Huan Zhou^1,#, Jin Kang^2,#, Jun Gao^2,*, Xiaoyuan Feng¹, Li Zhou², Xia Xiao², Zhengliang Meng², Chengwen Guo²

Congenital Heart Disease, Vol.17, No.6, pp. 697-707, 2022, DOI:10.32604/chd.2022.022648

Abstract Background: Real-time three-dimensional echocardiography (RT-3DE) could obtain ventricular volume and ejection fraction rapidly and non-invasively without relying on ventricular morphology. This study aims to use RT-3DE to evaluate the changes in biventricular volume and systolic function in children with ventricular septal defect (VSD) and moderate to severe pulmonary hypertension (PH) before surgery. Methods: In this study 18 children with VSD and moderate to severe PH (VSD + PH Group) and 18 healthy children of the same age (Control Group) were recruited. Biventricular volume and systolic function were evaluated by RT-3DE. The measurements included: left and right ventricular volume indexed to… More > Graphic Abstract

Catherine E. Tomasulo^1,*, Lindsay S. Rogers¹, Lauren Andrade^1,2, Michael L. O’Byrne^1,3,4

Congenital Heart Disease, Vol.17, No.2, pp. 193-199, 2022, DOI:10.32604/chd.2022.017721

Abstract The majority of patients with congenitally corrected transposition of the great arteries, also known as transposition of the great arteries {S,L,L} have ventricular septal defects (VSD), most commonly perimembranous VSD (pmVSD). Transcatheter device closure of pmVSD in these patients has not been widely described. We present a case of device closure of pmVSD in L-TGA with an Amplatzer Duct Occluder II (ADOII) device using a deployment starting in the subpulmonary left ventricle. The case demonstrates some of the technical advantages of the ADOII device for VSD closure, specifically its low profile, symmetric shape, and soft material. These characteristics are advantageous… More >

Wenqian Zhang^1,2,#, Chaojie Wang^1,3,#, Lingmei Zhou^2,4,#, Junjie Li², Jijun Shi², Yumei Xie², Mingyang Qian², Shushui Wang², Zhiwei Zhang^1,2,*

Congenital Heart Disease, Vol.16, No.5, pp. 519-528, 2021, DOI:10.32604/CHD.2021.015527

Abstract Objective: This study aims to evaluate the morphology and function of the aortic valve after transcatheter closure of ventricular septal defect (VSD) with aortic valve prolapse (AVP) abased on clinical and radiological outcomes. Methods: From January 2013 to November 2014, 164 consecutive patients (97 males, 59.1%) with VSD and AVP were treated by transcatheter closure. The patients were divided into the mild AVP group (n = 63), moderate AVP group (n = 89) and severe AVP group (n = 12). The clinical and radiological outcomes of these patients were analyzed retrospectively. Results: In total, 146 (89.0%) patients were successfully treated… More >

Jinyang Liu¹, Xianchao Jiang¹, Runsi Wang², Li Li³, Ju Zhao⁴, Fuxia Yan⁵, Run Yuan⁶, Qiang Wang^1,*

Congenital Heart Disease, Vol.16, No.3, pp. 245-254, 2021, DOI:10.32604/CHD.2021.014881

Abstract Background: Never had literatures characterized the relationship between the property of major aortopulmonary collateral arteries (MAPCAs) and outcomes of selective unifocalization of pulmonary atresia with ventricular septal defects and MAPCAs. Methods: This is a case-series study. Thirteen patients were included. Angiography-based assessment was conducted to determine whether collateral arteries should be unifocalized or treated with intraoperative ligature. Specimens were collected and stained by HE and ET+VG. Results: Twelve patients underwent one-stage unifocalization at a median age of 37 months (range: 6–228 months) and a median weight of 14.0 kg (range: 5.0–49.0 kg), which produced a favorable right ventricle to aortic… More >

Hongxiao Sun, Gang Luo, Zhanhui Du, Zhixian Ji, Silin Pan^*

Congenital Heart Disease, Vol.16, No.2, pp. 151-157, 2021, DOI:10.32604/CHD.2021.014770

Abstract Objective: To evaluate the efficacy of Amplatzer duct occluder II (ADO II) in the treatment of perimembranous ventricular septal defect (pmVSD) in children. Methods: Between June 2017 and June 2020, 13 patients with pmVSD had attempted transcatheter closure using ADO II, seven of patients were used antegrade approach and six of them were used retrograde approach. Results: There were 8 males and 5 females, age from 1 to 7 years, weight from 10.5 to 31.0 kg, and VSD size from 2.0 to 4.0 mm. Procedure was successful in all cases with the outer diameter of the occluders ranging from 4… More >

