Zhe Liu¹, Charlie Maere^1,*, Yuqing Song¹

CMC-Computers, Materials & Continua, Vol.59, No.2, pp. 669-686, 2019, DOI:10.32604/cmc.2019.04590

Abstract Accurately finding the region of interest is a very vital step for segmenting organs in medical image processing. We propose a novel approach of automatically identifying region of interest in Computed Tomography Image (CT) images based on temporal and spatial data . Our method is a 3 stages approach, 1) We extract organ features from the CT images by adopting the Hounsfield filter. 2)We use these filtered features and introduce our novel approach of selecting observable feature candidates by calculating contours’ area and automatically detect a seed point. 3) We use a novel approach to More >

Tyler J. Fraum¹, Daniel R. Ludwig¹, Eric H. Kim², Paul Schroeder³, Thomas A. Hope⁴, Joseph E. Ippolito¹

Canadian Journal of Urology, Vol.25, No.4, pp. 9371-9383, 2018

Abstract Introduction: In the past, positron emission tomography (PET) has played a relatively limited role in prostate cancer imaging. However, in recent years, several new PET tracers have emerged, offering potential improvements in diagnostic performance for both the detection of prostate cancer metastases at initial staging and the localization of recurrent disease.
Materials and methods: We reviewed the literature for prostate cancer PET tracers that are either being used for patient management or being evaluated in clinical research trials. For each tracer, we compiled clinically relevant background information and evidence supporting clinical use, with the intention of providing… More >

Jeong Yong Jeon^*1, Misu Lee^*†1, Sang Hyun Whang^*, Jung-Whan Kim^‡, Arthur Cho^*, Mijin Yun^*

Oncology Research, Vol.26, No.1, pp. 71-81, 2018, DOI:10.3727/096504017X14902648894463

Abstract Altered energy metabolism is a biochemical fingerprint of cancer cells. Hepatocellular carcinoma (HCC) shows reciprocal [¹⁸F]fluorodeoxyglucose (FDG) and [¹¹C]acetate uptake, as revealed by positron emission tomography/computed tomography (PET/CT). Previous studies have focused on the role of FDG uptake in cancer cells. In this study, we evaluated the mechanism and roles of [¹¹C]acetate uptake in human HCCs and cell lines. The expression of monocarboxylate transporters (MCTs) was assessed to determine the transporters of [¹¹C]acetate uptake in HCC cell lines and human HCCs with different [¹¹C]acetate uptake. Using two representative cell lines with widely different [¹¹C]acetate uptake (HepG2 for high… More >

Lidia R. Bons¹, Lucas Uchoa de Assis¹, Silvy Dekker¹, Robert M. Kauling¹, Judith A.A.E. Cuypers¹, Hence J.M. Verhagen², Ricardo P.J. Budde³, Jolien W. Roos‐Hesselink¹

Congenital Heart Disease, Vol.13, No.6, pp. 988-996, 2018, DOI:10.1111/chd.12663

Abstract Objective: The aim is to present current clinical practice of thoracic aorta screening in a tertiary referral center. We identified how often imaging techniques were used for screening and established the value of transthoracic echocardiography (TTE) in com‐ parison with computed tomography (CT) to detect aortic dilation. We also investigated which additional abnormalities of the heart, aorta or smaller arteries were discovered.
Design: All patients ≥15 years who visited our tertiary center in 2012‐2016 for first thoracic aortic screening were retrospectively included. Diameters of the sinus of Valsalva (SoV) and maximum ascending aorta (AA) were compared between… More >

Yuxiang Huang¹, Chuliu He¹, Jiaqiu Wang², Yuehong Miao¹, Tongjin Zhu¹, Ping Zhou¹, Zhiyong Li^1,2,*

Molecular & Cellular Biomechanics, Vol.15, No.2, pp. 117-125, 2018, DOI:10.3970/mcb.2018.02478

Abstract Intravascular optical coherence tomography (IVOCT) is becoming more and more popular in clinical diagnosis of coronary atherosclerotic. However, reading IVOCT images is of large amount of work. This article describes a method based on image feature extraction and support vector machine (SVM) to achieve semi-automatic segmentation of IVOCT images. The image features utilized in this work including light attenuation coefficients and image textures based on gray level co-occurrence matrix. Different sets of hyper-parameters and image features were tested. This method achieved an accuracy of 83% on the test images. Single class accuracy of 89% for More >

