Jianfa Wu^1,2,3, Huang Chen³, Sihong Wang^1,2, Lei Peng^1,2, Xiaoying Hu^1,2, Zhou Liu^1,2,*

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.070542 - 30 December 2025

Abstract Objectives: Ribosomal protein S6 kinase A2 (RPS6KA2) has been identified as a potential prognostic biomarker in several cancers, including breast cancer, glioblastoma, and prostate cancer. However, its functional significance in ovarian cancer is not well characterized. This study was designed to explore the therapeutic relevance of modulating RPS6KA2 in the context of ovarian cancer, particularly in relation to cisplatin resistance. Methods: The expression levels of RPS6KA2 and key regulators involved in autophagy and ferroptosis were assessed using quantitative reverse transcription-PCR, immunofluorescence staining, immunohistochemistry, and western blotting. Prognostic associations were conducted using the Kaplan-Meier Plotter database.… More >

Sandra Kałużna^1,*, Monika Świerczewska^1,2, Sylwia Ciesiółka¹, Małgorzata Partyka¹, Michał Nowicki¹, Karolina Wojtowicz¹

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.070356 - 30 December 2025

Abstract The last research focuses on the role of exosomes in cancer treatment. Exosomes are extracellular vesicles. They can be secreted by cancer cells, and they can modulate chemotherapy sensitivity. Determining exosomal content opens the possibility for guiding treatment strategies for cancer diseases. Exosomal microRNA are considered one of the prime candidates for exosomal biomarkers. Exosomal circular RNAs represent excellent biomarkers for liquid biopsy because of their stability in many types of cancer. Exosomal proteins remain reliable biomarkers also. Exosomes have emerged as promising therapeutic candidates. Their biological properties render them ideal vectors for drug delivery.… More >

Rabindranath Bera^1,#, Yotaro Ochi^2,3, Ying-Jung Huang¹, Ming-Chung Kuo^1,4, Kenichi Yoshida⁵, Seishi Ogawa², Lee-Yung Shih^1,4,*

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.070259 - 30 December 2025

Abstract Background: Breakpoint Cluster Region-Abelson (BCR::ABL1) fusion protein is essential in the pathogenesis of chronic myeloid leukemia (CML); however, the chronic-to-blast phase transformation remains elusive. We identified novel kinesin light chain 2 (KLC2) mutations in CML-myeloid blast phase patients. We aimed to examine the functional role of KLC2 mutations in leukemogenesis. Methods: To evaluate the biological role of KLC2 mutants (MT) in CML cells, we expressed KLC2-MT in different human CML cell lines harboring BCR::ABL1 and performed immunoblot, immunofluorescence, cell proliferation, differentiation, and apoptosis; Tyrosine kinase inhibitor (TKI)-drug activities; and clonogenic assays for in vitro functional analyses. We co-expressed KLC2-MT… More >

F. F. Tong^a,*, J. L. Han^b

Chalcogenide Letters, Vol.22, No.8, pp. 719-733, 2025, DOI:10.15251/CL.2025.228.719

Abstract In this study, hierarchical ZnS–CNT hybrids were synthesized via a solvothermal reaction at 180 °C for 48 h, producing ∼200 nm ZnS spheres uniformly anchored onto oxidized multiwalled carbon nanotubes. Structural analyses by XRD confirmed the cubic sphalerite phase, while SEM and TEM revealed a “pearl-necklace” morphology and effective nanoparticle dispersion. XPS spectra verified Zn²⁺ and oxygen-containing surface groups on the composite. Nitrogen adsorption–desorption measurements showed that incorporating CNTs transformed the material’s isotherm from type III to type IV, increasing the BET surface area from 68 to 155 m² /g and introducing mesoporosity. When drop-cast onto More >

Guang Chen¹, Shiwang Dang¹, Fanpeng Kong², Lingchong Hu¹, Zhiming Zhang¹, Yi Guo³, Xue Pei¹, Jichao Li^1,4,*

FDMP-Fluid Dynamics & Materials Processing, Vol.21, No.11, pp. 2721-2740, 2025, DOI:10.32604/fdmp.2025.068889 - 01 December 2025

Abstract To enhance the navigation efficiency of inland new-energy ships and reduce energy consumption and emissions, this study investigates wind load coefficients under 13 conditions, combining a wind speed of 2.0 m/s with wind direction angles ranging from 0° to 180° in 15° increments. Using Computational Fluid Dynamics (CFD) simulations, the wind load is decomposed into along-course (C_X) and transverse (C_Y) components, and their variation with wind direction is systematically analyzed. Results show that C_X is maximal under headwind (0°), decreases approximately following a cosine trend, and reaches its most negative value under tailwind (180°). C_Y peaks at More >

Sonexai Kidoikhammouan¹, Charupong Saengboonmee^2,3, Sopit Wongkham^2,3, Wunchana Seubwai^3,4,*

