Guozhen Wang^1,2, Yong An^1,2,*

Congenital Heart Disease, Vol.20, No.3, pp. 347-355, 2025, DOI:10.32604/chd.2025.065354 - 11 July 2025

Abstract Background: Anomalous origin of the left coronary artery from the pulmonary artery (ALCAPA) is a rare congenital anomalous coronary artery origin disorder. Objective: We sought to summarize the clinical experience and prognostic characteristics of surgical treatment of ALCAPA. Methods: We retrospectively analyzed clinical information on patients who had ALCAPA and underwent surgery at our center from February 2016 to October 2023. Results: This comparative study of 23 ALCAPA patients (9 infants <1 year; 14 children >1 year) demonstrated significant age-dependent outcomes. Infant patients exhibited markedly prolonged mechanical ventilation (183 ± 105.6 vs. 48.5 ± 62.2 min, p =… More >

Wilhelm Mistiaen^*

Congenital Heart Disease, Vol.20, No.3, pp. 305-323, 2025, DOI:10.32604/chd.2025.064675 - 11 July 2025

Abstract The presence of a bicuspid aortic valve (BAV) is the most common congenital heart anomaly, which can remain asymptomatic for decades, if it is not a part of a syndrome, such as Turner syndrome or genetic connective tissue disorders. There are several classifications for BAV, each with its advantages and drawbacks. The condition can lead to valvular malfunction such as regurgitation and stenosis, but is often associated with dilatation of the aortic root, the ascending aorta, the aortic arch, or a combination. Altered flow patterns due to the valve dysfunction as well as the breakdown… More >

Xiao Jian Tan^1,2,3,*, Wai Loon Cheor², Ee Meng Cheng^4,5, Chee Chin Lim^3,4, Khairul Shakir Ab Rahman⁶

CMC-Computers, Materials & Continua, Vol.84, No.2, pp. 2015-2060, 2025, DOI:10.32604/cmc.2025.063407 - 03 July 2025

Abstract This study systematically reviews the applications of generative artificial intelligence (GAI) in breast cancer research, focusing on its role in diagnosis and therapeutic development. While GAI has gained significant attention across various domains, its utility in breast cancer research has yet to be comprehensively reviewed. This study aims to fill that gap by synthesizing existing research into a unified document. A comprehensive search was conducted following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, resulting in the retrieval of 3827 articles, of which 31 were deemed eligible for analysis. The included studies were… More >

Xu Tang^1,2, Fang Li^1,3,*, Biyun Wu⁴

Journal of Psychology in Africa, Vol.35, No.2, pp. 215-221, 2025, DOI:10.32604/jpa.2025.067163 - 30 June 2025

Abstract This study explored the connection between childhood psychological maltreatment and online trolling, as well as the influence of moral disengagement and mindfulness in that relationship. A total of 984 college students (54% females, Mean age = 20.9 years, SD = 1.57 years) took part in the current research. The students responded to standardized measures of childhood psychological maltreatment, online trolling, moral disengagement, mindfulness. Results following the regression and the mediation analyses showed that childhood psychological maltreatment was associated with higher online trolling among college students. Moral disengagement played a mediating role in the link between More >

KHANH TOAN NGUYEN^*, THI HUONG PHAM, VAN LAM NGO, VAN TUAN BUI, VAN NHAT NGUYEN, THI PHUONG THAO NGUYEN, THI KHANH HA NGUYEN, THI THUY VAN NGUYEN

Oncology Research, Vol.33, No.7, pp. 1667-1677, 2025, DOI:10.32604/or.2025.061905 - 26 June 2025

Abstract Aims: The study aimed to evaluate the effectiveness and adverse events of tyrosine kinase inhibitors (TKIs) in the first-line treatment of advanced non-small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) mutations. Methods: A retrospective study on advanced NSCLC patients with EGFR mutations treated with TKIs as a first-line therapy at Nghe An Oncology Hospital, Vietnam between January 2017 and August 2023. The primary endpoints included objective response rate, progression-free survival, and tolerability. The secondary endpoint was overall survival. Results: A total of 211 patients received first-line treatment with Erlotinib (n = 74), Gefitinib (n… More >

LINGJIE XU¹, YIQIN XIA¹, QIN QIN¹, GUIQUN WANG¹, KAI TAO², WEI WEI^1,*

Oncology Research, Vol.33, No.7, pp. 1649-1666, 2025, DOI:10.32604/or.2025.056176 - 26 June 2025

