Vol.45, No.4, 2021, pp.823-833, doi:10.32604/biocell.2021.013864
OPEN ACCESS
REVIEW
Cell cycle regulation through primary cilium: A long-forgotten story
  • LIN LIU, ZHOUWEN XU, YUYAN JIANG, MD REZAUL KARIM, XIAO HUANG*
Institute of Cell and Developmental Biology, College of Life Sciences, Zhejiang University, Hangzhou, 310058, China
* Address correspondence to: Xiao Huang,
(This article belongs to this Special Issue: Kinesin Motors and Cell Cycle)
Received 25 August 2020; Accepted 21 December 2020; Issue published 22 April 2021
Abstract
Protruded from cytomembrane, primary cilium is a widespread cell organelle that can be found in almost all cell types in Mammalia. Because of its comprehensive requirement in various cellular activities and various functions in different organs, primary cilium has been a valuable research area of human pathology research since the turn of the millennium. And the potential application of the interaction between primary cilia and cell cycle regulation may be the most promising direction as many primary cilium-caused diseases are found to be caused by cell cycle dysregulation resulted from primary cilia defects. Therefore, a deep understanding of the interaction between primary cilia and the cell cycle is in great need. Hence in this review, we mainly described how the interaction between primary cilia and cell cycle proceeds and demonstrated three hypotheses raised from much different research. These hypotheses include (1) Primary cilium as a cellular signaling hub to regulate the cell cycle, (2) Primary cilium as a reservoir of cell cycle regulation-related factors, and (3) Primary cilium as a cell cycle checkpoint or a brake. Nonetheless, we also call for more attention on research of interaction between cell cycle and primary cilia and tried to point out some possible research directions for those who are interested.
Keywords
Signaling pathway, Cell cycle checkpoint, Ciliopathy, Cancer
Cite This Article
LIU, L., XU, Z., JIANG, Y., KARIM, M. R., HUANG, X. (2021). Cell cycle regulation through primary cilium: A long-forgotten story. BIOCELL, 45(4), 823–833.
This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.