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Induction of adaptive response in utero by ionizing radiation: A radiation quality dependent phenomenon


National Institutes for Quantum Science and Technology, Chiba, 263-8555, Japan

* Corresponding Authors: Bing Wang, email; Mitsuru Nenoi, email

(This article belongs to the Special Issue: Reproductive Health and Embryonic Development)

BIOCELL 2022, 46(10), 2315-2325.


Investigation on possible induction of adaptive response (AR) by high-liner energy transfer (LET) particle radiation for protection against low-LET photon radiation-induced detrimental effects has not yet been performed in utero. This study verified if an AR could be induced by high-LET particle radiation from accelerated heavy ions against low-LET X-ray radiation-induced detrimental effects on fetal mice. Total body irradiation of pregnant C57BL/6J mice were performed by delivering a priming dose ranging from 10 mGy to 320 mGy of particle radiation on gestation day 11 followed one day later by a challenge dose at 3500 mGy from X-ray radiation. The monoenergetic beams of carbon, silicon and iron with the LET values of about 15, 55, and 200 KeV/μm, respectively, were examined. Significant suppression by the priming radiation of the detrimental effects (fetal death, malformation, or low body weight) was used as the endpoints for judgment of a successful AR induction on gestation day 18. Existence of AR was not observed. On the other hand, the priming dose of high-LET particle radiation, in some cases, even increased the detrimental effects induced by the challenge dose from low-LET X-ray radiation. Although existence of AR induced by high-LET radiation in cultured mammalian cells in vitro and in certain tissues of laboratory mice in vivo was demonstrated, the present study did not suggest that low dose of high-LET particle radiation could induce an AR in fetal mice in utero under the setup of our experimental system.


Cite This Article

APA Style
WANG, B., TANAKA, K., MARUYAMA, K., NINOMIYA, Y., KATSUBE, T. et al. (2022). Induction of adaptive response <i>in utero </i>by ionizing radiation: A radiation quality dependent phenomenon. BIOCELL, 46(10), 2315-2325.
Vancouver Style
WANG B, TANAKA K, MARUYAMA K, NINOMIYA Y, KATSUBE T, NENOI M. Induction of adaptive response <i>in utero </i>by ionizing radiation: A radiation quality dependent phenomenon. BIOCELL . 2022;46(10):2315-2325
IEEE Style
B. WANG, K. TANAKA, K. MARUYAMA, Y. NINOMIYA, T. KATSUBE, and M. NENOI "Induction of adaptive response <i>in utero </i>by ionizing radiation: A radiation quality dependent phenomenon," BIOCELL , vol. 46, no. 10, pp. 2315-2325. 2022.

cc This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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