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  • Open Access

    ARTICLE

    Generalized Model of Blood Flow in a Vertical Tube with Suspension of Gold Nanomaterials: Applications in the Cancer Therapy

    Anees Imtiaz1, Oi-Mean Foong2, Aamina Aamina1, Nabeel Khan1, Farhad Ali3, 4, *, Ilyas Khan5

    CMC-Computers, Materials & Continua, Vol.65, No.1, pp. 171-192, 2020, DOI:10.32604/cmc.2020.011397 - 23 July 2020

    Abstract Gold metallic nanoparticles are generally used within a lab as a tracer, to uncover on the presence of specific proteins or DNA in a sample, as well as for the recognition of various antibiotics. They are bio companionable and have properties to carry thermal energy to tumor cells by utilizing different clinical approaches. As the cancer cells are very smaller so for the infiltration, the properly sized nanoparticles have been injected in the blood. For this reason, gold nanoparticles are very effective. Keeping in mind the above applications, in the present work a generalized model… More >

  • Open Access

    ARTICLE

    Cell viability in the cadmium-stressed cell suspension cultures of tobacco is regulated by extracellular ATP, possibly by a reactive oxygen species-associated mechanism

    Zhenzhen SHI, Jiaxin CAO, Hailong PANG, Lingyun JIA, Kun SUN, Hanqing FENG*

    BIOCELL, Vol.44, No.1, pp. 89-99, 2020, DOI:10.32604/biocell.2020.08059 - 01 March 2020

    Abstract Cadmium (Cd) is one of the most widespread and toxic heavy metals to plants. Extracellular ATP (exATP) is thought to be an extracellular effector in regulating the physiological responses of plant cells to environmental stresses. However, the function of exATP in Cd-stressed plant cells is much unknown. The present work showed that treating tobacco (Nicotiana tabacum L. cv. Bright Yellow-2) cell-suspension cultures with exogenous CdCl2 reduced the cell viability, exATP level, and Mg content. However, the production of reactive oxygen species (ROS), Cd content, and electrolyte leakage of the cells were enhanced by exogenous CdCl2. When the… More >

  • Open Access

    ARTICLE

    Torin 1, TOR Inhibitor Enhances Cellular Proliferation in NT-1 Tobacco Suspension Cell Cultures

    Grisel Fierros-Romero1,*, M. Elena Mellado-Rojas2, Reynaldo C. Pless3, Juan Ignacio Valiente-Banuet1, Ashutosh Sharma1 and Elda M. Beltrán-Peña2

    Phyton-International Journal of Experimental Botany, Vol.88, No.2, pp. 131-137, 2019, DOI:10.32604/phyton.2019.05036

    Abstract Torin 1 is an ATP-competitive TOR inhibitor which inhibits the signaling of TOR and S6K kinase in mammals and plants. The objective of this research is to determine the effect of Torin 1 in a relatively simple and homogeneous plant system such as the NT-1 tobacco suspension cell cultures. Cultures of NT-1 cells were tested with 5, 50, 150 and 250 nM of Torin 1. During kinetics growth of NT-1 tobacco suspension cell cultures, 150 and 250 nM Torin 1 inhibits the early growth and later enhanced the cellular proliferation during exponential growth by means More >

  • Open Access

    ARTICLE

    Suspension state promotes extravasation of breast tumor cells by increasing integrin β1 expression

    Bingbing ZHANG1, 2, Ying ZHANG1, 2, Xiaomei ZHANG1, 2, Yonggang LV1, 2

    BIOCELL, Vol.42, No.1, pp. 17-24, 2018, DOI:10.32604/biocell.2018.06115

    Abstract Mechanical microenvironment can strongly affect the metastatic efficiency of circulating tumor cells. However, the effect of suspension state on their extravasation and the mechanisms involved are still unclear. To explore the influence of suspension state on extravasation (including adhesion, spreading and transendothelial migration) of breast tumor cells and its relevant molecular mechanism, MDA-MB-231 cells were cultured on poly (2-hydroxyethyl methacrylate) coated 6-well plates to minic the suspension state. Suspension state promoted adhesion, spreading and transendothelial migration of MDA-MB-231 cells to EAhy926 endothelial cells (ECs) monolayer under both the static condition and 0.5 dyne/cm2 flow shear stress More >

  • Open Access

    ARTICLE

    Data-Driven Upscaling of Orientation Kinematics in Suspensions of Rigid Fibres

    Adrien Scheuer1, 3, *, Amine Ammar2, Emmanuelle Abisset-Chavanne3, Elias Cueto4, Francisco Chinesta5, Roland Keunings1, Suresh G. Advani6

    CMES-Computer Modeling in Engineering & Sciences, Vol.117, No.3, pp. 367-386, 2018, DOI:10.31614/cmes.2018.04278

