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Melanoma-derived extracellular vesicles transfer proangiogenic factors

by MAGDALENA WILCZAK1,2,#, MAGDALENA SURMAN1,#,*, MAłGORZATA PRZYBYłO1,*

1 Department of Glycoconjugate Biochemistry, Faculty of Biology, Institute of Zoology and Biomedical Research, Jagiellonian University, Krakow, 30-387, Poland
2 Doctoral School of Exact and Natural Sciences, Jagiellonian University, Krakow, 30-348, Poland

* Corresponding Authors: MAGDALENA SURMAN. Email: email; MAłGORZATA PRZYBYłO. Email: email
# Authors contributed equally to the manuscript

Oncology Research 2025, 33(2), 245-262. https://doi.org/10.32604/or.2024.055449

Abstract

Angiogenesis, the expansion of pre-existing vascular networks, is crucial for normal organ growth and tissue repair, but is also involved in various pathologies, including inflammation, ischemia, diabetes, and cancer. In solid tumors, angiogenesis supports growth, nutrient delivery, waste removal, and metastasis. Tumors can induce angiogenesis through proangiogenic factors including VEGF, FGF-2, PDGF, angiopoietins, HGF, TNF, IL-6, SCF, tryptase, and chymase. This balance is disrupted in tumors, and extracellular vesicles (EVs) contribute to this by transferring proangiogenic factors and increasing their expression in endothelial cells (ECs). Malignant melanoma, a particular type of skin cancer, accounts for only 1% of skin cancer cases but more than 75% of deaths. Its incidence has risen significantly, with a 40% increase between 2012 and 2022, especially in fair-skinned populations. Advanced metastatic stages have a high mortality due to delayed diagnosis. This review examines the molecular basis of angiogenesis in melanoma, focusing on melanoma-derived EVs and their possible use in new antiangiogenic therapies.

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APA Style
WILCZAK, M., SURMAN, M., PRZYBYłO, M. (2025). Melanoma-derived extracellular vesicles transfer proangiogenic factors. Oncology Research, 33(2), 245–262. https://doi.org/10.32604/or.2024.055449
Vancouver Style
WILCZAK M, SURMAN M, PRZYBYłO M. Melanoma-derived extracellular vesicles transfer proangiogenic factors. Oncol Res. 2025;33(2):245–262. https://doi.org/10.32604/or.2024.055449
IEEE Style
M. WILCZAK, M. SURMAN, and M. PRZYBYłO, “Melanoma-derived extracellular vesicles transfer proangiogenic factors,” Oncol. Res., vol. 33, no. 2, pp. 245–262, 2025. https://doi.org/10.32604/or.2024.055449



cc Copyright © 2025 The Author(s). Published by Tech Science Press.
This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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