Keqiang Wang¹, Pengyang Zhao¹, Changjian Wang², Zimeng Zhang¹, Yu Zhang¹, Jia Lu¹, Zedong Yang^2,*

Energy Engineering, Vol.121, No.4, pp. 1091-1108, 2024, DOI:10.32604/ee.2023.044016

Abstract The rising frequency of extreme disaster events seriously threatens the safe and secure operation of the regional integrated electricity-natural gas system (RIENGS). With the growing level of coupling between electric and natural gas systems, it is critical to enhance the load restoration capability of both systems. This paper proposes a coordinated optimization strategy for resilience-enhanced RIENGS load restoration and repair scheduling and transforms it into a mixed integer second-order cone programming (MISOCP) model. The proposed model considers the distribution network reconfiguration and the coordinated repair strategy between the two systems, minimizing the total system load loss cost and repair time.… More >

Jae Hong Lee¹, Sungkyu Cho^2,*, Jae Gun Kwak², Hye Won Kwon², Woong-Han Kim², Mi Kyoung Song³, Sang-Yun Lee³, Gi Beom Kim³, Eun Jung Bae³

Congenital Heart Disease, Vol.19, No.1, pp. 69-83, 2024, DOI:10.32604/chd.2024.045137

Abstract Background: The optimal surgical timing and clinical outcomes of ventricular septal defect (VSD) closure in neonates remain unclear. We aimed to evaluate the clinical outcomes of VSD closure in neonates (age ≤ 30 days). Methods: We retrospectively reviewed 50 consecutive neonates who underwent VSD closure for isolated VSDs between August 2003 and June 2021. Indications for the procedure included congestive heart failure/failure to thrive and pulmonary hypertension. Major adverse events (MAEs) were defined as the composite of all-cause mortality, reoperation, persistent atrioventricular block, and significant (≥grade 2) valvular dysfunction. Results: The median age and body weight at operation were 26.0… More >

Jie Huang^*, Rongbin Jiang, Xiaobo Sun, Yingyong Shuai

Journal of Renewable Materials, Vol.12, No.1, pp. 187-201, 2024, DOI:10.32604/jrm.2023.044232

Abstract The reuse of waste recycled concrete from harsh environments has become a research hotspot in the field of construction. This study investigated the repair effect of carbonation treatment on second-generation recycled fine aggregate (SRFA) obtained from recycled fine aggregate concrete (RFAC) subjected to freeze-thaw (FT) cycles. Before and after carbonation, the properties of SRFA were evaluated. Carbonated second-generation recycled fine aggregate (CSRFA) at five substitution rates (0%, 25%, 50%, 75%, 100%) to replace SRFA was used to prepare carbonated second-generation recycled fine aggregate concrete (CSRFAC). The water absorption, porosity and mechanical properties of CSRFAC were tested, and its frost-resisting durability… More >

Ali Akbar Firoozi^1,*, Ali Asghar Firoozi²

Structural Durability & Health Monitoring, Vol.18, No.1, pp. 1-18, 2024, DOI:10.32604/sdhm.2023.044573

Abstract The discipline of damage tolerance assessment has experienced significant advancements due to the emergence of smart materials and self-repairable structures. This review offers a comprehensive look into both traditional and innovative methodologies employed in damage tolerance assessment. After a detailed exploration of damage tolerance concepts and their historical progression, the review juxtaposes the proven techniques of damage assessment with the cutting-edge innovations brought about by smart materials and self-repairable structures. The subsequent sections delve into the synergistic integration of smart materials with self-repairable structures, marking a pivotal stride in damage tolerance by establishing an autonomous system for immediate damage identification… More >

CHIWEN BU^1,2, LIGANG ZHAO¹, LISHAN WANG¹, ZEQIAN YU¹, JIAHUA ZHOU^1,*

Oncology Research, Vol.31, No.4, pp. 495-503, 2023, DOI:10.32604/or.2023.029309

Abstract Pancreatic cancer is one of the most aggressive cancers with a median survival time of less than 5 months, and conventional chemotherapeutics are the main treatment strategy. Poly(ADP-ribose) polymerase (PARP) inhibitors have been recently approved for BRCA1/2-mutant pancreatic cancer, opening a new era for targeted therapy for this disease. However, most pancreatic cancer patients carry wild-type BRCA1/2 with resistance to PARP inhibitors. Here, we reported that mammalian target of rapamycin complex 2 (mTORC2) kinase is overexpressed in pancreatic cancer tissues and promotes pancreatic cancer cell growth and invasion. Moreover, we found that knockdown of the mTORC2 obligate subunit Rictor sensitized… More > Graphic Abstract

