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  • Open Access


    Transcriptome analysis reveals tumor antigen and immune subtypes of melanoma


    Oncology Research, Vol.31, No.3, pp. 389-403, 2023, DOI:10.32604/or.2023.029274

    Abstract Purpose: To screen potential tumor antigens for melanoma vaccine development and identify different immune subtypes. Methods: Transcriptional data (HTSEQ-FPKM) and clinical information of a 472 Melanoma cohort GDC TCGA Melanoma (SKCM) were downloaded from the UCSC XENA website (). Subsequently, transcriptome data and clinical information of 210 melanoma cohort GSE65904 were downloaded from Gene Expression Omnibus (GEO), a large global public database. All the transcriptome expression data matrices were log2 transformed for subsequent analysis. GEPIA, TIMER, and IMMPORT databases are also used for analysis. Cell function experiments were performed to validate the role of the IDO1 gene in melanoma cell… More >

  • Open Access


    Fake News Encoder Classifier (FNEC) for Online Published News Related to COVID-19 Vaccines

    Asma Qaiser1, Saman Hina1, Abdul Karim Kazi1,*, Saad Ahmed2, Raheela Asif3

    Intelligent Automation & Soft Computing, Vol.37, No.1, pp. 73-90, 2023, DOI:10.32604/iasc.2023.036784

    Abstract In the past few years, social media and online news platforms have played an essential role in distributing news content rapidly. Consequently. verification of the authenticity of news has become a major challenge. During the COVID-19 outbreak, misinformation and fake news were major sources of confusion and insecurity among the general public. In the first quarter of the year 2020, around 800 people died due to fake news relevant to COVID-19. The major goal of this research was to discover the best learning model for achieving high accuracy and performance. A novel case study of the Fake News Classification using… More >

  • Open Access


    COVID-19 vaccine related hypermetabolic lymph nodes on PET/CT: Implications of inflammatory findings in cancer imaging


    Oncology Research, Vol.31, No.2, pp. 117-124, 2023, DOI:10.32604/or.2023.027705

    Abstract We observed several patients presenting 2-[18F]FDG uptake in the reactive axillary lymph node at PET/CT imaging, ipsilateral to the site of the COVID-19 vaccine injection. Analog finding was documented at [18F]Choline PET/CT. The aim of our study was to describe this source of false positive cases. All patients examined by PET/CT were included in the study. Data concerning patient anamnesis, laterality, and time interval from recent COVID-19 vaccination were recorded. SUVmax was measured in all lymph nodes expressing tracer uptake after vaccination. Among 712 PET/CT scans with 2-[18F]FDG, 104 were submitted to vaccination; 89/104 patients (85%) presented axillary and/or deltoid… More >

  • Open Access


    GA-Stacking: A New Stacking-Based Ensemble Learning Method to Forecast the COVID-19 Outbreak

    Walaa N. Ismail1,2,*, Hessah A. Alsalamah3,4, Ebtesam Mohamed2

    CMC-Computers, Materials & Continua, Vol.74, No.2, pp. 3945-3976, 2023, DOI:10.32604/cmc.2023.031194

    Abstract As a result of the increased number of COVID-19 cases, Ensemble Machine Learning (EML) would be an effective tool for combatting this pandemic outbreak. An ensemble of classifiers can improve the performance of single machine learning (ML) classifiers, especially stacking-based ensemble learning. Stacking utilizes heterogeneous-base learners trained in parallel and combines their predictions using a meta-model to determine the final prediction results. However, building an ensemble often causes the model performance to decrease due to the increasing number of learners that are not being properly selected. Therefore, the goal of this paper is to develop and evaluate a generic, data-independent… More >

  • Open Access


    Sigmoidal Particle Swarm Optimization for Twitter Sentiment Analysis

    Sandeep Kumar1, Muhammad Badruddin Khan2, Mozaherul Hoque Abul Hasanat2, Abdul Khader Jilani Saudagar2,*, Abdullah AlTameem2, Mohammed AlKhathami2

    CMC-Computers, Materials & Continua, Vol.74, No.1, pp. 897-914, 2023, DOI:10.32604/cmc.2023.031867

    Abstract Social media, like Twitter, is a data repository, and people exchange views on global issues like the COVID-19 pandemic. Social media has been shown to influence the low acceptance of vaccines. This work aims to identify public sentiments concerning the COVID-19 vaccines and better understand the individual’s sensitivities and feelings that lead to achievement. This work proposes a method to analyze the opinion of an individual’s tweet about the COVID-19 vaccines. This paper introduces a sigmoidal particle swarm optimization (SPSO) algorithm. First, the performance of SPSO is measured on a set of 12 benchmark problems, and later it is deployed… More >

