Haris Alam Zuberi¹, Madan Lal¹, Amol Singh¹, Nurul Amira Zainal^2,3,*, Ali J. Chamkha⁴

CMES-Computer Modeling in Engineering & Sciences, Vol.142, No.2, pp. 1839-1864, 2025, DOI:10.32604/cmes.2024.056661 - 27 January 2025

Abstract Nanotechnology holds immense importance in the biomedical field due to its ability to revolutionize healthcare on a molecular scale. Motivated by the imperative of enhancing patient outcomes, a comprehensive numerical simulation study on the dynamics of blood flow in a stenosed artery, focusing on the effects of copper and alumina nanoparticles, is conducted. The study employs a 2-dimensional Newtonian blood flow model infused with copper and alumina nanoparticles, considering the influence of a magnetic field, thermal radiation, and various flow parameters. The governing differential equations are first non-dimensionalized to facilitate analysis and subsequently solved using… More >

Jiajun Xu^1,#, Zhuo Shi^2,#, Shanshan Shi^1,*, Xiangming Fan^2,*

Congenital Heart Disease, Vol.19, No.5, pp. 535-540, 2024, DOI:10.32604/chd.2024.057558 - 31 December 2024

Abstract Interrupted Aortic Arch (IAA) combined with aortic stenosis (AS) is a rare and complex congenital cardiac anomaly that presents significant challenges in clinical management. In this letter, we aim to share our experience in performing hybrid procedures on an infant diagnosed with IAA combined with bicuspid AS. This child exhibited significant recovery during follow-up. More >

Catalina Vargas-Acevedo¹, Gareth J. Morgan¹, Rhynn Soderstrom², Richard Ing³, Nicholas Houska³, Jenny E. Zablah^1,*

Congenital Heart Disease, Vol.19, No.4, pp. 389-397, 2024, DOI:10.32604/chd.2024.055121 - 31 October 2024

Abstract Introduction: Pulmonary hemorrhage (PHm) is a life-threatening complication that can occur after catheter-based interventions in patients with pulmonary vein stenosis (PVS). Inhaled racemic epinephrine (iRE) and tranexamic acid (iTXA) have been used in other conditions, but a standardized approach in PVS has not been described. We aimed to describe the current management of PHm after PVS catheter-based interventions. Methods: We present a retrospective review of episodes of PHm from July 2022 to February 2024. PHm was defined as frank blood suctioned from the endotracheal tube including blood-tinged secretions and >3% decrease in saturations and/or ventilatory… More >

Toshi Maeda^*, Hiroki Ito, Keiichi Hirose, Kisaburo Sakamoto

Congenital Heart Disease, Vol.19, No.2, pp. 177-183, 2024, DOI:10.32604/chd.2024.050945 - 16 May 2024

Abstract Congenital aortic stenosis (cAS) frequently requires intervention during the neonatal or infantile period. However, surgical repair is challenging because of the narrow surgical space. We performed bicuspidization using the open-sleeve technique for cAS with a unicuspid aortic valve in two patients. Postoperatively, the patients were doing well without reintervention for the aortic valve for 8 and 6 years, respectively. Their aortic annular diameter increased along with somatic growth. Bicuspidization for neonates or infancy can be performed safely using the open-sleeve technique as its midterm results have been satisfactory. More > Graphic Abstract

Salah Alzghoul^1,*, Othman Smadi¹, Ali Al Bataineh², Mamon Hatmal³, Ahmad Alamm⁴

Intelligent Automation & Soft Computing, Vol.37, No.1, pp. 455-470, 2023, DOI:10.32604/iasc.2023.038338 - 29 April 2023

Abstract Currently, the decision of aortic valve replacement surgery time for asymptomatic patients with moderate-to-severe aortic stenosis (AS) is made by healthcare professionals based on the patient’s clinical biometric records. A delay in surgical aortic valve replacement (SAVR) can potentially affect patients’ quality of life. By using ML algorithms, this study aims to predict the optimal SAVR timing and determine the enhancement in moderate-to-severe AS patient survival following surgery. This study represents a novel approach that has the potential to improve decision-making and, ultimately, improve patient outcomes. We analyze data from 176 patients with moderate-to-severe aortic… More >