    Abstract Describing the orientation state of the particles is often critical in fibre suspen-sion applications. Macroscopic descriptors, the so-called second-order orientation tensor (or moment) leading the way, are often preferred due to their low computational cost. Clo-sure problems however arise when evolution equations for the moments are derived from the orientation distribution functions and the impact of the chosen closure is often unpre-dictable. In this work, our aim is to provide macroscopic simulations of orientation that are cheap, accurate and closure-free. To this end, we propose an innovative data-based approach to the upscaling of orientation kinematics… More >

  • Open Access

    ARTICLE

    Formation of Highly Oriented Cellulose Nanocrystal Films by Spin Coating Film from Aqueous Suspensions

    Mingzhe Jiang1, S. Nicole DeMass1, D. Ross Economy2, Thomas Shackleton1, Christopher L. Kitchens1*

    Journal of Renewable Materials, Vol.4, No.5, pp. 377-387, 2016, DOI:10.7569/JRM.2016.634131

    Abstract Spin coating was used to cast a uniform film of cellulose nanocrystals with low surface roughness and variable thickness as a function of operational parameters that include rotational speed and dispense suspension concentration. The film thickness was controllable from 40 nm up to 1 μm with surface roughness an order of magnitude less than blade-coating methods. The degree of radial orientation was qualitatively assessed and shown to be variable with processing parameters. Under specific processing conditions, the formation of striation patterns was observed and associated with film drying instability. The striation patterns are periodic in… More >

  • Open Access

    ARTICLE

    A Multiscale Method Based on the Fibre Configuration Field, IRBF and DAVSS for the Simulation of Fibre Suspension Flows

    H.Q. Nguyen1, C.-D. Tran1, T. Tran-Cong1

    CMES-Computer Modeling in Engineering & Sciences, Vol.109-110, No.4, pp. 361-403, 2015, DOI:10.3970/cmes.2015.109.361

    Abstract In this paper, an Integrated Radial Basis Function (IRBF)-based multiscale method is used to simulate the rheological properties of dilute fibre suspensions. For the approach, a fusion of the IRBF computation scheme, the Discrete Adaptive Viscoelastic Stress Splitting (DAVSS) technique and the Fibre Configuration Field has been developed to investigate the evolution of the flow and the fibre configurations through two separate computational processes. Indeed, the flow conservation equations, which are expressed in vorticity-stream function formulation, are solved using IRBF-based numerical schemes while the evolution of fibre configuration fields governed by the Jeffery’s equation is… More >

  • Open Access

    ARTICLE

    Interval Uncertain Optimization of Vehicle Suspension for Ride Comfort

    C. Jiang1,2, S. Yu1, H.C. Xie1, B.C. Li1

    CMES-Computer Modeling in Engineering & Sciences, Vol.98, No.4, pp. 443-467, 2014, DOI:10.3970/cmes.2014.098.443

    Abstract Based on the interval analysis method, this paper proposes an uncertain optimization model for the ride comfort in vehicles and achieves the optimal design of vehicle ride comfort under the condition of complicated uncertainty. The spring stiffness and shock absorber damping of suspension is regarded as the design parameters, while the root mean square (RMS) of the vehicle body acceleration is treated as the design objective and the corresponding constraints are composed of suspension stiffness, natural frequency and RMS of suspension dynamic deflection. Moreover, the uncertainties of key parameters, such as sprung mass, tire stiffness, More >

  • Open Access

    ARTICLE

    Protective effect of aqueous suspension of dried latex of Calotropis procera against oxidative stress and renal damage in diabetic rats

    VIJAY L. KUMAR* AND BISWA M. PADHY

    BIOCELL, Vol.35, No.3, pp. 63-70, 2011, DOI:10.32604/biocell.2011.35.063

    Abstract Calotropis species have been used in the traditional medicinal system for the treatment of diseases of the liver and abdomen. In view of the antioxidant and anti-hyperglycemic properties of an aqueous suspension obtained from the dried latex of Calotropis procera, the present study was carried out to evaluate its efficacy in affording protection against alloxan induced changes in rat kidney. A single intraperitoneal injection of alloxan (150 mg/kg) in rats produced hyperglycemia within 3 days and altered kidney functions over a period of 90 days. Daily oral administration of the aqueous suspension (100 and 400 mg/kg) in… More >

  • Open Access

    ARTICLE

    Flow-Induced Forces in Agglomerates

    J.J. Derksen1, D. Eskin2

    FDMP-Fluid Dynamics & Materials Processing, Vol.7, No.4, pp. 341-356, 2011, DOI:10.3970/fdmp.2011.007.341

    Abstract Direct simulations of laminar solid-liquid flow in micro-channels with full resolution of the solid-liquid interfaces have been performed. The solids phase consists of simple agglomerates, assembled of monosized, spherical particles. The flow of the interstitial liquid is solved with the lattice-Boltzmann method. Solids and fluid dynamics are two-way coupled. The simulations keep track of the flow-induced forces in the agglomerates. The effects of agglomerate type (doublets, triplets, and quadruplets), solids loading, and channel geometry on (the statistics of the) flow and collision-induced forces have been investigated. By comparing these forces with agglomerate strength, we would More >

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