G. Uganya^*, Radhika Baskar

Computer Systems Science and Engineering, Vol.45, No.1, pp. 641-658, 2023, DOI:10.32604/csse.2023.028341

Abstract Internet of Things (IoT) is an emerging technology that moves the world in the direction of smart things. But, IoT security is the complex problem due to its centralized architecture, and limited capacity. So, blockchain technology has great attention due to its features of decentralized architecture, transparency, immutable records and cryptography hash functions when combining with IoT. Cryptography hash algorithms are very important in blockchain technology for secure transmission. It converts the variable size inputs to a fixed size hash output which is unchangeable. Existing cryptography hash algorithms with digital signature have issues of single node accessibility and accessed up… More >

JIAMING ZHAN, WEIHUA WANG, YANLEI TANG, NING ZHOU, DAOWEN JIANG^*

BIOCELL, Vol.46, No.12, pp. 2601-2613, 2022, DOI:10.32604/biocell.2022.021300

Abstract Esophageal cancer (EC) was an aggressive malignant neoplasm characterized by high morbidity and poor prognosis. Identifying the changes in DNA damage repair genes helps to better understand the mechanisms of carcinoma progression. In this study, by comparing EC samples and normal samples, we found a total of 132 DDR expression with a significant difference. Moreover, we revealed higher expression of POLN, PALB2, ATM, PER1, TOP3B and lower expression of HMGB1, UBE2B were correlated to longer OS in EC. In addition, a prognostic risk score based on 7 DDR gene expression (POLN, HMGB1, TOP3B, PER1, UBE2B, ATM, PALB2) was constructed for… More >

Mouna Bedoui^1,*, Belgacem Bouallegue^1,2, Abdelmoty M. Ahmed², Belgacem Hamdi^1,3, Mohsen Machhout¹, Mahmoud¹, M. Khattab²

Computer Systems Science and Engineering, Vol.44, No.3, pp. 2177-2193, 2023, DOI:10.32604/csse.2023.026516

Abstract Since the end of the 1990s, cryptosystems implemented on smart cards have had to deal with two main categories of attacks: side-channel attacks and fault injection attacks. Countermeasures have been developed and validated against these two types of attacks, taking into account a well-defined attacker model. This work focuses on small vulnerabilities and countermeasures related to the Elliptic Curve Digital Signature Algorithm (ECDSA) algorithm. The work done in this paper focuses on protecting the ECDSA algorithm against fault-injection attacks. More precisely, we are interested in the countermeasures of scalar multiplication in the body of the elliptic curves to protect against… More >

Bennian Dou^1,*, Lei Xu¹, Xiaoling Yu², Lin Mei¹, Cong Zuo³

CMC-Computers, Materials & Continua, Vol.73, No.3, pp. 5219-5231, 2022, DOI:10.32604/cmc.2022.030270

Abstract This paper proposes the first code-based quantum immune sequential aggregate signature (SAS) scheme and proves the security of the proposed scheme in the random oracle model. Aggregate signature (AS) schemes and sequential aggregate signature schemes allow a group of potential signers to sign different messages respectively, and all the signatures of those users on those messages can be aggregated into a single signature such that the size of the aggregate signature is much smaller than the total size of all individual signatures. Because of the aggregation of many signatures into a single short signature, AS and SAS schemes can reduce… More >

Latika Kakkar¹, Deepali Gupta¹, Sarvesh Tanwar², Sapna Saxena³, Khalid Alsubhi⁴, Divya Anand⁵, Irene Delgado Noya^6,7, Nitin Goyal^1,*

CMC-Computers, Materials & Continua, Vol.73, No.3, pp. 6151-6168, 2022, DOI:10.32604/cmc.2022.023769

Abstract To provide faster access to the treatment of patients, healthcare system can be integrated with Internet of Things to provide prior and timely health services to the patient. There is a huge limitation in the sensing layer as the IoT devices here have low computational power, limited storage and less battery life. So, this huge amount of data needs to be stored on the cloud. The information and the data sensed by these devices is made accessible on the internet from where medical staff, doctors, relatives and family members can access this information. This helps in improving the treatment as… More >

