 (pre-pandemic), 2020 (early pandemic), 2021… More >

Man Liu¹, Zhuoheng Lv^1,#, Hongjing Wang^2,*, Lu Liu^1,*

Psycho-Oncologie, Vol.18, No.4, pp. 305-316, 2024, DOI:10.32604/po.2024.054098 - 04 December 2024

Abstract Objective: Non-small cell lung cancer (NSCLC) patients often experience significant fear of recurrence. To facilitate precise identification and appropriate management of this fear, this study aimed to compare the efficacy and accuracy of a Backpropagation Neural Network (BPNN) against logistic regression in modeling fear of cancer recurrence prediction. Methods: Data from 596 NSCLC patients, collected between September 2023 and December 2023 at the Cancer Hospital of the Chinese Academy of Medical Sciences, were analyzed. Nine clinically and statistically significant variables, identified via univariate logistic regression, were inputted into both BPNN and logistic regression models developed… More >

Lu Liu^#, Zhuoheng Lv^#, Yousheng Mao, Yan Liu^*, Man Liu^*

Psycho-Oncologie, Vol.18, No.4, pp. 317-328, 2024, DOI:10.32604/po.2024.053678 - 04 December 2024

Abstract Background: Lung cancer, one of the most prevalent and deadly malignancies worldwide, not only poses a significant physical burden but also a profound psychological challenge to patients. Among these psychological challenges, the fear of recurrence stands out as a particularly distressing issue. This fear, often rooted in the patients’ past experiences with the disease and its treatment, can significantly impact their quality of life, mental health, and even compliance with follow-up care. Moreover, this fear can be exacerbated by the lack of understanding and support from healthcare professionals and family members, further isolating patients and… More >

Yu-Feng Ren, Dong-Li Ji^*, Yu Wu, Ru-Qin Ben, Hai-Xia Wei

Psycho-Oncologie, Vol.18, No.4, pp. 329-336, 2024, DOI:10.32604/po.2024.053098 - 04 December 2024

Abstract Background: The constructing PERMA model in psychological intervention was applied to patients with chronic cancer pain to provide data reference for reducing pain, fear of cancer recurrence, and improving the level of psychological capital. Aim: To explore the clinical effects of constructing PERMA model in psychological intervention for patients with chronic cancer pain. Methods: A total of 98 patients with chronic cancer pain admitted to our hospital from March 2021 to March 2023 were randomly divided into two groups, 49 cases in each group. The control group received routine intervention, while the research group constructed PERMA… More >

Huimin Zheng, Minghui Wang^*, Miao Ye

Psycho-Oncologie, Vol.18, No.3, pp. 169-179, 2024, DOI:10.32604/po.2024.052703 - 12 September 2024

Abstract Background: Although fear of cancer recurrence (FCR) is the most important factor affecting the life quality of young breast cancer patients, and it may be affected by the patient’s personality, marital relationship and communication, there is a lack of research on the relationship between adult attachment, self-disclosure and FCR in patients. This study investigated the current situation of FCR in young breast cancer patients, its correlation with adult attachment and self-disclosure and its influencing factors, in order to predict the impact of adult attachment and self-disclosure of patients to spouse on FCR. Methods: A survey… More >

Şerife Büyükokudan¹, Öznur Körükcü^2,*

Psycho-Oncologie, Vol.18, No.3, pp. 147-158, 2024, DOI:10.32604/po.2024.046627 - 12 September 2024

Abstract Although some types of gynecological cancer have a poor prognosis and high recurrence rate, less is known about the fear of cancer recurrence (FCR) in gynecological cancer patients than in other cancer populations. Psychosocial problems may be experienced more in gender-specific cancers. In order to prevent future health problems related to FCR, it is critical to identify the factors affecting FCR in different subgroups and to develop various interventions. The aim of this study was to review the literature on the factors affecting the FCR in women diagnosed with gynecological cancer and interventions to reduce… More >

CHENG-GONG LUO^1,2,#, JIAO ZHANG^1,#, YUN-ZHAO AN¹, XUAN LIU¹, SHUAI-JIE LI¹, WEI ZHANG¹, KAI LI¹, XU ZHAO¹, DONG-BO YUAN¹, LING-YUE AN¹, WEI CHEN², YE TIAN^1,*, BIN XU^1,*

BIOCELL, Vol.48, No.5, pp. 771-792, 2024, DOI:10.32604/biocell.2024.048878 - 06 May 2024

Abstract Background: Ferroptosis, a lipid peroxidation-mediated programmed cell death, is closely linked to tumor development, including prostate cancer (PCa). Despite established connections between ferroptosis and PCa, a comprehensive investigation is essential for understanding its impact on patient prognosis. Methods: A risk model incorporating four ferroptosis-related genes was developed and validated. Elevated risk scores correlated with an increased likelihood of biochemical recurrence (BCR), diminished immune infiltration, and adverse clinicopathological characteristics. To corroborate these results, we performed validation analyses utilizing datasets from both the Cancer Genome Atlas Cohort (TCGA) and the Gene Expression Synthesis Cohort (GEO). Moreover, we conducted… More >