Yajun Li^1,#, Yumeng Cui^1,#, Bingjie Wang¹, Yue Li¹, Mengmeng Zhang², Silan Dai¹, He Huang^1,*

Phyton-International Journal of Experimental Botany, Vol.91, No.4, pp. 869-888, 2022, DOI:10.32604/phyton.2022.018659

Abstract Genetic transformation is one of the key steps in the molecular breeding of chrysanthemum, which relies on an optimal regeneration and transformation system. However, the regeneration system of different chrysanthemum cultivars varies, and the regeneration time of most cultivars is long. To screen cultivars with highly efficient regeneration, leaves and shoot tip thin cell layers (tTCL) from eight chrysanthemum cultivars with different flower colors and flower types were cultured on Murashige and Skoog media (MS) supplemented with 1.0–5.0 mg L⁻¹ 6-benzylaminopurine (6-BA) and 0.1–1.0 mg L⁻¹ α-naphthaleneacetic (NAA). The results showed that the most efficient regeneration media were MS +… More >

YANYAN LI¹, SHAHANAVAJ KHAN^2,3,4, ANIS AHMAD CHAUDHARY⁵, HASSAN AHMED RUDAYNI⁵, ABDUL MALIK², ASHWAG SHAMI⁶

BIOCELL, Vol.46, No.1, pp. 87-95, 2022, DOI:10.32604/biocell.2022.016509

Abstract Available reports have confirmed a link between bacterial infection and the progression of different types of cancers, including colon, lungs, and prostate cancer. Here we report the Chlamydia pneumonia proteins targeting in endoplasmic reticulum (ER) using in-silico approaches and their possible role in lung cancer etiology. We predicted 48 proteins that target human ER, which may be associated with protein folding and protein-protein interactions during infection. The results showed C. pneumoniae proteins targeting human ER and their implications in lung cancer growth. These targeted proteins may be involved in competitive interactions between host and bacterial proteins, which may change the… More >

FAZLUR RAHMAN^1,#, SHAMS TABREZ^1,#, RAHAT ALI¹, SAJJADUL KADIR AKAND¹, MOHAMMED A. ALAIDAROUS^2,3, MOHAMMED ALSAWEED², BADER MOHAMMED ALSHEHRI², SAEED BANAWAS^2,3, ABDUR RUB^1,*, ABDUL AZIZ BIN DUKHYIL^2,*

BIOCELL, Vol.45, No.6, pp. 1601-1610, 2021, DOI:10.32604/biocell.2021.016682

Abstract Leishmaniasis is a vector-borne parasitic neglected tropical disease caused by a group of about 30 different species of the genus Leishmania. It is transmitted by the bite of female phlebotomies sand fly. Three main clinical manifestations of leishmaniasis include cutaneous, visceral, and mucocutaneous leishmaniasis. Visceral leishmaniasis (VL) caused by Leishmania donovani, is an infection of reticuloendothelial system and fatal if untreated. Cholesterol, a sterol that is prominent in the mammalian cell membranes whereas stigmasterol and ergosterol are more prevalent in plants, yeast, and protozoa, respectively. Ergosterols which is absent in human being, is an important constituent of parasite membrane. Sterol… More >

XINJUN YANG¹, AFTAB ALAM², NAIYAR IQBAL³, KHALID RAZA^4,*

BIOCELL, Vol.45, No.6, pp. 1569-1583, 2021, DOI:10.32604/biocell.2021.017019

Abstract

Tuberculosis (TB) disease has become one of the major public health concerns globally, especially in developing countries. Numerous research studies have already been carried out for TB, but we are still struggling for a complete and quick cure for it. The progress of Mycobacterium tuberculosis (MTB) strains resistant to existing drugs makes its cure and control very complicated. Therefore, it is the need of the hour to search for newer and effective drugs that can inhibit an increasing number of putative drug targets. We applied the drug repurposing concept to identify promising FDA-approved drugs against five key-regulatory genes (FurB, IdeR,… More >

Harshit Kaushik¹, Dilbag Singh², Shailendra Tiwari³, Manjit Kaur², Chang-Won Jeong⁴, Yunyoung Nam^5,*, Muhammad Attique Khan⁶

CMC-Computers, Materials & Continua, Vol.69, No.3, pp. 3459-3475, 2021, DOI:10.32604/cmc.2021.017337

