NILAM BHUSARE, MAUSHMI KUMAR^*

Oncology Research, Vol.32, No.5, pp. 849-875, 2024, DOI:10.32604/or.2024.047042

Abstract Glioblastoma, the most aggressive form of brain tumor, poses significant challenges in terms of treatment success and patient survival. Current treatment modalities for glioblastoma include radiation therapy, surgical intervention, and chemotherapy. Unfortunately, the median survival rate remains dishearteningly low at 12–15 months. One of the major obstacles in treating glioblastoma is the recurrence of tumors, making chemotherapy the primary approach for secondary glioma patients. However, the efficacy of drugs is hampered by the presence of the blood-brain barrier and multidrug resistance mechanisms. Consequently, considerable research efforts have been directed toward understanding the underlying signaling pathways involved in glioma and developing… More > Graphic Abstract

EFFAT ALEMZADEH¹, LEILA ALLAHQOLI², AFROOZ MAZIDIMORADI³, ESMAT ALEMZADEH^1,4, FAHIMEH GHASEMI^4,5, HAMID SALEHINIYA⁶, IBRAHIM ALKATOUT^7,*

Oncology Research, Vol.32, No.5, pp. 831-847, 2024, DOI:10.32604/or.2024.031006

Abstract Ovarian cancer is among the most lethal gynecological cancers, primarily due to the lack of specific symptoms leading to an advanced-stage diagnosis and resistance to chemotherapy. Drug resistance (DR) poses the most significant challenge in treating patients with existing drugs. The Food and Drug Administration (FDA) has recently approved three new therapeutic drugs, including two poly (ADP-ribose) polymerase (PARP) inhibitors (olaparib and niraparib) and one vascular endothelial growth factor (VEGF) inhibitor (bevacizumab) for maintenance therapy. However, resistance to these new drugs has emerged. Therefore, understanding the mechanisms of DR and exploring new approaches to overcome them is crucial for effective… More >

Weiwu Jiang¹, Xiaowei Gao^1,2,*

CMES-Computer Modeling in Engineering & Sciences, Vol.140, No.1, pp. 41-76, 2024, DOI:10.32604/cmes.2024.048313

Abstract The collocation method is a widely used numerical method for science and engineering problems governed by partial differential equations. This paper provides a comprehensive review of collocation methods and their applications, focused on elasticity, heat conduction, electromagnetic field analysis, and fluid dynamics. The merits of the collocation method can be attributed to the need for element mesh, simple implementation, high computational efficiency, and ease in handling irregular domain problems since the collocation method is a type of node-based numerical method. Beginning with the fundamental principles of the collocation method, the discretization process in the continuous domain is elucidated, and how… More >

Huaiguang Wu, Yibo Peng, Yaqiong He^*, Jinlin Fan

CMES-Computer Modeling in Engineering & Sciences, Vol.140, No.1, pp. 77-108, 2024, DOI:10.32604/cmes.2024.046758

Abstract In recent years, the number of smart contracts deployed on blockchain has exploded. However, the issue of vulnerability has caused incalculable losses. Due to the irreversible and immutability of smart contracts, vulnerability detection has become particularly important. With the popular use of neural network model, there has been a growing utilization of deep learning-based methods and tools for the identification of vulnerabilities within smart contracts. This paper commences by providing a succinct overview of prevalent categories of vulnerabilities found in smart contracts. Subsequently, it categorizes and presents an overview of contemporary deep learning-based tools developed for smart contract detection. These… More > Graphic Abstract

JHILAM PRAMANIK^1,#, AKASH KUMAR², SARVESH RUSTAGI^3,#, MEHAK KATYAL⁴, SHEETAL THAKUR⁵, JUTISHNA BORA⁶, SUMIRA MALIK^6,7,*, ANCHAL TREHAN⁸, NAYAN TALUKDAR⁹, PETR SLAMA^10,*

BIOCELL, Vol.48, No.4, pp. 541-557, 2024, DOI:10.32604/biocell.2023.029031

Abstract Many phytochemicals and their derived metabolites produced by plants are extensively employed in commercial goods, pharmaceutical products as well as in the environmental and medical fields. However, these secondary metabolites obtained from plants are in low amounts, and it is difficult to synthesize them at the industrial level. Despite these challenges, they may be utilized for a variety of medicinal products that are either available in the market or are being researched and tested. Secondary metabolites are complex compounds that exhibit chirality. Further, under controlled conditions with elicitors, desired secondary metabolites may be produced from plant cell cultures. This review… More > Graphic Abstract

