Dawei Song^1,*, Nicholas Hugenberg², Assad A Oberai¹

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 45-45, 2019, DOI:10.32604/mcb.2019.07138

Abstract Tractions exerted by cells on the extracellular matrix (ECM) are critical in many important physiological and pathological processes such as embryonic morphogenesis, cell migration, wound healing, and cancer metastasis. Traction Force Microscopy (TFM) is a robust tool to quantify cellular tractions during cell-matrix interactions. It works by measuring the motion of fiducial markers inside the ECM in response to cellular tractions and using this information to infer the traction field. Most applications of this technique have heretofore assumed that the ECM is homogeneous and isotropic [1], although the native ECM is typically composed of fibrous networks, and thus heterogeneous and… More >

Yue Mei^1,2,3, Stephane Avril^3,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 44-44, 2019, DOI:10.32604/mcb.2019.07034

Abstract Characterizing regional variations of material properties in soft tissues is essential for biomedical engineering and clinical medicine, including but not limited to cancerous disease detection and patient-specific surgical planning of cardiovascular diseases. Identification of nonhomogeneous material property distribution usually requires solving inverse problems in nonlinear elasticity. Generally, inverse algorithms can be categorized into two groups: iterative inversion and direct inversion. In direct inversion, the material property distribution of soft tissues is estimated directly from the equilibrium equations, while the inverse problem is posed as an optimization problem in iterative inversion. In this presentation, we compare the performance of one direct… More >

Zhen Wang¹, Yi Sui¹, Wen Wang¹, Dominique Barthѐs-Biesel², Anne-Virginie Salsac^2,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 42-43, 2019, DOI:10.32604/mcb.2019.07148

Abstract Capsules are liquid droplets enclosed by a thin membrane which can resist shear deformation. They are widely found in nature (e.g. red blood cells) and in numerous applications (e.g. food, cosmetic, biomedical and pharmaceutical industries [1]), where they often flow through a complicated network of tubes or channels: this is the case for RBCs in the human circulation or for artificial capsules flowing through microfluidic devices. Central to these flows is the dynamic motion of capsules at bifurcations, in particular the question of path selection. A good understanding of this problem is indeed needed to elucidate some intriguing phenomena in… More >

Fuzhou Tang¹, Jin Chen¹, Shichao Zhang¹, Zuquan Hu¹, Lina Liu¹, Long Li¹, Yan Ouyang¹, Zhu Zeng^1,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 40-41, 2019, DOI:10.32604/mcb.2019.07082

Abstract As potent antigen presenting cells, dendritic cells (DCs) are utilized to deliver the signals essential for the initiation of immune responses. The motility of DCs is crucial for migration of immature DCs (imDCs) in peripheral tissue and the interaction between mature DCs (mDCs) and naïve T cells in the secondary lymph node. From biomechanical viewpoint, the deformability of cells is necessary for their motility. Deformation of cells can be divided into active deformation (e.g. chemotaxis) and passive deformation (e.g. migration under shear stress of blood flow). However, there is no detailed study on the deformability of DCs including imDCs and… More >

Ken-ichi Tsubota^1,2,*, Yuya Kodama¹, Hiroyoshi Aoki², Yutaka Yamagata²

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 38-39, 2019, DOI:10.32604/mcb.2019.07285

Abstract We measured a blood flow in a polydimethysiloxane micro channel to reflect the complex geometry of a microvascular network. A flow rate was compared between two working fluids: water and blood. The measured flow rate reflected the bifurcation effects on the apparent viscosity determined by hematocrit, as well as the effects of the surrounding flow channels as bypasses. More >

Peng Jing¹, Xiaolong Wang¹, Shigeho Noda², Xiaobo Gong^1,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 36-37, 2019, DOI:10.32604/mcb.2019.07111

Abstract The motion of circulating tumor cells (CTCs) in microcirculatory system is one of the critical steps during cancer metastasis. The moving behavior and stress distribution of circulating tumor cells under different geometry and flow conditions are important basis for studying the adhesion between circulating tumor cells and vessel walls. In the present work, the motion and deformation of circulating tumor cells in capillary tubes are numerically studied using the immersed boundary method (IBM). The membrane stress distribution of CTCs in confined tubes are investigated with under vessel diameters, hematocrit (Ht) values and capillary numbers (Ca). The results show that the… More >

Peirong Jiang¹, Zhensen Chen², Daniel S. Hippe², Hiroko Watase³, Bin Sun¹, Ruolan Lin¹, Zheting Yang¹, Yunjing Xue^1,*, Xihai Zhao^4,*, Chun Yuan^2,4

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 34-35, 2019, DOI:10.32604/mcb.2019.07394

Abstract This article has no abstract. More >

Navid Mohammad Mirzaei¹, Pak-Wing Fok^1,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 32-33, 2019, DOI:10.32604/mcb.2019.07088

Abstract Atherosclerosis is a disease considered to be one of the leading causes of death. Understanding the behavior and dynamics of the vessel wall before and after atherosclerosis has been a motivation for many studies. We investigate this phenomenon as a combination of mechanical deformation of the vessel wall along with cell and chemical dynamics that occur within. We consider the vessel wall as a growing hyperelastic material with three layers; intima,media and adventitia. Each of these layers have a different set of mechanical properties [1]. To describe tissue growth, we use morphoelasticity as the mathematical framework. The growth tensor in… More >

Caining Zhang¹, Huaguang Li², Xiaoya Guo³, David Molony⁴, Xiaopeng Guo², Habib Samady⁴, Don P. Giddens^4,5, Lambros Athanasiou⁶, Rencan Nie^2,*, Jinde Cao^3,*, Dalin Tang^1,*,7

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 31-31, 2019, DOI:10.32604/mcb.2019.06983

Abstract Cardiovascular diseases are closely associated with deteriorating atherosclerotic plaques. Optical coherence tomography (OCT) is a recently developed intravascular imaging technique with high resolution approximately 10 microns and could provide accurate quantification of coronary plaque morphology. However, tissue segmentation of OCT images in clinic is still mainly performed manually by physicians which is time consuming and subjective. To overcome these limitations, two automatic segmentation methods for intracoronary OCT image based on support vector machine (SVM) and convolutional neural network (CNN) were performed to identify the plaque region and characterize plaque components. In vivo IVUS and OCT coronary plaque data from 5… More >

Dominique P. Pioletti^1,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 29-30, 2019, DOI:10.32604/mcb.2019.07050

Abstract From a mechanical point of view, articular cartilage can be considered as a viscoelastic porous material. Its dissipation capabilities are therefore central for its functional behavior. Based on this observation, we focused our studies of dissipative aspects in cartilage either from a biomechanical or mechanobiological point of view. In particular, we capitalized on the new obtained insight of dissipative behavior or sources in materials for the development of functional biomaterials for cartilage tissue engineering. We pioneered in proposing dissipation as a mechanobiological variable for cartilage tissue engineering [1]. As can be observed on Fig. 1, a correlation exists between the… More >