  • Open Access


    Polarized Autologous Macrophages (PAM) Can Be a Tumor Vaccine

    Dongqing Wang1,*, Heying Chen1, Yi Hu2,*

    Oncologie, Vol.24, No.3, pp. 441-449, 2022, DOI:10.32604/oncologie.2022.024898

    Abstract Immunotherapy is currently recognized as one of the most promising anticancer strategies. In the tumor microenvironment, tumor-associated macrophages are mainly M2-type macrophages with tumor-promoting effects. Therefore, the reprogramming of tumor-associated macrophages from M2 to M1 type is a potential strategy for cancer therapy. We have previously shown the anticancer effects of implantable allogeneic M1 macrophages in mice. Here, we further engineered autologous mouse bone marrow cells into M1 macrophages and then embedded them into a sodium alginate gel to prepare an implantable immunotherapeutic agent (M1@Gel). We demonstrate that M1@Gel repolarizes M2 macrophages to M1 type and activates the immune responses… More >

  • Open Access


    Prospects and Challenges of Utilizing Solar Energy for the COVID-19 Vaccine Cold Storage in Remote Clinics of Tropical Countries: Review

    Indra Mamad Gandidi1,*, Apri Wiyono1, Nugroho Agung Pambudi2,*, Rahmat Romadhon3, Alfan Sarifudin2

    Energy Engineering, Vol.119, No.4, pp. 1403-1418, 2022, DOI:10.32604/ee.2022.019200

    Abstract The rapid spread of COVID-19 pandemic has forced several countries in the world to store vaccines in cold storage towards ensuring their protection from being damaged and to maintain their stability. However, most remote clinics, especially those in the equator and islands, are faced with the challenges of hot climates and the inability to afford electricity resources needed to power the cold storage facility. Meanwhile, the hot equatorial region has abundant solar energy to power the vaccine cold storage but previous studies showed that several field workers do not have the ability to maintain the vaccine storage temperature as indicated… More >

  • Open Access


    Should we continue breastfeeding after SARS-CoV-2 infection or mRNA vaccination?


    BIOCELL, Vol.46, No.6, pp. 1425-1433, 2022, DOI:10.32604/biocell.2022.019868

    Abstract The coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has posed a potential threat to infant health. The World Health Organization recommended that the benefits of breastfeeding far outweigh the potential risk of transmission, but there is no denying that the current evidence is insufficient. Moreover, although the COVID-19 mRNA vaccine has played an effective role in protection against infection, individuals have increasing concerns about the safety of breastfeeding after vaccination, and which have caused some breastfeeding women to postpone vaccination or stop breastfeeding early. Thus, in this review, we provide an in-depth… More >

  • Open Access


    Acceptability of Elderly Cancer Patients and Tolerance to COVID-19 Vaccination in the Brittany Region
    L’acceptabilité du Patient Âgé Porteur de Cancer et la Tolérance à la Vaccination Anti-COVID-19 dans la Région Bretagne

    Delphine Déniel1,2,*, Fabienne Le Goc-Le Sager1, Paul Touchard3, Véronique Marty4, Laurence Hasle5, Véronique Jestin Le Tallec6, Monique Jegaden7, Annaïk Pestel8, Virginie Jannou5, Sophie Pentecôte9, Laurence Guen1,2, Christophe Perrin1,10, Sandrine Estivin1,3

    Oncologie, Vol.23, No.4, pp. 453-461, 2021, DOI:10.32604/oncologie.2021.019964

    Abstract Context: Since January 2021, vaccination for COVID-19 has been made possible in France for people aged 75 and over. Patients suffering from a cancer disease are part of a group at risk to develop severe complications to COVID-19. Method: The « Unité de coordination en Onco-Gériatrie région Bretagne » (the Brittany This work is licensed under a Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Coordinating Unit in Onco-Geriatrics) has wished to set up an inquest about the acceptability and the tolerance to COVID-19 vaccination… More >

  • Open Access


    Prediction of Suitable Candidates for COVID-19 Vaccination

    R. Sujatha1, B. Venkata Siva Krishna1, Jyotir Moy Chatterjee2, P. Rahul Naidu1, NZ Jhanjhi3,*, Challa Charita1, Eza Nerin Mariya1, Mohammed Baz4

    Intelligent Automation & Soft Computing, Vol.32, No.1, pp. 525-541, 2022, DOI:10.32604/iasc.2022.021216

    Abstract In the current times, COVID-19 has taken a handful of people’s lives. So, vaccination is crucial for everyone to avoid the spread of the disease. However, not every vaccine will be perfect or will get success for everyone. In the present work, we have analyzed the data from the Vaccine Adverse Event Reporting System and understood that the vaccines given to the people might or might not work considering certain demographic factors like age, gender, and multiple other variables like the state of living, etc. This variable is considered because it explains the unmentioned variables like their food habits and… More >

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