DHANYA K. NAMBIAR¹, DEEPALI MISHRA², RANA P. SINGH^2,3,*

Oncology Research, Vol.31, No.4, pp. 405-421, 2023, DOI:10.32604/or.2023.028310

Abstract Ionizing radiation is frequently used to treat solid tumors, as it causes DNA damage and kill cancer cells. However, damaged DNA is repaired involving poly-(ADP-ribose) polymerase-1 (PARP-1) causing resistance to radiation therapy. Thus, PARP-1 represents an important target in multiple cancer types, including prostate cancer. PARP is a nuclear enzyme essential for single-strand DNA breaks repair. Inhibiting PARP-1 is lethal in a wide range of cancer cells that lack the homologous recombination repair (HR) pathway. This article provides a concise and simplified overview of the development of PARP inhibitors in the laboratory and their clinical applications. We focused on the… More > Graphic Abstract

Andrei George Iosifescu^1,2,*, Roxana Enache^1,3, Ioana Marinică⁴, Corina Radu², Vlad Anton Iliescu^1,2

Congenital Heart Disease, Vol.18, No.1, pp. 67-72, 2023, DOI:10.32604/chd.2023.026598

Abstract Left main coronary compression syndrome (LMCS) may complicate pulmonary artery aneurysms (PAA), usually developed in the context of pulmonary arterial hypertension (PAH). We report the case of a 51-year-old female patient with an atrial septal defect (unsuitable for device closure) complicated by a PAA generating a 90% left main stenosis. The significant PAH held us back from immediate surgery. After specific dual PAH-targeted therapy (sildenafil and bosentan), the atrial septal defect could be closed with a unidirectional valved patch; the PAA-induced LMCS was treated by reductive arterioplasty. The postoperative course was uneventful. Follow-up showed clinical improvement, but PAH treatment was… More > Graphic Abstract

Yuan Hu¹, Xiaohui Yang², Jie Dong³, Peng Huang², Jinwen Luo², Guangxian Yang², James D. St. Louis⁴, Xicheng Deng^2,*

Congenital Heart Disease, Vol.17, No.6, pp. 687-695, 2022, DOI:10.32604/chd.2022.024333

Abstract Background: Interventricular septal hematoma is a rare complication after congenital cardiac repair. The management varies according to the literature. We present our experience with this rare complication. Methods: Echocardiography database were reviewed with the term ‘‘hematoma’’ or “hypoechoic mass” for patients who underwent congenital heart surgery from January 2018 to December 2021 at our institution to identify potential interventricular septal hematoma cases. Relevant data of the patients identified were collected. Focus was put on the presentation, management, outcomes according to patent medical charts and serial echocardiographic report data. Results: In total, there were 5 patients included. The mean age and… More > Graphic Abstract

Aya Miyazaki^1,2,*, Hideki Uemura², Yasuyo Takeuchi³, Junya Tomida⁴, Yasuo Ono¹, Yoshifumi Fujimoto¹, Norie Mitsushita¹, Akio Ikai¹

Congenital Heart Disease, Vol.17, No.6, pp. 647-652, 2022, DOI:10.32604/chd.2022.021837

Abstract Appropriate heart rate in a failing pulmonary ventricle remains unknown, particularly in congenital heart disease with unique hemodynamics. A 71-year-old male with repaired tetralogy of Fallot and a pacemaker for a sinus node dysfunction suffered from heart failure symptoms with preserved left ventricular function. Simply changing the pacemaker’s lower rate from 60 to 75 bpm, New York Heart Association classification improved from III to II, and hemodynamic parameters drastically improved. We regarded this case as informative. Appropriate heart rate could be higher in congenital patients with failing right and non-failing left ventricles than in adults with malfunctioning LV. More > Graphic Abstract

JIAMING ZHAN, WEIHUA WANG, YANLEI TANG, NING ZHOU, DAOWEN JIANG^*

BIOCELL, Vol.46, No.12, pp. 2601-2613, 2022, DOI:10.32604/biocell.2022.021300

Abstract Esophageal cancer (EC) was an aggressive malignant neoplasm characterized by high morbidity and poor prognosis. Identifying the changes in DNA damage repair genes helps to better understand the mechanisms of carcinoma progression. In this study, by comparing EC samples and normal samples, we found a total of 132 DDR expression with a significant difference. Moreover, we revealed higher expression of POLN, PALB2, ATM, PER1, TOP3B and lower expression of HMGB1, UBE2B were correlated to longer OS in EC. In addition, a prognostic risk score based on 7 DDR gene expression (POLN, HMGB1, TOP3B, PER1, UBE2B, ATM, PALB2) was constructed for… More >