FRANCESCO PADUANO^1,2,*, EMANUELA ALTOMARE^2,3, BENEDETTA MARRELLI¹, VINCENZO DATTILO⁴, HAIZAL MOHD HUSSAINI⁵, PAUL ROY COOPER⁵, MARCO TATULLO⁶

BIOCELL, Vol.46, No.8, pp. 1827-1835, 2022, DOI:10.32604/biocell.2022.020462

Abstract Oral Cancer (OC) is one of the most recurrent cancers in the head and neck squamous cancer (SCCHN) category. Recently, the genome-wide association studies (GWAS) have gained growing interest in the scientific community. GWAS have identified several pathways involved in the interactions among general risk factors and genomic variants affecting SCCHN. This systematic overview aims to critically evaluate the latest data reported within the scientific literature. The aim was to investigate the impact of genetic aspects on SCCHN onset and prognosis, involving other clinical and systemic co-factors. PubMed, Google Scholar, and Cancer Genetics Web databases have been systematically investigated for… More >

FUAD GANDHI TORIZAL^1,2,*, FRANSISCUS FIANO ANTHONY KERANS³, ANNISA KHUMAIRA¹

BIOCELL, Vol.46, No.8, pp. 1885-1891, 2022, DOI:10.32604/biocell.2022.019591

Abstract The potential of mesenchymal stem cells (MSCs) in regenerative medicine has been largely known due to their capability to induce tissue regeneration in vivo with minimum inflammation during implantation. This adult stem cell type exhibit unique features of tissue repair mechanism and immune modulation mediated by their secreted factors, called secretome. Recently, the utilization of secretome as a therapeutic agent provided new insight into cell-free therapy. Nevertheless, a sufficient amount of secretome is necessary to realize their applications for translational medicine which required a proper biomanufacturing process. Several factors related to their production need to be considered to produce a… More >

MASSIMO CONESE^1,*, AURELIO PORTINCASA²

BIOCELL, Vol.46, No.8, pp. 1815-1826, 2022, DOI:10.32604/biocell.2022.019448

Abstract The treatment of nonhealing and chronic cutaneous wounds still needs a clinical advancement to be effective. Both mesenchymal stem cells (MSCs), obtained from different sources, and their secretome derived thereof (especially exosomes) can activate signaling pathways related to promotion of cell migration, vascularization, collagen deposition, and inflammatory response demonstrating prohealing, angiogenetic and anti-scarring capacities. On the other hand, biodegradable biomimetic scaffolds can facilitate endogenous cell attachment and proliferation as well as extracellular matrix production. In this Review, we revise the complex composites made by biomimetic scaffolds, mainly hydrogels, and MSC-derived exosomes constructed for cutaneous wound healing. Studies demonstrate that there… More >

XIAOXIA WANG^1,#, ZHONGYUAN YAO^1,2,#, DI LIU¹, CHUNHONG YU^3,*, HUI LI^1,3,*

BIOCELL, Vol.46, No.8, pp. 1803-1806, 2022, DOI:10.32604/biocell.2022.019731

Abstract Each stage of embryonic development, including normal gamete maturation, fertilization, zygotic genome activation, and cleavage, is crucial for human reproduction. Early embryo arrest is a common phenomenon. It is estimated that about 40%–70% of human embryos are arrested at early developmental stages. However, the exact mechanism remains largely uncertain. Embryos can be investigated in vitro by way of the development of in vitro fertilization/intracytoplasmic sperm injection. In addition to iatrogenic factors related to abnormal oocyte/embryo development, multiple gene mutations have been found to be involved in such phenotypes. Based on the knowledge of known etiological factors, several therapies are proposed… More >

PRANAB DUTTA^1,*, GOMATHY MUTHUKRISHNAN^2,*, SABARINATHAN KUTALINGAM GOPALASUBRAMAIAM², RAJAKUMAR DHARMARAJ², ANANTHI KARUPPAIAH³, KARTHIBA LOGANATHAN⁴, KALAISELVI PERIYASAMY⁵, M. ARUMUGAM PILLAI², GK UPAMANYA⁶, SARODEE BORUAH⁷, LIPA DEB¹, ARTI KUMARI¹, MADHUSMITA MAHANTA¹, PUNABATI HEISNAM⁸, AK MISHRA⁹

