Muhammad Imran^1,*, Brett McKinney¹, Azhar Iqbal Kashif Butt²

CMES-Computer Modeling in Engineering & Sciences, Vol.142, No.2, pp. 1899-1931, 2025, DOI:10.32604/cmes.2024.059552 - 27 January 2025

Abstract The co-infection of corona and influenza viruses has emerged as a significant threat to global public health due to their shared modes of transmission and overlapping clinical symptoms. This article presents a novel mathematical model that addresses the dynamics of this co-infection by extending the SEIR (Susceptible-Exposed-Infectious-Recovered) framework to incorporate treatment and hospitalization compartments. The population is divided into eight compartments, with infectious individuals further categorized into influenza infectious, corona infectious, and co-infection cases. The proposed mathematical model is constrained to adhere to fundamental epidemiological properties, such as non-negativity and boundedness within a feasible region.… More >

SOROUSH SOLEYMANI¹, MOHAMMAD DOROUDIAN^2,*, MAHDIEH SOEZI^3,4, ALI BELADI⁵, KIARASH ASGARI², ASO MOBARAKSHAHI², ARYANA AGHAEIPOUR², RONAN MACLOUGHLIN^6,7,8,*

Oncology Research, Vol.33, No.1, pp. 15-26, 2025, DOI:10.32604/or.2024.053069 - 20 December 2024

Abstract Brain metastasis and primary glioblastoma multiforme represent the most common and lethal malignant brain tumors. Its median survival time is typically less than a year after diagnosis. One of the major challenges in treating these cancers is the efficiency of the transport of drugs to the central nervous system. The blood-brain barrier is cooperating with advanced stages of malignancy. The blood-brain barrier poses a significant challenge to delivering systemic medications to brain tumors. Nanodrug delivery systems have emerged as promising tools for effectively crossing this barrier. Additionally, the development of smart nanoparticles brings new hope More >

WEI ZHANG^1,3,#, WEICHENG WANG^1,#, RUI WANG¹, XIAO HAN¹, LIJUN ZHU¹, WENJIE GUO^2,*, YANHONG GU^1,*

Oncology Research, Vol.33, No.1, pp. 225-234, 2025, DOI:10.32604/or.2024.050047 - 20 December 2024

Abstract Background: As a novel blocker of vascular endothelial growth factor receptor (VEGFR), fruquintinib has been approved for treating colorectal cancer (CRC). However, its dosage and therapeutic efficacy are limited by its widespread adverse reactions. Venetoclax, recognized as the initial inhibitor of B-cell lymphoma protein 2 (BCL2), has shown potential in boosting the effectiveness of immunotherapy against CRC. This study investigated the efficacy and mechanisms of fruquintinib combined with venetoclax in treating CRC. Methods and Materials: We developed a colon cancer mouse model with the CT26 colon cell line to demonstrate fruquintinib and venetoclax’s efficacy against tumors.… More > Graphic Abstract

Xiaofeng Wang^#, Chenyu Li^#, Xia Li, Zhongyuan Lu, Xu Wang^*

Congenital Heart Disease, Vol.19, No.6, pp. 617-626, 2024, DOI:10.32604/chd.2025.058712 - 27 January 2025

Abstract Objectives: Fluid overload is common after congenital cardiac surgeries. This requires early application of peritoneal dialysis (PD) in infants to improve surgical outcomes. The objective of this study is to ascertain the factors correlated with the necessity for PD in infants, thereby informing the prophylactic placement of PD catheters intraoperatively. Methods: This was a single-center retrospective study. Infants aged three months or younger who underwent congenital cardiac procedures at the Fuwai Hospital between 2021 and 2022 were included. Patients with chronic renal failure or without RACHS-1 categories were excluded. Based on whether postoperative PD treatment… More >

ELMIRA YAKUPOVA¹, VALENTINA BABENKO^1,2, ALEXEY BOCHARNIKOV¹, KSENIYA FEDULOVA¹, DENIS SILACHEV^1,2, EGOR PLOTNIKOV^1,2,*

BIOCELL, Vol.48, No.12, pp. 1827-1834, 2024, DOI:10.32604/biocell.2024.058496 - 30 December 2024