Vitaliy Suvorov^*, Vladimir Zaitsev, Nikolay Pilyugov, Olga Tereshenko, Michail Komissarov

Congenital Heart Disease, Vol.18, No.1, pp. 57-65, 2023, DOI:10.32604/chd.2023.025522 - 09 January 2023

Abstract Critical aortic valve stenosis in newborns is the cause of a severe clinical condition with the onset of symptoms during first hours after birth. We present a clinical case of a successful surgical correction of a critical aortic stenosis using a hybrid method applied in a newborn during the first day of life. The infant was diagnosed with a hypoplastic left heart complex with an intact atrial septum (aortic and mitral valves stenosis variant), that led to the cardiogenic shock and acute pulmonary edema. The procedure included bilateral banding of the pulmonary artery branches and More > Graphic Abstract

PANKE CHEN^*, SHUAI MA

BIOCELL, Vol.46, No.8, pp. 1903-1909, 2022, DOI:10.32604/biocell.2022.018651 - 22 April 2022

Abstract This work aimed to investigate the effects of calcitonin gene-related peptide (CGRP)-modified mesenchymal stem cells (MSCs) on vascular stenosis in carotid balloon-injured rats. The CGRP gene labeled with EGFP was transfected into bone marrow MSCs, and CGRP protein expression in MSCs was confirmed by immunofluorescence assays. A rat carotid balloon injury model was established using a surgical method. CGRP-modified MSCs were orthotopically transplanted into the injured area of the rats. At 28 days after cell transplantation, EGFP and CD31 expression was detected by immunofluorescence staining. Hematoxylin-eosin (H&E) staining was used to detect the intima/media area… More >

Olivia Lenoir^1,2, Daniel Quandt^1,2, Oliver Kretschmar^1,2, Walter Knirsch^1,2,*

Congenital Heart Disease, Vol.17, No.2, pp. 161-172, 2022, DOI:10.32604/chd.2022.016598 - 26 January 2022

Abstract Objectives: Factors influencing results of balloon valvuloplasty (BVP) of pulmonary valve stenosis (PS) in children are investigated. Background: BVP has become the standard of care for PS, medium-term results are not uniform and depend on various preconditions. Methods: We analysed the medium-term results of BVP of PS in children in an observational, single centre study. Need for additional procedure was defined as outcome after initial BVP. Results: We included 143 children (83 female) at a median (IQR) age of 2.6 (0.26–9.24) months and body weight of 5 (3.4–8) kg at BVP with a follow–up of 5.04 (1.6–10.2)… More >

Justin Loloi¹, Susan M. MacDonald²

Canadian Journal of Urology, Vol.28, No.1, pp. 10560-10564, 2021

Abstract Pyodermagangrenosum(PG)isacutaneousinfammatory disorderthatresultsinpainfululcers. IsolatedpenilePG is an exceedingly rare entity that has only been reported in a handful of cases.
This case highlights the course of a 71-year old man with a locally destructive, nonhealing penile ulceration who was ultimately diagnosed with PG. He underwent extensive work up to reach the diagnosis. His disease progression was halted with systemic steroids and Methotrexate.Wepresenthisclinicalcourseandareview oftheliteraturetohighlighttheneedforearlyrecognition of this potentially devastating condition and to outline management options. More >

Din Prathumwan¹, Inthira Chaiya², Kamonchat Trachoo^2,*

CMC-Computers, Materials & Continua, Vol.69, No.3, pp. 3645-3657, 2021, DOI:10.32604/cmc.2021.018241 - 24 August 2021

Abstract Lumbar spine stenosis (LSS) is a narrowing of the spinal canal that results in pressure on the spinal nerves. This orthopedic disorder can cause severe pain and dysfunction. LSS is a common disabling problem amongst elderly people. In this paper, we developed a finite element model (FEM) to study the forces and the von Mises stress acting on the spine when people bend down. An artificial lumbar spine (L3) was generated from CT data by using the FEM, which is a powerful tool to study biomechanics. The proposed model is able to predict the effect… More >