Abstract In March 2020, the World Health Organization declared the coronavirus disease (COVID-19) outbreak as a pandemic due to its uncontrolled global spread. Reverse transcription polymerase chain reaction is a laboratory test that is widely used for the diagnosis of this deadly disease. However, the limited availability of testing kits and qualified staff and the drastically increasing number of cases have hampered massive testing. To handle COVID-19 testing problems, we apply the Internet of Things and artificial intelligence to achieve self-adaptive, secure, and fast resource allocation, real-time tracking, remote screening, and patient monitoring. In addition, we implement a cloud platform for… More >

Md. Rezwan Molla^1,2,4, Md. Motiar Rohman^2,*, Mahmuda Binte Monsur², Mirza Hasanuzzaman^3,*, Lutful Hassan⁴

Phyton-International Journal of Experimental Botany, Vol.90, No.5, pp. 1425-1443, 2021, DOI:10.32604/phyton.2021.015591

Abstract This study was undertaken to investigate oxidative stress tolerant mechanisms in chilli (Capsicum annuum L.) under drought genotypes through evaluating morphological, physiological, biochemical and stomatal parameters. Twenty genotypes were evaluated for their genetic potential to drought stress tolerant at seedling stage. Thirty days old seedlings were exposed to drought stress induced by stop watering for the following 10 days and rewatering for the following one week as recovery. Based on their survival performance, two tolerant genotypes viz. BD-10906 and BD-109012 and two susceptible genotypes viz. BD-10902 and RT-20 were selected for studying the oxidative stress tolerance mechanism. Drought reduced root… More >

Hiran Thabrew^1,*, Harshali Kumar¹, Vanessa Garcia-Hoyos², Felicity Goodyear-Smith³

International Journal of Mental Health Promotion, Vol.23, No.2, pp. 221-230, 2021, DOI:10.32604/IJMHP.2021.015033

Abstract Objective: Young people with congenital heart disease (CHD) are at increased risk of psychosocial issues, including anxiety and depression that can affect their medical care and quality of life. This open trial investigated the acceptability, feasibility and preliminary effectiveness of YouthCHAT, a tablet-based screener, designed to identify similar issues to a face to face psychosocial assessment, with young people who have CHD. Methods: YouthCHAT was administered to 44 such young people aged 15–25 years attending a specialist outpatient clinic at a New Zealand tertiary hospital. Key outcomes were (i) acceptability and (ii) feasibility of YouthCHAT, assessed via feedback from young… More >

G. Oldrini, P. Henrot, F. Marchal

Oncologie, Vol.21, No.1, pp. 17-21, 2019, DOI:10.3166/onco-2019-0033

Abstract Breast cancer is the first female cancer in France and its early detection is essential. Breast MRI is an element of choice in its diagnosis but it has high direct and indirect costs because of its duration which slows down its wider use. Given its elements, the use of an abbreviated protocol develops to overcome these disadvantages. Early literature data suggests that this faster examination also allows for a shorter interpretation time. In addition, the sensitivity and specificity of the examination are not inferior to that of the complete protocol. This article explains the new concept and its interest, compares… More >

Ruikun Zou¹, Yifei Wang^1,*, Chengcheng Pang², Yunxia Sun¹, Chen Chen¹, Jian Zhuang³

Congenital Heart Disease, Vol.16, No.2, pp. 159-170, 2021, DOI:10.32604/CHD.2021.015050

Abstract Aim: To determine the profiles of clinical features including four-limb blood pressure (BP), saturations of peripheral oxygen (SpO₂), and echocardiographic features in infants with coarctation of aorta (CoA) to facilitate congenital heart diseases screening. Methods: The charts of infants with CoA were retrospectively reviewed. All in-hospital infants suspected of congenital heart diseases by clinical teams were prospectively measured of four limbs BPs and SpO₂ in a regional cardiac transferring center during 2013 and 2019. Echocardiography as a gold standard test was followed within 2 days after suspicion. All infants were divided into non-significant CoA group or significant CoA group based… More >

Fouzia Nawaz¹, Muhammad Ramzan¹, Khalid Mehmood¹, Hikmat Ullah Khan², Saleem Hayat Khan^3,4, Muhammad Raheel Bhutta^5,*

CMC-Computers, Materials & Continua, Vol.66, No.2, pp. 1631-1645, 2021, DOI:10.32604/cmc.2020.012887

Abstract Diabetic retinopathy (DR) is a retinal disease that causes irreversible blindness. DR occurs due to the high blood sugar level of the patient, and it is clumsy to be detected at an early stage as no early symptoms appear at the initial level. To prevent blindness, early detection and regular treatment are needed. Automated detection based on machine intelligence may assist the ophthalmologist in examining the patients’ condition more accurately and efficiently. The purpose of this study is to produce an automated screening system for recognition and grading of diabetic retinopathy using machine learning through deep transfer and representational learning.… More >