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Search Results (17)
  • Open Access

    ARTICLE

    Analysis of Risk Factors for Central Venous Catheter-Associated Thrombosis in Children after Congenital Heart Surgery

    Hanfang Deng1,2, Zhimin Yang1, Wenlan Zhang3, Zhuomin Xu1, Lin Chen1, Yueyue Zhang1, Li Yuan1,*, Wenyi Luo4,*

    Congenital Heart Disease, Vol.19, No.6, pp. 603-615, 2024, DOI:10.32604/chd.2025.057681 - 27 January 2025

    Abstract Objective: To investigate the status and influencing factors of central venous catheter-associated thrombosis in children after congenital heart surgery and to provide evidence for preventive measures. Methods: From January 2024 to March 2024, hospitalized children with central venous catheters (CVC) in the Shanghai Grade III Children’s Hospital intensive care unit were selected. Catheter-related thrombosis (CRT) was evaluated using bedside ultrasound technology combined with visible thrombus after CVC extraction, dividing the patients into the thrombus and non-thrombus groups. Univariate and LASSO regression analyses were used to analyze the factors influencing CRT in children after congenital heart More >

  • Open Access

    ARTICLE

    CFD Study on Hemodynamic Characteristics of Inferior Vena Cava Filter Affected by Blood Vessel Diameter

    Shiyue Zhang1, Xue Song1,2, Jingying Wang1,*, Wen Huang3,*, Yue Zhou4, Mingrui Li1

    Molecular & Cellular Biomechanics, Vol.20, No.2, pp. 81-94, 2023, DOI:10.32604/mcb.2023.044445 - 01 November 2023

    Abstract Pulmonary embolism (PE), caused by deep venous thrombosis (DVT), is a disease with high morbidity and mortality. Implantation of inferior vena cava filters is an important method for the clinical prevention of PE. The hemodynamic characteristics of filters implanted in the inferior vena cava (IVC) have a significant impact on their performance. However, IVC diameters vary among patients. This may have a direct impact on the hemodynamic properties of the filter. At present, there is no research on this kind of problem to be investigated. In this paper, the hemodynamic properties of the VenaTech convertible… More > Graphic Abstract

    CFD Study on Hemodynamic Characteristics of Inferior Vena Cava Filter Affected by Blood Vessel Diameter

  • Open Access

    ARTICLE

    Utility of ultrasonography in preoperative assessment of tumor thrombi in kidney cancer

    Reza Nabavizadeh1,*, Grace Lee1,*, Katherine Bobrek1, Dattatraya Patil1, Mehrdad Alemozaffar2, Courtney Moreno3, Viraj A. Master1,4

    Canadian Journal of Urology, Vol.29, No.5, pp. 11300-11306, 2022

    Abstract Introduction: This study examined the clinical accuracy of ultrasonography compared to magnetic resonance imaging (MRI) and intraoperative findings for evaluation of tumor thrombi level in patients with renal cell carcinoma.
    Materials and methods: We retrospectively identified 38 patients at our institution who underwent both ultrasonography and MRI before undergoing open radical nephrectomy with tumor thrombectomy between 2010 and 2019. We compared tumor thrombus level findings of both ultrasonography and MRI, as well as the diagnostic accuracy of each to intraoperative findings. Agreement between ultrasonography, MRI, and surgery was tested with kappa. Logistic regression models identified factors that… More >

  • Open Access

    ARTICLE

    A 20-Year Follow-up after the Fontan Operation in a Population with Hypoplastic Left Heart Syndrome

    Eleni P. Asimacopoulos*, Steven J. Staffa, Peter C. Laussen, Kirsten C. Odegard

    Congenital Heart Disease, Vol.17, No.5, pp. 579-590, 2022, DOI:10.32604/chd.2022.020334 - 06 September 2022

    Abstract Background: Thromboembolic events are a cause of significant morbidity and mortality in the Fontan population. We previously reported on coagulation profile changes in a cohort of patients with hypoplastic left heart syndrome (HLHS) from Stage I through Fontan completion. In this report, we examine their clinical status, anticoagulation and incidence of thromboembolic events up to 20 years post Fontan. Methods: A retrospective chart review was conducted for twenty (20) surviving patients, from 1998 through December 2020. Patients who underwent orthotopic heart transplantation (OTx) were followed until their transplant. Patients who were found in the original study… More >

  • Open Access

    ARTICLE

    Congenital Coronary Artery Fistula in Children: A Review of 28 Cases with Clinical and Imaging Outcomes

    Pornrawee Plearntummakun1, Chodchanok Vijarnsorn1,*, Kritvikrom Durongpisitkul1, Prakul Chanthong1, Paweena Chungsomprasong1, Supaluck Kanjanauthai1, Thita Pacharapakornpong1, Jarupim Soongswang1, Thaworn Subtaweesin2

    Congenital Heart Disease, Vol.17, No.4, pp. 463-478, 2022, DOI:10.32604/chd.2022.021545 - 04 July 2022

    Abstract Background: Congenital coronary artery fistula (CCAF) is a rare anomaly. Treatment strategies tend to close the defect with a symptomatic and significant shunt, primarily based on expert consensus and case series. Results for long-term follow-up in children are limited Methods: We conducted a retrospective study to assess clinical and imaging outcomes of children with CCAF at Siriraj Hospital, Thailand during 2000–2020. Patients with single ventricle were excluded. Treatment strategies [surgical closure (SC), and percutaneous closure (PC)] were classified and the clinical outcomes at the follow-up in 2021, including coronary thrombosis, myocardial ischemia, and the results of… More > Graphic Abstract

