Yuhan Wang, Yimei Meng, Wanqiu Xia, Yusen Liang, Yaru Wang, Peiling Li^*, Lei Fang^*

Oncology Research, Vol.33, No.8, pp. 2141-2159, 2025, DOI:10.32604/or.2025.064367 - 18 July 2025

Abstract Background: Ovarian cancer (OC) is a representative malignancy of the female reproductive system, with a poor prognosis. Long non-coding RNAs (lncRNAs) crucially affect tumor development. This study aimed to identify lncRNAs that potentially participated in OC. Methods: LncRNA expression in cells and tissues was quantified using reverse transcription-quantitative PCR, while fluorescence in situ hybridization determined their cellular localization. Various in vitro assays, together with a mouse xenograft model, were employed to elucidate the function of CYMP antisense RNA 1 (CYMP-AS1) in OC. The molecular mechanisms underlying CYMP-AS1 regulation were investigated through RNA pull-down and immunoprecipitation assays, immunofluorescence… More > Graphic Abstract

LIBO LIANG¹, XINYI WANG^2,3,4, YUPING ZENG^2,3,4, HAO CHEN^2,3,4, WEN ZHOU¹, HONGYING MU^2,3,4, GA LIAO^5,6,*

Oncology Research, Vol.33, No.6, pp. 1405-1421, 2025, DOI:10.32604/or.2024.056708 - 29 May 2025

Abstract Objectives: Exosomal long noncoding RNAs (lncRNAs) might facilitate epithelial–mesenchymal transition (EMT) in liver cancer after transarterial chemoembolization (TACE), thereby enhancing tumor cell invasiveness and migration. This study investigated the prognostic role of plasma exosomal long noncoding RNA-plasmacytoma variant translocation 1 (lncRNA-PVT1) in TACE treated hepatocellular carcinoma (HCC). Methods: Plasma exosomal lncRNA-PVT1 was evaluated via qPCR before and after TACE. Hepatoma cell behavior was investigated in different HCC cell lines. A lncRNA-PVT1 plasmid was synthesized and overexpressed, and si-lncRNA PVT1 was transfected into poorly invasive cells to reveal its influence on cell characteristics. The lncRNA-PVT1–FoxM1 interaction… More > Graphic Abstract

BIAO WU^1,#, XIANLIN GUO^2,#, ZHISHI WU¹, LIANG CHEN^1,*, SUQING ZHANG^3,*

Oncology Research, Vol.33, No.4, pp. 975-988, 2025, DOI:10.32604/or.2025.058085 - 19 March 2025

Abstract Objectives: Although Yes-associated protein 1 (YAP1) is an important oncogene in hepatocellular carcinoma (HCC) progression, its nuclear localization prevents it from being considered a potential therapeutic target. Recently, studies have reported that coatomer protein complex subunit beta 2 (COPB2) also plays a critical role in HCC development; however its mechanism of action is unclear. This study aimed to investigate the role of COPB2 and YAP1 in the progression of HCC and to elucidate the underlying mechanisms. Methods: COPB2 and YAP1 expression in HCC tissues were first analyzed by database searches and immunohistochemistry. Nomogram and artificial… More >

Ivan Couée^*

Phyton-International Journal of Experimental Botany, Vol.93, No.11, pp. 2707-2714, 2024, DOI:10.32604/phyton.2024.058101 - 30 November 2024

Abstract The 15-carbon terpenoid abscisic acid (ABA) acts in vascular plants as a versatile hormone playing essential roles in reproductive development, vegetative development and growth, stress-development interactions, and physiological responses to abiotic and biotic stresses. Over the past 60 years, ABA dynamics, regulation, and responses have been progressively characterized: synthesis, transport and translocation, conjugation and deconjugation, metabolism, sensing, signal transduction, and downstream responses. In this context, the discovery of ABA exporters and importers has added novel dimensions to the understanding of ABA regulation. Moreover, since the initial discovery of the adenosine triphosphate-binding cassette (ABC) AtABCG25 exporter… More >

Oncology Research Editorial Office

Oncology Research, Vol.32, No.9, pp. 1527-1527, 2024, DOI:10.32604/or.2024.056120 - 23 August 2024