BIOCELL, Vol.46, No.8, pp. 1843-1859, 2022, DOI:10.32604/biocell.2022.019291

Abstract

Plant growth-promoting rhizobacteria (PGPR) are specialized bacterial communities inhabiting the root rhizosphere and the secretion of root exudates helps to, regulate the microbial dynamics and their interactions with the plants. These bacteria viz., Agrobacterium, Arthobacter, Azospirillum, Bacillus, Burkholderia, Flavobacterium, Pseudomonas, Rhizobium, etc., play important role in plant growth promotion. In addition, such symbiotic associations of PGPRs in the rhizospheric region also confer protection against several diseases caused by bacterial, fungal and viral pathogens. The biocontrol mechanism utilized by PGPR includes direct and indirect mechanisms direct PGPR mechanisms include the production of antibiotic, siderophore, and hydrolytic enzymes, competition for space and… More >

PANKE CHEN^*, SHUAI MA

BIOCELL, Vol.46, No.8, pp. 1903-1909, 2022, DOI:10.32604/biocell.2022.018651

Abstract This work aimed to investigate the effects of calcitonin gene-related peptide (CGRP)-modified mesenchymal stem cells (MSCs) on vascular stenosis in carotid balloon-injured rats. The CGRP gene labeled with EGFP was transfected into bone marrow MSCs, and CGRP protein expression in MSCs was confirmed by immunofluorescence assays. A rat carotid balloon injury model was established using a surgical method. CGRP-modified MSCs were orthotopically transplanted into the injured area of the rats. At 28 days after cell transplantation, EGFP and CD31 expression was detected by immunofluorescence staining. Hematoxylin-eosin (H&E) staining was used to detect the intima/media area of the injured carotid artery… More >

Gang Xu¹, Yibo Cao¹, Shiyuan Xu¹, Xin Liu^2,*, Xiu-Bo Chen³, Yiying Yu¹, Xiaojun Wang⁴

CMC-Computers, Materials & Continua, Vol.72, No.3, pp. 5429-5441, 2022, DOI:10.32604/cmc.2022.028562

Abstract With the increasing popularity of cloud storage, data security on the cloud has become increasingly visible. Searchable encryption has the ability to realize the privacy protection and security of data in the cloud. However, with the continuous development of quantum computing, the standard Public-key Encryption with Keyword Search (PEKS) scheme cannot resist quantum-based keyword guessing attacks. Further, the credibility of the server also poses a significant threat to the security of the retrieval process. This paper proposes a searchable encryption scheme based on lattice cryptography using blockchain to address the above problems. Firstly, we design a lattice-based encryption primitive to… More >

Khudran M. Alzhrani^*

CMC-Computers, Materials & Continua, Vol.72, No.3, pp. 5459-5479, 2022, DOI:10.32604/cmc.2022.028512

Abstract Multitasking and multioutput neural networks models jointly learn related classification tasks from a shared structure. Hard parameters sharing is a multitasking approach that shares hidden layers between multiple task-specific outputs. The output layers’ weights are essential in transforming aggregated neurons outputs into tasks labels. This paper redirects the multioutput network research to prove that the ensemble of output layers prediction can improve network performance in classifying multi-label classification tasks. The network’s output layers initialized with different weights simulate multiple semi-independent classifiers that can make non-identical label sets predictions for the same instance. The ensemble of a multi-output neural network that… More >

Jung-In Baik, Ji-Hwan Kim, Beom-Sik Shin, Ji-Hye Oh, Hyoung-Kyu Song^*

CMC-Computers, Materials & Continua, Vol.72, No.3, pp. 5807-5821, 2022, DOI:10.32604/cmc.2022.028434

Abstract With the rapid evolution of Internet of things (IoT), many edge devices require simultaneous connection in 5G communication era. To afford massive data of IoT devices, multiple input multiple output non-orthogonal multiple access (MIMO-NOMA) method has been considered as a promising technology. However, there are numerous drawbacks due to error propagation and inter-user interferences. Therefore, proposed scheme aims to improve the reliability of the MIMO-NOMA system with digital beamforming and intra-cluster cooperative multi point (CoMP) to efficiently support IoT system. In the conventional MIMO-NOMA system, user entities are grouped into clusters. Block diagonalization (BD) is applied to efficiently eliminate the… More >

Charnon Chupong, Boonyang Plangklang^*

CMC-Computers, Materials & Continua, Vol.72, No.3, pp. 5415-5427, 2022, DOI:10.32604/cmc.2022.028416

Abstract This article presents hourly load forecasting by using an incremental learning model called Online Sequential Extreme Learning Machine (OS-ELM), which can learn and adapt automatically according to new arrival input. However, the use of OS-ELM requires a sufficient amount of initial training sample data, which makes OS-ELM inoperable if sufficiently accurate sample data cannot be obtained. To solve this problem, a synthesis of the initial training sample is proposed. The synthesis of the initial sample is achieved by taking the first data received at the start of working and adding random noises to that data to create new and sufficient… More >