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Triterpenoids from Uncaria rhynchophylla and Their PTP1B Inhibitory Activity

Shuaibin Luo1, Xuemei Zhang2, Kang He1, Juan Zou1,*, Chang-An Geng2,*

1 Guizhou University of Traditional Chinese Medicine, Guiyang, 550025, China
2 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming, 650201, China

* Corresponding Authors: Juan Zou. Email: email; Chang-An Geng. Email: email

Phyton-International Journal of Experimental Botany 2022, 91(8), 1809-1816. https://doi.org/10.32604/phyton.2022.020935

Abstract

Uncaria rhynchophylla (Gouteng) is a famous traditional Chinese medicine used for psychiatric and hypotensive purposes in China. In this study, the ethyl acetate (EtOAc) part of U. rhynchophylla was revealed with protein tyrosine phosphatase 1B (PTP1B) inhibitory activity. Subsequent investigation on the EtOAc part yielded one new triterpenoid, 3β-formyloxy-6β,19α-dihydroxyurs-12-en-28-oic acid (1) and four known ones, 3β,6β,19α-trihydroxyurs-12-en-28-oic acid (2), 2-oxopomolic acid (3), 3β,19α-dihydroxy-6-oxo-olean-12-en-28-oic acid (4) and sumaresinolic acid (5). The structure of compound 1 was determined by extensive HRESIMS, IR, 1D and 2D NMR spectroscopic analyses. Two ursane-type triterpenoids (2 and 3) showed selective inhibition on PTP1B with IC50 values of 48.2 and 178.7 μM. The enzyme kinetic study suggested that compounds 2 and 3 were mix-type inhibitors on PTP1B with Ki values of 15.6 and 132.5 μM. This investigation manifests the antidiabetic potency of U. rhynchophylla with triterpenoids as the active constituents.

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APA Style
Luo, S., Zhang, X., He, K., Zou, J., Geng, C. (2022). Triterpenoids from uncaria rhynchophylla and their PTP1B inhibitory activity. Phyton-International Journal of Experimental Botany, 91(8), 1809-1816. https://doi.org/10.32604/phyton.2022.020935
Vancouver Style
Luo S, Zhang X, He K, Zou J, Geng C. Triterpenoids from uncaria rhynchophylla and their PTP1B inhibitory activity. Phyton-Int J Exp Bot. 2022;91(8):1809-1816 https://doi.org/10.32604/phyton.2022.020935
IEEE Style
S. Luo, X. Zhang, K. He, J. Zou, and C. Geng "Triterpenoids from Uncaria rhynchophylla and Their PTP1B Inhibitory Activity," Phyton-Int. J. Exp. Bot., vol. 91, no. 8, pp. 1809-1816. 2022. https://doi.org/10.32604/phyton.2022.020935



cc This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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