Zhichao Liu^1,2, Jun Zhang^2,*, Dongling Yu³, Libing Jin¹, Bingquan Song³

Structural Durability & Health Monitoring, Vol.20, No.5, 2026, DOI:10.32604/sdhm.2026.081186 - 24 August 2026

Abstract The chloride ion penetration resistance of manufactured sand concrete (MSC) critically determines the durability of marine concrete structures. However, its accurate prediction is challenging due to high uncertainty from complex influencing factors. To address this, a back-propagation neural network model optimized by a hybrid Whale Optimization Algorithm and Adaptive Moment Estimation strategy (WOA-Adam-BPNN) was developed to predict the electrical flux. The model was trained and tested on 245 experimental datasets covering eight key parameters and validated across four typical mix proportions. Results show that the WOA-Adam hybrid strategy effectively combines global search capability with adaptive More >

Hongyan Liu, Fang Wang, Jie Zhao, Feng Wu^*

Structural Durability & Health Monitoring, Vol.20, No.5, 2026, DOI:10.32604/sdhm.2026.079457 - 24 August 2026

Abstract This study investigates the thermo-mechanical behavior and residual strength of full-scale reinforced concrete (RC) beams subjected to ISO-834 fire exposure, emphasizing temperature-dependent material degradation and bond-slip effects. A sequentially coupled numerical framework was developed in ABAQUS, integrating a temperature-indexed Concrete Damage Plasticity (CDP) model for concrete, elastoplastic steel constitutive laws, and a temperature-dependent bond-slip model implemented via nonlinear SPRING2 elements. The model explicitly accounts for post-peak concrete softening, steel yield degradation, and interface deterioration, and was calibrated against full-scale experiments. Experimental measurements included internal and surface temperatures, load–midspan deflection, and residual strength after natural cooling. More >

Mingxuan Jia, Chenglong Shi, Yang Ye, Wen Huang, Jian Peng^*

CMC-Computers, Materials & Continua, Vol.89, No.1, 2026, DOI:10.32604/cmc.2026.084123 - 13 August 2026

Abstract With the development of electronic voting schemes, traditional on-site voting is gradually being replaced because of its organizational inconveniences. However, electronic voting takes place in an uncontrollable environment, which opens up the possibility of voter coercion. In this paper, we propose an electronic voting scheme with the property of coercion resistance and privacy preservation. In particular, we introduce the concept of somewhat deniable voting. Somewhat deniable voting gives up verifiability to some extent but not all in exchange for coercion resistance under the condition that the election result remains unchanged. Besides, a somewhat deniable voting More >

Chun-Nun Chao^1,2, Chiung-Yao Fang^2,3, Chia-Hsin Hou¹, Jen-Tsung Yang^4,5, Yu-Ping Wu^4,6, Jui-Chieh Chen^6,*

Oncology Research, Vol.34, No.9, 2026, DOI:10.32604/or.2026.083962 - 13 August 2026

Abstract Objectives: Temozolomide (TMZ) resistance remains a major challenge in glioblastoma (GBM) treatment. This study investigated the role of miR-152-3p and its downstream target, transforming growth factor-α (TGF-α), in regulating TMZ sensitivity in GBM. Methods: Public GEO and CGGA datasets were analyzed to evaluate the expression and prognostic significance of miR-152-3p. TMZ-resistant GBM cell lines (U87MGR and DBTRG-05MGR) were established by continuous TMZ exposure. Gain- and loss-of-function experiments were performed using miR-152-3p mimics and inhibitors. Cell viability, apoptosis, and TGF-α expression were assessed by MTT, qRT-PCR, and Western blot analyses. Results: miR-152-3p expression was significantly decreased in recurrent… More >

Heng Xu^1,#, Jiaan Lu^1,#, Zizhang Wang^1,#, Jiayu Xu², Shihui Peng³, Haiqing Chen⁴, Qiang Cao^5,*, Qing Sun^6,*, Shangke Huang^7,*

Oncology Research, Vol.34, No.9, 2026, DOI:10.32604/or.2026.083919 - 13 August 2026

Abstract Despite the potential of current cancer immunotherapies, tumor cells frequently evade immune surveillance by forming an immunosuppressive microenvironment, leading to treatment resistance. Current inquiry positions the sympathetic nervous system (SNS) at the forefront of tumor immunology as a critical driver of this immune evasion. This review delineates the cellular pharmacology of SNS-mediated immune regulation across the tumor ecosystem. Operating predominantly through the cyclic adenosine monophosphate-protein kinase A (cAMP-PKA) signaling axis, the SNS engages in bidirectional regulation with immune cells of the tumor microenvironment (TME). Norepinephrine and epinephrine interact with β₂-adrenergic receptors (β₂-ARs), triggering G-protein dissociation, adenylyl… More >

