Sajid Ali^*, Yong-Sun Moon^*

Phyton-International Journal of Experimental Botany, Vol.94, No.5, pp. 1419-1451, 2025, DOI:10.32604/phyton.2025.064284 - 29 May 2025

Abstract This review focused on the role of plant growth-promoting rhizobacteria (PGPR) in enhancing plant growth and protecting against pathogens, highlighting their mechanisms of action, ecological benefits, and challenges. PGPR mediate plant growth through several mechanisms, including nutrient acquisition, production of antimicrobial compounds and induction of systemic resistance. These mechanisms are critical in improving crop yields, especially under stressful conditions. This review examines the molecular mechanisms of PGPR-mediated plant pathogen control, cellular mechanisms of PGPR in plant pathogen control, ecological and environmental benefits of PGPR application. Despite their potential, PGPR application is limited by environmental variability,… More >

Oncology Research Editorial Office

Oncology Research, Vol.33, No.6, pp. 1509-1509, 2025, DOI:10.32604/or.2024.062048 - 29 May 2025

Abstract This article has no abstract. More >

DEXUE FAN^1,#, WEI SU^2,#, ZHAOWEN BI³, XINXING WANG¹, XIANWEN XU¹, MINGZE MA⁴, LICHAO ZHU⁵, ZHENHAI ZHANG^1,3,*, JUNLIN GAO^2,*

Oncology Research, Vol.33, No.6, pp. 1459-1472, 2025, DOI:10.32604/or.2025.060407 - 29 May 2025

Abstract Objectives: Apatinib has been reported to be a promising treatment for sorafenib-resistant hepatocellular carcinoma (HCC) patients. However, the underlying mechanism remains ambiguous. The study aimed to explore the efficacy of apatinib in sorafenib-resistant HCC and the underlying mechanism both in vitro and in vivo. Methods: After observing epithelial-mesenchymal transformation (EMT) changes in HepG2 and HepG2/Sorafenib cells, we treated them with varying concentrations of apatinib to assess its impact on sorafenib-resistant HCC. Subsequently, specific inhibitors of c-Jun N-terminal kinase (JNK, SP600125) and extracellular signal-regulated kinase (ERK, PD98059) were introduced to investigate whether apatinib influenced sorafenib-resistant HCC via modulation… More >

YU HONG^1,#, YUNXIANG TANG^1,#, WENYAN ZHOU¹, HANYUE LUO², LINLIN BU², HUI QIU^3,*, QIUJI WU^3,*

Oncology Research, Vol.33, No.6, pp. 1347-1361, 2025, DOI:10.32604/or.2025.059327 - 29 May 2025

Abstract As a rising immune checkpoint on tumor cells, CD24 is closely related to tumorigenesis and progression. CD24 can directly regulate the malignant behavior of tumor cells and indirectly inhibit the function of immune cells in the meantime, which promotes the immune escape of tumor cells, induces cancer invasion and causes poor prognosis. The basic principle of cancer treatment is to induce cell death and inhibit cell survival. Resistance to chemoradiotherapy is a critical challenge in oncology, which limits the effectiveness of anti-cancer treatments. Many studies have shown a strong association between CD24 and chemoradiotherapy More >

Jae Hyeong Kim¹, Yuna Youn¹, Jin-Hyeok Hwang^1,2,*

BIOCELL, Vol.49, No.4, pp. 681-700, 2025, DOI:10.32604/biocell.2025.062144 - 30 April 2025

Abstract Objectives: SLFN11 (Schlafen-11) enhances sensitivity to DNA-damaging agents (DDAs) and DNA damage response (DDR) inhibitors in various cancer types. However, its function in pancreatic cancer (PC) remains largely unknown. This research aims to investigate the expression patterns of SLFN11 and other SLFN family members in PC and their correlation with drug sensitivity. Methods: SLFN11 expression and genetic alterations were analyzed using publicly available datasets (TCGA and GTEx). Functional studies, including cell cycle, apoptosis assays, and proliferation assays, were performed in SLFN11-knockdown and SLFN11-knockout (KO) PC cells. The relationship between SLFN11 expression and drug responsiveness was assessed via the CellMiner… More >

MOEKA NAKASHIMA, NAOKO SUGA, AKARI FUKUMOTO, SAYURI YOSHIKAWA, SATORU MATSUDA^*

Oncology Research, Vol.33, No.5, pp. 1007-1017, 2025, DOI:10.32604/or.2025.059657 - 18 April 2025

