ZHIWANG LI, HAN YU, YUPING LIU, WEISHENG WU, HAIJING ZENG, EN LI^*

BIOCELL, Vol.47, No.11, pp. 2409-2422, 2023, DOI:10.32604/biocell.2023.031186

Abstract Familial adenomatous polyposis (FAP) is an autosomal dominant disease with a high probability of becoming cancerous. Many RNAs potentially associated with FAP have not been identified. In this study, a circRNA (circular RNA) expression profile of FAP was established using a circRNA microarray, and differentially expressed circRNAs were verified by RT-qPCR. The effects of hsa_circ_0036740 on the malignant behavior of tumor cells (proliferation, apoptosis, and epithelial mesenchymal transition) and the levels of C3A complement protein expression were evaluated. Moreover, neutrophils were isolated and co-cultured with colorectal cancer cells (CRCs), followed by measurements of MPO-DNA, citrullinated histone H3, interleukin (IL)-1β, IL-6,… More > Graphic Abstract

ZIYU LIU^1,2, AKIKO OKANO^3,4, EMIKO SANADA^1,3,4, YUSHI FUTAMURA^3,4, TOSHIHIKO NOGAWA^3,5, KOSUKE ISHIKAWA⁶, KENTARO SEMBA^7,8, JIANG LI⁹, XIAOMENG LI¹⁰, HIROYUKI OSADA^3,4,11,*, NOBUMOTO WATANABE^1,2,4,*

Oncology Research, Vol.31, No.5, pp. 655-666, 2023, DOI:10.32604/or.2023.030248

Abstract

Myc belongs to a family of proto-oncogenes that encode transcription factors. The overexpression of c-Myc causes many types of cancers. Recently, we established a system for screening c-Myc inhibitors and identified antimycin A by screening the RIKEN NPDepo chemical library. The specific mechanism of promoting tumor cell metastasis by high c-Myc expression remains to be explained. In this study, we screened approximately 5,600 microbial extracts using this system and identified a broth prepared from Streptomyces sp. RK19-A0402 strongly inhibits c-Myc transcriptional activity. After purification of the hit broth, we identified compounds closely related to the aglycone of cytovaricin and had… More > Graphic Abstract

XINTONG LIU^1,2,3, EMIKO SANADA^1,3,4, JIANG LI⁵, XIAOMENG LI⁶, HIROYUKI OSADA^1,4,7,*, NOBUMOTO WATANABE^1,2,3,*

Oncology Research, Vol.31, No.5, pp. 645-654, 2023, DOI:10.32604/or.2023.030240

Abstract β-transducin repeat-containing protein (β-TrCP) is an F-box protein subunit of the E3 Skp1-Cullin-F box (SCF) type ubiquitin-ligase complex, and provides the substrate specificity for the ligase. To find potent ligands of β-TrCP useful for the proteolysis targeting chimera (PROTAC) system using β-TrCP in the future, we developed a high-throughput screening system for small molecule β-TrCP ligands. We screened the chemical library utilizing the system and obtained several hit compounds. The effects of the hit compounds on in vitro ubiquitination activity of SCF^β-TrCP1 and on downstream signaling pathways were examined. Hit compounds NPD5943, NPL62020-01, and NPL42040-01 inhibited the TNFα-induced degradation of… More > Graphic Abstract

Rajesh Bharati^*, Vahida Attar

Intelligent Automation & Soft Computing, Vol.37, No.1, pp. 763-775, 2023, DOI:10.32604/iasc.2023.035503

Abstract Online Transaction Processing (OLTP) gets support from data partitioning to achieve better performance and scalability. The primary objective of database and application developers is to provide scalable and reliable database systems. This research presents a novel method for data partitioning and load balancing for scalable transactions. Data is efficiently partitioned using the hybrid graph partitioning method. Optimized load balancing (OLB) approach is applied to calculate the weight factor, average workload, and partition efficiency. The presented approach is appropriate for various online data transaction applications. The quality of the proposed approach is examined using OLTP database benchmark. The performance of the… More >

Mohamed Amine Ouamri^1,2, Reem Alkanhel^3,*, Daljeet Singh⁴, El-sayed M. El-kenaway⁵, Sherif S. M. Ghoneim⁶

Computer Systems Science and Engineering, Vol.46, No.1, pp. 73-92, 2023, DOI:10.32604/csse.2023.034461

Abstract Increasing the coverage and capacity of cellular networks by deploying additional base stations is one of the fundamental objectives of fifth-generation (5G) networks. However, it leads to performance degradation and huge spectral consumption due to the massive densification of connected devices and simultaneous access demand. To meet these access conditions and improve Quality of Service, resource allocation (RA) should be carefully optimized. Traditionally, RA problems are nonconvex optimizations, which are performed using heuristic methods, such as genetic algorithm, particle swarm optimization, and simulated annealing. However, the application of these approaches remains computationally expensive and unattractive for dense cellular networks. Therefore,… More >

