Xiaopan Zou^1,2, Meiyang Sun³, Xin Jiang¹, Jingze Yu², Xiaomeng Li^4,*, Bingyu Nie^1,*

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.066662 - 30 December 2025

Abstract Objective: Triple-negative breast cancer (TNBC) is highly aggressive and lacks an effective targeted therapy. This study aimed to elucidate the functions and possible mechanisms of action of zinc finger miz-type containing 2 (ZMIZ2) and minichromosome maintenance complex component 3 (MCM3) in TNBC progression. Methods: The relationship between ZMIZ2 expression and clinical characteristics of TNBC was investigated. In vitro and in vivo experiments were performed to investigate the role of ZMIZ2 dysregulation in TNBC cell malignant behaviors. The regulatory relationship between ZMIZ2 and MCM3 was also explored. Transcriptome sequencing was performed to elucidate possible mechanisms underlying the ZMIZ2/MCM3… More >

S. Çelik^a,*, M. Temiz^b

Chalcogenide Letters, Vol.22, No.1, pp. 89-96, 2025, DOI:10.15251/CL.2025.221.89

Abstract In this study, PbZnS thin films with varying concentrations of lead (Pb) and zinc (Zn) were successfully produced using the spray pyrolysis method. The structural, optical and surface properties of the films were systematically investigated as a function of the Pb/Zn ratio. Xray diffraction (XRD) analysis confirmed the polycrystalline nature of the films, showing a cubic zinc blende structure with improved crystallinity as Pb content increased. Initially, with the increase in Pb concentration, larger crystallite sizes and decreased microstress were observed, but with the increase of Pb addition, the formation of secondary phases and the… More >

T. L. Yang^a, P. Y. Lin^b, Y. S. Fu^c, C. Y. Luo^c, K. C. Hsu^a,*

Chalcogenide Letters, Vol.22, No.7, pp. 625-636, 2025, DOI:10.15251/CL.2025.227.625

Abstract In this study, high-crystallinity zinc sulfide (ZnS) at the nanoscale was synthesized using a combination of electrospinning and hydrothermal techniques. Initially, polyvinyl butyral (PVB)/ZnS composite nanofibers were fabricated via electrospinning. Subsequently, a hydrothermal reaction was employed to induce a dissolution-recrystallization mechanism, enabling the gradual formation of highly crystalline ZnS nanoparticles. The structural, morphological, and compositional characteristics of the ZnS nanoparticles were analyzed using scanning electron microscopy (SEM), X-ray diffraction (XRD), transmission electron microscopy (TEM) and energy-dispersive X-ray spectroscopy (EDS). Finally, the photocatalytic activity of three different ZnS materials—synthesized via electrospinning, hydrothermal treatment, and hydrothermal-assisted electrospinning—were More >

Cheng Song^1,*, Iftikhar Hussein Shah², Ghulam Abbas Ashraf³, Muhammad Arif⁴, Muhammad Aamir Manzoor^1,5,*

Phyton-International Journal of Experimental Botany, Vol.94, No.11, pp. 3427-3451, 2025, DOI:10.32604/phyton.2025.070778 - 01 December 2025

Abstract Heavy metal pollution has become a pervasive environmental issue affecting numerous regions worldwide. Recently, there has been significant attention given to the application of nano-enabled technologies with the purpose of enhancing plant development and alleviating heavy metal stress. This study aimed to illustrate the potential of zinc oxide nanoparticles (ZnO-NPs) to enhance the morphological traits of D. huoshenense exposed to cadmium (Cd) stress. The chemical structure and elemental composition of the ZnO-NPs were characterised by a series of analytical methods, including X-ray diffraction, UV-Vis spectrometry, XPS, and TEM. Plant samples used were collected at 0, 5,… More > Graphic Abstract

Yinglai Tang, Jiale Xie, Yujie Chen, Xingxu Liu, Xiaomin Kang^*

Journal of Polymer Materials, Vol.42, No.3, pp. 587-619, 2025, DOI:10.32604/jpm.2025.067647 - 30 September 2025

Abstract With the rapid development of flexible and wearable electronic devices, the demand for flexible power sources with high energy density and long service life is imminent. Zinc-air batteries have long been regarded as an important development direction in the future due to their high safety, environmental efficiency, abundant reserves and low cost. However, problems such as zinc dendrite growth, corrosion, by-product generation, hydrogen evolution and leakage, and evaporation of electrolyte affect the commercialization of zinc-air batteries. In addition, currently widely used aqueous electrolytes lead to larger batteries, which is not conducive to the development of… More >

