VITTORIO PICCHIO¹, FRANCESCA PAGANO², ISOTTA CHIMENTI^1,3,*

BIOCELL, Vol.46, No.8, pp. 1875-1877, 2022, DOI:10.32604/biocell.2022.020181

Abstract Cardiac stromal cells have faced through the years a significant evolution in their definitions concerning their phenotypes, markers, and functions. They are surging to key roles in physiopathology, becoming important targets to be exploited for cardiac repair. In this perspective, we briefly discuss their role in novel therapeutic strategies for enhancing cardiac repair and regeneration. More >

Fang Zhao¹, Dongming Xiang^2,*, Guanjun Liu¹, Changjun Jiang¹, Honghao Zhu³

CMES-Computer Modeling in Engineering & Sciences, Vol.131, No.3, pp. 1337-1363, 2022, DOI:10.32604/cmes.2022.018872

Abstract Workflow system has become a standard solution for managing a complex business process. How to guarantee its correctness is a key requirement. Many methods only focus on the control-flow verification, while they neglect the modeling and checking of data-flows. Although some studies are presented to repair the data-flow errors, they do not consider the effect of delete operations or weak circulation relations on the repairing results. What's more, repairing some data-flow errors may bring in new errors. In order to solve these problems, we use workflow net with data (WFD-net) systems to model and analyze a workflow system. Based on… More >

YINGHUI WU^#, HONG ZHANG^#, QIANG WANG, SUOYUAN LI, JUN SHEN^*

BIOCELL, Vol.46, No.6, pp. 1363-1364, 2022, DOI:10.32604/biocell.2022.018360

Abstract Transcription factor Brachyury, a protein containing 435 amino acids, has been widely investigated and reported in notochord differentiation and nucleus pulposus development. The crucial functions and underlying mechanisms by Brachyury are discussed in this paper, which suggests Brachyury can be developed into a potential novel target for the therapy of intervertebral disc degeneration. More >

Elena Panaioli^1,2,3,#, Duarte Martins^1,4,#, Marc Antoine Isorni⁵, Diala Khraiche¹, Antoine Legendre¹, Nathalie Boddaert⁶, Damien Bonnet¹, Filippo Crea^2,3, Francesca Raimondi^1,6,7,8,*

Congenital Heart Disease, Vol.17, No.2, pp. 117-128, 2022, DOI:10.32604/chd.2022.018779

Abstract Background: Repaired Tetralogy of Fallot (rTOF) patients may have residual lesions such as main (MPA) and branch pulmonary artery stenosis (BPAS). While MPA stenosis is well studied, few data are available on BPAS in rTOF. We aimed to describe pulmonary perfusion in a large paediatric cohort of rTOF and its impact on right ventricular and outflow-tract hemodynamics using 4D flow CMR. Methods: 130 consecutive patients (mean age at CMR 14.3 ± 4.6 years) were retrospectively reviewed. 96 patients had transannular patch without valve preservation while 34 patients had conserved annulus or valved conduit. A pulmonary blood flow ratio (right pulmonary artery (RPA)/left… More > Graphic Abstract

Biying Deng¹ , Desheng Zheng^{1, *}, Zhifeng Liu¹ , Yanling Lai¹, Zhihong Zhang²

Journal of Quantum Computing, Vol.3, No.3, pp. 119-126, 2021, DOI:10.32604/jqc.2021.017250

Abstract There are two difficult in the existing image restoration methods. One is that the method is difficult to repair the image with a large damaged, the other is the result of image completion is not good and the speed is slow. With the development and application of deep learning, the image repair algorithm based on generative adversarial networks can repair images by simulating the distribution of data. In the process of image completion, the first step is trained the generator to simulate data distribution and generate samples. Then a large number of falsified images are quickly generated using the generative… More >

Muslum S. Inal^1,2, Dilek Unal^1,*, Bengu Turkyilmaz Unal^3,*, Munir Ozturk⁴

Phyton-International Journal of Experimental Botany, Vol.91, No.3, pp. 583-598, 2022, DOI:10.32604/phyton.2022.018223