Diqi Zhu¹, Xiaohong Gu², Jie Shen^1,*, Fen Li^1,*

Congenital Heart Disease, Vol.16, No.2, pp. 147-150, 2021, DOI:10.32604/CHD.2021.014360

Abstract Background: Communication between the right pulmonary artery (RPA) and left atrium (LA) is a rare cause of central cyanosis in pediatric patients. Case presentation: We describe a 3-year-old female patient with an oxygen saturation of 70% at admission. The echocardiogram indicated an abnormal color flow Doppler in the LA and she underwent standard cardiac catheterization. The angiography of pulmonary artery revealed a 7.4 mm × 7.6 mm fistula between the RPA and LA and achieved successful closure using ventricular septal defect occlusion. Conclusion: The fistula between pulmonary artery and left atrium is an extremely rare but treatable congenital defect. It… More >

Jinyang Liu^1,#, Bo Peng^1,#, Xianchao Jiang^1,#, Simeng Zhang¹, Jiachen Li¹, Lizhi Lv¹, Qiang Wang^1,2,*, Xiang Li^3,*

Congenital Heart Disease, Vol.16, No.1, pp. 65-72, 2021, DOI:10.32604/CHD.2021.013462

Abstract Background: This study aims to explore the efficacy of selective unifocalization (UF) for major aortopulmonary collateral arteries (MAPCAs) unifocalization in children with pulmonary atresia with ventricular septal defect (PA/VSD). Methods: A retrospective analysis of 13 patients with PA/VSD/MAPCAs who underwent surgery from June 2017 to December 2019. Sex, age, preoperative cardiovascular angiography test results and McGoon ratio were collected. The properties of the collateral arteries were evaluated by angiography, and selective UF for the “dendritic” MAPCAs and ligation of MAPCAs demonstrating distortion and resistance. Results: A total of 13 severe patients underwent one-stage repair, of which 1 case underwent ventricular… More >

Mika Saito^1,2, Dragulescu Andreea^1,2, Shi-Joon Yoo^1,2,3,*

Congenital Heart Disease, Vol.16, No.1, pp. 1-16, 2021, DOI:10.32604/CHD.2021.011694

Abstract Objective: Overriding/straddling of an atrioventricular valve is a consequence of atrial-ventricular septal malalignment. We sought to characterize the malalignment by analogizing it to a flap-door and using structured approach. Methods: The echocardiograms and magnetic resonance images of 35 patients with overriding/straddling tricuspid or mitral valve were evaluated to assess the following modifiers; the malaligned part of the septum, the reference structure, and the mechanism, direction and severity of malalignment. Results: The pathology included classic overriding tricuspid valve in 15, classic overriding mitral valve in 12, and overriding tricuspid valve with left juxtaposition of atrial appendages in 8. In classic overriding… More >

Nurdan Ozturk Tasar¹, Pelin Kosger², Nevzat Uzuner³, Birsen Ucar²

Congenital Heart Disease, Vol.13, No.6, pp. 1038-1044, 2018, DOI:10.1111/chd.12678

Abstract Objective: We aimed to investigate the effect of ventricular septal defect (VSD) and heart failure on cerebral blood flow (CBF) in children, whether heart failure treatment improves CBF, and if there is any relationship between CBF and serum N‐ terminal pro‐brain natriuretic peptide (NT‐proBNP) level.
Method: Forty children with VSD (13 with heart failure) aged between 1 and 36 months were studied. The control group comprised 25 healthy children in the same age group. Maximum, minimum, and mean blood flow velocities and pulsatility indices of the right and left middle cerebral arteries were assessed using transcranial Doppler ultrasonography. Measurements of… More >

Phong Teck Lee, Felix Maverick Uy, Jie Sheng Foo, Ju Le Tan

Congenital Heart Disease, Vol.13, No.6, pp. 1005-1011, 2018, DOI:10.1111/chd.12667

Abstract Background: Ventricular septal defect (VSD) is one of the most common congenital heart anomalies in childhood and there is an increasing prevalence of VSDs in the adult population. The long‐term risk of infective endocarditis (IE) is of concern. The aim of this study was to clarify and compare the incidence of IE in adults with re‐ paired and unrepaired VSDs.
Methods: Patients with VSDs were identified using the Adult Congenital Heart Disease registry at the National Heart Centre Singapore. Patients were divided into Group 1 (repaired VSD) and Group 2 (unrepaired VSDs). The electronic medical re‐ cords were searched for… More >