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miR-132 Targets FOXA1 and Exerts Tumor-Suppressing Functions in Thyroid Cancer

Xin Chen*, Mingzhe Li, Hongwei Zhou*, Li Zhang*

* Department of Radiology, the First Hospital of Jilin University, Changchun, Jilin, P.R. China
† China–Japan Union Hospital of Jilin University, Changchun, P.R. China

Oncology Research 2019, 27(4), 431-437. https://doi.org/10.3727/096504018X15201058168730

Abstract

MicroRNA-132 (miR-132) has been demonstrated to be a tumor suppressor in several types of tumors. However, the expression and the role of miR-132 in human thyroid cancer are still poorly understood. The aim of the present study was to examine the potential roles and molecular mechanism of miR-132 in thyroid cancer. We found that miR-132 expression levels were significantly downregulated in thyroid cancer tissues and cell lines. Function assays showed that overexpression of miR-132 in TPC1 cells inhibited cell proliferation, migration, and invasion. Forkhead box protein A1 (FOXA1) was identified as a direct target of miR-132 in thyroid cancer cells. Knockdown of FOXA1 in TPC1 cells significantly inhibited cell proliferation, migration, and invasion, which mimicked the suppressive effect induced by miR-132 overexpression. Restoration of FOXA1 expression partially reversed the suppressive effect induced by miR-132 overexpression. Taken together, these results suggested that miR-132 acts as a tumor suppressor in thyroid cancer through targeting FOXA1.

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Cite This Article

Chen, X., Li, M., Zhou, H., Zhang, L. (2019). miR-132 Targets FOXA1 and Exerts Tumor-Suppressing Functions in Thyroid Cancer. Oncology Research, 27(4), 431–437.



This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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