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  • Open Access


    Physiological and Transcriptome Analysis Illuminates the Molecular Mechanisms of the Drought Resistance Improved by Alginate Oligosaccharides in Triticum aestivum L.

    Yunhong Zhang1,2,*, Yonghui Yang1,2, Jiawei Mao1,2

    Phyton-International Journal of Experimental Botany, Vol.93, No.2, pp. 185-212, 2024, DOI:10.32604/phyton.2023.046811

    Abstract Alginate oligosaccharides (AOS) enhance drought resistance in wheat (Triticum aestivum L.), but the definite mechanisms remain largely unknown. The physiological and transcriptome responses of wheat seedlings treated with AOS were analyzed under drought stress simulated with polyethylene glycol-6000. The results showed that AOS promoted the growth of wheat seedlings and reduced oxidative damage by improving peroxidase and superoxide dismutase activities under drought stress. A total of 10,064 and 15,208 differentially expressed unigenes (DEGs) obtained from the AOS treatment and control samples at 24 and 72 h after dehydration, respectively, were mainly enriched in the biosynthesis of secondary metabolites (phenylpropanoid biosynthesis,… More >

  • Open Access


    CMTM6 deletion affects chemoresistance and macrophage M2 polarization in colorectal cancer cells

    YANG XU1,#, HONGYUN LI1,#, GE YOU2,*

    BIOCELL, Vol.48, No.2, pp. 229-237, 2024, DOI:10.32604/biocell.2023.045030

    Abstract Background: Colorectal cancer (CRC) constitutes the leading cause of death worldwide. Chemoresistance and tumor immune evasion are critical contributors to therapeutic failure in cancer patients. CKLF-like MARVEL transmembrane domain-containing 6 (CMTM6) is aberrantly expressed in various cancers and can regulate tumor immunity. However, its role in chemoresistance and tumor immunity of CRC is not well understood. Methods: Online bioinformatics tools were used to analyze expression and prognosis of CMTM6 in CRC patients. CRC cells were transfected with si-CMTM6. Subsequently, the effects on CRC cell viability and chemoresistance were investigated by CCK-8 assay and flow cytometer. Furthermore, CRC cell-induced macrophage recruitments… More > Graphic Abstract

    CMTM6 deletion affects chemoresistance and macrophage M2 polarization in colorectal cancer cells

  • Open Access


    CircTHSD4 promotes the malignancy and docetaxel (DTX) resistance in prostate cancer by regulating miR-203/HMGA2 axis


    Oncology Research, Vol.32, No.3, pp. 529-544, 2024, DOI:10.32604/or.2023.031511

    Abstract Objective: Circular ribose nucleic acids (circRNAs) are implicated in tumor progression and drug resistance of prostate cancer (PCa). The current work explored the function of circ_0005203 (circTHSD4) in the malignancy and docetaxel (DTX) resistance of PCa. Methods: circTHSD4 expression within PCa as well as matched non-carcinoma samples was measured through real-time reverse transcription-quantitative polymerase chain reaction (RT-qPCR). In addition, a subcellular fraction assay was conducted to determine circTHSD4 subcellular localization within PCa cells. In addition, we performed a Western blot (WB) assay to detect high-mobility-group A2 protein (HMGA2) levels. Besides, functional associations of two molecules were investigated through dual luciferase… More >

  • Open Access


    Optimization of Center of Gravity Position and Anti-Wave Plate Angle of Amphibious Unmanned Vehicle Based on Orthogonal Experimental Method

    Deyong Shang1,2, Xi Zhang1, Fengqi Liang1, Chunde Zhai1, Hang Yang1, Yanqi Niu1,2,*

    CMES-Computer Modeling in Engineering & Sciences, Vol.139, No.2, pp. 2027-2041, 2024, DOI:10.32604/cmes.2023.045750

    Abstract When the amphibious vehicle navigates in water, the angle of the anti-wave plate and the position of the center of gravity greatly influence the navigation characteristics. In the relevant research on reducing the navigation resistance of amphibious vehicles by adjusting the angle of the anti-wave plate, there is a lack of scientific selection of parameters and reasonable research of simulation results by using mathematical methods, and the influence of the center of gravity position on navigation characteristics is not considered at the same time. To study the influence of the combinations of the angle of the anti-wave plate and the… More >

  • Open Access


    Experimental Study of the Electrical Resistance of Graphene OxideReinforced Cement-Based Composites with Notch or Rebar

    Yangao Hu1,*

    The International Conference on Computational & Experimental Engineering and Sciences, Vol.27, No.3, pp. 1-1, 2023, DOI:10.32604/icces.2023.09773

