Tamilselvan SUBRAMANI^1,2, Suresh RAO², Kamatchiammal SENTHILKUMAR³, Soundararajan PERIASAMY⁴, Noorjahan Banu ALITHEEN¹

BIOCELL, Vol.37, No.3, pp. 71-76, 2013, DOI:10.32604/biocell.2013.37.071

Abstract The present study demonstrates that the expression of c-Jun and c-Fos are elevated in gingival fibroblast cells treated with angiotensin II and cyclosporine. The healthy human gingival tissues were collected and gingival fibroblasts were isolated and cultured. We used RT-PCR and Western blot analysis to identify the expression of c-Jun and c-Fos in cyclosporine and angiotensin II treated human gingival fibroblast cells. We found that angiotensin II in combination with cyclosporine induces c-Jun and c-Fos expressions significantly; however, the angiotensin II antagonist losartan inhibits the expression of c-Jun and c-Fos (p < 0.01). The data suggest that angiotensin II in… More >

Chan RL

Phyton-International Journal of Experimental Botany, Vol.78, pp. 5-10, 2009, DOI:10.32604/phyton.2009.78.005

Abstract Transcription factors (TFs) are proteins able to specifically recognize DNA sequences in the regulatory regions of their target genes. They bind these specific sequences, an event that leads to the activation or repression of whole signal transduction pathways. In plants about 1500 TFs were informatically identified; identification was mainly based in the presence of DNA-binding domains in the translated sequences. They were classified in families and subfamilies according to several features, including the conservation of the DNA binding domain, the genes structures and the functions they exert. Among transcription factors, several seem to be potential powerful biotechnological tools to improve… More >