Ting Wei^1,2,#, Pengli Wei^2,3,#, Yalei Wang^1,2, Yaqiu Mao^2,3, Jian Yan², Xiaotong Hu², Zhenze Qi², Xu Cai², Changkai Jia², Zhiyuan Zhao², Bingkun Li², Min Qiao², Yaxin Zou^2,3, Tingting Yang⁴, Shiyang Sun², Xuesong Feng³, Pengyun Li^2,*, Hongzhou Shang^1,*, Zhibing Zheng²

Oncology Research, Vol.33, No.10, pp. 2981-3006, 2025, DOI:10.32604/or.2025.065123 - 26 September 2025

Abstract Objectives: Immunomodulatory drugs (IMiDs), functioning as molecular glue degraders, have been approved for treating various hematological malignancies; however, the inevitable acquired drug resistance resulting from their skeletal similarity and hematological toxicities poses significant obstacles to their clinical treatment. The study aimed to develop degraders with potent efficiency and low toxicity. Methods: Phenotypic profiling, elaborate structure-activity relationships (SAR), rational drug design and degradation profiles investigations, quantitative proteomics analysis and cell-based functional studies, and pharmacokinetic studies were conducted to develop more potent degraders. Results: This study developed novel CRBN-binding moieties through methylene deletion in lenalidomide’s isoindole core. Lead… More > Graphic Abstract

Yuhang Jiang^#, Yijun Xu^#, Qi Zhu, Yingxia Wu, Zhe Wang, Shuang He, Shiyong Yu^*, Honggang Xiang^*

Oncology Research, Vol.33, No.9, pp. 2379-2398, 2025, DOI:10.32604/or.2025.063501 - 28 August 2025

Abstract Background: Colorectal cancer (CRC) is common and deadly, often leading to metastasis, challenging treatment, and poor outcomes. Understanding its molecular basis is crucial for developing effective therapies. Aims: This study aimed to investigate the role of Myosin Heavy Chain 11 (MYH11) in CRC progression, especially its effects on epithelial-mesenchymal transition (EMT) and cell behavior, and to explore its potential regulation by the EMT transcription factor zinc finger E-box binding homeobox 1 (ZEB1). Methods: Differential expression analysis was performed in the GSE123390 and TCGA-READ datasets, and 317 intersection genes were identified. The hub gene MYH11 was identified… More >

Alejandra Sánchez-Reyna¹, Yolanda González-García², Ángel Gabriel Alpuche-Solís³, Gregorio Cadenas-Pliego⁴, Adalberto Benavides-Mendoza^5,6, Antonio Juárez-Maldonado^6,7,*

Phyton-International Journal of Experimental Botany, Vol.94, No.7, pp. 2097-2116, 2025, DOI:10.32604/phyton.2025.067092 - 31 July 2025

Abstract Tomato is an economically important crop that is susceptible to biotic and abiotic stresses, situations that negatively affect the crop cycle. Biotic stress is caused by phytopathogens such as Fusarium oxysporum f. sp. lycopersici (FOL), responsible for vascular wilt, a disease that causes economic losses of up to 100% in crops of interest. Nanomaterials represent an area of opportunity for pathogen control through stimulations that modify the plant development program, achieving greater adaptation and tolerance to stress. The aim of this study was to evaluate the antimicrobial capacity of the nanoparticles and the concentrations used in tomato… More >

Meryam Manzoor¹, Konstantin Korolev², Maryam³, Riaz Ahmad^4,*

Phyton-International Journal of Experimental Botany, Vol.94, No.5, pp. 1401-1418, 2025, DOI:10.32604/phyton.2025.063930 - 29 May 2025

Abstract The productivity of fruit crops is badly affected by abrupt changes in climatic conditions. It is a matter of concern for fruit tree researchers to feed the huge population within the available resources. The adverse effects of abiotic stresses are increasing due to fluctuations in climate change. Several abiotic stresses (salinity, drought, water logging, minerals deficiency, temperature extremities and heavy metals) are reducing the overall productivity of crops. Therefore, the application of different management approaches, i.e., phytohormones, nanoparticles, organic amendments, microbes and molecular aspects are effective for the mitigation of abiotic stresses in fruit crops.… More >

Anton Tkachenko^*

BIOCELL, Vol.49, No.5, pp. 721-741, 2025, DOI:10.32604/biocell.2025.063301 - 27 May 2025

Abstract Ferroptosis is an iron-driven, phospholipid hydroperoxide-mediated cell death, which has recently emerged as an attractive tool in cancer research due to its ability to govern the anti-tumor immune response. A growing research interest in ferroptosis biology has revealed the contribution of this regulated cell death to multiple diseases. In addition to iron, ferroptosis has been reported to be triggered by multiple heavy metals, which sheds light on the novel aspects of heavy metals-induced cytotoxicity. In this review, the ability of zinc, an essential biogenic element with a wide array of biological functions, to modulate ferroptosis… More >