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miR-142-5p Inhibits Cell Invasion and Migration by Targeting DNMT1 in Breast Cancer

Hui Li*1, Han-Han Li†1, Qian Chen‡1, Yu-Yang Wang, Chang-Chang Fan, Yuan-Yuan Duan, You Huang, Hui-Min Zhang, Jia-Peng Li, Xiao-Yu Zhang, Yuan Xiang, Chao-Jiang Gu, Li Wang§, Xing-Hua Liao, Tong-Cun Zhang‡¶

* Department of Hematology and Nephrology, Tianyou Hospital Affiliated to Wuhan University of Science and Technology, Hubei, P.R. China
† Nanjing Vazyme Biotech Co. Ltd., Nanjing, P.R. China
‡ College of Life Sciences and Health, Wuhan University of Science and Technology, Hubei, P.R. China
§ School of Resource and Environmental Engineering, Wuhan University of Science and Technology, Hubei, P.R. China
¶ Key Laboratory of Industrial Fermentation Microbiology, Ministry of Education and Tianjin, College of Biotechnology, Tianjin University of Science and Technology, Tianjin, P.R. China

Oncology Research 2020, 28(9), 885-897. https://doi.org/10.3727/096504021X16274672547967

Abstract

Abnormal cell proliferation caused by abnormal transcription regulation mechanism seems to be one of the reasons for the progression of breast cancer and also the pathological basis. MicroRNA-142-5p (miR-142-5p) is a low-expressed miRNA in breast cancer. The role of MKL-1’s regulation of DNMT1 in breast cancer cell proliferation and migration is still unclear. MKL-1 (myocardin related transcription factor A) can bind to the conserved cis-regulatory element CC (A/T) 6GG (called CarG box) in the promoter to regulate the transcription of miR-142-5p. The expressions of miR-142-5p and MKL-1 are positively correlated. In addition, it has been proved that DNMT1 is the target of miR-142-5p, which inhibits the expression of DNMT1 by targeting the 3¢-UTR of DNMT1, thereby forming a feedback loop and inhibiting the migration and proliferation of breast cancer. Our data provide important and novel insights into the MKL-1/miR-142-5p/DNMT1/maspin signaling pathway and may become a new idea for breast cancer diagnosis, treatment, and prognosis.

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APA Style
Li, H., Li, H., Chen, Q., Wang, Y., Fan, C. et al. (2020). Mir-142-5p inhibits cell invasion and migration by targeting DNMT1 in breast cancer. Oncology Research, 28(9), 885-897. https://doi.org/10.3727/096504021X16274672547967
Vancouver Style
Li H, Li H, Chen Q, Wang Y, Fan C, Duan Y, et al. Mir-142-5p inhibits cell invasion and migration by targeting DNMT1 in breast cancer. Oncol Res. 2020;28(9):885-897 https://doi.org/10.3727/096504021X16274672547967
IEEE Style
H. Li et al., "miR-142-5p Inhibits Cell Invasion and Migration by Targeting DNMT1 in Breast Cancer," Oncol. Res., vol. 28, no. 9, pp. 885-897. 2020. https://doi.org/10.3727/096504021X16274672547967



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