Kai Gui^1,#, Tianyi Yang^1,#, Chengying Xiong¹, Yue Wang¹, Zhiqiang He¹, Wuxian Li^2,3,*, Min Tang^1,*

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.070143 - 30 December 2025

Abstract Objectives: The mechanism by which specific tumor subsets in colorectal cancer (CRC) use alternative metabolic pathways, particularly those modulated by hypoxia and fructose, to alter the tumor microenvironment (TME) remains unclear. This study aimed to identify these malignant subpopulations and characterize their intercellular signaling networks and spatial organization through an integrative multi-omics approach. Methods: Leveraging bulk datasets, single-cell RNA sequencing, and integrative spatial transcriptomics, we developed a prognostic model based on hypoxia-and fructose metabolism-related genes (HFGs) to delineate tumor cell subpopulations and their intercellular signaling networks. Results: We identified a specific subset of stanniocalcin-2 positive (STC2+)… More > Graphic Abstract

Taehoon Kim, Sehun Lee, Junho Ahn^*

CMC-Computers, Materials & Continua, Vol.86, No.2, pp. 1-30, 2026, DOI:10.32604/cmc.2025.071597 - 09 December 2025

Abstract As large, room-scale environments become increasingly common, their spatial complexity increases due to variable, unstructured elements. Consequently, demand for room-scale service robots is surging, yet most technologies remain corridor-centric, and autonomous navigation in expansive rooms becomes unstable even around static obstacles. Existing approaches face several structural limitations. These include the labor-intensive requirement for large-scale object annotation and continual retraining, as well as the vulnerability of vanishing point or line-based methods when geometric cues are insufficient. In addition, the high cost of LiDAR and 3D perception errors caused by limited wall cues and dense interior clutter… More >

Illia Khurtin^*, Mukesh Prasad

CMC-Computers, Materials & Continua, Vol.86, No.2, pp. 1-15, 2026, DOI:10.32604/cmc.2025.067481 - 09 December 2025

Abstract The field of artificial intelligence has advanced significantly in recent years, but achieving a human-like or Artificial General Intelligence (AGI) remains a theoretical challenge. One hypothesis suggests that a key issue is the formalisation of extracting meaning from information. Meaning emerges through a three-stage interpretative process, where the spectrum of possible interpretations is collapsed into a singular outcome by a particular context. However, this approach currently lacks practical grounding. In this research, we developed a model based on contexts, which applies interpretation principles to the visual information to address this gap. The field of computer… More >

Igor Musikhin^*

Revue Internationale de Géomatique, Vol.34, pp. 939-957, 2025, DOI:10.32604/rig.2025.071168 - 09 December 2025

Abstract Urban environmental quality research is crucial, as cities become competitive centers concentrating human talent, industrial activity, and financial resources, contributing significantly to national economies. Municipal and government priorities include retaining residents, preventing skilled worker outflow, and meeting the evolving needs of urban populations. The study presents the development and application of a scenario-based spatial analysis tool for assessing urban environmental quality at a detailed spatial scale within the city of Novosibirsk. Using advanced geoinformatics, GIS techniques, and an expert knowledge base, the tool integrates diverse thematic data layers with user-defined scenarios to compute and visualize… More >

Tiantian Wang^1,2, Zhihua Hu^3,*

CMES-Computer Modeling in Engineering & Sciences, Vol.145, No.2, pp. 2357-2381, 2025, DOI:10.32604/cmes.2025.073640 - 26 November 2025

Abstract Rain streaks introduced by atmospheric precipitation significantly degrade image quality and impair the reliability of high-level vision tasks. We present a novel image deraining framework built on a three-stage dual-residual architecture that progressively restores rain-degraded content while preserving fine structural details. Each stage begins with a multi-scale feature extractor and a channel attention module that adaptively emphasizes informative representations for rain removal. The core restoration is achieved via enhanced dual-residual blocks, which stabilize training and mitigate feature degradation across layers. To further refine representations, we integrate cross-dimensional spatial attention supervised by ground-truth guidance, ensuring that More >

