Lei Luo¹, Fengju Guan¹, Zhankun Wang², Bin Li¹, Xuemei Ding¹, Leilei Song¹, Lijiang Sun^1,*

Oncology Research, Vol.34, No.7, 2026, DOI:10.32604/or.2026.080621 - 16 June 2026

Abstract Background: Resistance to sunitinib represents a major clinical obstacle in the management of clear cell renal cell carcinoma (ccRCC). This investigation aims to identify genes associated with sunitinib resistance and elucidate potential molecular pathways in ccRCC. Methods: To identify differentially expressed genes (DEGs) in sunitinib-resistant ccRCC cells and their parental cells, bioinformatic analysis was performed on the GSE216494 dataset. Protein-protein interaction (PPI) network and topological analyses pinpointed a hub gene. Sunitinib-resistant A498 and 786-O cell lines were employed for in vitro validation. Sunitinib sensitivity and cell proliferation were evaluated using functional assays, such as colony formation and… More >

Changyul Kim^1,2,#, Yu Ju Jung^2,#, Da Hee Son², Na Young Kim², Se Gie Kim³, Hee Sung Park^1,*

Oncology Research, Vol.34, No.7, 2026, DOI:10.32604/or.2026.078448 - 16 June 2026

Abstract Backgrounds: Autocrine motility factor (AMF) represents a paradoxical protein with dual roles in cancer progression and therapy. This study investigated AMF-derived tetradecapeptides as novel chemosensitizing agents to overcome multidrug resistance (MDR) in hematological malignancies (HMs). Methods: Seven AMF variants were screened for anticancer activity across 14 human cancer cell lines using MTT and Cell Counting Kit-8 (CCK-8) assays. Four tetradecapeptides (AMF-derived peptides AAP, HGP, HTP, and SKP) corresponding to the AMF206-219 region were designed and evaluated in three HM cell lines (HL-60, CCRF-CEM, IM-9) for growth inhibition, cellular internalization, reactive oxygen species (ROS) production, mitochondrial membrane… More >

Avetis Tsaturyan^1,2, Heghine Hakobyan¹, Kristina Hovsepyan¹, Anna Mkrtchyan^1,2, Tatevik Sargsyan^1,2,*, Raffaele Pastore³, Germano Guerra³, Giovanni N. Roviello^4,*

Oncology Research, Vol.34, No.7, 2026, DOI:10.32604/or.2026.078405 - 16 June 2026

Abstract Cancer is regarded as one of the leading causes of death worldwide, despite the progress of traditional therapies. Chemotherapy, radiotherapy, and surgery are often accompanied by significant side effects and the development of drug resistance contributes to making the fight against cancer even more challenging, which clearly highlights the urgent need to develop new therapeutic molecular approaches. In this context, natural peptides were introduced into the pharmaceutical market in the last decade and have replenished the ranks of effective anticancer agents due to their structural diversity, biocompatibility, and ability to selectively target tumor cells. Natural… More >

Marwa Balaha¹, Saad A. Aldosari², Ahmed A. Alamer², Nehad Ahmed², Mohamed F. Balaha^2,*

Oncology Research, Vol.34, No.7, 2026, DOI:10.32604/or.2026.077965 - 16 June 2026

Abstract Objectives: Tissue-agnostic oncology personalizes treatments based on shared molecular biomarkers, addressing challenges like assay variability, control-arm rigor, and non-proportional hazards. Integrating efficacy, safety, and resistance factors with consistent estimands is essential for evaluating biomarker-matched therapies across histologies. This review aims to quantify and compare their efficacy and safety, and to identify determinants of resistance, using PRISMA-compliant methods. Methods: We conducted a systematic review and random-effects meta-analysis of 38 studies (15,018 participants), employing dual screening, standardized bias assessment, and evaluations of heterogeneity and small-study effects. Hazard ratios (HRs) with 95% CIs were estimated for time-to-event outcomes, and… More > Graphic Abstract

Jinhui Che^1,2, Zhiyuan Chen¹, Feng Zhang^3,4, Shuo Zhu², Shengya Cao⁵, Ou Li¹, Rong Li^4,*, Jun Zheng^3,4,*, Yubin Liu^1,*

Oncology Research, Vol.34, No.7, 2026, DOI:10.32604/or.2026.067443 - 16 June 2026

Abstract Objective: Advanced liver cancer, a highly lethal and increasingly prevalent malignancy, frequently develops sorafenib resistance, with aberrant mitochondrial dynamics and metabolism implicated in its pathogenesis. This study aimed to investigate their interplay and assess combination therapies against sorafenib-resistant liver cancer. Methods: Mitochondrial morphology was assessed using immunofluorescent staining. Besides, the mitochondrial metabolic profile was evaluated by measuring the oxygen consumption rate, glucose uptake, and lactate production. Dynamin-related protein 1 (Drp1) expression was determined through immunohistochemical staining, western blotting, and reverse transcription-quantitative polymerase chain reaction (RT-qPCR). Cell counting, colony formation, and cell cycle assays were conducted to… More >

