Elda A. Flores-Contreras¹, Everardo González-González^2,3, Ana I. Zarazúa-Niño¹, Elsa N. Garza-Treviño¹, Natalia Martínez-Acuña¹, Viviana C. Zomosa-Signoret⁴, Román Vidaltamayo⁴, Gerardo E. Muñoz-Maldonado⁵, Raquel Garza-Guajardo⁶, Manuel de J. García-Solís⁷, Alejandro Abarca-Blanco³, Ana M. G. Rivas-Estilla¹, Carlos Córdova-Fletes^1,*

Oncologie, Vol.23, No.3, pp. 373-392, 2021, DOI:10.32604/oncologie.2021.017786

Abstract Breast cancer (BC) is one of the leading causes of death in women worldwide. A major challenge in BC is chemoresistance, which is often modulated by epigenetic regulators such as long non-coding RNAs (lncRNAs). Because these regulator lncRNAs may play diverse roles, determining their specific pathways and/or functions is crucial to identify possible biomarkers and/or therapeutic targets for BC. In this study, we used gene expression microarrays in order to identify lncRNAs related to the BC biology. We found, among six differentially expressed (DE) lncRNAs, that the expression of lnc-ERP44-3:6 was consistently down-regulated in all breast tumor tissues compared to… More >

Xuehua Luo^1,#, Huijun Xie^2,#, Li Han¹, Qiaoming Zhong³, Meng Xu^4,*, Ling Jin^1,*

Oncologie, Vol.23, No.3, pp. 425-438, 2021, DOI:10.32604/Oncologie.2021.017267

Abstract Tetrandrine has a variety of anti-tumor effects including against or reversal of tumor chemoresistance, but its mechanism of against tumor chemoresistance is still unclear. Therefore, the analytical method of network pharmacology and molecular docking was used to investigate the mechanism by which tetrandrine acts in tumor chemoresistance. We used public databases (PubChem, SwissADEM, SwissTargetPrediction) to obtain the physicochemical information and targets of tetrandrine, and used gene databases (GeneCards and OMIM) to collected disease targets, respectively. The intersection targets of disease and drug were analyzed by RStudio. We built protein-protein interaction network through the STRING database, and used Cystoscope to screen… More >

Jiangyong Liu^1,#,*, Mingming Gu^2,#, Yang Xue¹, Qiong Wang³, Yong Ren³, Wencai Huang^1,*

Oncologie, Vol.23, No.3, pp. 439-452, 2021, DOI:10.32604/oncologie.2021.017220

Abstract Cavitary lung cancer is a rare type of lung cancer. Generally, the relationship between cavitary lung adenocarcinoma (LUAD) and specific immune checkpoints remains unknown. In this study, we aimed to detect the expression of programmed cell death ligand-1(PD-L1) and the density of CD8-positive (CD8⁺) tumor-infiltrating lymphocytes (TILs) to evaluate their clinicopathological significance in the case of patients with cavitary LUAD. This study included 65 patients with cavitary LUAD. Patient specimens were obtained from surgery. The expression of PD-L1 protein and CD8⁺ TIL status was detected by traditional immunohistochemistry and multiplex quantitative immunofluorescence technology. The correlation of PD-L1 expression and CD8⁺… More >

Yongxia He¹, Zheng Wang¹, Yue Wang², Man Sun^3,*

Oncologie, Vol.23, No.3, pp. 351-357, 2021, DOI:10.32604/Oncologie.2021.014772

Abstract Gastric cancer is a highly malignant disease with complex pathogenic mechanisms, and has high incidence and mortality rate. At present, the diagnosis of gastric cancer mainly includes gastroscopy, serum analysis and needle biopsy, and the treatment methods include conventional surgical resection, radiotherapy and chemotherapy. Yet, some limitations were involved in these diagnostic and therapeutic methods, so accurate targeted therapy has received considerable attention. MicroRNAs (miRNAs) are non-coding RNA that can interact with the 3-terminal non-translational region of the target gene mRNA to reduce the expression of the target gene, participate in the regulation of multiple signaling pathways, and play an… More >

M. J. Huntul^1,*, Taki-Eddine Oussaeif²

Computer Systems Science and Engineering, Vol.40, No.3, pp. 1109-1126, 2022, DOI:10.32604/csse.2022.020175

