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Microfluidic platform for circulating tumor cells isolation and detection

JIAHAO ZHANG1,2,3, JIE REN4, ZIRUI LI1,2,3,*, YIXING GOU1,2,3,*

1 School of Mechanical Engineering, Hebei University of Technology, Tianjin, 300401, China
2 State Key Lab of Reliability and Intelligence of Electrical Equipment, Tianjin, 300401, China
3 National Engineering Research Center for Technological Innovation Method and Tool, Tianjin, 300401, China
4 College of Biological, Chemical Sciences and Engineering, Jiaxing University, Jiaxing, 314001, China

* Corresponding Authors: ZIRUI LI. Email: email; YIXING GOU. Email: email

BIOCELL 2023, 47(7), 1439-1447. https://doi.org/10.32604/biocell.2023.028628

Abstract

Circulating tumor cells (CTCs) are essential biomarkers for liquid biopsies, which are important in the early screening, prognosis, and real-time monitoring of cancer. However, CTCs are less abundant in the peripheral blood of patients, therefore, their isolation is necessary. Recently, the use of microfluidics for CTC sorting has become a research hotspot owing to its low cost, ease of integration, low sample consumption, and unique advantages in the manipulation of micron-sized particles. Herein, we review the latest research on microfluidics-based CTC sorting. Specifically, we consider active sorting using external fields (electric, magnetic, acoustic, and optical tweezers) and passive sorting using the flow effects of cells in specific channel structures (microfiltration sorting, deterministic lateral displacement sorting, and inertial sorting). The advantages and limitations of each method and their recent applications are summarized here. To conclude, a forward-looking perspective is presented on future research on the microfluidic sorting of CTCs.

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APA Style
ZHANG, J., REN, J., LI, Z., GOU, Y. (2023). Microfluidic platform for circulating tumor cells isolation and detection. BIOCELL, 47(7), 1439-1447. https://doi.org/10.32604/biocell.2023.028628
Vancouver Style
ZHANG J, REN J, LI Z, GOU Y. Microfluidic platform for circulating tumor cells isolation and detection. BIOCELL . 2023;47(7):1439-1447 https://doi.org/10.32604/biocell.2023.028628
IEEE Style
J. ZHANG, J. REN, Z. LI, and Y. GOU "Microfluidic platform for circulating tumor cells isolation and detection," BIOCELL , vol. 47, no. 7, pp. 1439-1447. 2023. https://doi.org/10.32604/biocell.2023.028628



cc This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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