Lei Hu^1,2,#, Meng Chen^2,3,#, Haiming Dai^2,3,4, Hongzhi Wang^2,3,4,*, Wulin Yang^2,3,4,*

Oncologie, Vol.24, No.4, pp. 803-822, 2022, DOI:10.32604/oncologie.2022.026419

Abstract Background and Aim: Hundreds of consistently altered metabolic genes have been identified in breast cancer (BC), but their prognostic value remains to be explored. Therefore, we aimed to build a prediction model based on metabolism-related genes (MRGs) to guide BC prognosis. Methods: Current work focuses on constructing a novel MRGs signature to predict the prognosis of BC patients using MRGs derived from the Virtual Metabolic Human (VMH) database, and expression profiles and clinicopathological data from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. Results: The 3-MRGs-signature constructed by SERPINA1, QPRT and PXDNL was found to be an… More >

Noor Gul^1,2, Saeed Ahmed^1,3, Su Min Kim¹, Muhammad Sajjad Khan⁴, Junsu Kim^1,*

CMC-Computers, Materials & Continua, Vol.74, No.3, pp. 5209-5227, 2023, DOI:10.32604/cmc.2023.026945

Abstract A cognitive radio network (CRN) intelligently utilizes the available spectral resources by sensing and learning from the radio environment to maximize spectrum utilization. In CRNs, the secondary users (SUs) opportunistically access the primary users (PUs) spectrum. Therefore, unambiguous detection of the PU channel occupancy is the most critical aspect of the operations of CRNs. Cooperative spectrum sensing (CSS) is rated as the best choice for making reliable sensing decisions. This paper employs machine-learning tools to sense the PU channels reliably in CSS. The sensing parameters are reconfigured to maximize the spectrum utilization while reducing sensing error and cost with improved… More >

Xiaoye Shi^1,*, Fei Ding^1,2, Haiting Zhu¹, Zhaowei Zhang¹, Lei Zhang¹

CMC-Computers, Materials & Continua, Vol.74, No.3, pp. 4819-4830, 2023, DOI:10.32604/cmc.2023.018637

Abstract The simultaneous wireless information and power transfer (SWIPT) relay system is one of the emerging technologies. Xiaomi Corporation and Motorola Inc. recently launched indoor wireless power transfer equipment is one of the most promising applications. To tap the potential of the system, hybrid automatic repeat request (HARQ) is introduced into the SWIPT relay system. Firstly, the time slot structure of HARQ scheme based on full duplex two-way amplify and forward (AF) SWIPT relay is given, and its retransmission status is analyzed. Secondly, the equivalent signal-to-noise ratio and outage probability of various states are calculated by approximate simplification. Thirdly, the energy… More >

Mohammad Alkhawatrah^*

Computer Systems Science and Engineering, Vol.45, No.2, pp. 1187-1197, 2023, DOI:10.32604/csse.2023.030699

Abstract Cooperative non-orthogonal multiple access (NOMA) is heavily studied in the literature as a solution for 5G and beyond 5G applications. Cooperative NOMA transmits a superimposed version of all users’ messages simultaneously with the aid of a relay, after that, each user decodes its own message. Accordingly, NOMA is deemed as a spectral efficient technique. Another emerging technique exploits orbital angular momentum (OAM), where OAM is an attractive character of electromagnetic waves. OAM gathered a great deal of attention in recent years (similar to the case with NOMA) due to its ability to enhance electromagnetic spectrum exploitation, hence increasing the achieved… More >

Sajjad Ahmad¹, Imran Raza¹, M. Hasan Jamal¹, Sirojiddin Djuraev², Soojung Hur³, Imran Ashraf^3,*

CMC-Computers, Materials & Continua, Vol.74, No.2, pp. 2363-2377, 2023, DOI:10.32604/cmc.2023.032694

Abstract Vehicle-to-grid technology is an emerging field that allows unused power from Electric Vehicles (EVs) to be used by the smart grid through the central aggregator. Since the central aggregator is connected to the smart grid through a wireless network, it is prone to cyber-attacks that can be detected and mitigated using an intrusion detection system. However, existing intrusion detection systems cannot be used in the vehicle-to-grid network because of the special requirements and characteristics of the vehicle-to-grid network. In this paper, the effect of denial-of-service attacks of malicious electric vehicles on the central aggregator of the vehicle-to-grid network is investigated… More >