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The role of FZR1 in tumorigenesis: Focus on cell-cycle control

HUI LI1, CHENGFANG ZHOU2, MEI KUANG2, YUN LIU1,*, JIEPING CHEN1,2,*

1 Guizhou Provincial College-Based Key Lab for Tumor Prevention and Treatment with Distinctive Medicines, Zunyi Medical University, Zunyi, 563000, China
2 Department of Hematology, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, 400038, China

* Corresponding Authors: YUN LIU. Email: email; JIEPING CHEN. Email: email

BIOCELL 2023, 47(10), 2177-2186. https://doi.org/10.32604/biocell.2023.029373

Abstract

Fizzy-related protein homolog 1 (FZR1) mainly functions as a specific activator of the anaphase-promoting complex/cyclosome (APC/C) in the cell cycle and controls the G0 and G1 phases of the cell cycle. We highlight recent work that has studied the role of FZR1 in tumorigenesis, growth, differentiation, and genome stability through cell-cycle control. We summarize the current state of knowledge regarding FZR1 structure, function, and the distinct ways of APC/C dysregulation in solid tumors and hematologic malignancies. We also discuss novel approaches for targeting the FZR1 as a cancer therapy and research area for future work.

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APA Style
LI, H., ZHOU, C., KUANG, M., LIU, Y., CHEN, J. (2023). The role of FZR1 in tumorigenesis: focus on cell-cycle control. BIOCELL, 47(10), 2177-2186. https://doi.org/10.32604/biocell.2023.029373
Vancouver Style
LI H, ZHOU C, KUANG M, LIU Y, CHEN J. The role of FZR1 in tumorigenesis: focus on cell-cycle control. BIOCELL . 2023;47(10):2177-2186 https://doi.org/10.32604/biocell.2023.029373
IEEE Style
H. LI, C. ZHOU, M. KUANG, Y. LIU, and J. CHEN "The role of FZR1 in tumorigenesis: Focus on cell-cycle control," BIOCELL , vol. 47, no. 10, pp. 2177-2186. 2023. https://doi.org/10.32604/biocell.2023.029373



cc This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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