Jinfeng Ji¹, Geunseok Yang^2,*

CMC-Computers, Materials & Continua, Vol.86, No.3, 2026, DOI:10.32604/cmc.2025.071733 - 12 January 2026

Abstract Automated Program Repair (APR) techniques have shown significant potential in mitigating the cost and complexity associated with debugging by automatically generating corrective patches for software defects. Despite considerable progress in APR methodologies, existing approaches frequently lack contextual awareness of runtime behaviors and structural intricacies inherent in buggy source code. In this paper, we propose a novel APR approach that integrates attention mechanisms within an autoencoder-based framework, explicitly utilizing structural code affinity and execution context correlation derived from stack trace analysis. Our approach begins with an innovative preprocessing pipeline, where code segments and stack traces are… More >

Bing Wei, Ming Zhong, Qian Chen, Yi Wu^*, Yubin Li

CMC-Computers, Materials & Continua, Vol.86, No.2, pp. 1-20, 2026, DOI:10.32604/cmc.2025.069910 - 09 December 2025

Abstract In erasure-coded storage systems, updating data requires parity maintenance, which often leads to significant I/O amplification due to “write-after-read” operations. Furthermore, scattered parity placement increases disk seek overhead during repair, resulting in degraded system performance. To address these challenges, this paper proposes a Cognitive Update and Repair Method (CURM) that leverages machine learning to classify files into write-only, read-only, and read-write categories, enabling tailored update and repair strategies. For write-only and read-write files, CURM employs a data-difference mechanism combined with fine-grained I/O scheduling to minimize redundant read operations and mitigate I/O amplification. For read-write files,… More >

Xiaolin Cui¹, Khoon Lim^2,*

The International Conference on Computational & Experimental Engineering and Sciences, Vol.33, No.1, pp. 1-2, 2025, DOI:10.32604/icces.2025.011173

Abstract 1 Introduction
Joint and cardiovascular diseases, such as osteoarthritis (OA) and myocardial infarction (MI), pose significant clinical challenges due to their limited regenerative capacity. The key to mitigating tissue damage and preventing the progression of OA and MI is to repair or even regenerate the infarcted tissue. At present, cell-based therapy is the primary strategy for tissue repair. Delivered cells could either differentiate into functional cells or secrete paracrine signals to promote onsite cell function. Both mechanisms have demonstrated potential in cartilage and cardiac tissue repair, both preclinically and clinically. In addition to cell therapy,… More >

Yifan Li^1,#, Xu Huang^2,#, Bingyu Ma³, Ling Sun¹, Shushui Wang¹, Zhiwei Zhang¹, Yumei Xie^1,*

Congenital Heart Disease, Vol.20, No.4, pp. 463-475, 2025, DOI:10.32604/chd.2025.068286 - 18 September 2025

Abstract Objective: The aim of the present study was to investigate long-term efficacy and safety of percutaneous stent implantation for residual pulmonary artery stenosis (PAS) in pediatric patients after surgical repair of complicated congenital heart diseases (CHDs). Methods: All pediatric patients diagnosed with residual PAS after surgical repair of complicated CHDs between 1996 and 2020 were retrospectively enrolled in the study. Results: A total of 41 patients (30 males, 11 females; median age 5.0 years, median weight 17 kg) were followed-up for a median of 7.1 years. Follow-up echocardiography results demonstrated that the target vessel diameter increased from… More >

Emrah Şişli^1,*, Pelin Köşger²

Congenital Heart Disease, Vol.20, No.4, pp. 531-537, 2025, DOI:10.32604/chd.2025.067271 - 18 September 2025

Abstract Residual atrioventricular valve regurgitation after correction of complete atrioventricular septal defect (cAVSD) is still not ideal. As a modification of the double-patch method, our technique comprises a suture-bite-wide strip of a third patch that is incorporated to the upper margin of the left side of the ventricular septal defect (VSD) patch. This third patch counteracts not only the valvular tissue loss caused by the suture bites but also the rightward displacement of the VSD patch in a bulged fashion that occurs with increased left ventricular pressure after weaning from cardiopulmonary bypass. This unfavorable outcome was More >

Wilhelm Mistiaen^*

Congenital Heart Disease, Vol.20, No.3, pp. 305-323, 2025, DOI:10.32604/chd.2025.064675 - 11 July 2025

