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  • Open Access

    ARTICLE

    Ultrasound genomics related mitochondrial gene signature for prognosis and neoadjuvant chemotherapy resistance in triple negative breast cancer

    HUAFANG HUANG1,2,#, GUILIN WANG3,#, DONGYUN ZENG4,5, LUZ ANGELA TORRES-DE LA ROCHE2, RUI ZHUO1,2, RUDY LEON DE WILDE2, WANWAN WANG6, ULF D. KAHLERT7,*, WENJIE SHI7,*

    Oncology Research, Vol.33, No.3, pp. 631-640, 2025, DOI:10.32604/or.2024.054642 - 28 February 2025

    Abstract Background: Neoadjuvant chemotherapy (NAC) significantly enhances clinical outcomes in patients with triple-negative breast cancer (TNBC); however, chemoresistance frequently results in treatment failure. Consequently, understanding the mechanisms underlying resistance and accurately predicting this phenomenon are crucial for improving treatment efficacy. Methods: Ultrasound images from 62 patients, taken before and after neoadjuvant therapy, were collected. Mitochondrial-related genes were extracted from a public database. Ultrasound features associated with NAC resistance were identified and correlated with significant mitochondrial-related genes. Subsequently, a prognostic model was developed and evaluated using the GSE58812 dataset. We also assessed this model alongside clinical factors… More >

  • Open Access

    ARTICLE

    Partial gland ablation with high intensity focal ultrasound impact on genito-urinary function and quality of life: our initial experience

    Ioana Fugaru1, David Bouhadana1, Gautier Marcq2,3, Joseph Moryousef4, Alexis Rompré-Brodeur1, Andrew Meng4, Oleg Loutochin1, George Loutochin1, Maurice Anidjar1, Frank Bladou5, Rafael Sanchez-Salas1

    Canadian Journal of Urology, Vol.31, No.1, pp. 11784-11793, 2024

    Abstract Introduction: Partial gland ablation (PGA) using high intensity focal ultrasound (HIFU) is an alternative to active surveillance for low to intermediate risk localized prostate cancer. This pilot study assessed quality of life (QoL) outcomes during the implementation of PGA HIFU at our institution.
    Materials and methods: We prospectively enrolled 25 men with a diagnosis of localized low/intermediate risk prostate cancer who elected to undergo PGA-HIFU in a pilot study at our institution between 2013 and 2016. Patients underwent pre-treatment mpMRI and transrectal ultrasound-guided biopsies. The primary endpoints were impact on patient-reported functional outcomes (erectile, urinary function, QoL)… More >

  • Open Access

    RESIDENT’S CORNER

    Hand, foot, and mouth disease presenting with a testicular mass in an adult

    Sarah Azari, Darcy Wolfman2, Armine Smith3

    Canadian Journal of Urology, Vol.31, No.2, pp. 11854-11857, 2024

    Abstract The majority of solid testicular tumors are treated with orchiectomy given the high risk of malignancy. We present a case of a testicular mass in an adult patient in the setting of recent hand, foot, and mouth disease that was managed conservatively with serial ultrasounds. Even though cases of viral-associated testicular masses are rare, this differential diagnosis should be considered in patients with a new testicular mass in the setting of recent viral infection and negative tumor markers. For these patients, observation may be an option instead of immediate orchiectomy. More >

  • Open Access

    ARTICLE

    A costing and health-related quality of life study of high intensity focused ultrasound in primary treatment of localized low or intermediate risk prostate cancer in Ontario

    Bassem Toeama1, Nathan Perlis2, Paul Grootendorst1, William Orovan3, Emmanuel Papadimitropoulos1,4

    Canadian Journal of Urology, Vol.31, No.4, pp. 11963-11970, 2024

    Abstract Introduction: Prostate cancer is the third leading cause of death from cancer among Canadian men. High intensity focused ultrasound (HIFU) is a novel approach for primary treatment of localized prostate cancer. Little is known, however, about its costs. We aimed to collect the direct costs and health-related quality of life (HRQoL) data of HIFU in primary treatment of localized low and intermediate risk prostate cancer in Ontario.
    Materials and methods: We collected direct costs and HRQoL data of 20 patients with localized low or intermediate risk prostate cancer who received whole gland HIFU at a privately owned… More >

  • Open Access

    ARTICLE

    Bioactive Compounds Recovery from Larrea tridentata by Green Ultrasound-Assisted Extraction

    Muyideen Olaitan Bamidele1, José Sandoval-Cortés1, María Liliana Flores-López2, Olga Berenice Álvarez Pérez1, Monica Lizeth Chavez González1, Cristóbal Noe Aguilar1,*

    Phyton-International Journal of Experimental Botany, Vol.93, No.11, pp. 3091-3107, 2024, DOI:10.32604/phyton.2024.058422 - 30 November 2024

    Abstract Postharvest losses remain a significant challenge, particularly in developing countries that have inadequate infrastructure. Medicinal plants offer an eco-friendly and sustainable solution for managing diseases and pests in agricultural systems. These plants are rich in bioactive compounds, such as alkaloids, flavonoids, terpenoids, phenolics, and essential oils, many of which have proven antimicrobial, antifungal, insecticidal, and antioxidant properties. These characteristics make medicinal plants viable candidates for postharvest disease and pest control. Among these, Larrea tridentata (creosote bush) is particularly notable for its bioactive compounds with strong antifungal properties. Their potential applications include agriculture, food preservation, and medicine.… More > Graphic Abstract

