Cheng Zhu^1,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 11-11, 2019, DOI:10.32604/mcb.2019.08411

Abstract The immune response is orchestrated by a variety of immune cells. The function of each cell is determined by the collective signals from various immunoreceptors whose expression and activity depend on the developmental stages of the cell and its environmental context. Recent studies have highlighted the presence of mechanical forces on specific immunoreceptor–ligand bonds, which are transmitted across the cell membrane, potentially inducing mechanotransduction. As mechanobiology intersects with immunology, the interest to explore how immune cells sense, respond and adapt to their mechanical environment is rapidly growing. In this talk, I will review recent advances in the emerging field of… More >

Guixue Wang^1,*, Li Yang¹

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 10-10, 2019, DOI:10.32604/mcb.2019.08410

Abstract The biomechanics research of Chongqing University (CQU) began in the late 1970s, which has always been guided and helped by Prof. YC Fung. Prof. YP Wu, Prof. GR Wang at CQU were two of the earliest four Chinese scholars to visit and study in Fung's laboratory in the United States. In the autumn of 1979, Fung held a biomechanical workshop in CQU and the former Huazhong Institute of Technology. With the help of him, Prof. YP Wu founded the first Biomechanics Research Lab in China in the late 1970s. The first program for master’s degree on biomechanics was approved to… More >

William Leineweber¹, Stephanie I. Fraley^1,2,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 9-9, 2019, DOI:10.32604/mcb.2019.08504

Abstract Cell-extracellular matrix (ECM) interactions are critical modulators of repair and regeneration. However, variability within individual cells of the same cell type and within the ECM microenvironment can lead to heterogeneous outcomes that may limit the reliable application of cell-biomaterial constructs in regenerative medicine. Understanding the origins of heterogeneity is critical to overcoming this challenge and requires measurement of cell-ECM interactions at the single cell level. There are four core biophysical modules that cells employ to interact with their surrounding ECM: protrusion, adhesion, contractility, and matrix remodeling. Conventional approaches measure these interactions in separate experiments on separate cells, resulting in bulk… More >

Erik B. Kistler¹, Geert W. Schmid-Schönbein^2,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 8-8, 2019, DOI:10.32604/mcb.2019.07256

Abstract A longstanding question in research on organ failure after physiological shock (such as trauma, burns, sepsis, surgery and medical emergencies) is the underlying mechanism for a progressive loss of cell and tissue functions. Our systematic analysis of this problem has served to identify digestive enzymes as key players [1, 2]. After synthesis and discharge from the pancreas, the digestive enzymes are usually contained inside the lumen of the small intestine where they break down food every day. Escape of the digestive enzymes out of the lumen of the intestine is kept to a minimum by the mucosal barrier in the… More >

Shu Q. Liu^1,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 5-7, 2019, DOI:10.32604/mcb.2019.06960

Abstract This article has no abstract. More >

J.D. Humphrey^1,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 3-4, 2019, DOI:10.32604/mcb.2019.07639

Abstract This article has no abstract. More >

Savio L-Y. Woo^1,*, Peter C-Y Chen²

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 1-2, 2019, DOI:10.32604/mcb.2019.07631

Abstract This article has no abstract. More >

Shu Chien

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 1-2, 2019, DOI:10.32604/mcb.2019.07695

Abstract Professor Y.C. Fung has made tremendous impacts on science, engineering and humanity through his research and its applications, educating many students and their students, and providing his exemplary leadership [1-3]. He has applied his profound knowledge and elegant analytical methods to the study of biomedical problems with rigor and excellence. He established the basic principles of biomechanics in living tissues and organs. He opened up new vista for bioengineering, from organs-systems to molecules-genes, and he has provided the foundation of research activities in many institutions in the United States and the world. He has made outstanding contributions to education in… More >

Yu Gao¹, Meiyue Wang¹, Yanting He¹, Lanlan Li¹, Xiaodong Cui¹, Min Cheng^1,*, Xiaoyun Zhang^1,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.1, pp. 93-93, 2019, DOI:10.32604/mcb.2019.05758

Abstract This study examines the effects of P53 in transdifferentiation of endothelial progenitor cells (EPCs) into smooth muscle cells induced by oscillatory shear stress. Endothelial progenitor cells (EPCs) were planted on slide and treated with 4 dyne/cm2 oscillatory shear stress (OSS). Results showed that the expression P53 was decreased time dependent after OSS. The OSS also attenuated the endothelial cells marker vWF and CD31 expression but enhanced the marker of smooth muscle cell α-SMA and SM22 expression in EPCs. After EPCs were pretreated with P53 agonist, the changes of angiogenesis in vitro were detected by matrix gel, and the expressions of… More >

Xiumei Guan¹, Hong Li¹, Xin Li¹, Xiaoyun Zhang¹, Xiaodong Cui¹, Hong Yan¹, Yuzhen Wang², Shunmei Liu², Min Cheng^3,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.1, pp. 91-91, 2019, DOI:10.32604/mcb.2019.05755

Abstract Aims: Endothelial progenitor cells (EPCs) play an important role in postnatal angiogenesis and neovascularization. Previous studies have revealed shear stress could accelerate EPC proliferation, differentiation, migration and so on, which contribute to postnatal angiogenesis and neovascularization. Moreover, some studies indicate that autophagy actively participates angiogenesis by affecting EPC migration and differentiation. Here, we try to elucidate the possible roles of autophagy of EPC differentiation induced by shear stress. Methods and Results: EPCs were exposed to shear stress (12 dyne/cm²). And then the expression of autophagy markers, such as LC3Ⅱ/Ⅰ, P62andATG5, were analyzed using Western blot. The results have shown that… More >