Open Access

REVIEW

Development and application prospect of stem cell combined with 3D printing technology for oral disease

by YIXIAN YOU^1,3,#, YIHUNG LEE^2,#, YUSHIN HU², YOUHUI XU³, JOUCHEN CHEN², WEI JIANG¹, CHANGHAI LIU¹, ENQIANG CHEN¹, HONG TANG¹, HUA ZHANG^4,*, DONGBO WU^1,*

1 Center of Infectious Diseases, West China Hospital of Sichuan University, Chengdu, 610041, China
2 West China College of Stomatology, Sichuan University, Chengdu, 610041, China
3 West China School of Medicine, Sichuan University, Chengdu, 610041, China
4 Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, State Key Laboratory of Biotherapy, West China Second University Hospital, Sichuan University, Chengdu, 610041, China

* Corresponding Authors: HUA ZHANG. Email: ; DONGBO WU. Email:
# Yixian You and Yihung Lee contributed equally to this work

BIOCELL 2025, 49(1), 45-59. https://doi.org/10.32604/biocell.2024.057259

Received 13 August 2024; Accepted 11 November 2024; Issue published 24 January 2025

Abstract

With organ transplantation facing many dilemmas, tissue and organ regeneration as an alternative has bright prospects. In regenerative medicine, Three-dimensional (3D) printing technology and stem cells has been widely applied to the treatment of diseases related to tissue or organ replacement in dentistry, respectively. However, there are very few studies on the combination of the two, and even fewer clinical studies have been reported in dentistry. In this review, the current oral tissue engineering in vivo and in vitro based on 3D printing and stem cell technology will be summarized, and the discussion on the development prospects of this research direction will be given. Besides, the working principles and advantages & disadvantages of several types of 3D printers, as well as the mechanism of stem cells in tissue engineering will be elucidated. This review provides clinicians and researchers with the current state of research and trends in the combination of stem cells and 3D printing technology to treat oral-related diseases. In the future, 3D bioprinters are poised for ongoing innovation with the advancement of relevant technologies, catalyzing an increase in clinical studies focused on treating oral diseases using stem cells and 3D scaffolds. Consequently, these developments will further advance the field of oral tissue engineering.

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Keywords

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