Abstract In this paper, we consider the unique solvability of the inverse problem of determining the right-hand side of a parabolic equation whose leading coefficient depends on time variable under nonlocal integral overdetermination condition. We obtain sufficient conditions for the unique solvability of the inverse problem. The existence and uniqueness of the solution of the inverse parabolic problem upon the data are established using the fixed point theorem. This inverse problem appears extensively in the modelling of various phenomena in engineering and physics. For example, seismology, medicine, fusion welding, continuous casting, metallurgy, aircraft, oil and gas production during drilling and operation… More >

K. Abhirami^1,*, M. K. Kavitha Devi²

Computer Systems Science and Engineering, Vol.40, No.3, pp. 1127-1144, 2022, DOI:10.32604/csse.2022.020013

Abstract With the advent of computing and communication technologies, it has become possible for a learner to expand his or her knowledge irrespective of the place and time. Web-based learning promotes active and independent learning. Large scale e-learning platforms revolutionized the concept of studying and it also paved the way for innovative and effective teaching-learning process. This digital learning improves the quality of teaching and also promotes educational equity. However, the challenges in e-learning platforms include dissimilarities in learner’s ability and needs, lack of student motivation towards learning activities and provision for adaptive learning environment. The quality of learning can be… More >

Maher Alsharif¹, Shailendra Mishra^2,*, Mohammed AlShehri¹

Computer Systems Science and Engineering, Vol.40, No.3, pp. 1153-1166, 2022, DOI:10.32604/csse.2022.019938

Abstract Today, security is a major challenge linked with computer network companies that cannot defend against cyber-attacks. Numerous vulnerable factors increase security risks and cyber-attacks, including viruses, the internet, communications, and hackers. Internets of Things (IoT) devices are more effective, and the number of devices connected to the internet is constantly increasing, and governments and businesses are also using these technologies to perform business activities effectively. However, the increasing uses of technologies also increase risks, such as password attacks, social engineering, and phishing attacks. Humans play a major role in the field of cybersecurity. It is observed that more than 39%… More >

Namit Gupta^1,*, Kunwar Singh Vaisla², Arpit Jain³, Adesh Kumar⁴, Rajeev Kumar³

Computer Systems Science and Engineering, Vol.40, No.3, pp. 1073-1084, 2022, DOI:10.32604/csse.2022.019911

Abstract Wireless sensor network (WSN) is a group of interconnected sensor nodes that work wirelessly to capture the information of surroundings. The routing of the network is a challenging task. The routing of WSN is classified as proactive, reactive, and hybrid. Adhoc on-demand distance vector (AODV) routing is an example of reactive routing based on the demand route formations among different nodes in the network. The research article emphasizes the design and simulation of the AODV routing hardware chip using very-high-speed integrated circuit hardware description language (VHDL) programming in Xilinx integrated synthesis environment (ISE) 14.7 software. The performance of the chip… More >

Mohammad Monirujjaman Khan¹, Arifa Sultana¹, Mehedi Masud^2,*, Gurjot Singh Gaba³, Hesham A. Alhumyani⁴

Computer Systems Science and Engineering, Vol.40, No.3, pp. 1183-1198, 2022, DOI:10.32604/csse.2022.019872

Abstract This paper presents the design and analysis of a miniaturized and novel wearable ultra-wideband (UWB) band-notch textile antenna for Body Area Networks (BANs). The major goal of building the antenna for wearable applications with band notch in X-band is to reject the downlink band (7.25 to 7.75 GHz) of satellite communication in the UWB frequency ranges of 3.1–10.6 GHz to keep away from interference. Computer Simulation Technology (CST) TM Microwave Studio, which is user-friendly and reliable, was used to model and simulate the antenna. The radiating element of the antenna is designed on Jeans’ textile substrate, which has a relative… More >

Ahad Alloqmani¹, Omimah Alsaedi¹, Nadia Bahatheg¹, Reem Alnanih^1,*, Lamiaa Elrefaei^1,2

Computer Systems Science and Engineering, Vol.40, No.3, pp. 1023-1042, 2022, DOI:10.32604/csse.2022.019704

Abstract Interactive learning tools can facilitate the learning process and increase student engagement, especially tools such as computer programs that are designed for human-computer interaction. Thus, this paper aims to help students learn five different methods for solving nonlinear equations using an interactive learning tool designed with common principles such as feedback, visibility, affordance, consistency, and constraints. It also compares these methods by the number of iterations and time required to display the result. This study helps students learn these methods using interactive learning tools instead of relying on traditional teaching methods. The tool is implemented using the MATLAB app and… More >