Abstract This article has no abstract. More >

Yanwen Lu^1,#, Wenliang Ma^1,#, Xiang Dong^1,#, Mackenzie Brown², Tong Lu^3,*, Weidong Gan^1,*

CMES-Computer Modeling in Engineering & Sciences, Vol.136, No.1, pp. 347-362, 2023, DOI:10.32604/cmes.2023.024909 - 05 January 2023

Abstract This study aims to apply ResNet-18 convolutional neural network (CNN) and XGBoost to preoperative computed tomography (CT) images and clinical data for distinguishing Xp11.2 translocation renal cell carcinoma (Xp11.2 tRCC) from common subtypes of renal cell carcinoma (RCC) in order to provide patients with individualized treatment plans. Data from 45 patients with Xp11.2 tRCC from January 2007 to December 2021 are collected. Clear cell RCC (ccRCC), papillary RCC (pRCC), or chromophobe RCC (chRCC) can be detected from each patient. CT images are acquired in the following three phases: unenhanced, corticomedullary, and nephrographic. A unified framework More >

WEICHEN ZHAO¹, PINGFAN ZHOU¹, BENZHEN LOU¹, YAQI JIANG¹, YUANBO LI¹, MINGSHU LI¹, NOMAN SHAKOOR¹, YUKUI RUI^1,2,3,4,*

BIOCELL, Vol.47, No.3, pp. 493-502, 2023, DOI:10.32604/biocell.2023.025740 - 03 January 2023

Abstract As the climate worsens and the demand for food grows, so does the interest in nanoagriculture. The interaction between plants and nanomaterials (NMs) has been extensively and intensively examined. However, stopping at the outcome of a phenomenon is often insufficient. Therefore, we introduce three important processes of nanoparticle-plant interactions: translocation, transformation, and plant metabolism. During the migration of nanoparticles, size and surface electrical properties are the main determining factors. Additionally, the interaction of nanoparticles with cell membranes is another key aspect of research. The transformation of nanoparticles in plants is mainly due to redox substances. More >

Nandhi Kesavan^*, Latha

Intelligent Automation & Soft Computing, Vol.36, No.1, pp. 327-337, 2023, DOI:10.32604/iasc.2023.030910 - 29 September 2022

Abstract Climate change is the most serious causes and has a direct impact on biodiversity. According to the world’s biodiversity conservation organization, reptile species are most affected since their biological and ecological qualities are directly linked to climate. Due to a lack of time frame in existing works, conservation adoption affects the performance of existing works. The proposed research presents a knowledge-driven Decision Support System (DSS) including the assisted translocation to adapt to future climate change to conserving from its extinction. The Dynamic approach is used to develop a knowledge-driven DSS using machine learning by applying More >

Chin-Feng Lee, Kuo-Chung Chan^*

Computer Systems Science and Engineering, Vol.44, No.2, pp. 1551-1566, 2023, DOI:10.32604/csse.2023.026294 - 15 June 2022

Abstract Dual-image reversible data hiding (RDH) is a technique for hiding important messages. This technology can be used to safely deliver secret messages to the recipient through dual images in an open network without being easily noticed. The recipient of the image must receive the two stego-images before the secret message can be completely retrieved. Imperceptibility is one of the main advantages of data hiding technology; to increase the imperceptibility, the quality requirements of the stego-images are relatively important. A dual steganographic image RDH method, called a DS-CF scheme that can achieve a better steganographic image… More >

AMYLLY SANUELLY DA PAZ MARTINS¹, SAMARA BOMFIM GOMES CAMPOS², MARÍLIA OLIVEIRA FONSECA GOULART^1,2,3, FABIANA ANDRÉA MOURA^4,*

BIOCELL, Vol.45, No.3, pp. 461-481, 2021, DOI:10.32604/biocell.2021.014332 - 03 March 2021

Abstract Inflammatory bowel disease (IBD), which includes Crohn’s disease and ulcerative colitis, has a not yet completely defined aetiology and is characterized by a progressive chronic inflammation that involves nitroxidative stress and dysbiosis. Extraintestinal manifestations can occur and affect several organs, including the liver and bile ducts, joints, skin, eyes, and less frequently, the heart, brain, and kidneys, increasing the risk of morbidity and mortality. These repercussions may be associated with the activity or severity of IBD. The present review proposes to report and analyse the participation of dysbiosis and nitroxidative stress in the genesis of More >