Open Access

REVIEW

Therapeutic and regenerative potential of different sources of mesenchymal stem cells for cardiovascular diseases

YARA ALZGHOUL, HALA J. BANI ISSA, AHMAD K. SANAJLEH, TAQWA ALABDUH, FATIMAH RABABAH, MAHA AL-SHDAIFAT, EJLAL ABU-EL-RUB^*, FATIMAH ALMAHASNEH, RAMADA R. KHASAWNEH, AYMAN ALZU’BI, HUTHAIFA MAGABLEH

Department of Basic Medical Sciences, Faculty of Medicine, Yarmouk University, Irbid, Jordan

* Corresponding Author: EJLAL ABU-EL-RUB. Email:

(This article belongs to the Special Issue: Perspectives on Stem Cells and Regenerative Medicine)

BIOCELL 2024, 48(4), 559-569. https://doi.org/10.32604/biocell.2024.048056

Received 26 November 2023; Accepted 16 January 2024; Issue published 09 April 2024

Abstract

Mesenchymal stem cells (MSCs) are ideal candidates for treating many cardiovascular diseases. MSCs can modify the internal cardiac microenvironment to facilitate their immunomodulatory and differentiation abilities, which are essential to restore heart function. MSCs can be easily isolated from different sources, including bone marrow, adipose tissues, umbilical cord, and dental pulp. MSCs from various sources differ in their regenerative and therapeutic abilities for cardiovascular disorders. In this review, we will summarize the therapeutic potential of each MSC source for heart diseases and highlight the possible molecular mechanisms of each source to restore cardiac function.

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Keywords

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