Abstract Putrescine is reported to be necessary for cold acclimation under low-temperature stress. In this study, the effect of low-temperature on some physiological and biochemical parameters has been investigated using the green algae Chlamydomonas reinhardtii. The lipid peroxidation rate, amount of Rubisco protein, activities of antioxidant enzymes and gene expression of polyamine biosynthesis (odc2, and spd1), heat shock proteins (hsp70c, hsp90a, and hsp90c), and PSII repair mechanisms (psba, rep27, and tba1) were determined to understand the low-temperature response. Exogenous putrescine application significantly increased Rubisco protein concentration and catalase enzyme activities under low-temperature stress. Moreover, real-time RT-PCR results and gene expression analysis… More >

Mina Tewfik^1,2,*, Maiy El-Sayed¹, Alaa Roushdy¹, Soha Romeih^2,3, Dina Ezzeldin¹, Hebatalla Attia¹

Congenital Heart Disease, Vol.17, No.1, pp. 71-85, 2022, DOI:10.32604/CHD.2022.018372

Abstract Background: Bidirectional Glenn shunts have long been available as palliative procedures for patients with single ventricle physiology that is, patients unsuitable for biventricular repair. In our country they are performed at an older age than that recommended by the literature. So, we aim to assess post bidirectional Glenn shunt patients to detect the presence of any complications and to evaluate their functional capacity. Methods: This was a descriptive study that included all patients who underwent a bidirectional Glenn shunt and were referred for follow up in Ain shams university hospitals. History taking including NYHA class and physical activity, clinical examination,… More >

Helena Staehler¹, Carina Hopfner², Masamichi Ono^1,*, Jürgen Hörer¹

Congenital Heart Disease, Vol.17, No.1, pp. 25-30, 2022, DOI:10.32604/CHD.2022.018366

Abstract We report a very rare case of successful intracardiac correction in a patient with heterotaxy syndrome. The cardiac malformations included dextrocardia, double outlet right ventricle, pulmonary stenosis, interrupted inferior vena cava, hemiazygos continuation and total anomalous pulmonary venous return. One-stage correction was performed. The atrial procedure consisted of intra- and extraatrial rerouting of the anomalous systemic and pulmonary venous return. The hepatic veins were detached and diverted to the left atrium via an extracardiac conduit. The correction of the double outlet right ventricle was accomplished by intraventricular redirection of the blood flow from the left ventricle to the aorta. The… More >

JIUCHUN GUO¹, JIE PAN^2,*, QIANQIAN GUO²

BIOCELL, Vol.46, No.2, pp. 505-510, 2022, DOI:10.32604/biocell.2021.015785

Abstract The excessive energy of light, especially the invisible rays with lower wavelength, is basically absorbed by retinal pigment epithelium (RPE) and usually causes DNA damage. The molecular mechanism behind DNA damage repair response to this frequent stress in RPE is not clearly understood. In this study, we determined that the Fanconi anemia (FA) pathway was activated in human RPE ARPE-19 cells after ultraviolet (UV) B and C treatment. Moreover, immunoprecipitation (IP) of FANCD2 indicated that denticleless E3 ubiquitin protein ligase homolog (DTL) closely interacted with FANCD2. Knockdown of DTL weakened the activity of the FA pathway in ARPE-19 cells responding… More >

PENG LIU^1,2, ANFANG ZOU³, QI CHEN⁴, BIAO CHENG^1,*, QIN LI^1,*

BIOCELL, Vol.45, No.1, pp. 27-39, 2021, DOI:10.32604/biocell.2021.012601

Abstract The diabetic ulcer is one of the serious complications of diabetes. In this study, we aimed to establish an exosomal microRNA (miRNA)-targeted messenger RNA (mRNA) regulatory network for screening new biomarkers for diabetic ulcer treatment. For this purpose, exosomes were extracted from bone marrow stem cells (BMSCs) collected from diabetic ulcer patients and healthy adults. The miRNAs in exosomes was detected by high-throughput sequencing analysis. The Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis of the differential miRNAs were performed. The miRNA-mRNA regulatory network between candidate miRNAs and their target genes were constructed by… More >