Bo Ling, Zuliang Huang, Suoyi Huang, Li Qian, Genliang Li, Qianli Tang

Oncology Research, Vol.28, No.6, pp. 561-578, 2020, DOI:10.3727/096504020X15907428281601

Abstract There is growing evidence on the clinical significance of tumor microenvironment (TME) cells in predicting prognosis and therapeutic effects. However, cell interactions in tumor microenvironments have not been thoroughly studied or systematically analyzed so far. In this study, 22 immune cell components in the lung adenocarcinoma (LUAD) TME were analyzed using gene expression profile from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO). The TME-based molecular subtypes of LUAD were defined to evaluate further the relationship between molecular subtypes, prognosis, and clinical characteristics. A TME risk score model was constructed by using the differentially expressed genes (DEGs) of… More >

Magdy M. Fadel^1,*, Sally M. El-Ghamrawy², Amr M. T. Ali-Eldin¹, Mohammed K. Hassan³, Ali I. El-Desoky¹

CMC-Computers, Materials & Continua, Vol.73, No.2, pp. 2293-2312, 2022, DOI:10.32604/cmc.2022.028287

Abstract Distributed denial-of-service (DDoS) attacks are designed to interrupt network services such as email servers and webpages in traditional computer networks. Furthermore, the enormous number of connected devices makes it difficult to operate such a network effectively. Software defined networks (SDN) are networks that are managed through a centralized control system, according to researchers. This controller is the brain of any SDN, composing the forwarding table of all data plane network switches. Despite the advantages of SDN controllers, DDoS attacks are easier to perpetrate than on traditional networks. Because the controller is a single point of failure, if it fails, the… More >

FEIFEI TIAN¹, HUAN HU¹, DI WANG¹, HUAN DING¹, QINGJIA CHI², HUAPING LIANG³, WENLI ZENG^4,*

BIOCELL, Vol.46, No.10, pp. 2291-2301, 2022, DOI:10.32604/biocell.2022.020198

Abstract This study used transcriptome and epigenetic data to predict the prognosis of immune-related genes (IRGs) Apelin (APLN) in patients with hepatocellular carcinoma (HCC). The TCGA database has gene expression and clinical data for HCC. And DNA methylation 450 k data for HCC was download from the University of California Santa Cruz (UCSC) Xena browser. Performing clinical and prognostic analysis of APLN expression, results show that APLN is highly expressed in tumor samples. And it has an increasing trend with the development of clinical stage and T stage. To explore the prognostic role of APLN, the Immune-related DNA methylation (DNAm) sites… More >

HUILI ZHU¹, LINA XIAO¹, XIA YIN¹, SHIBING XIANG¹, CHUNHUI WANG^2,*

BIOCELL, Vol.46, No.10, pp. 2241-2256, 2022, DOI:10.32604/biocell.2022.020389

Abstract Pancreatic ductal adenocarcinoma (PDAC) is highly heterogeneous, making its prognosis prediction difficult. The arachidonic acid (AA) cascade is involved in carcinogenesis. Therefore, the metabolic enzymes of the AA cascade consist of lipoxygenases (LOXs), phospholipase A2s (PLA2s), and cyclooxygenases (COXs) along with their metabolic products, including leukotrienes. Nevertheless, the prognostic potential of AA metabolism-associated PDAC has not been explored. Herein, the mRNA expression patterns and the matching clinical information of individuals with PDAC were abstracted from online data resources. We employed the LASSO Cox regression model to develop a multigene clinical signature in the TCGA queue. The GEO queue and the… More >

J. Priya^*, C. Palanisamy

Intelligent Automation & Soft Computing, Vol.35, No.1, pp. 243-259, 2023, DOI:10.32604/iasc.2023.025719

Abstract The Internet of Things (IoT) and Cloud computing are gaining popularity due to their numerous advantages, including the efficient utilization of internet and computing resources. In recent years, many more IoT applications have been extensively used. For instance, Healthcare applications execute computations utilizing the user’s private data stored on cloud servers. However, the main obstacles faced by the extensive acceptance and usage of these emerging technologies are security and privacy. Moreover, many healthcare data management system applications have emerged, offering solutions for distinct circumstances. But still, the existing system has issues with specific security issues, privacy-preserving rate, information loss, etc.… More >