SALLY NEGM^1,2, MOHAMMAD EL-METWALLY³, WESAM ELDIN SABER⁴, SAHAR ABO-NEIMA⁵, MAHMOUD MOUSTAFA^6,7,*, ATTALLA EL-KOTT^6,8

BIOCELL, Vol.45, No.1, pp. 119-127, 2021, DOI:10.32604/biocell.2021.012011

Abstract The need for the bacterial proteinase is rapidly growing, urging to catch a lowcost medium for the microbial fermentation, nanoparticles can play a vital role in this respect. The proteinase of Talaromyces purpureogenus was produced on the tubers of Helianthus tuberosus that also operated as solid support for the fermentation process. The interface amongst nitrogen sources (NH₄Cl and yeast extract) was investigated, applying the statistical modeling of central composite design under solid-state fermentation. The optimum medium for proteinase secretion was stimulated by 979.82 mg NH₄Cl and 437.68 mg yeast extract per 100 g substrate, yielding 108.15 U/g tubers. Using Plackett-Burman… More >

Jaswinder Kaur¹, Manish Vyas², Joginder Singh¹, Ram Prasad^3,*, Jeena Gupta^1,*

Phyton-International Journal of Experimental Botany, Vol.89, No.4, pp. 795-803, 2020, DOI:10.32604/phyton.2020.09420

Abstract In recent years, there has been an increase in epidemiological studies to highlight the health benefits of plant secondary metabolites. Flavonoids (polyphenolic plant secondary metabolites) are recently emerging as an important source for the discovery of new drugs increasing their pharmaceuticals, nutraceutical and medicinal applications. Naringenin is a flavanone, enriched in citrus fruits, tomatoes, bergamot, etc. which has been evaluated extensively for managing diabetes. However, in addition to this, naringenin had been ascribed to various important biological activities like antioxidant, antiviral, anticancer, anti-inflammatory, antiestrogenic, etc. This article aims at highlighting the therapeutic value of naringenin in managing disorders other than… More >

Benjamin Bric, Paolo Raile^*

International Journal of Mental Health Promotion, Vol.22, No.3, pp. 133-147, 2020, DOI:10.32604/IJMHP.2020.011375

Abstract It was particularly important that the SFU Outpatient Clinic, which plays a relevant role in Vienna’s psychotherapeutic care, has established a corresponding offer during the COVID-19 crisis and continue to provide professional help. In times of insecurity and fear, we have created a safe contact point to which people could turn for help. In the following article the experiences of setting up an innovative psychotherapeutic Helpline, which is in operation since 21st of March 2020 at 12:00 at the psychotherapeutic outpatient clinic of the Sigmund Freud Private University in Vienna, will be discussed. Furthermore, statistical data on the number of… More >

Felicit e Kamdem^1,2, Danielle Kedy Koum^2,3, Ba Hamadou^1,4, Melanie Yemdji¹, Henry Luma^1,4, Marie Solange Doualla^1,4, Diomède Noukeu⁵, Esther Barla⁵, Christophe Akazong⁵, Anastase Dzudie^1,4, Henry Ngote¹, Yves Monkam¹, Sidiki Mouliom¹, Samuel Kingue^4,6

Congenital Heart Disease, Vol.13, No.1, pp. 113-117, 2018, DOI:10.1111/chd.12529

Abstract Introduction: Cardiovascular diseases in pediatric pathologies have emerged in the recent years in sub-Saharan Africa (SSA), with congenital heart diseases (CHDs) being the most frequent. Unfortunately, their diagnosis is usually delayed, thereby increasing childhood morbidity and mortality.
Objectives: Describe the clinical, echocardiographic, and therapeutic aspects of CHDs of children at Douala General Hospital.
Methods: We carried out a cross-sectional descriptive study over a 10-year period, from January 2006 to December 2015. Files and reports of cardiac ultrasounds of patients aged ≤ 15 years were reviewed.
Results: We reviewed the medical records of 1616 children, of which 370 (22.9%) had CHD.… More >

Praveena R^{1, *}

CMC-Computers, Materials & Continua, Vol.63, No.1, pp. 85-95, 2020, DOI:10.32604/cmc.2020.08629

Abstract Digital design of a digital signal processor involves accurate and high-speed mathematical computation units. DSP units are one of the most power consuming and memory occupying devices. Multipliers are the common building blocks in most of the DSP units which demands low power and area constraints in the field of portable biomedical devices. This research works attempts multiple power reduction technique to limit the power dissipation of the proposed LUT multiplier unit. A lookup table-based multiplier has the advantage of almost constant area requirement’s irrespective to the increase in bit size of multiplier. Clock gating is usually used to reduce… More >

Yingxiao Wang^1,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 79-79, 2019, DOI:10.32604/mcb.2019.07268

Abstract Genetically-encoded biosensors based on fluorescence proteins (FPs) and fluorescence resonance energy transfer (FRET) have enabled the specific targeting and visualization of signaling events in live cells with high spatiotemporal resolutions. Single-molecule FRET biosensors have been successfully developed to monitor the activity of variety of signaling molecules, including tyrosine/serine/threonine kinases. We have a developed a general high-throughput screening (HTS) method based on directed evolution to develop sensitive and specific FRET biosensors. We have first applied a yeast library and screened for a mutated binding domain for phosphorylated peptide sequence. When this mutated binding domain and the peptide sequence are connected by… More >

Yan Cai^1,1, Zhiyong Li^1,2,*

Molecular & Cellular Biomechanics, Vol.14, No.2, pp. 59-81, 2017, DOI:10.3970/mcb.2017.014.057

Abstract To investigate the dynamic changes of solid tumor and neo-vasculature in response to chemotherapeutic agent, we proposed a multi-discipline three-dimensional mathematical model by coupling tumor growth, angiogenesis, vessel remodelling, microcirculation and drug delivery. The tumor growth is described by the cell automaton model, in which three cell phenotypes (proliferating cell, quiescent cell and necrotic cell) are assumed to reflect the dynamics of tumor progress. A 3D tree-like architecture network with different orders for vessel diameter is generated as pre-existing vasculature in host tissue. The chemical substances including oxygen, vascular endothelial growth factor, extra-cellular matrix and matrix degradation enzymes are calculated… More >

J. A. Ferreira¹, P. de Oliveira², P. M. da Silva³

CMES-Computer Modeling in Engineering & Sciences, Vol.76, No.3&4, pp. 163-174, 2011, DOI:10.3970/cmes.2011.076.163

Abstract In two previous papers the authors presented mathematical models that simulate the mass of drug delivered, in vitro Ferreira, Oliveira, Silva, Carreira, Gil and Murta (2010) and in vivo Ferreira, Oliveira, Silva and Murta (2011), from a therapeutic contact lens. In the present paper the time it takes to reach an equilibrium state is studied. A closed formula based on the concept of effective time is derived and the influence of the parameters of the model is analyzed. More >

R. Praveena¹, S. Nirmala²

CMC-Computers, Materials & Continua, Vol.53, No.1, pp. 37-47, 2017, DOI:10.3970/cmc.2017.053.039

Abstract DSP operation in a Biomedical related therapeutic hardware need to be performed with high accuracy and with high speed. Portable DSP hardware’s like pulse/heart beat detectors must perform with reduced operational power due to lack of conventional power sources. This work proposes a hybrid biomedical hardware chip in which the speed and power utilization factors are greatly improved. Multipliers are the core operational unit of any DSP SoC. This work proposes a LUT based unsigned multiplication which is proven to be efficient in terms of high operating speed. For n bit input multiplication n*n memory array of 2n bit size… More >