S. Gopalakrishnan^{1, *}, A. Kandaswamy²

CMES-Computer Modeling in Engineering & Sciences, Vol.114, No.2, pp. 141-152, 2018, DOI:10.3970/cmes.2018.114.141

Abstract Delineation of the lung parenchyma in the thoracic Computed Tomography (CT) is an important processing step for most of the pulmonary image analysis such as lung volume extraction, lung nodule detection and pulmonary vessel segmentation. An automatic method for accurate delineation of lung parenchyma in thoracic Computed Tomography images is presented in this paper. The proposed method involves a segmentation phase followed by a lung boundary correction technique. The tissues in the thoracic Computed Tomography can be represented by a number of Gaussians. We propose a histogram utilized Adaptive Multilevel Thresholding (AMT) for estimating the More >

Raunak D. Patel, Colton Walker, Daniel J. Canter

Canadian Journal of Urology, Vol.24, No.1, pp. 8670-8672, 2017

Abstract Diffuse large B-cell lymphomas (DLBCL) are the most common lymphomas worldwide. They also appear to be the most common primary retroperitoneal lymphomas, but this presentation is relatively uncommon in the literature. Retroperitoneal masses, including lymphomas, often present with nonspecifc symptoms and laboratory values, necessitating radiographic assessment and consideration of mass biopsy prior to the initiation of treatment. Here we present a case of a primary retroperitoneal DLBCL as well as a review of the clinical presentation, imaging fndings, and differential diagnosis of such tumors. More >

Andrew Cohen, Blake Anderson, Glenn Gerber

Canadian Journal of Urology, Vol.24, No.3, pp. 8832-8837, 2017

Abstract Introduction: We aim to determine the optimal method for measuring Hounsfield Units (HU) of calculi for the clinical urologist.
Materials and methods: We present a single institution prospective study from 2014-2015 for 125 consecutive patients. Demographics, baseline characteristics, imaging, and stone analysis were collected. CT scanners and settings were heterogeneous. Hounsfield units were measured by use of ellipsoid tool and free hand outline by two independent urology graders using Philips iSite PACs.
Results: Stone analysis demonstrated 26 pure calcium oxalate (CaOx) stones, 15 pure calcium phosphate (CaP) stones, and 7 uric acid stones, among other mixed types. Excellent… More >

Athanasios Koutsoukis¹, Xavier Halna du Fretay², Patrick Dupouy³, Phalla Ou⁴, Jean-Pierre Laissy⁴, Jean-Michel Juliard⁵, Fabien Hyafil⁶, Pierre Aubry⁵

Congenital Heart Disease, Vol.12, No.6, pp. 726-732, 2017, DOI:10.1111/chd.12504

Abstract Objective: The diagnosis of anomalous connections of the coronary arteries (ANOCOR) requires an appropriate identification for the management of the patients involved. We studied the observer variability in the description and classification of ANOCOR between a nonexpert group of physicians and a group of expert physicians, using the ANOCOR cohort.
Patients and design: Consecutive patients identified by 71 referring cardiologists were included in the ANOCOR cohort. Anomalous connection was diagnosed by invasive and/or computed tomography coronary angiography. Angiographic images were reviewed by an angiographic committee with experience in this field. Both investigators and angiographic committee filled out… More >

Waldemar F. Carlo¹, Steven T. Clark², Santiago Borasino³, Jeffrey A. Alten³

Congenital Heart Disease, Vol.12, No.4, pp. 540-545, 2017, DOI:10.1111/chd.12482

Abstract Objective: Acute kidney injury (AKI) is a frequent complication after cardiopulmonary bypass (CBP) for cardiac surgery in neonates. It is unclear if exposure to computed tomography angiography (CTA) in the preoperative period increases the risk of AKI. We hypothesized a short interval between CTA and CPB surgery would be associated with higher rates of AKI in infants.
Design: In this single center retrospective review of patients between 2012 and 2015, neonates less than one month old were analyzed if they had CTA prior to cardiac surgery with CPB. Baseline, demographic, fluid balance, and laboratory data was analyzed.… More >