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  • Open Access

    ARTICLE

    Protective effect of aqueous suspension of dried latex of Calotropis procera against oxidative stress and renal damage in diabetic rats

    VIJAY L. KUMAR* AND BISWA M. PADHY

    BIOCELL, Vol.35, No.3, pp. 63-70, 2011, DOI:10.32604/biocell.2011.35.063

    Abstract Calotropis species have been used in the traditional medicinal system for the treatment of diseases of the liver and abdomen. In view of the antioxidant and anti-hyperglycemic properties of an aqueous suspension obtained from the dried latex of Calotropis procera, the present study was carried out to evaluate its efficacy in affording protection against alloxan induced changes in rat kidney. A single intraperitoneal injection of alloxan (150 mg/kg) in rats produced hyperglycemia within 3 days and altered kidney functions over a period of 90 days. Daily oral administration of the aqueous suspension (100 and 400 mg/kg) in diabetic rats produced… More >

  • Open Access

    ARTICLE

    Suspension state promotes extravasation of breast tumor cells by increasing integrin β1 expression

    Bingbing ZHANG1, 2, Ying ZHANG1, 2, Xiaomei ZHANG1, 2, Yonggang LV1, 2

    BIOCELL, Vol.42, No.1, pp. 17-24, 2018, DOI:10.32604/biocell.2018.06115

    Abstract Mechanical microenvironment can strongly affect the metastatic efficiency of circulating tumor cells. However, the effect of suspension state on their extravasation and the mechanisms involved are still unclear. To explore the influence of suspension state on extravasation (including adhesion, spreading and transendothelial migration) of breast tumor cells and its relevant molecular mechanism, MDA-MB-231 cells were cultured on poly (2-hydroxyethyl methacrylate) coated 6-well plates to minic the suspension state. Suspension state promoted adhesion, spreading and transendothelial migration of MDA-MB-231 cells to EAhy926 endothelial cells (ECs) monolayer under both the static condition and 0.5 dyne/cm2 flow shear stress (FSS). The number of… More >

  • Open Access

    ARTICLE

    Torin 1, TOR Inhibitor Enhances Cellular Proliferation in NT-1 Tobacco Suspension Cell Cultures

    Grisel Fierros-Romero1,*, M. Elena Mellado-Rojas2, Reynaldo C. Pless3, Juan Ignacio Valiente-Banuet1, Ashutosh Sharma1 and Elda M. Beltrán-Peña2

    Phyton-International Journal of Experimental Botany, Vol.88, No.2, pp. 131-137, 2019, DOI:10.32604/phyton.2019.05036

    Abstract Torin 1 is an ATP-competitive TOR inhibitor which inhibits the signaling of TOR and S6K kinase in mammals and plants. The objective of this research is to determine the effect of Torin 1 in a relatively simple and homogeneous plant system such as the NT-1 tobacco suspension cell cultures. Cultures of NT-1 cells were tested with 5, 50, 150 and 250 nM of Torin 1. During kinetics growth of NT-1 tobacco suspension cell cultures, 150 and 250 nM Torin 1 inhibits the early growth and later enhanced the cellular proliferation during exponential growth by means of an increased expression of… More >

  • Open Access

    ARTICLE

    Block Stratification of Sedimenting Granular Matter in a Vessel due to Vertical Vibrations

    V.G. Kozlov1,2, A.A. Ivanova3, P. Evesque1

    FDMP-Fluid Dynamics & Materials Processing, Vol.2, No.3, pp. 203-210, 2006, DOI:10.3970/fdmp.2006.002.203

    Abstract Sedimentation of granular matter in a vertical channel filled with a viscous liquid and subject to longitudinal translational vibration is studied, starting froma compact suspension. A new vibrational effect is foundexperimentally and described theoretically; it is the formation of blocks (with a relatively high density) of sedimenting granular matter with stable lower and upper horizontal demarcations and a sharp density discontinuity. Owing to this phenomenon the sedimentation velocity of such granular matter is reduced. A new theoreticalmodel based on viscous vibrational particle interactionin the limit of concentrated suspensions is elaborated, assuming particle-particle attraction in direction parallel tovibration and particle-particle repulsion… More >

  • Open Access

    ARTICLE

    Data-Driven Upscaling of Orientation Kinematics in Suspensions of Rigid Fibres

    Adrien Scheuer1, 3, *, Amine Ammar2, Emmanuelle Abisset-Chavanne3, Elias Cueto4, Francisco Chinesta5, Roland Keunings1, Suresh G. Advani6

    CMES-Computer Modeling in Engineering & Sciences, Vol.117, No.3, pp. 367-386, 2018, DOI:10.31614/cmes.2018.04278

