Jing Cai^1,#, Haoyun Zhu^1,#, Weiling Guo¹, Ting Huang¹, Pangzhou Chen^1,2, Wen Zhou¹, Ziyun Guan^1,3,*

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.069902 - 30 December 2025

Abstract Background: Therapeutic responses of breast cancer vary among patients and lead to drug resistance and recurrence due to the heterogeneity. Current preclinical models, however, are inadequate for predicting individual patient responses towards different drugs. This study aimed to investigate the patient-derived breast cancer culture models for drug sensitivity evaluations. Methods: Tumor and adjacent tissues from female breast cancer patients were collected during surgery. Patient-derived breast cancer cells were cultured using the conditional reprogramming technique to establish 2D models. The obtained patient-derived conditional reprogramming breast cancer (CRBC) cells were subsequently embedded in alginate-gelatin methacryloyl hydrogel microspheres… More >

Di Wu¹, Chunguang Ren¹, Liangliang Li¹, Chongpei Zheng², Wenwen Su^1,*

Phyton-International Journal of Experimental Botany, Vol.94, No.12, pp. 4079-4090, 2025, DOI:10.32604/phyton.2025.072856 - 29 December 2025

Abstract To identify the pathogen responsible for fruit rot disease in Rosa roxburghii Tratt. from Guiding County, Guizhou Province, China, diseased fruit samples were collected. The pathogen was isolated, purified, and identified through morphological, molecular, and pathogenic analyses. Subsequently, its biological characteristics were evaluated. Furthermore, to determine the agent with the strongest toxicity against the identified pathogen, the antifungal activity of six chemical and biological agents was evaluated through indoor toxicity assays. Finally, Neopestalotiopsis clavispora was identified as the pathogen responsible for fruit rot disease in R. roxburghii Tratt. The diameter of the pathogen grown under different carbon and… More >

Boxuan Han^1,2,#, Shaokun Liu^3,#, Ridhima Das³, Shiqian Liu⁴, Yang Zhang^1,2,*

Oncology Research, Vol.33, No.12, pp. 3633-3656, 2025, DOI:10.32604/or.2025.071296 - 27 November 2025

Abstract Organoid technology, characterized by high fidelity in mimicking the in vivo microenvironment, preservation of tumor heterogeneity, and capacity for high-throughput operations, has emerged as a critical tool in head and neck cancer research. To address clinical challenges in head and neck cancer management—including marked tumor heterogeneity, therapeutic resistance, and significant prognostic variability—this review focuses on four key translational applications of organoid technology: In mechanistic studies, organoid models provide a reliable platform for investigating tumorigenesis, progression, and drug resistance mechanisms. In personalized therapy, organoid-based drug sensitivity testing enables data-driven clinical decision-making. For biomarker discovery, organoids facilitate the More >

Khlood M. Mehdar¹, Toufique A. Soomro^2,3,*, Ahmed Ali⁴, Faisal Bin Ubaid⁵, Muhammad Irfan^6,*, Sabah Elshafie Mohammed Elshafie¹, Aisha M. Mashraqi⁷, Abdullah A. Asiri⁸, Nagla Hussien Mohamed Khalid⁸, Hanan T. Halawani⁷

CMES-Computer Modeling in Engineering & Sciences, Vol.143, No.3, pp. 3091-3132, 2025, DOI:10.32604/cmes.2025.065471 - 30 June 2025

Abstract Breast cancer remains one of the most pressing global health concerns, and early detection plays a crucial role in improving survival rates. Integrating digital mammography with computational techniques and advanced image processing has significantly enhanced the ability to identify abnormalities. However, existing methodologies face persistent challenges, including low image contrast, noise interference, and inaccuracies in segmenting regions of interest. To address these limitations, this study introduces a novel computational framework for analyzing mammographic images, evaluated using the Mammographic Image Analysis Society (MIAS) dataset comprising 322 samples. The proposed methodology follows a structured three-stage approach. Initially,… More >

Gülay Zulkadir^*

Phyton-International Journal of Experimental Botany, Vol.94, No.6, pp. 1879-1896, 2025, DOI:10.32604/phyton.2025.064144 - 27 June 2025

Abstract Soil salinization is a prominent global environmental issue that considerably affects the sustainable development of agriculture worldwide. Maize, a key crop integral to the global agricultural economy, is especially susceptible to the detrimental impacts of salt stress, which can impede its growth and development from the germination phase through to the seedling stage. Soil salinity tends to escalate due to improper irrigation methods, particularly in arid and semi-arid environments. Consequently, it is essential to evaluate potential genotypes and select those with high salt tolerance. In this study, 39 popcorn kernel genotypes were examined under varying… More >

CHUCHU ZHANG^1,#, YING LIU^2,#, ZEHUI CHEN¹, YI LIU³, QIYUAN MAO⁴, GE ZHANG⁵, HONGSHENG LIN⁴, JIABIN ZHENG^6,*, HAIYAN LI^1,*

Oncology Research, Vol.33, No.6, pp. 1437-1458, 2025, DOI:10.32604/or.2025.059290 - 29 May 2025