Abstract Background: The centrosome, a crucial cellular structure involved in the mitotic process of eukaryotic cells, plays a significant role in tumor progression by regulating the growth and differentiation of neoplastic cells. This makes the centrosome a promising target for therapeutic strategies in cancer treatment. Methods: Utilizing data from the TCGA database, we identified centrosome-related genes and constructed a prognostic model for 518 lung adenocarcinoma patients. Prognosis-associated genes were initially screened using univariate Cox regression, with overfitting minimized by applying LASSO regression to remove collinearity. Finally, a set of 12 genes was selected through multivariable Cox… More >

Joshua Winograd¹, Rebecca Kindler², Cassidy Lleras², Alia Codelia-Anjum³, Naeem Bhojani⁴, Dean Elterman⁵, Michael A. Diefenbach³, Daniel Ufearo², Katharine Kechejian², Siri Drangsholt², Bilal Chughtai^3,*

Canadian Journal of Urology, Vol.32, No.3, pp. 219-227, 2025, DOI:10.32604/cju.2025.064404 - 27 June 2025

Abstract Introduction: Benign prostatic hypertrophy (BPH) is a common condition affecting men later in life, significantly impacting quality of life (QOL). Surgical intervention is often pursued when medical management fails, but patient satisfaction with outcomes varies. Decisional regret can affect perceived success and patient satisfaction post-surgery. This study evaluates the relationship between post-surgical symptoms and decisional regret across BPH procedures. Methods: A prospective, multicenter cohort study included 54 patients undergoing BPH surgery between March 2023 and February 2024. Patients completed the International Prostate Symptom Score-QOL (IPSS-QOL) scale preoperatively and at least three months postoperatively, along with… More >

Murat Yavuz Koparal¹, Burak Elmas^2,*, Serhat Gurocak¹, Cihat Aytekin¹, Mustafa Ozgur Tan¹

Canadian Journal of Urology, Vol.32, No.3, pp. 199-207, 2025, DOI:10.32604/cju.2025.063616 - 27 June 2025

Abstract Aim: The aim of this study was to investigate the factors affecting treatment success in children that got either pyeloplasty or J stent placement in ureteropelvic junction obstruction (UPJO). Patients and Methods: The study comprised 126 patients who either J stent placement or pyeloplasty performed by the same physician for UPJO from 2012 to 2022. The criteria for surgical intervention adhered to the European Association of Urology (EAU) recommendations. Symptomatic patients with verified obstruction, with a split renal function (SRF) over 40%, low-grade hydronephrosis (Society of Fetal Urology grade 2), and an obstructive segment measuring less… More >

Gloria Krajnc¹, Lara Metlika², Uroš Potočnik^1,2,3, Boris Gole^2,*

BIOCELL, Vol.49, No.6, pp. 991-1017, 2025, DOI:10.32604/biocell.2025.063486 - 24 June 2025

Abstract Vedolizumab is a humanized monoclonal antibody and one of the safest biologics for the treatment of both forms of inflammatory bowel disease (IBD)-Crohn’s disease and ulcerative colitis. It targets the α4β7 integrin and blocks leukocyte trafficking to the gut. Regardless of its efficacy in many patients, non-response to vedolizumab treatment poses a significant clinical challenge. In this review, we synthesize recent findings on genomic, transcriptomic, proteomic, and cellular biomarkers of vedolizumab response, emphasizing their roles in predicting therapeutic outcomes and understanding non-responsiveness. Key insights include the identification of epigenetic and transcriptomic signatures, the involvement of More >

Tongtong Wang^1,#, Zhenhui Pan^2,#, Di Zhang², Hui Shi^1,2,*, Murat Yılmaz³, Amit Kumar⁴, Gaurav Sharma⁴, Tao Liu^2,*

Journal of Renewable Materials, Vol.13, No.6, pp. 1103-1137, 2025, DOI:10.32604/jrm.2025.02024-0043 - 23 June 2025

Abstract With the rapid development of industry, the environmental problems caused by heavy metal arsenic and antimony are becoming increasingly serious. Therefore, it is urgent to solve the problem of arsenic and antimony pollution in the water environment. Renewable carbon-based materials, as a kind of adsorbent widely used in wastewater treatment, have been the focus of scholars’ research for many years. In this review, the preparation methods, characteristics, and applications of renewable carbon-based materials (biochar, activated carbon, carbon nanotubes, and graphene) for the removal of arsenic and antimony are described in detail. Based on adsorption kinetics,… More > Graphic Abstract