    Abstract Describing the orientation state of the particles is often critical in fibre suspen-sion applications. Macroscopic descriptors, the so-called second-order orientation tensor (or moment) leading the way, are often preferred due to their low computational cost. Clo-sure problems however arise when evolution equations for the moments are derived from the orientation distribution functions and the impact of the chosen closure is often unpre-dictable. In this work, our aim is to provide macroscopic simulations of orientation that are cheap, accurate and closure-free. To this end, we propose an innovative data-based approach to the upscaling of orientation kinematics in the context of fibre… More >

  • Open Access

    ABSTRACT

    A Hybrid Damper and Its Application for Semi-Active Control of Vehicle Suspension System

    Y.W. Yun, M.K. Park

    The International Conference on Computational & Experimental Engineering and Sciences, Vol.9, No.1, pp. 25-26, 2009, DOI:10.3970/icces.2009.009.025

    Abstract This paper presents a semi-active control of vehicle suspension system with a hybrid damper. This damper consists of a conventional oil damper and magnetorheological fluidic (MRF) accumulator, which comprises gas accumulator and MRF device. The shaft of MRF device, fitted to in series the side of gas accumulator, is connected with a floating piston that divided into gas chamber and oil chamber. During the oil damper piston motion, the floating piston also behaves in the same direction of piston and the pressure of gas chamber varies. MRF accumulator will provides a force to the damper through retarding the movement of… More >

  • Open Access

    ARTICLE

    Formation of Highly Oriented Cellulose Nanocrystal Films by Spin Coating Film from Aqueous Suspensions

    Mingzhe Jiang1, S. Nicole DeMass1, D. Ross Economy2, Thomas Shackleton1, Christopher L. Kitchens1*

    Journal of Renewable Materials, Vol.4, No.5, pp. 377-387, 2016, DOI:10.7569/JRM.2016.634131

    Abstract Spin coating was used to cast a uniform film of cellulose nanocrystals with low surface roughness and variable thickness as a function of operational parameters that include rotational speed and dispense suspension concentration. The film thickness was controllable from 40 nm up to 1 μm with surface roughness an order of magnitude less than blade-coating methods. The degree of radial orientation was qualitatively assessed and shown to be variable with processing parameters. Under specific processing conditions, the formation of striation patterns was observed and associated with film drying instability. The striation patterns are periodic in nature where the wavelength and… More >

  • Open Access

    ARTICLE

    A Multiscale Method Based on the Fibre Configuration Field, IRBF and DAVSS for the Simulation of Fibre Suspension Flows

    H.Q. Nguyen1, C.-D. Tran1, T. Tran-Cong1

    CMES-Computer Modeling in Engineering & Sciences, Vol.109-110, No.4, pp. 361-403, 2015, DOI:10.3970/cmes.2015.109.361

    Abstract In this paper, an Integrated Radial Basis Function (IRBF)-based multiscale method is used to simulate the rheological properties of dilute fibre suspensions. For the approach, a fusion of the IRBF computation scheme, the Discrete Adaptive Viscoelastic Stress Splitting (DAVSS) technique and the Fibre Configuration Field has been developed to investigate the evolution of the flow and the fibre configurations through two separate computational processes. Indeed, the flow conservation equations, which are expressed in vorticity-stream function formulation, are solved using IRBF-based numerical schemes while the evolution of fibre configuration fields governed by the Jeffery’s equation is captured using the principle of… More >

  • Open Access

    ARTICLE

    Interval Uncertain Optimization of Vehicle Suspension for Ride Comfort

    C. Jiang1,2, S. Yu1, H.C. Xie1, B.C. Li1

    CMES-Computer Modeling in Engineering & Sciences, Vol.98, No.4, pp. 443-467, 2014, DOI:10.3970/cmes.2014.098.443

    Abstract Based on the interval analysis method, this paper proposes an uncertain optimization model for the ride comfort in vehicles and achieves the optimal design of vehicle ride comfort under the condition of complicated uncertainty. The spring stiffness and shock absorber damping of suspension is regarded as the design parameters, while the root mean square (RMS) of the vehicle body acceleration is treated as the design objective and the corresponding constraints are composed of suspension stiffness, natural frequency and RMS of suspension dynamic deflection. Moreover, the uncertainties of key parameters, such as sprung mass, tire stiffness, vehicle speed and road roughness,… More >

  • Open Access

    ARTICLE

    Towards an Analysis of Shear Suspension Flows Using Radial Basis Functions

    K. Le-Cao1, N. Mai-Duy1, C.-D. Tran1, T. Tran-Cong1

    CMES-Computer Modeling in Engineering & Sciences, Vol.67, No.3, pp. 265-294, 2010, DOI:10.3970/cmes.2010.067.265

    Abstract In this paper, radial basis functions are utilised for numerical prediction of the bulk properties of particulate suspensions under simple shear conditions. The suspending fluid is Newtonian and the suspended particles are rigid. Results obtained are compared well with those based on finite elements in the literature. More >

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