Karen E. Schultz¹, George K. Lui^1,2, Doff B. McElhinney¹, Jin Long³, Vidhya Balasubramanian³, Charlotte Sakarovitch³, Susan M. Fernandes^1,2, Anne M. Dubin¹, Ian S. Rogers^1,2, Anitra W. Romfh^1,2, Kara S. Motonaga¹, Mohan N. Viswanathan², Scott R. Ceresnak¹

Congenital Heart Disease, Vol.14, No.3, pp. 410-418, 2019, DOI:10.1111/chd.12736

Abstract Background: Arrhythmias are a leading cause of death in adults with congenital heart disease (ACHD). While 24‐48‐hour monitors are often used to assess arrhythmia burden, extended continuous ambulatory rhythm monitors (ECAM) can record 2 weeks of data. The utility of this device and the arrhythmia burden identified beyond 48‐hour monitoring have not been evaluated in the ACHD population. Additionally, the impact of ECAM has not been studied to determine management recommendations.
Objective: To address the preliminary question, we hypothesized that clinically sig‐ nificant arrhythmias would be detected on ECAM beyond 48 hours and this would lead to clinical management changes.
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Patrick D. Evers^1,*, Tarek Alsaied^1,2,*, Jeffrey B. Anderson¹, James F. Cnota¹, Allison A. Divanovic¹

Congenital Heart Disease, Vol.14, No.2, pp. 221-229, 2019, DOI:10.1111/chd.12713

Abstract Objective: Maternal anti-Ro/SSA and anti-La/SSB antibodies can lead to fetal complete heart block (CHB). Current guidelines recommend weekly echocardiographic screening between 16 and 28 weeks gestation. Given the cost of screening and the rarity of conduction abnormalities in fetuses of mothers with low anti-Ro levels (<50 U/mL), we sought to identify a strategy that optimizes resource utilization.
Design: Decision analysis cost-utility modeling was performed for three screening paradigms: “standard screening” (SS) in which mid-gestation mothers are screened weekly, “limited screening” (LS) in which fetal echocardiograms are avoided unless the fetus develops bradycardia, and “targeted screening by maternal antibody level” (TS)… More >

Ali E. Dabiri^1,2,*, Erik Samwel³, Ghassan S. Kassab¹

Molecular & Cellular Biomechanics, Vol.17, No.2, pp. 75-83, 2020, DOI:10.32604/mcb.2020.08775

Abstract Nearly two billion people are afflicted with iron deficiency and approximately 300 million children globally have anemia. Most of those affected are unaware of their lack of iron, in part because detection of iron deficiency requires a blood test. It is becoming increasingly important to screen these individuals to reduce medical cost and avoid chronic disease conditions. There are limited settings of laboratory infrastructure for standard blood-based tests around the world to routinely accomplish this important screening test. We propose a new concept to use either human hair or nail as a screening method to detect steady state iron content… More >

Yao Guo¹, Yijiang Song², Yu Zhang¹, Li Yang^1,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 119-119, 2019, DOI:10.32604/mcb.2019.07134

Abstract Osteoarthritis (OA), with its high disability and mortality rate, is the most common arthritis throughout the world [1]. Exposure of articular cartilage to excessive mechanical stress is deeply involved in the pathogenesis of osteoarthritis (OA) [2,3]. However, the mechanism of how mechanical stress causes cartilage degradation is not clear yet. Here we report that bioinformatics-based integrative analyses can assist in the study of mechanisms modulated by mechanical stress within OA pathology, and we reveal that B-cell Translocation Gene 2 (BTG2) can be a mechanosensitive gene involved in OA development. We obtained OA-associated differentially expressed genes from human and rat datasets… More >

H. Payer¹, T. Haschke¹, R. Reichardt¹, G. Li², K. Graf^2,3, W. Wiechert^1,3

FDMP-Fluid Dynamics & Materials Processing, Vol.4, No.2, pp. 61-76, 2008, DOI:10.3970/fdmp.2008.004.061

Abstract Microstructured surfaces are of steadily increasing importance in a large variety of technological applications. For the purpose of quality assurance, e.g. during variation studies of experimental parameters or for comparison with results from simulations, the surface geometry must be precisely measured and described in terms of geometric parameters. An analysis tool for regularly structured surfaces is presented that performs a highly automated evaluation of surface scanning data and derives geometric quality control parameters. To demonstrate the power of the analysis tool it is exemplarily applied for the investigation of microcraters emerging after the evaporation of micrometer-sized toluene droplets on a… More >