Zhiyi Peng^*1, Guohong Cao^†1, Qinming Hou^‡, Ling Li^§, Shihong Ying^*, Junhui Sun^¶, Guanhui Zhou^¶, Jian Zhou^#, Xin Zhang^*, Wenbin Ji^**, Zhihai Yu^††, Tiefeng Li^‡‡, Dedong Zhu^§, Wenhao Hu^§§, Jiansong Ji^¶¶, Haijun Du^##, Changsheng Shi^***, Xiaohua Guo^†††, Jian Fang^‡‡‡, Jun Han^§§§, Wenjiang Gu^¶¶¶, Xiaoxi Xie^###, Zhichao Sun^****, Huanhai Xu^††††, Xia Wu^‡‡‡‡, Tingyang Hu^§§§§, Jing Huang^¶¶¶¶, Hongjie Hu^‡‡‡‡, Jiaping Zheng^####, Jun Luo^####, Yutang Chen^####, Wenqiang Yu^§§§§, Guoliang Shao^####

Oncology Research, Vol.28, No.3, pp. 249-271, 2020, DOI:10.3727/096504019X15766663541105

Abstract This study aimed to investigate the efficacy, safety, and prognostic factors of drug-eluting beads transarterial chemoembolization (DEB-TACE) in treating Chinese patients with liver cancer. A total of 367 liver cancer patients from 24 medical centers were consecutively enrolled in this multiple-center, prospective cohort study, including 275 hepatocellular carcinoma (HCC) cases, 37 intrahepatic cholangiocarcinoma (ICC) cases, and 55 secondary liver cancer cases. All the patients received CalliSpheres^® DEB-TACE treatment. Treatment response, overall survival (OS), change of liver function, and adverse events (AEs) were assessed. DEB-TACE treatment achieved 19.9% complete response (CR) and 79.6% objective response rate (ORR), with mean OS of… More >

Huan Ma¹, Cong Nie¹, Ying Chen, Jinmiao Li, Yanjie Xie, Zhixin Tang, Yang Gao, Siming Ai, Yuxiang Mao, Qian Sun, Rong Lu

Oncology Research, Vol.28, No.7-8, pp. 745-761, 2020, DOI:10.3727/096504021X16130322409507

Abstract Cell cycle deregulation is involved in the pathogenesis of many cancers and is often associated with protein kinase aberrations, including the polo-like kinase 1 (PLK1). We used retinoblastoma, an intraocular malignancy that lacks targeted therapy, as a disease model and set out to reveal targetability of PLK1 with a small molecular inhibitor ON-01910.Na. First, transcriptomic analysis on patient retinoblastoma tissues suggested that cell cycle progression was deregulated and confirmed that PLK1 pathway was upregulated. Next, antitumor activity of ON-01910.Na was investigated in both cellular and animal levels. Cytotoxicity induced by ON-01910.Na was tumor specific and dose dependent in retinoblastoma cells,… More >

Hsiang-Lin Tsai^*†, Yen-Cheng Chen^*‡, Tzu-Chieh Yin^*§¶, Wei-Chih Su^*‡, Po-Jung Chen^*,Tsung-Kun Chang^*†, Ching-Chun Li^*, Ching-Wen Huang^*†, Jaw-Yuan Wang^{*†‡#**††‡‡}

Oncology Research, Vol.29, No.1, pp. 47-61, 2021, DOI:10.3727/096504022X16451187313084

Abstract Uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1) polymorphism plays a crucial role in the increased susceptibility and toxicity of patients to irinotecan. This retrospective, observational study compared the clinical outcomes and adverse events (AEs) in RAS wild-type metastatic colorectal cancer (mCRC) patients treated with cetuximab or bevacizumab plus FOLFIRI with UGT1A1 genotyping and irinotecan dose escalation as the first-line therapy. In total, 173 patients with mCRC with RAS wild-type were enrolled. Among them, 98 patients were treated with cetuximab, whereas 75 patients were treated with bevacizumab. All patients received irinotecan dose escalation based on UGT1A1 genotyping. We compared the progression-free survival (PFS),… More >

Shuai Liu^*†1, Lu Lu^*†1, Feng Pan^‡, Chunsheng Yang^*†, Jing Liang^§, Jinfeng Liu^¶, Jian Wang^#, Rong Shen^**, Fu-Ze Xin^††, Nan Zhang^*†

Oncology Research, Vol.29, No.1, pp. 25-31, 2021, DOI:10.3727/096504022X16427607626672

Abstract Fruquintinib, also called HMPL-013, was first discovered by Hutchison Whampoa Pharmaceuticals Co. Ltd., Shanghai, China, and it is an oral vascular endothelial growth factor receptor (VEGFR) inhibitor. In clinical trials, fruquintinib has demonstrated a survival benefit in metastatic colorectal cancer (mCRC) patients. The purpose of this study was to retrospectively evaluate the efficacy and toxicity of fruquintinib in real-world patients. We collected data from patients with mCRC treated with oral fruquintinib from 2018 to 2020 in six different institutions. Patients with mCRC initially received 5 mg of oral fruquintinib daily for 3 weeks. Progression-free survival (PFS) was evaluated using the… More >