    Abstract This paper investigates the effects of graphene oxide (GO), notch depth, rebar, and load on the resistivity of cement paste and mortar. The electrical conductivity of GO/cement composite reaches its maximum value when the GO content is 0.03%, which is approximately 50% higher compared to the composite without GO. The resistivity of GO/cement composite shows significant changes with increasing load from 0 to 40 kN. The gauge factor for compressive loading varies from about 26 to 73 for different GO contents. Moreover, the resistivity variation with the notch depth in GO/cement is found to be much greater than that in… More >

  • Open Access


    Extensive prediction of drug response in mutation-subtype-specific LUAD with machine learning approach


    Oncology Research, Vol.32, No.2, pp. 409-419, 2024, DOI:10.32604/or.2023.042863

    Abstract Background: Lung cancer is the most prevalent cancer diagnosis and the leading cause of cancer death worldwide. Therapeutic failure in lung cancer (LUAD) is heavily influenced by drug resistance. This challenge stems from the diverse cell populations within the tumor, each having unique genetic, epigenetic, and phenotypic profiles. Such variations lead to varied therapeutic responses, thereby contributing to tumor relapse and disease progression. Methods: The Genomics of Drug Sensitivity in Cancer (GDSC) database was used in this investigation to obtain the mRNA expression dataset, genomic mutation profile, and drug sensitivity information of NSCLS. Machine Learning (ML) methods, including Random Forest… More >

  • Open Access


    TGF-β-regulated different iron metabolism processes in the development and cisplatin resistance of ovarian cancer

    JIANFA WU1,2,#, QIANYI LIAO3,#, LI ZHANG1,2,#, SUQIN WU1,2,*, ZHOU LIU1,2,*

    Oncology Research, Vol.32, No.2, pp. 373-391, 2024, DOI:10.32604/or.2023.031404

    Abstract The impact of different iron metabolism processes (DIMP) on ovarian cancer remains unclear. In this study, we employed various gene chips and databases to investigate the role of DIMP in the initiation and development of ovarian cancer. cBioPortal was used to determine mutations in DIMP-associated genes in ovarian cancer. Kaplan-Meier plotter was used to examine the influence of DIMP on the prognosis of ovarian cancer. By analyzing 1669 serous ovarian cancer cases, we identified a range of mutations in iron metabolism genes, notably in those coding for the transferrin receptor (19%), melanotransferrin (19%), and ceruloplasmin (10%) in the iron import… More >

  • Open Access


    Identification of TNFRSF1A as a novel regulator of carfilzomib resistance in multiple myeloma


    Oncology Research, Vol.32, No.2, pp. 325-337, 2024, DOI:10.32604/or.2023.030770

    Abstract Multiple myeloma (MM) is a hematological tumor with high mortality and recurrence rate. Carfilzomib is a new-generation proteasome inhibitor that is used as the first-line therapy for MM. However, the development of drug resistance is a pervasive obstacle to treating MM. Therefore, elucidating the drug resistance mechanisms is conducive to the formulation of novel therapeutic therapies. To elucidate the mechanisms of carfilzomib resistance, we retrieved the GSE78069 microarray dataset containing carfilzomib-resistant LP-1 MM cells and parental MM cells. Differential gene expression analyses revealed major alterations in the major histocompatibility complex (MHC) and cell adhesion molecules. The upregulation of the tumor… More >

  • Open Access


    Bearing Fault Diagnosis with DDCNN Based on Intelligent Feature Fusion Strategy in Strong Noise

    Chaoqian He1,2, Runfang Hao1,2,*, Kun Yang1,2, Zhongyun Yuan1,2, Shengbo Sang1,2, Xiaorui Wang1,2

    CMC-Computers, Materials & Continua, Vol.77, No.3, pp. 3423-3442, 2023, DOI:10.32604/cmc.2023.045718

    Abstract Intelligent fault diagnosis in modern mechanical equipment maintenance is increasingly adopting deep learning technology. However, conventional bearing fault diagnosis models often suffer from low accuracy and unstable performance in noisy environments due to their reliance on a single input data. Therefore, this paper proposes a dual-channel convolutional neural network (DDCNN) model that leverages dual data inputs. The DDCNN model introduces two key improvements. Firstly, one of the channels substitutes its convolution with a larger kernel, simplifying the structure while addressing the lack of global information and shallow features. Secondly, the feature layer combines data from different sensors based on their… More >

  • Open Access



    Etim S. Udoetok*

    Frontiers in Heat and Mass Transfer, Vol.4, No.2, pp. 1-5, 2013, DOI:10.5098/hmt.v4.2.3008

    Abstract A model for the coefficient of thermal conductivity of binary mixtures of gases has been derived. The theory presented is based on the assumption of random fluctuations between two possible extreme arrangements of a binary gas mixture. The results obtained from the new model compared favorably with published experimental results. The proposed new model provides a simple approach without sacrificing much accuracy compared to previous models. It is applicable to any binary mixture of gases which includes monoatomic gas mixture, polyatomic gas mixtures and mixtures involving rare gases. The new model can be very useful in analysis like combustion where… More >

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