    Congenital Coronary Artery Fistula in Children: A Review of 28 Cases with Clinical and Imaging Outcomes

  • Open Access

    ARTICLE

    Relationship between operative duration and perioperative outcomes after radical cystectomy

    Kassem S. Faraj1, Nathanael Judge1, Gail Blodgett2, Mark D. Tyson II1

    Canadian Journal of Urology, Vol.28, No.2, pp. 10603-10609, 2021

    Abstract Introduction: Prolonged operative times have been associated with an increased risk of complications in other major abdominal surgeries. This study tests the hypothesis that longer operative times will be associated with an increased risk of perioperative complications after radical cystectomy (RC).
    Materials and methods: Adult patients who underwent RC from January 1, 2012, through December 31, 2016, were identified from the National Surgical Quality Improvement Program (NSQIP) database. A natural log transformation was used to determine cutoff points for operative times at the 33rd, 67th, and 90th percentiles: 272, 371, and 479 minutes, respectively. Cohorts were divided… More >

  • Open Access

    ARTICLE

    Computational Fluid Dynamics Simulations at Micro-Scale Stenosis for Microfluidic Thrombosis Model Characterization

    Yunduo Charles Zhao1,2,#, Parham Vatankhah1,#, Tiffany Goh1,2,3, Jiaqiu Wang4, Xuanyi Valeria Chen1, Moein Navvab Kashani5,6, Keke Zheng7, Zhiyong Li4, Lining Arnold Ju1,2,3,*

    Molecular & Cellular Biomechanics, Vol.18, No.1, pp. 1-10, 2021, DOI:10.32604/mcb.2021.012598 - 26 January 2021

    Abstract Platelet aggregation plays a central role in pathological thrombosis, preventing healthy physiological blood flow within the circulatory system. For decades, it was believed that platelet aggregation was primarily driven by soluble agonists such as thrombin, adenosine diphosphate and thromboxane A2. However, recent experimental findings have unveiled an intriguing but complementary biomechanical mechanism—the shear rate gradients generated from flow disturbance occurring at sites of blood vessel narrowing, otherwise known as stenosis, may rapidly trigger platelet recruitment and subsequent aggregation. In our Nature Materials 2019 paper [1], we employed microfluidic devices which incorporated micro-scale stenoses to elucidate the… More >

  • Open Access

    ARTICLE

    Numerical Investigation of an Idealized Total Cavopulmonary Connection Physiology Assisted by the Axial Blood Pump With and Without Diffuser

    Zhenxin Zhao1,#, Tong Chen2,#, Xudong Liu3, Shengzhang Wang2,4,*, Haiyan Lu5,*

    CMES-Computer Modeling in Engineering & Sciences, Vol.125, No.3, pp. 1173-1184, 2020, DOI:10.32604/cmes.2020.013702 - 15 December 2020

    Abstract In order to improve the surgical treatment of the congenital heart disease patient with single ventricle defect, two axial flow blood pumps, one with diffuser and the other without diffuser, were designed and virtually implanted into an idealized total cavopulmonary connection (TCPC) model to form two types of Pump-TCPC physiological structure. Computational fluid dynamics (CFD) simulations were performed to analyze the variations of the hemodynamic characteristics, such as flow field, wall shear stress (WSS), oscillatory shear index (OSI), relative residence time (RRT), between the two Pump-TCPC models. Numerical results indicate that the Pump-TCPC with diffuser More >

  • Open Access

    ABSTRACT

    Diabetes and Thrombosis: The Dark Side of the Force

    Lining Arnold Ju1,2,3,4,6,†,*, James McFadyen4,†, Saheb Al-Daher4,†, Imala Alwis1,2,3,4, Yunfeng Chen6,7,8, Mark E. Cooper9, Cheng Zhu1,2,3,5,6,7, Shaun P. Jackson1,2,3,4,8

    Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 96-96, 2019, DOI:10.32604/mcb.2019.06979

    Abstract Thrombotic diseases where platelets form clots and obstruct blood vessels remains the leading cause of death and disability in the world. Despite intense investigation over the last 40 years into the discovery and development of more effective drugs, less than 1 in 6 patients taking anti-thrombotic therapies avoid a fatal event. This situation is likely to worsen in younger generations due to the rapidly growing incidence of diabetes, which makes people more prone to thrombosis and resistant to existing anti-thrombotics with unknown reasons.
    To investigate this, I have developed the ‘Biomembrane Force Probe’ as the… More >

  • Open Access

    ABSTRACT

    The Degree of Question Mark of Aorta Can Predict the Thrombosis Rate in the False Lumen of a Type-B Aortic Dissection After TEVAR

    Da Li1,#, Liqing Peng2,#, Yi Wang3, Ding Yuan4, Tinghui Zheng1,*

    Molecular & Cellular Biomechanics, Vol.16, Suppl.1, pp. 39-39, 2019, DOI:10.32604/mcb.2019.05718

    Abstract Objective: Thoracic endovascular aortic repair (TEVAR) of type B aortic dissection (AD) is to initiate the thrombosis in the false lumen to eventually result in aortic remodeling. We aim to find out whether the false lumen (FL) thrombosis rate after TEVAR can be predicted accurately by an index that expresses the degree of aortic arch angulation. Method: Three-dimensional aortic arch geometry of 39 type B AD patients (mean age: 48 years) after TEVR were reconstructed from post-operative CT images. For the first time, the question mark which takes into account the curvature of both aortic arch… More >

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