Xueping Zhu^1,2,3,#, Misi He^1,2,3,#, Ling Wang^1,2,3,#, Rui Su⁴, Lin Zhong^1,2,3, Ting Guo^1,2,3,4, Haixia Wang^1,2,3,*, Dongling Zou^1,2,3,*

Oncology Research, Vol.34, No.9, 2026, DOI:10.32604/or.2026.083902 - 13 August 2026

Abstract Nucleocytoplasmic transport (NCT) regulates the spatial distribution of proteins and RNA between the nucleus and cytoplasm. NCT dysregulation can mislocalize tumor suppressors, DNA-repair factors, transcription factors, and drug targets in cancer. In this review, we conceptualize NCT-dependent protein mislocalization as a spatial regulatory framework for anticancer drug resistance, rather than as a catalogue of transport components. We systematically discuss how nuclear pore complex (NPC) remodeling, transport-receptor imbalance, post-translational modification (PTM)-regulated cargo routing, signaling-NCT crosstalk, nuclear localization signal/nuclear export signal (NLS/NES) alterations, and tumor microenvironmental pressures jointly drive aberrant nucleocytoplasmic distribution. These processes can further regulate… More >

Jie Wu^1,2, Zhewei Zhang^1,2, Kit Ying Chan^1,2, Tat San Lau^1,2,*, Chi Chiu Wang^1,2,3,*

Oncology Research, Vol.34, No.9, 2026, DOI:10.32604/or.2026.083359 - 13 August 2026

Abstract Ovarian cancer is the most lethal gynecological malignancy, with most patients diagnosed at an advanced stage and eventually relapsed after post-platinum-taxane chemotherapy. High intratumoral heterogeneity, extensive peritoneal dissemination, and acquired chemoresistance continue to restrict the clinical benefits of current therapeutic strategies. Increasing evidence indicates that ovarian cancer stem cells (OCSCs), a rare but highly plastic subpopulation characterized by self-renewal, multilineage differentiation, quiescence, tumor-initiating capacity, and intrinsic stress tolerance, play pivotal roles in tumor initiation, metastasis, recurrence, and therapeutic resistance. In this review, we systematically summarize current knowledge regarding the identification and functional characterization of OCSCs More >

Yanhong Wang^1,#, Junbo Liu^2,#, Qiaoping Xu^3,#, Zhao Ma^4,*

Oncology Research, Vol.34, No.9, 2026, DOI:10.32604/or.2026.082432 - 13 August 2026

Abstract In renal cell carcinoma (RCC), alterations in cellular metabolism are a defining feature, among which impaired mitochondrial function stands out as a key factor influencing both tumor aggressiveness and patient responses to therapy. The aim of this review is to systematically synthesize current knowledge on the role of mitochondrial dysfunction in RCC pathogenesis and to explore emerging therapeutic strategies targeting mitochondrial vulnerabilities. This comprehensive analysis examines the integrated dysregulation of core mitochondrial processes—bioenergetic metabolism, organelle dynamics, programmed cell death pathways, redox homeostasis, and selective autophagy—in driving RCC pathogenesis. Our synthesis reveals how genetic drivers, molecular… More >

Chao Han, Ming Hou, Ruifeng Yang, Xiaoping Wei, Cheng Wang^*

Oncology Research, Vol.34, No.9, 2026, DOI:10.32604/or.2026.081222 - 13 August 2026

Abstract Esophageal Squamous Cell Carcinoma (ESCC) is a highly aggressive malignancy characterized by a poor long-term prognosis. Aberrant activation of the canonical Wnt/β-catenin pathway serves as a central oncogenic driver in ESCC, with large-scale genomic analyses revealing that most patients harbor alterations in pathway-associated genes. This signaling axis orchestrates a wide array of malignant phenotypes, including tumor proliferation, invasion, epithelial-mesenchymal transition (EMT), cancer stemness, and therapeutic resistance. Therefore, this review aims to provide a comprehensive synthesis of the multifaceted crosstalk between various ncRNA classes and the Wnt/β-catenin axis, highlighting their roles in ESCC progression and their… More >

Jurica Duvnjak¹, Daniel Kujundzic², Katarina Sunic Budimir¹, John C. D’Auria², Valentina Spanic^1,*

Phyton-International Journal of Experimental Botany, Vol.95, No.7, 2026, DOI:10.32604/phyton.2026.082576 - 30 July 2026

Abstract In this study, metabolomic profiling using gas chromatography–mass spectrometry (GC-MS) revealed clear distinctions between Fusarium-infected and control wheat spikes, as shown by the separate clustering of infected samples. Out of 222 detected features, eight were found to be significantly altered in infected spikes compared to controls, highlighting specific metabolic changes associated with the plant’s response to Fusarium head blight (FHB) stress. In response to Fusarium infection, wheat exhibited significant metabolic reprogramming, with both reductions and accumulations of key metabolites. A decrease in 3-methoxytyramine (28.9–85.3%), octylamine, malic acid, and homonojirimycin suggests their early involvement in defence-related pathways… More >