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  • Open Access

    REVIEW

    Exercise and exerkine upregulation: Brain-derived neurotrophic factor as a potential non-pharmacological therapeutic strategy for Parkinson’s disease

    VIRAAJ VISHNU PRASAD, JENNIFER SALLY SAMSON, VENKATACHALAM DEEPA PARVATHI*

    BIOCELL, Vol.48, No.5, pp. 693-706, 2024, DOI:10.32604/biocell.2024.048776

    Abstract Physical activity and exercise have several beneficial roles in enhancing both physiological and psychological well-being of an individual. In addition to aiding the regulation of aerobic and anaerobic metabolism, exercise can stimulate the synthesis of exerkine hormones in the circulatory system. Among several exerkines that have been investigated for their therapeutic potential, Brain-derived neurotrophic factor (BDNF) is considered the most promising candidate, especially in the management of neurodegenerative diseases. Owing to the ability of physical activity to enhance BDNF synthesis, several experimental studies conducted so far have validated this hypothesis and produced satisfactory results at the pre-clinical level. This review… More > Graphic Abstract

    Exercise and exerkine upregulation: Brain-derived neurotrophic factor as a potential non-pharmacological therapeutic strategy for Parkinson’s disease

  • Open Access

    ARTICLE

    Research on Scheduling Strategy of Flexible Interconnection Distribution Network Considering Distributed Photovoltaic and Hydrogen Energy Storage

    Yang Li1,2, Jianjun Zhao2, Xiaolong Yang2, He Wang1,*, Yuyan Wang1

    Energy Engineering, Vol.121, No.5, pp. 1263-1289, 2024, DOI:10.32604/ee.2024.046784

    Abstract Distributed photovoltaic (PV) is one of the important power sources for building a new power system with new energy as the main body. The rapid development of distributed PV has brought new challenges to the operation of distribution networks. In order to improve the absorption ability of large-scale distributed PV access to the distribution network, the AC/DC hybrid distribution network is constructed based on flexible interconnection technology, and a coordinated scheduling strategy model of hydrogen energy storage (HS) and distributed PV is established. Firstly, the mathematical model of distributed PV and HS system is established, and a comprehensive energy storage… More >

  • Open Access

    ARTICLE

    Reinforcement Learning Based Quantization Strategy Optimal Assignment Algorithm for Mixed Precision

    Yuejiao Wang, Zhong Ma*, Chaojie Yang, Yu Yang, Lu Wei

    CMC-Computers, Materials & Continua, Vol.79, No.1, pp. 819-836, 2024, DOI:10.32604/cmc.2024.047108

    Abstract The quantization algorithm compresses the original network by reducing the numerical bit width of the model, which improves the computation speed. Because different layers have different redundancy and sensitivity to data bit width. Reducing the data bit width will result in a loss of accuracy. Therefore, it is difficult to determine the optimal bit width for different parts of the network with guaranteed accuracy. Mixed precision quantization can effectively reduce the amount of computation while keeping the model accuracy basically unchanged. In this paper, a hardware-aware mixed precision quantization strategy optimal assignment algorithm adapted to low bit width is proposed,… More >

  • Open Access

    ARTICLE

    Unsteady MHD Casson Nanofluid Flow Past an Exponentially Accelerated Vertical Plate: An Analytical Strategy

    T. Aghalya, R. Tamizharasi*

    CMES-Computer Modeling in Engineering & Sciences, Vol.140, No.1, pp. 431-460, 2024, DOI:10.32604/cmes.2024.046635

    Abstract In this study, the characteristics of heat transfer on an unsteady magnetohydrodynamic (MHD) Casson nanofluid over an exponentially accelerated vertical porous plate with rotating effects were investigated. The flow was driven by the combined effects of the magnetic field, heat radiation, heat source/sink and chemical reaction. Copper oxide () and titanium oxide () are acknowledged as nanoparticle materials. The nondimensional governing equations were subjected to the Laplace transformation technique to derive closed-form solutions. Graphical representations are provided to analyze how changes in physical parameters, such as the magnetic field, heat radiation, heat source/sink and chemical reaction, affect the velocity, temperature… More >

  • Open Access

    ARTICLE

    Deep Learning-Based Secure Transmission Strategy with Sensor-Transmission-Computing Linkage for Power Internet of Things

    Bin Li*, Linghui Kong, Xiangyi Zhang, Bochuo Kou, Hui Yu, Bowen Liu

    CMC-Computers, Materials & Continua, Vol.78, No.3, pp. 3267-3282, 2024, DOI:10.32604/cmc.2024.047193

    Abstract The automatic collection of power grid situation information, along with real-time multimedia interaction between the front and back ends during the accident handling process, has generated a massive amount of power grid data. While wireless communication offers a convenient channel for grid terminal access and data transmission, it is important to note that the bandwidth of wireless communication is limited. Additionally, the broadcast nature of wireless transmission raises concerns about the potential for unauthorized eavesdropping during data transmission. To address these challenges and achieve reliable, secure, and real-time transmission of power grid data, an intelligent security transmission strategy with sensor-transmission-computing… More >

