Božo Damjanović^*, Pejo Konjatić, Marko Katinić

CMES-Computer Modeling in Engineering & Sciences, Vol.145, No.2, pp. 1735-1753, 2025, DOI:10.32604/cmes.2025.072256 - 26 November 2025

Abstract Ensuring the structural integrity of piping systems is crucial in industrial operations to prevent catastrophic failures and minimize shutdown time. This study investigates a transportation-damaged pipe exposed to high-temperature conditions and cyclic loading, representing a realistic challenge in plant operation. The objective was to evaluate the service life and integrity assessment parameters of the damaged pipe, subjected to 22,000 operational cycles under two daily charge and discharge conditions. The flaw size in the damaged pipe was determined based on a failure assessment procedure, ensuring a conservative and reliable input. The damage was characterized as a… More >

Sara Y. Aldeghaither, Jawaher Alsughayyir, Sabiha Fatima, Mohammad A. Alfhili^*

BIOCELL, Vol.49, No.11, pp. 2167-2180, 2025, DOI:10.32604/biocell.2025.071827 - 24 November 2025

Abstract Objectives: Targeting epigenetic modifications in anticancer therapy is a promising approach to overcoming cancer cell chemoresistance. The histone deacetylase/DNA methyltransferase inhibitor, parthenolide (PTL), has antitumor activity, but contrasting findings exist on its effect in normal cells. This study aims to examine the non-genomic toxic mechanisms of PTL in human erythrocytes. Methods: Cell death as stimulated by 20–200 μM of PTL for 24 h at 37°C was assessed using fluorescence-assorted cell sorting and spectrophotometric assays. Canonical markers of cell death, including membrane scrambling, oxidative stress, and Ca²⁺ mobilization, were captured by annexin V-fluorescein isothiocyanate, 2^′,7^′-dichlorodihydrofluorescein diacetate, and… More >

Jung-Yeon Kim^#, Min Hui Park^#, Kiryeong Kim, Jaechan Leem^*

BIOCELL, Vol.49, No.11, pp. 2147-2166, 2025, DOI:10.32604/biocell.2025.070188 - 24 November 2025

Abstract Background: Cisplatin (CDDP) is a cornerstone chemotherapeutic agent for many solid tumors, but its clinical use is severely limited by dose-dependent nephrotoxicity, which results in acute kidney injury (AKI) in a significant proportion of patients. CDDP-induced AKI involves interconnected mechanisms, including inflammation, oxidative stress, and tubular cell death. In this study, we aimed to investigate the renoprotective effects of esculetin (ES), a natural antioxidant coumarin, in a murine model of CDDP-induced AKI. Methods: Male C57BL/6 mice (8–10 weeks) received a single intraperitoneal injection of CDDP (20 mg/kg) with or without ES (40 mg/kg/day, oral gavage).… More >

Eduard Belskikh^1,*, Yuliya Marsyanova², Denis Melnikov³, Oleg Uryasev¹, Valentina Zvyagina²

BIOCELL, Vol.49, No.11, pp. 2093-2123, 2025, DOI:10.32604/biocell.2025.069272 - 24 November 2025

Abstract Elevated homocysteine is a clinically relevant metabolic signal in chronic obstructive pulmonary disease (COPD). Higher circulating levels track with oxidative stress, endothelial dysfunction, mitochondrial impairment, and pulmonary vascular remodeling, rise with disease severity, and may contribute to the excess cardiovascular risk—although effect sizes and causality remain uncertain. This review centers on the homocysteine–carnitine relationship in COPD pathophysiology. Carnitine deficiency, prevalent in COPD, can worsen mitochondrial bioenergetics, promote accumulation of acyl intermediates, and reduce nitric oxide bioavailability via endothelial nitric oxide synthase uncoupling (eNOS). Conversely, restoring carnitine status in experimental and early clinical settings has been… More >

Russel J. Reiter^1,*, Ramaswamy Sharma^2,*, Walter Manucha³, Walter Balduini⁴, Doris Loh⁵, Demetrios A. Spandidos⁶, Alejandro Romero⁷, Vasiliki E. Georgakopoulou⁸, Wei Zhu⁹

BIOCELL, Vol.49, No.11, pp. 2033-2067, 2025, DOI:10.32604/biocell.2025.067661 - 24 November 2025