Abstract The presence of a bicuspid aortic valve (BAV) is the most common congenital heart anomaly, which can remain asymptomatic for decades, if it is not a part of a syndrome, such as Turner syndrome or genetic connective tissue disorders. There are several classifications for BAV, each with its advantages and drawbacks. The condition can lead to valvular malfunction such as regurgitation and stenosis, but is often associated with dilatation of the aortic root, the ascending aorta, the aortic arch, or a combination. Altered flow patterns due to the valve dysfunction as well as the breakdown… More >

RAQUEL GÓMEZ-MOLINA^1,*, RAQUEL MARTÍNEZ^2,3,4, MIGUEL SUÁREZ^2,3,4,*, ANA PEÑA-CABIA¹, MARíA CONCEPCIóN CALDERÓN¹, JORGE MATEO^3,4

Oncology Research, Vol.33, No.7, pp. 1531-1545, 2025, DOI:10.32604/or.2025.063951 - 26 June 2025

Abstract Lynch syndrome (LS), also known as hereditary non-polyposis colorectal cancer (HNPCC), is an inherited condition associated with a higher risk of colorectal cancer (CRC) and other cancers. It is caused by germline mutations in DNA mismatch repair (MMR) genes, including MLH1, MSH2, MSH6 and PMS2. These mutations lead to microsatellite instability (MSI) and defective DNA repair mechanisms, resulting in increased cancer risk. Early detection of LS is crucial for effective management and cancer prevention. Endoscopic surveillance, particularly regular colonoscopy, is recommended for individuals with LS to detect CRC at early stages. Additionally, universal screening of CRC for More > Graphic Abstract

Yiqin He^1,2, Chenhan Hu^1,2, Xiangshu Meng^1,2, Rundong Ma^1,2, Kexin Duan^1,2, Yu Guo^2,3, Changqing Liu^1,2, Caiyun Ma^1,2, Gaofeng Liu^1,2,*, Chunjing Wang^1,2,*

BIOCELL, Vol.49, No.6, pp. 1037-1055, 2025, DOI:10.32604/biocell.2025.064633 - 24 June 2025

Abstract Background: Mesenchymal stem cells (MSCs) have shown great potential in treating neurodegenerative diseases, including Parkinson’s disease (PD), due to their ability to differentiate into neurons and secrete neurotrophic factors. Genetic modification of MSCs for PD treatment has become a research focus. Methods: In this study, rat pulmonary mesenchymal stem cells (PMSCs) were transduced with lentiviral vectors carrying Lmx1a/NeuroD1 to establish genetically engineered PMSCs (LN-PMSCs) and induce their differentiation into dopaminergic neurons. The LN-PMSCs were then transplanted into the right medial forebrain bundle region of PD model rats prepared using the 6-Hydroxydopamine (6-OHDA) method. Four weeks… More >

Jacob PL Ho¹, Carol WK Ng², Wilfred HS Wong³, Yiu-fai Cheung^1,3,*

Congenital Heart Disease, Vol.20, No.2, pp. 201-211, 2025, DOI:10.32604/chd.2025.063217 - 30 April 2025

Abstract Background: The role of cardiothoracic ratio (CTR) from the chest radiograph for assessment of ventricular enlargement and function in repaired tetralogy of Fallot (TOF) is conflicting. This study aimed to determine the associations between CTR and cardiac magnetic resonance (CMR)-derived ventricular volumes and indices of ventricular function in adolescents and young adults with repaired TOF. Methods: The CTR and CMR findings, performed within 12 months of each other, were reviewed in 76 patients aged 22.1 ± 6.4 years. Associations between CTR and CMR parameters including right (RV) and left ventricular (LV) volumes and ejection fraction were… More >

Gabrielle Yankelevich^1,*, Jessica Swaim¹, Ian Coate¹, Margaret Stroud¹, William Stallings¹, Virgilio George², M. Lance Tavana³, Harry Clarke¹

Canadian Journal of Urology, Vol.32, No.1, pp. 37-42, 2025, DOI:10.32604/cju.2025.064684 - 20 March 2025

Abstract Objectives: To assess outcomes of rectourethral fistula repair utilizing a gracilis flap in a largely radiated cohort. Patients and Methods: We performed a retrospective review of all gracilis interposition flap reconstruction surgeries performed for RUF at a university hospital in South Carolina between January 2010 and June 2023. All repairs utilized a multidisciplinary approach with urology, colorectal, and plastic surgery teams. Post-operatively, patients were maximally drained with foley catheter and suprapubic tube (SPT). Initial voiding cystourethrogram (VCUG) was performed at 4 weeks post-repair. If there was a persistent leak, catheter drainage was maintained for 4 additional… More >