Open Access
ARTICLE
Overexpression of LACTB, a Mitochondrial Protein That Inhibits Proliferation and Invasion in Glioma Cells
Hai-Tao Li, Dao-Yong Dong, Qiang Liu, Yi-Qin Xu, Langbo Chen
Department of Neurosurgery, The First People’s Hospital of Chongqing Liang Jiang New Area, Chongqing, P.R. China
Oncology Research 2019, 27(4), 423-429. https://doi.org/10.3727/096504017X15030178624579
Abstract
LACTB, a mitochondrial protein, was ubiquitously expressed in different mammalian tissues, such as liver,
heart, and skeletal muscle. It has been shown that LACTB is downexpressed in breast cancers, and it suppresses the proliferation and promotes the apoptosis of breast cancers. However, its role in the progression
and prognosis of glioma remains unknown. In this study, we analyzed the clinicopathological features and
outcomes of LACTB expression in 98 glioma patients and investigated the effects of LACTB overexpression
on the proliferation, invasion, and angiogenesis of glioma cells in vitro. We observed a significant decrease in
LACTB expression in glioma, and downexpression of LACTB is correlated with a poor prognosis of glioma
patients. Moreover, Cox regression analysis reveals that the LACTB is an independent prognostic indicator
for glioma patients. Overexpression of LACTB could suppress the proliferation, invasion, and angiogenesis of
glioma cells. In addition, overexpression of LACTB could inhibit the expression of PCNA, MMP2, MMP9,
and VEGF. Taken together, these data indicate that LACTB may serve as a promising therapeutic target for
gliomas.
Keywords
Cite This Article
Li, H., Dong, D., Liu, Q., Xu, Y., Chen, L. (2019). Overexpression of LACTB, a Mitochondrial Protein That Inhibits Proliferation and Invasion in Glioma Cells.
Oncology Research, 27(4), 423–429.