Abstract The development of cancer cell resistance to conventional treatments continues to be a major obstacle in the successful treatment of tumors of many types. The discovery of a highly efficient direct and indirect free radical scavenger, melatonin, in the mitochondrial matrix may be a factor in determining both the occurrence of cancer cell drug insensitivity as well as radioresistance. This relates to two of the known hallmarks of cancer, i.e., exaggerated free radical generation in the mitochondria and the development of Warburg type metabolism (glycolysis). The hypothesis elaborated in this report assumes that the high… More >

Fengnan Guo^1,*, Yiming Li¹, Hua Zhang¹, Jianwei Cui²

The International Conference on Computational & Experimental Engineering and Sciences, Vol.33, No.4, pp. 1-3, 2025, DOI:10.32604/icces.2025.011409

Abstract The stress intensity factor (SIF) is one of the most crucial parameters in fracture mechanics, as it can effectively characterize the state of the crack and determine its propagation behavior. The methods for evaluating the stress intensity factor mainly include the J-integral method, interaction integral method, and displacement extrapolation method [1,2]. However, the conventional J-integral and interaction integral methods involve derivative terms of material parameters, which cause a great difficulty in applying these methods to deal with non-homogeneous materials containing material interfaces. In order to overcome this difficulty, an improved interaction integral method has been… More >

Rui Xu¹, Chaogan Gao¹, Jiale Shi², Guorui Yu¹, Quhao Li^2,*

CMES-Computer Modeling in Engineering & Sciences, Vol.145, No.1, pp. 1-16, 2025, DOI:10.32604/cmes.2025.071942 - 30 October 2025

Abstract To address the design challenges of helicopter hub central components under high-performance requirements, this paper conducts safe-life topology optimization design research considering fatigue performance for rotor hub central components under multi-load conditions, combined with helicopter fatigue strength engineering design theory. For dealing with the issues of derivative calculation difficulties when directly considering fatigue constraints in existing topology optimization methods, this study establishes a mathematical formulation suitable for structural topology optimization of hub central components by combining modified structural safety fatigue limits based on iso-life curves. Then the sensitivity analysis of design variables is derived, and More >

Abdulnaser M. Alshoaibi^*, Yahya Ali Fageehi

CMES-Computer Modeling in Engineering & Sciences, Vol.145, No.1, pp. 189-214, 2025, DOI:10.32604/cmes.2025.071583 - 30 October 2025

Abstract Fatigue crack growth is a critical phenomenon in engineering structures, accounting for a significant percentage of structural failures across various industries. Accurate prediction of crack initiation, propagation paths, and fatigue life is essential for ensuring structural integrity and optimizing maintenance schedules. This paper presents a comprehensive finite element approach for simulating two-dimensional fatigue crack growth under linear elastic conditions with adaptive mesh generation. The source code for the program was developed in Fortran 95 and compiled with Visual Fortran. To achieve high-fidelity simulations, the methodology integrates several key features: it employs an automatic, adaptive meshing… More >

Xing Lin¹, Junning Wu¹, Shixue Liang^1,2,*

CMES-Computer Modeling in Engineering & Sciences, Vol.145, No.1, pp. 215-239, 2025, DOI:10.32604/cmes.2025.070846 - 30 October 2025

Abstract Random media like concrete and ceramics exhibit stochastic crack propagation due to their heterogeneous microstructures. This study establishes a Conditional Generative Adversarial Network (CGAN) combined with random field modeling for the efficient prediction of stochastic crack patterns and stress-strain responses. A total dataset of 500 samples, including crack propagation images and corresponding stress-strain curves, is generated via random Finite Element Method (FEM) simulations. This dataset is then partitioned into 400 training and 100 testing samples. The model demonstrates robust performance with Intersection over Union (IoU) scores of 0.8438 and 0.8155 on training and testing datasets, More >

Zhi-Yun Zhang^1,*, Yaqiong Wu¹, Chenshi Deng², Peng Wang³, Weiguaju Nong^4,*

International Journal of Mental Health Promotion, Vol.27, No.10, pp. 1533-1551, 2025, DOI:10.32604/ijmhp.2025.070883 - 31 October 2025

Abstract Objectives: Medical students often rely on recreational internet media to relieve the stress caused by immense academic and life pressures, and among these media, short-form videos, which are an emerging digital medium, have gradually become the mainstream choice of students to relieve their stress. However, the addiction caused by their usage has attracted the widespread attention of both academia and society, which is why the purpose of this study is to systematically explore the underlying mechanisms that link perceived stress, entertainment gratification, emotional gratification, short-form video usage intensity, and short-form video addiction based on multiple… More >