Antonio Pizzi^1,*, Marie-Pierre Laborie^2,3, Zeki Candan⁴

Journal of Renewable Materials, Vol.12, No.3, pp. 397-425, 2024, DOI:10.32604/jrm.2023.046074

Abstract Condensed and hydrolysable tannins are non-toxic natural polyphenols that are a commercial commodity industrialized for tanning hides to obtain leather and for a growing number of other industrial applications mainly to substitute petroleum-based products. They are a definite class of sustainable materials of the forestry industry. They have been in operation for hundreds of years to manufacture leather and now for a growing number of applications in a variety of other industries, such as wood adhesives, metal coating, pharmaceutical/medical applications and several others. This review presents the main sources, either already or potentially commercial of this forestry by-materials, their industrial… More > Graphic Abstract

AMRITA SHARMA, P. P. PANDE

Journal of Polymer Materials, Vol.36, No.2, pp. 175-194, 2019, DOI:10.32381/JPM.2019.36.02.6

Abstract ‘Comb-like polymers’ are a special class of polymers. These are consisting of two types of chains, first one is the backbone chain and second is long side chains. The structure of such a polymer is very similar to hair comb. Usually, every monomer unit in the backbone has a long n-alkyl side chain. Comb like polymers have an intrinsic ability towards forming ordered structure. Now-a-days, these polymers find wide range of applications because of their excellent physicochemical properties. Some applications are in preparation of polysoaps (polymeric disinfectants), as dispersing agent for ink and paints, textile industry, in surface modification of… More >

NEETU TRIPATHI, DIBYENDU S. BAG^*, MAYANK DWIVEDI

Journal of Polymer Materials, Vol.40, No.3-4, pp. 227-269, 2023, DOI:10.32381/JPM.2023.40.3-4.8

Abstract Over the last three decades, there has been considerable interest in the captivating mechanical properties displayed by auxetic materials, highlighting the advantages stemming from their distinct negative Poisson's ratio. The negative Poisson's ratio observed in auxetic polymeric materials is a result of the distinctive geometries of their unit cells. These unit cells, encompassing structures such as chiral, re-entrant, and rotating rigid configurations, are carefully engineered to collectively generate the desired auxetic behaviour. This comprehensive review article explores the field of auxetic polymeric materials, offering a detailed exploration of their geometries, fabrication methods, mechanical properties, and characterisation. The diverse applications of… More >

THIRUMALAISAMY SURYAPRABHA^A, CHUNGHYUN CHOI^A, ZUBAIR AHMED CHANDIO^B, LAWRENCE ROBERT MSALILWA^B, TAEGWANG YUN^C,*, JUN YOUNG CHEONG^B,*, BYUNGIL HWANG^A,*

Journal of Polymer Materials, Vol.40, No.3-4, pp. 191-204, 2023, DOI:10.32381/JPM.2023.40.3-4.5

Abstract Magnetorheological fluids (MRFs) is a smart fluid system that exhibits swift and reversible alterations in their rheological characteristics when exposed to an external magnetic field. MRFs are used for applications in various areas, including automotive systems, robotics, aerospace, and civil engineering. The performance of MRFs depends on the behavior of the dispersed magnetic particles, necessitating thoughtful consideration of particle traits to optimize fluid performance. Carbonyl Iron Powders (CIPs), high purity iron (>98%) reduced from penta carbonyl iron, are widely employed in MRFs due to their exceptional magnetic characteristics. Nevertheless, the innate surfaces of CIPs tend to conglomerate, leading to compromises… More >

ARCHNA RANI

Journal of Polymer Materials, Vol.39, No.1-2, pp. 17-35, 2022, DOI:10.32381/JPM.2022.39.1-2.2

Abstract Accumulation of Microplastics (MPs) in diverse ecosystems is a growing global problem of our time. These are entering into the environment directly (micro-sized plastics manufactured purposefully) and by degradation of plastic products. Due to a diverse range of polymers and additives used to manufacture plastic products, the MPs of different chemical compositions are abundant in the environment. A detailed literature survey revealed that MPs -environment interaction is largely governed by these chemicals and other intrinsic properties of MPs viz. shape, size, density, surface charge, etc. The current investigation primarily aims to review different chemical and physical factors of MPs that… More >