Abstract Malignant tumors are heterogeneous diseases characterized by uncontrolled cell proliferation, invasion, metastasis, and/or recurrence of their malignancies. In particular, cancer stem cells (CSCs) within these tumors might be responsible for the property of invasiveness and/or therapies-resistance. CSCs are a self-renewing, awfully tumorigenic subpopulation of cancer cells, which are notorious for strong chemoresistance and are frequently responsible the aggravated invasion, metastasis, and/or recurrence. Developing targeting therapies against CSCs, therefore, may be deliberated a more encouraging mission for the greater cancer therapy. Innovation for a more potent anti-CSC treatment has been required as soon as possible.… More > Graphic Abstract

JIAHUI WANG^1,#, HONGCHENG GE^2,3,#, ZHENGYUAN YU^1,*, LINGZHI WU^1,*

Oncology Research, Vol.33, No.5, pp. 1033-1054, 2025, DOI:10.32604/or.2024.058256 - 18 April 2025

Abstract Lung cancer is a common cause of cancer-related death globally. The majority of lung cancer patients initially benefit from chemotherapy and immunotherapy. However, as the treatment cycle progresses and the disease evolves, the emergence of acquired resistance leads to treatment failure. Many researches have shown that non-coding RNAs (ncRNAs) not only influence lung cancer progression but also act as potential mediators of immunotherapy and chemotherapy resistance in lung cancer, mediating drug resistance by regulating multiple targets and pathways. In addition, the regulation of immune response by ncRNAs is dualistic, forming a microenvironment for inhibits/promotes More >

Weiliang Qi^1,2,3,4,*, Wancang Sun⁵, Li Ma⁵, Xiaolong Li¹, Haiqing Liu¹, Cairong Yang⁶, Ziyao Wei¹

Phyton-International Journal of Experimental Botany, Vol.94, No.3, pp. 739-762, 2025, DOI:10.32604/phyton.2025.060712 - 31 March 2025

Abstract Brassica napus L. (B. napus), recognized as a significant cash and oil crop, faces challenges in popularization and application in northern China due to its limited cold resistance. Clarifying the mechanism of cold stress on gene regulation and signal transduction in B. napus is crucial. To address these issues, we conducted transcriptome sequencing and gene expression analysis, along with gene ontology (GO) and Kyoto encyclopedia of genes and genomes (KEGG) pathway profiling under natural (25°C) and cold (4°C) conditions in cold tolerant 16VHNTS309 and weak cold-resistant Tianyou 2238 B. napus seedlings. Enhanced genomic annotation was achieved through additional sequencing.… More >

Shanlong Che, Guangliang Qu, Jin Ding^*, Guochen Wang, Yunyan Hao, Dianchen Li

Journal of Polymer Materials, Vol.42, No.1, pp. 221-236, 2025, DOI:10.32604/jpm.2025.058587 - 27 March 2025

Abstract Acrylonitrile–butadiene–styrene (ABS) is the main material used in fused deposition modeling (FDM), which has good toughness and strength, but the single ABS material has poor heat resistance, which tends to cause warping and deformation during the printing process. Polycarbonate (PC) exhibits good performance in heat resistance, allowing it to maintain stable performance at higher temperatures. In this work, PC was used as a blending modifier to prepare five kinds of ABS/PC composite filaments, and the mechanical and thermal properties of the ABS/PC (Acrylonitrile–butadiene–styrene/Polycarbonate) composite filaments were studied and analyzed. Results showed that the glass transition… More >

Hongjuan Guo¹, Dan Liu^1,2, Ruyu Yan^1,2, Tianjing Zhang³, Kecheng Zhou^1,2,*, Minxia Liu^1,*

BIOCELL, Vol.49, No.3, pp. 483-502, 2025, DOI:10.32604/biocell.2025.062143 - 31 March 2025

Abstract Objectives: Non-small cell lung cancer (NSCLC) represents a formidable malignancy characterized by its marked metastatic potential and intrinsic resistance to therapeutic interventions. The identification of potential biomarkers delineating the progression and metastatic cascade of NSCLC assumes paramount importance in fostering advancements toward enhanced patient outcomes and prognostic stratification. Methods: The expression level of the actin-related protein 2/3 complex; subunit 1A (ARPC1A) in NSCLC was evaluated using The Cancer Genome Atlas (TCGA) and Gene Expression Profiling Interactive Analysis (GEPIA) databases; along with the LinkedOmics database for co-expression genes. Further verification of ARPC1A expression in normal lung cells… More >