Oncology Research, Vol.33, No.12, pp. 3679-3699, 2025, DOI:10.32604/or.2025.069027 - 27 November 2025

Abstract Cholangiocarcinoma (CCA) is an aggressive cancer originating from bile duct epithelium. Surgical resection remains the primary curative treatment for CCA. However, most CCA patients are diagnosed at an advanced stage, which limits the applicability of surgical resection. Gemcitabine is widely used as a first-line chemotherapeutic agent for unresectable CCA. Its efficacy is often compromised by the development of drug resistance, which leads to poor clinical outcomes and low survival rates of CCA patients. At present, the mechanisms underlying gemcitabine resistance in CCA remain unclear. This review aimed to comprehensively summarize the current knowledge on the More >

Yizhen Zhang^1,2,#, Juan Li^1,3,#, Huanqing Liu^1,4,#, Hong Xia¹, Jian Su^1,5, Fang Liu¹, Bo Su^6,*, Qi Su^1,*

Oncology Research, Vol.33, No.12, pp. 3869-3886, 2025, DOI:10.32604/or.2025.068689 - 27 November 2025

Abstract Objectives: Gastric cancer (GC) is often associated with high invasiveness, epithelial-mesenchymal transition (EMT), and resistance to 5-fluorouracil (5-FU), highlighting the need for novel therapeutic targets. This study explored whether diallyl disulfide (DADS) upregulates retinoic acid-related orphan receptor alpha (ROR) to weaken the protein kinase C alpha (PKC)/RORα-mediated RORα/β-catenin pathway, thereby inhibiting GC cell invasion, epithelial-mesenchymal transition (EMT), and enhancing 5-FU sensitivity. Methods: Human GC cell lines MGC-803 and SGC7901 were treated with DADS, RORα agonist SR1078/antagonist T0901317, and PKCα agonist TPA/antagonist GO6976. Cell proliferation (MTT), migration (scratch assay), invasion (Transwell), protein expression (Western blot), protein… More >

Huan Wang^1,#, Jindong Xie^1,#, Na Li¹, Qianwen Liu¹, Wenqi Song¹, Wenkuan Chen¹, Cheng Peng^2,*, Hailin Tang^1,*

Oncology Research, Vol.33, No.12, pp. 3789-3800, 2025, DOI:10.32604/or.2025.067592 - 27 November 2025

Abstract Solid tumors comprise the majority of the global cancer burden, with their incidence and associated mortality posing considerable challenges to public health systems. With population growth and aging, the burden of these tumors is anticipated to increase further in the coming decades. The progression of solid tumors depends on dynamic interactions between malignantly transformed cells and the tumor microenvironment (TME). Immune checkpoint inhibitor therapy improves T cell-mediated antitumor activity by suppressing regulatory pathways, such as programmed cell death protein 1/programmed death-ligand 1. Nonetheless, its widespread application is constrained by drug resistance. In this comprehensive review, More >

Ranran Yang^1,2,3,#, Dan Yuan^2,#, Chaohan Liang^4,#, Siying Zhu⁴, Jie Huang², Yingqi Zhang⁴, Weiling He⁵, Qinghai Li^1,*, Hong Zhang^2,*

Oncology Research, Vol.33, No.12, pp. 3945-3971, 2025, DOI:10.32604/or.2025.064463 - 27 November 2025

Abstract Background: Colorectal cancer (CRC) is a predominant contributor to global cancer-associated mortality worldwide. Oxaliplatin (OXP), a foundational chemotherapeutic agent for CRC, often exhibits limited efficacy due to the emergence of drug resistance. Although endothelin-1 (EDN1) has been implicated in tumor drug resistance, its role in oxaliplatin resistance in CRC remains poorly defined. This work aimed to define how EDN1 contributes to oxaliplatin resistance and to explore its potential as a therapeutic target. Methods: Public genomic datasets were analyzed to confirm EDN1 upregulation in colorectal cancer (CRC) and its association with poor prognosis. EDN1 expression was… More >

Mutamba Ropafadzo Peace¹, Thobeka Madide^1,2, Ntethelelo Sibiya^1,*

BIOCELL, Vol.49, No.11, pp. 2069-2091, 2025, DOI:10.32604/biocell.2025.068017 - 24 November 2025

Abstract The pathogenesis of insulin resistance is influenced by environmental factors, genetic predispositions, and several medications. Various drugs used to manage multiple ailments have been shown to induce insulin resistance, which could lead to Type II Diabetes mellitus (T2DM). Central to drug-induced insulin resistance is mitochondrial dysfunction. Amongst disturbed pathways in drug-induced mitochondrial toxicity is mitophagy, a process that removes dysfunctional mitochondria through the lysosomal pathways to maintain mitochondrial quality. A balance must always be maintained between mitochondrial dynamics and mitophagy, as any alterations may contribute to the pathogenesis of metabolic diseases such as diabetes mellitus.… More >