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MicroRNA-139-3p Suppresses Tumor Growth and Metastasis in Hepatocellular Carcinoma by Repressing ANXA2R

Zeng Cheng Zou*1, Min Dai*1, Zeng Yin Huang, Yi Lu, He Ping Xie*, Yi Fang Li§, Yue Li*, Ying Tan, Feng Lin Wang*

* Department of Integrated Traditional and Western Medicine, The Third Affiliated Hospital of SunYat-sen University, Guangzhou, P.R. China
† Department of Oncology Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou, P.R. China
‡ Department of Hepatobiliary Surgery, The Third Affiliated Hospital of SunYat-sen University, Guangzhou, P.R. China
§ Department of Acupuncture, Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou, P.R. China
¶ Department of Infertility and Sterility, Guangdong Provincial Family Planning Research Institute, Guangzhou, P.R. China
1 These authors provided equal contribution to this work and are co-first authors.

Oncology Research 2018, 26(9), 1391-1399. https://doi.org/10.3727/096504018X15178798885361

Abstract

The direct roles of miR-139-3p on hepatocellular carcinoma (HCC) cell growth and metastasis remain poorly understood. We attempted to demonstrate the regulatory role of miR-139-3p in HCC progression and its underlying mechanisms. Here we showed that miR-139-3p expression was significantly reduced in the HCC tissues compared to paratumor tissues. Exogenous overexpression of miR-139-3p inhibited the migration and invasion of HCC cells, whereas downregulation of miR-139-3p was able to induce HCC HepG2 and SNU-449 cell migration and invasion. In addition, miR-139-3p inhibited HCC growth and lung metastasis in an in vivo mouse model, which is mainly regulated by annexin A2 receptor (ANXA2R). Finally, we identified that the expression of miR-139-3p was inversely correlated with ANXA2R expression in human HCC tissue. All these results demonstrated that miR-139-3p inhibited the metastasis process in HCC by downregulating ANXA2R expression.

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Cite This Article

APA Style
Zou, Z.C., Dai, M., Huang, Z.Y., Lu, Y., Xie, H.P. et al. (2018). Microrna-139-3p suppresses tumor growth and metastasis in hepatocellular carcinoma by repressing ANXA2R. Oncology Research, 26(9), 1391-1399. https://doi.org/10.3727/096504018X15178798885361
Vancouver Style
Zou ZC, Dai M, Huang ZY, Lu Y, Xie HP, Li YF, et al. Microrna-139-3p suppresses tumor growth and metastasis in hepatocellular carcinoma by repressing ANXA2R. Oncol Res. 2018;26(9):1391-1399 https://doi.org/10.3727/096504018X15178798885361
IEEE Style
Z.C. Zou et al., "MicroRNA-139-3p Suppresses Tumor Growth and Metastasis in Hepatocellular Carcinoma by Repressing ANXA2R," Oncol. Res., vol. 26, no. 9, pp. 1391-1399. 2018. https://doi.org/10.3727/096504018X15178798885361



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