Angel Prado^1,*, Alejandro Alañón², Ricardo Castedo³, Anastasio Pedro Santos³, Lina María López³, María Chiquito³

CMES-Computer Modeling in Engineering & Sciences, Vol.147, No.2, 2026, DOI:10.32604/cmes.2026.079804 - 27 May 2026

Abstract This study presents a numerical investigation into the influence of reinforcement layout on the blast response of a reinforced concrete (RC) slab subjected to a close-in explosion. The reference scenario is based on a blast test from the SEGTRANS project using a 15 kg TNT equivalent charge. A validated LS-DYNA model was used, applying the Load Blast Enhanced method and the Continuous Surface Cap Model for concrete behaviour. Forty-nine reinforcement configurations were assessed, all with constant steel mass but varying numbers of longitudinal bars and stirrups. Damage metrics such as eroded elements and internal energy… More >

Bizhen Lin^1,#, Wenzhong Lin^2,#, Dongmei Lian¹, Susu Yuan¹, Weiying Wang^1,*

Phyton-International Journal of Experimental Botany, Vol.95, No.5, 2026, DOI:10.32604/phyton.2026.082698 - 27 May 2026

Abstract Grafting is a common strategy to control bacterial wilt (Ralstonia solanacearum) in susceptible crops, including pepper. However, the contribution of resistant rootstocks to scion immunity, beyond physical pathogen exclusion, requires further elucidation. In this study, susceptible ‘HF8’ scions were grafted onto six rootstock genotypes, and their resistance was evaluated via leaf-clip inoculation, which bypasses root-mediated physical barriers. Scions grafted onto resistant rootstocks exhibited restricted pathogen spread and higher survival rates; specifically, the NK4-HF8 combination demonstrated a 100% survival rate, compared to 11% in susceptible-rootstock combinations and 46% in self-grafted controls. Comparative transcriptomic profiling revealed distinct transcriptional… More >

Weixiang Song^1,#, Yanbo Zhang^2,#, Xubo Shen¹, Qin Yu¹, Yujin Liu¹, Yongchun Yu³, Rui Chen^1,*

Oncology Research, Vol.34, No.6, 2026, DOI:10.32604/or.2026.078665 - 21 May 2026

Abstract Objective: Osimertinib can selectively inhibit both epidermal growth factor receptor (EGFR) sensitizing and T790M gatekeeper mutations, and has shown remarkable therapeutic effects in patients with lung adenocarcinoma. However, almost all patients inevitably develop drug resistance. Herein, we sought to clarify the roles of exosomal lncRNA H19 in modulating osimertinib resistance, focusing on the PI3K-PTEN-Akt signaling axis. Methods: Functional assays, including cell viability assay, colony formation, cell apoptosis and xenograft mouse, employed in evaluate the effects of exosomal lncRNA H19 on cell growth and apoptosis. RNA quantitation and western blot were adopted to demonstrate the regulatory roles of… More >

Daniel Arcuschin de Oliveira¹, Melissa Yoshimi Sakamoto Maeda Nisimoto¹, Jaciara Moreira Sodré Hunnicutt¹, Eduarda Massa Sartori¹, Amanda Fáris Marques¹, Francisco Macedo Paschoal², Luciana Cavalheiro Marti^1,3, Miriam Galvonas Jasiulionis⁴, Miguel Sabino Neto¹, Renato Santos de Oliveira Filho^1,*

Oncology Research, Vol.34, No.6, 2026, DOI:10.32604/or.2026.077913 - 21 May 2026

Abstract Acral lentiginous melanoma (ALM) is characterized by a low mutational burden, frequent chromosomal rearrangements, and profound epigenetic dysregulation, distinguishing it from ultraviolet (UV)-induced melanoma. Among the epigenetic regulators, Enhancer of Zeste Homolog 2 (EZH2), the catalytic component of the Polycomb Repressive Complex 2 (PRC2), plays a central role in chromatin compaction and transcriptional repression through trimethylation of histone H3 on lysine 27 (H3K27me3). EZH2 overexpression or hyperactivation contributes to tumor progression, immune evasion, and therapeutic resistance. Recent multi-omic studies have highlighted the importance of EZH2 in regulating melanoma plasticity, immune modulation, and metabolic reprogramming. In… More > Graphic Abstract

Kirill V. Chernov^1,#, Artemii M. Savin^1,#, Daria E. Otvodnikova¹, Oleg A. Kuchur^1,2, Sergey A. Tsymbal^1,2,*

Oncology Research, Vol.34, No.6, 2026, DOI:10.32604/or.2026.077445 - 21 May 2026

Abstract The formation of drug resistance poses the ultimate threat in modern oncology. Targeted therapy lacks versatility, while conventional therapy is famous for its side effects. However, for the new therapeutics to address the challenge of drug resistance, such compounds should combine properties of both modalities. In this review, we argue that metal-based therapeutics are paramount substances for achieving this goal. The unique physico-chemical properties and metabolism of these compounds, as well as metals themselves, allow to realize unique activities in normal and cancer cells, including precise targeting, non-apoptotic cell death, and disruption of critical signaling More > Graphic Abstract