Mairaj Bibi¹, Muhammad Shoaib Arif ², Yasir Nawaz³, Nabil Kerdid^4,*

CMES-Computer Modeling in Engineering & Sciences, Vol.145, No.1, pp. 537-569, 2025, DOI:10.32604/cmes.2025.070362 - 30 October 2025

Abstract This study develops a high-order computational scheme for analyzing unsteady tangent hyperbolic fluid flow with variable thermal conductivity, thermal radiation, and coupled heat and mass transfer effects. A modified two-stage Exponential Time Integrator is introduced for temporal discretization, providing second-order accuracy in time. A compact finite difference method is employed for spatial discretization, yielding sixth-order accuracy at most grid points. The proposed framework ensures numerical stability and convergence when solving stiff, nonlinear parabolic systems arising in fluid flow and heat transfer problems. The novelty of the work lies in combining exponential integrator schemes with compact… More >

Sheeba Razzaq^1,*, Majid Iqbal Khan²

CMC-Computers, Materials & Continua, Vol.85, No.3, pp. 5377-5398, 2025, DOI:10.32604/cmc.2025.068539 - 23 October 2025

Abstract Multi-Object Tracking (MOT) represents a fundamental but computationally demanding task in computer vision, with particular challenges arising in occluded and densely populated environments. While contemporary tracking systems have demonstrated considerable progress, persistent limitations—notably frequent occlusion-induced identity switches and tracking inaccuracies—continue to impede reliable real-world deployment. This work introduces an advanced tracking framework that enhances association robustness through a two-stage matching paradigm combining spatial and appearance features. Proposed framework employs: (1) a Height Modulated and Scale Adaptive Spatial Intersection-over-Union (HMSIoU) metric for improved spatial correspondence estimation across variable object scales and partial occlusions; (2) a feature More >

Chenquan Gan^1,2,*, Xu Liu¹, Yu Tang², Xianrong Yu³, Qingyi Zhu¹, Deepak Kumar Jain⁴

CMC-Computers, Materials & Continua, Vol.85, No.3, pp. 5399-5421, 2025, DOI:10.32604/cmc.2025.068126 - 23 October 2025

Abstract Multimodal sentiment analysis aims to understand emotions from text, speech, and video data. However, current methods often overlook the dominant role of text and suffer from feature loss during integration. Given the varying importance of each modality across different contexts, a central and pressing challenge in multimodal sentiment analysis lies in maximizing the use of rich intra-modal features while minimizing information loss during the fusion process. In response to these critical limitations, we propose a novel framework that integrates spatial position encoding and fusion embedding modules to address these issues. In our model, text is… More >

Nur Sabrina Jamal, Nabilah Naharudin^*

Revue Internationale de Géomatique, Vol.34, pp. 751-776, 2025, DOI:10.32604/rig.2025.071091 - 17 October 2025

Abstract Multicriteria Decision Analysis (MCDA) has been integrated with GIS modelling by many studies to aid the decision-making process. This integration enhances modelling by incorporating spatial relationships and using advanced techniques, including the combination of Frequency Ratio (FR) and Analytical Hierarchical Process (AHP), also known as FR-AHP. Although methods like Two-Steps Floating Catchment Area (2SFCA), AHP, and FR are widely applied in measuring accessibility, they have limitations in terms of threshold sensitivity and subjectivity. Hence, this study used FR-AHP, which combines the data-driven strength of FR and the structured decision-making technique of AHP to provide a… More >

Miguel A. Millán^1,*, Rubén A. Galindo², Fausto Molina-Gómez¹

CMES-Computer Modeling in Engineering & Sciences, Vol.144, No.3, pp. 2923-2941, 2025, DOI:10.32604/cmes.2025.069356 - 30 September 2025

Abstract Volcanic terrains exhibit a complex structure of pyroclastic deposits interspersed with sedimentary processes, resulting in irregular lithological sequences that lack lateral continuity and distinct stratigraphic patterns. This complexity poses significant challenges for slope stability analysis, requiring the development of specialized techniques to address these issues. This research presents a numerical methodology that incorporates spatial variability, nonlinear material characterization, and probabilistic analysis using a Monte Carlo framework to address this issue. The heterogeneous structure is represented by randomly assigning different lithotypes across the slope, while maintaining predefined global proportions. This contrasts with the more common approach… More >