  • Open Access

    ARTICLE

    Privacy-Preserving Multi-Keyword Fuzzy Adjacency Search Strategy for Encrypted Graph in Cloud Environment

    Bin Wu1,2, Xianyi Chen3, Jinzhou Huang4,*, Caicai Zhang5, Jing Wang6, Jing Yu1,2, Zhiqiang Zhao7, Zhuolin Mei1,2

    CMC-Computers, Materials & Continua, Vol.78, No.3, pp. 3177-3194, 2024, DOI:10.32604/cmc.2023.047147

    Abstract In a cloud environment, outsourced graph data is widely used in companies, enterprises, medical institutions, and so on. Data owners and users can save costs and improve efficiency by storing large amounts of graph data on cloud servers. Servers on cloud platforms usually have some subjective or objective attacks, which make the outsourced graph data in an insecure state. The issue of privacy data protection has become an important obstacle to data sharing and usage. How to query outsourcing graph data safely and effectively has become the focus of research. Adjacency query is a basic and frequently used operation in… More >

  • Open Access

    ARTICLE

    Resilience-Oriented Load Restoration Method and Repair Strategies for Regional Integrated Electricity-Natural Gas System

    Keqiang Wang1, Pengyang Zhao1, Changjian Wang2, Zimeng Zhang1, Yu Zhang1, Jia Lu1, Zedong Yang2,*

    Energy Engineering, Vol.121, No.4, pp. 1091-1108, 2024, DOI:10.32604/ee.2023.044016

    Abstract The rising frequency of extreme disaster events seriously threatens the safe and secure operation of the regional integrated electricity-natural gas system (RIENGS). With the growing level of coupling between electric and natural gas systems, it is critical to enhance the load restoration capability of both systems. This paper proposes a coordinated optimization strategy for resilience-enhanced RIENGS load restoration and repair scheduling and transforms it into a mixed integer second-order cone programming (MISOCP) model. The proposed model considers the distribution network reconfiguration and the coordinated repair strategy between the two systems, minimizing the total system load loss cost and repair time.… More >

  • Open Access

    ARTICLE

    SYSTEMATIC STRATEGY FOR MODELING AND OPTIMIZATION OF THERMAL SYSTEMS WITH DESIGN UNCERTAINTIES

    Po Ting Lin, Hae Chang Gea, Yogesh Jaluria*

    Frontiers in Heat and Mass Transfer, Vol.1, No.1, pp. 1-20, 2010, DOI:10.5098/hmt.v1.1.3003

    Abstract Thermal systems play significant roles in the engineering practice and our lives. To improve those thermal systems, it is necessary to model and optimize the design and the operating conditions. More importantly, the design uncertainties should be considered because the failures of the thermal systems may be very dangerous and produce large loss. This review paper focuses on a systematic strategy of modeling and optimizing of the thermal systems with the considerations of the design uncertainties. To demonstrate the proposed strategy, one of the complicated thermal systems, Chemical Vapor Deposition (CVD), is simulated, parametrically modeled, and optimized. The operating conditions,… More >

  • Open Access

    ARTICLE

    KSKV: Key-Strategy for Key-Value Data Collection with Local Differential Privacy

    Dan Zhao1, Yang You2, Chuanwen Luo3,*, Ting Chen4,*, Yang Liu5

    CMES-Computer Modeling in Engineering & Sciences, Vol.139, No.3, pp. 3063-3083, 2024, DOI:10.32604/cmes.2023.045400

    Abstract In recent years, the research field of data collection under local differential privacy (LDP) has expanded its focus from elementary data types to include more complex structural data, such as set-value and graph data. However, our comprehensive review of existing literature reveals that there needs to be more studies that engage with key-value data collection. Such studies would simultaneously collect the frequencies of keys and the mean of values associated with each key. Additionally, the allocation of the privacy budget between the frequencies of keys and the means of values for each key does not yield an optimal utility tradeoff.… More >

  • Open Access

    ARTICLE

    RRT Autonomous Detection Algorithm Based on Multiple Pilot Point Bias Strategy and Karto SLAM Algorithm

    Lieping Zhang1,2, Xiaoxu Shi1,2, Liu Tang1,2, Yilin Wang3, Jiansheng Peng4, Jianchu Zou4,*

    CMC-Computers, Materials & Continua, Vol.78, No.2, pp. 2111-2136, 2024, DOI:10.32604/cmc.2024.047235

    Abstract A Rapid-exploration Random Tree (RRT) autonomous detection algorithm based on the multi-guide-node deflection strategy and Karto Simultaneous Localization and Mapping (SLAM) algorithm was proposed to solve the problems of low efficiency of detecting frontier boundary points and drift distortion in the process of map building in the traditional RRT algorithm in the autonomous detection strategy of mobile robot. Firstly, an RRT global frontier boundary point detection algorithm based on the multi-guide-node deflection strategy was put forward, which introduces the reference value of guide nodes’ deflection probability into the random sampling function so that the global search tree can detect frontier… More >

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