Abstract Objectives: Decades of clinical and fundamental research advancements in oncology have led to significant breakthroughs such as early screening, targeted therapies, and immunotherapy, contributing to reduced mortality rates in cancer patients. Despite these achievements, cancer continues to be a major public health challenge. This study employs bibliometric techniques to visually analyze the English literature on cancer prevention, screening, diagnosis, treatment, and rehabilitation. Methods: We systematically reviewed publications from 01 March 2014, to 01 March 2024, indexed in the Web of Science core collection. Tools such as VOSviewer Version 1.6.20 is characterized by its core idea… More > Graphic Abstract

Muhammad Imran Khan¹, Fahad Masoud Wattoo¹, Kamran Shehzad Bajwa^2,*, Zahid Akram¹, Sabahat Noor², Zaheer Abbas², Rashid Mehmood Rana¹, Muhammad Tahir Akram³, Shaukat Ali², Rai Muhammad Amir⁴, Ghulam Muhammad Ali⁵

Phyton-International Journal of Experimental Botany, Vol.94, No.4, pp. 1299-1318, 2025, DOI:10.32604/phyton.2025.062323 - 30 April 2025

Abstract The agricultural sector is notably affected by climate change, especially soybeans, which may face diminished yields because of severe water shortages. The evaluation of germplasm at morphological and molecular levels is an important pre-breeding step for crop improvement. This study employed 10 simple sequence repeat (SSR) markers to examine 60 soybean genotypes in the quest for drought-resistant lines during 2022–23. The results of the screening experiment (PEG-6000) revealed that the soybean genotypes SPS13, SPS195, PGRB83, and 39982 exhibited significant correlations in growth parameters. The results of molecular characterization indicated that five out of ten molecular… More >

MOHAMMAD ABOHASSAN, MESFER MOHAMMAD AL SHAHRANI, SARAH KHALED ALOUDA, PRASANNA RAJAGOPALAN^*

Oncology Research, Vol.33, No.3, pp. 675-685, 2025, DOI:10.32604/or.2024.056256 - 28 February 2025

Abstract Background: The JAK2^V617F mutation plays a crucial part in the pathogenesis of myeloproliferative neoplasms (MPN), which includes polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF) leading to aberrant proliferation and survival of hematopoietic cells. Alongside the challenges of drug resistance and side effects, identifying novel compounds that selectively target JAK2^V617F could provide more effective and safer therapeutic options for patients with MPNs. Materials and Methods: We employed computational approaches like high-throughput virtual screening, molecular dynamics simulations (MDS), and binding free energy calculations to identify inhibitors targeting wild and mutant JAK2 kinases. JAK2^V617F positive HEL, wild… More >

Samiah Hamad Al-Mijalli¹, Hanae Naceiri Mrabti², Amine Elbouzidi^3,*, Naglaa S. Ashmawy^4,5, Amine Batbat⁶, Emad M. Abdallah⁷, Wafa Laaboudi⁸, Mohammed Aladhadh⁹, Fahad M. Alshabrmi¹⁰, Sulaiman Mohammed Alnasser¹¹, Mohamed Addi³, Naoufal El Hachlafi¹²

Phyton-International Journal of Experimental Botany, Vol.94, No.1, pp. 209-227, 2025, DOI:10.32604/phyton.2025.060438 - 24 January 2025

Abstract Thymus serpyllum L., often known as wild thyme, has been used since ancient times due to its multifaceted culinary and medicinal attributes. It is usually utilized in folk medicine to manage different health issues. This work aimed to investigate the chemical composition and biological characteristics of T. serpyllum essential oil (EO), including its antimicrobial, antioxidant, and anti-inflammatory capabilities. Moreover, we have prompted an in-silico simulation to reveal the underlying mode of action of these properties. The chemical characterization of T. serpyllum (EO) by Gas Chromatography-Mass Spectrometry (GC-MS) indicated sabinene (17.33%), terpinen-4-ol (11.73%), phellandral (13.18%), and thymol (10.54%) as main… More >

Dongxue Su¹, Jiarui Zheng¹, Yuwei Yi¹, Shuyuan Zhang¹, Luxin Feng¹, Danzeng Quzhen², De Qiong³, Weiwei Zhang¹, Qijian Wang¹, Feng Xu^1,*

Phyton-International Journal of Experimental Botany, Vol.93, No.9, pp. 2317-2337, 2024, DOI:10.32604/phyton.2024.055350 - 30 September 2024

Abstract The multifaceted roles of MYB transcriptional regulators are pivotal in orchestrating the complex processes of secondary metabolism, stress tolerance mechanisms, and life cycle progression and development. This study extensively examined the JrMYB genes using whole genome and transcriptomic data, focusing on identifying putative MYB genes associated with fatty acid metabolism. 126 MYB genes were identified within the walnut genome, characterized by hydrophilic proteins spanning lengths ranging from 78 to 1890 base pairs. Analysis of cis-acting elements within the promoter regions of MYB genes revealed many elements linked to cell development, environmental stress, and phytohormones. Transcriptomic data was utilized… More > Graphic Abstract