Abstract Background: The active use of stem and progenitor cells in the therapy of various diseases requires the development of approaches for targeted modification of their properties. One such approach is the induction of a pro- or anti-inflammatory phenotype. Methods: In this study, we investigated the effect of a pro-inflammatory environment in vitro on multipotent mesenchymal stromal cells (MSC) by incubation with lipopolysaccharide (LPS). iCELLigence real-time cell analysis system was used for monitoring cell culture growth. Cell energy metabolism was assessed using the Seahorse XFp Analyzer. For the rat stroke experiment, we used a photoinduced thrombosis (PT)… More >

AMOURA M. ABOU-EL-NAGA¹, SHAKER A. MOUSA², FAYEZ ALTHOBAITI³, EMAN FAYAD^3,*, ENGY S. FAHIM¹

BIOCELL, Vol.48, No.12, pp. 1835-1837, 2024, DOI:10.32604/biocell.2024.054569 - 30 December 2024

Abstract This article has no abstract. More >

Zhiheng Hu^1,*, Hang Li Seet¹, Sharon Mui Ling Nai¹

The International Conference on Computational & Experimental Engineering and Sciences, Vol.31, No.4, pp. 1-1, 2024, DOI:10.32604/icces.2024.012118

Abstract Heat treatment is a common way for enhancing the mechanical properties of the aluminum alloys. For the alloys developed for laser powder bed fusion, changes in chemical composition, together with the non-equilibrium microstructures resulting from the ultrafast cooling rate during the process, potentially alter the effectiveness of heat treatment. This study investigates the effect of the heat treatments on a Al6xxx alloy fabricated by LPBF. The response to the same heat treatment varies depending on the initial microstructure, and similarly, different heat treatments yield distinct outcomes when applied to the same original microstructures. While there… More >

Guanpeng Huang^1,#, Ti Wu^1,2,#, Yinjie Zheng³, Qiyun Gu², Qiaobin Chen², Shoukai Lin^2,*, Jincheng Wu^2,*

Phyton-International Journal of Experimental Botany, Vol.93, No.11, pp. 2715-2735, 2024, DOI:10.32604/phyton.2024.056484 - 30 November 2024

Abstract Loquat (Eriobotrya japonica Lindl.), a rare fruit native to China, has a long history of cultivation in China. Low temperature is the key factor restricting loquat growth and severely affects yield. Low temperature induces the regeneration and metabolism of reduced glutathione (GSH) to alleviate stress damage via the participation of glutathione S-transferases (GSTs) in plants. In this study, 16 GSTs were identified from the loquat genome according to their protein sequence similarity with Arabidopsis GSTs. On the basis of domain characteristics and phylogenetic analysis of AtGSTs, these EjGSTs can be divided into 4 subclasses: Phi, Theta, Tau… More >

Wenshu Zhuang^1,#, Guangyang Jin^1,#, Yiting Zou¹, Zhong Bian¹, Dong Xie¹, Shuwei Zhang¹, Hadi Yeilaghi¹, Liangliang Yu³, Muiyun Wong⁴, Xiaolei Fan^1,2, Dongsheng Zhao^1,2, Qiaoquan Liu^1,2, Lin Zhang^1,2,*

Phyton-International Journal of Experimental Botany, Vol.93, No.11, pp. 2737-2754, 2024, DOI:10.32604/phyton.2024.054649 - 30 November 2024

Abstract Panicle size is one of the important factors in shaping yield potential in rice, but it shows plasticity in different environments, which leads to yield fluctuation. Variations in panicle size among varieties are largely determined by quantitative trait loci (QTLs). QTL analysis could elaborate on the environmental impact on trait plasticity using nearly isogenic lines (NILs) of different QTLs. Two QTLs, ipa1-2D and qPL6 are identified to have pleiotropic contributions to panicle size and plant architecture, but their responses to different growth conditions are still unclear. In this study, we developed NILs harboring a single locus… More >

Lei Wang^1,*, Blanca Rodriguez², Xiaoyu Luo³, Charles Augarde⁴

The International Conference on Computational & Experimental Engineering and Sciences, Vol.30, No.4, pp. 1-2, 2024, DOI:10.32604/icces.2024.013350

Abstract Cardiovascular disease is the leading cause of death worldwide. Disease-specific software, like FFRct from HeartFlow, and high-fidelity computational models within a general-purpose software, like Living Heart Project within Abaqus, are essential to revolutionise diagnosis and treatment of cardiovascular disease for clinicians and design of medical devices for industries. This talk presents our past researches on computational modelling of tear propagation in the aortic dissection [1-2] and of electromechanical coupling in the human heart with the finite element method [3], and our current exploration on high-fidelity and efficient computation and software development for diagnosis and treatment More >