Yujun Su¹, Xianghao Gao², Hong Qian², Xiaoyan Su^2,*

CMES-Computer Modeling in Engineering & Sciences, Vol.132, No.1, pp. 201-214, 2022, DOI:10.32604/cmes.2022.020541

Abstract Human Reliability Analysis (HRA) is an important part in safety assessment of a large complex system. Human Cognitive Reliability (HCR) model is a method of evaluating the probability that operators fail to complete during diagnostic decision making within a limited time, which is widely used in HRA. In the application of this method, cognitive patterns of humans are required to be considered and classified, and this process often relies on the evaluation opinions of experts which is highly subjective and uncertain. How to effectively express and process this uncertain and subjective information plays a critical role in improving the accuracy… More >

Weijun Pan^*, Jingkai Wang, Hao Wang, Yuming Luo

FDMP-Fluid Dynamics & Materials Processing, Vol.18, No.5, pp. 1495-1509, 2022, DOI:10.32604/fdmp.2022.019018

Abstract A model for the vortex distribution in the wake of an aircraft is elaborated to investigate the wake influence on the behaviour of other aircrafts potentially interacting with it. As a realistic case, the interaction of an ARJ21 aircraft with a (leading) A330-200 aircraft is considered. Different distances are considered, namely, 6 km, 7 km, 8 km, 9.3 km, and 10 km. Simulations based on the used wake dissipation mechanism are used to investigate different conditions, namely, the ARJ21 in take-off and level flight and the changes induced in the related lift by the front aircraft A330-200 during landing. The… More > Graphic Abstract

Yanman Li¹, Jun Zhang¹, Yang Hu¹, Yingnan Zhao^2,*, Yi Cao³

Computer Systems Science and Engineering, Vol.43, No.3, pp. 1219-1230, 2022, DOI:10.32604/csse.2022.028224

Abstract Safety helmet-wearing detection is an essential part of the intelligent monitoring system. To improve the speed and accuracy of detection, especially small targets and occluded objects, it presents a novel and efficient detector model. The underlying core algorithm of this model adopts the YOLOv5 (You Only Look Once version 5) network with the best comprehensive detection performance. It is improved by adding an attention mechanism, a CIoU (Complete Intersection Over Union) Loss function, and the Mish activation function. First, it applies the attention mechanism in the feature extraction. The network can learn the weight of each channel independently and enhance… More >

Kamel Shibbani¹, Daniel McLennan², Dunbar Ivy³, Gareth Morgan^3,*

Congenital Heart Disease, Vol.17, No.3, pp. 269-280, 2022, DOI:10.32604/chd.2022.019973

Abstract Objective: The Atrial Flow Regulator (AFR) is a double disc device made of self-expanding Nitinol wire mesh, structured around a central lumen. Once deployed via the transfemoral route, the device stents the atrial septum leaving a preselected fixed diameter atrial communication. We sought to evaluate the mid-term performance of the AFR by implanting the device in 5 healthy porcine hearts to assess safety and patency of the device fenestration over a period of 150 days. Method: Five AFR devices were implanted in 5 female Yucatan adult minipigs. The animals were survived to 150 days with periodic assessments at days +3,… More > Graphic Abstract

Xingjian Xue^1,*, Linjuan Ge², Longxin Zeng², Weiran Li², Rui Song², Neal N. Xiong³

CMC-Computers, Materials & Continua, Vol.72, No.3, pp. 5135-5148, 2022, DOI:10.32604/cmc.2022.027356

Abstract To study riding safety at intersection entrance, video recognition technology is used to build vehicle-bicycle conflict models based on the Bayesian method. It is analyzed the relationship among the width of non-motorized lanes at the entrance lane of the intersection, the vehicle-bicycle soft isolation form of the entrance lane of intersection, the traffic volume of right-turning motor vehicles and straight-going non-motor vehicles, the speed of right-turning motor vehicles, and straight-going non-motor vehicles, and the conflict between right-turning motor vehicles and straight-going non-motor vehicles. Due to the traditional statistical methods, to overcome the discreteness of vehicle-bicycle conflict data and the differences… More >

Wei Chen¹, Mi Liu^1,*, Xuhong Zhou², Jiandong Pan³, Haozhi Tan⁴

CMC-Computers, Materials & Continua, Vol.72, No.2, pp. 3159-3174, 2022, DOI:10.32604/cmc.2022.026664

Abstract In construction, it is important to check whether workers wear safety helmets in real time. We proposed using an unmanned aerial vehicle (UAV) to monitor construction workers in real time. As the small target of aerial photography poses challenges to safety-helmet-wearing detection, we proposed an improved YOLOv4 model to detect the helmet-wearing condition in aerial photography: (1) By increasing the dimension of the effective feature layer of the backbone network, the model's receptive field is reduced, and the utilization rate of fine-grained features is improved. (2) By introducing the cross stage partial (CSP) structure into path aggregation network (PANet), the… More >