    Bioactive Compounds Recovery from <i>Larrea tridentata</i> by Green Ultrasound-Assisted Extraction

  • Open Access

    PROCEEDINGS

    Ultrasound Overcomes Dendrite Puncture in Aqueous Zinc Batteries

    Fenghui Wang1,*, Hongye Zhang1

    The International Conference on Computational & Experimental Engineering and Sciences, Vol.31, No.1, pp. 1-1, 2024, DOI:10.32604/icces.2024.012441

    Abstract Aqueous zinc batteries have attracted wide interest due to the high safety of the non-flammable electrolyte. However, the inhomogeneous metal plating during the charging and discharging process generates uncontrollable dendrite growth on the anode surface, which seriously threatens the performance and lifetime of the battery. Herein, we provide a physical method to fragment zinc dendrites by using ultrasound to induce cavitation effects in the electrolyte, which can effectively improve the dielectric structure defects inside the battery and reduce the risk of short circuit. The experimental results show that the roughness and height of zinc deposits More >

  • Open Access

    ARTICLE

    Automatic Fetal Segmentation Designed on Computer-Aided Detection with Ultrasound Images

    Mohana Priya Govindarajan*, Sangeetha Subramaniam Karuppaiya Bharathi

    CMC-Computers, Materials & Continua, Vol.81, No.2, pp. 2967-2986, 2024, DOI:10.32604/cmc.2024.055536 - 18 November 2024

    Abstract In the present research, we describe a computer-aided detection (CAD) method aimed at automatic fetal head circumference (HC) measurement in 2D ultrasonography pictures during all trimesters of pregnancy. The HC might be utilized toward determining gestational age and tracking fetal development. This automated approach is particularly valuable in low-resource settings where access to trained sonographers is limited. The CAD system is divided into two steps: to begin, Haar-like characteristics were extracted from ultrasound pictures in order to train a classifier using random forests to find the fetal skull. We identified the HC using dynamic programming,… More >

  • Open Access

    ARTICLE

    A Numerical Investigation of the Effect of Boundary Conditions on Acoustic Pressure Distribution in a Sonochemical Reactor Chamber

    Ivan Sboev1,*, Tatyana Lyubimova2,3, Konstantin Rybkin3, Michael Kuchinskiy2,3

    FDMP-Fluid Dynamics & Materials Processing, Vol.20, No.6, pp. 1425-1439, 2024, DOI:10.32604/fdmp.2024.051341 - 27 June 2024

    Abstract The intensification of physicochemical processes in the sonochemical reactor chamber is widely used in problems of synthesis, extraction and separation. One of the most important mechanisms at play in such processes is the acoustic cavitation due to the non-uniform distribution of acoustic pressure in the chamber. Cavitation has a strong impact on the surface degradation mechanisms. In this work, a numerical calculation of the acoustic pressure distribution inside the reactor chamber was performed using COMSOL Multiphysics. The numerical results have revealed the dependence of the structure of the acoustic pressure field on the boundary conditions More > Graphic Abstract

    A Numerical Investigation of the Effect of Boundary Conditions on Acoustic Pressure Distribution in a Sonochemical Reactor Chamber

  • Open Access

    ARTICLE

    Investigation of Cavitation in NaCl Solutions in a Sonochemical Reactor Using the Foil Test Method

    Michael Kuchinskiy1,2,*, Tatyana Lyubimova1,2, Konstantin Rybkin2, Anastasiia Sadovnikova2, Vasiliy Galishevskiy2

    FDMP-Fluid Dynamics & Materials Processing, Vol.20, No.5, pp. 1093-1102, 2024, DOI:10.32604/fdmp.2024.050059 - 07 June 2024

    Abstract Ultrasonic baths and sonochemical reactors are widely used in industrial applications dealing with surface cleaning and chemical synthesis. The processes of erosion, cleaning and structuring of the surface can be typically controlled by changing relevant influential parameters. In particular, in this work, we experimentally investigate the effect of NaCl concentration (0–5.5 mol/L) on the erosion of an aluminum foil under ultrasonic exposure at a frequency of 28 kHz. Special attention is paid to the determination of cavitation zones and their visualization using heat maps. It is found that at low NaCl concentration (0.3 mol/L), the More > Graphic Abstract

    Investigation of Cavitation in NaCl Solutions in a Sonochemical Reactor Using the Foil Test Method

  • Open Access

    ARTICLE

    A Novel Approach to Breast Tumor Detection: Enhanced Speckle Reduction and Hybrid Classification in Ultrasound Imaging

    K. Umapathi1,*, S. Shobana1, Anand Nayyar2, Judith Justin3, R. Vanithamani3, Miguel Villagómez Galindo4, Mushtaq Ahmad Ansari5, Hitesh Panchal6,*

    CMC-Computers, Materials & Continua, Vol.79, No.2, pp. 1875-1901, 2024, DOI:10.32604/cmc.2024.047961 - 15 May 2024

    Abstract Breast cancer detection heavily relies on medical imaging, particularly ultrasound, for early diagnosis and effective treatment. This research addresses the challenges associated with computer-aided diagnosis (CAD) of breast cancer from ultrasound images. The primary challenge is accurately distinguishing between malignant and benign tumors, complicated by factors such as speckle noise, variable image quality, and the need for precise segmentation and classification. The main objective of the research paper is to develop an advanced methodology for breast ultrasound image classification, focusing on speckle noise reduction, precise segmentation, feature extraction, and machine learning-based classification. A unique approach… More >

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