Oncology Research Editorial Office

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.077268 - 30 December 2025

Abstract This article has no abstract. More >

Jing Shan¹, Catherine King^2,3, Harunor Rashid^3,4, Veysel Kayser^1,*

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.070851 - 30 December 2025

Abstract Objectives: B-cell maturation antigen (BCMA)-targeted antibody–drug conjugates (ADCs) have emerged as promising therapies for relapsed/refractory multiple myeloma (RRMM), but the overall efficacy and safety profile is unclear. This study aimed to synthesize the available evidence on the safety and efficacy of BCMA-ADCs in development for RRMM. Methods: A systematic search was conducted using six bibliographic databases and ClinicalTrials.gov up to November 2024. Studies were eligible if they were human clinical trials or animal studies evaluating BCMA-ADCs and reported efficacy and safety outcomes. Data extraction and quality assessments were conducted using validated tools, including ROBINS-I… More >

Lv Ling^1,#, Minying Lu^2,#, Ling Ye³, Yuanhang Chen², Sheng Lin², Jun Yang², Yu Rong^2,*, Guixiong Wu^4,*

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.069889 - 30 December 2025

Abstract Background: A significant proportion of patients still cannot benefit from existing targeted therapies and immunotherapies, making the search for new treatment strategies extremely urgent. In this study, we combined integrate public data analysis with experimental validation to identify novel prognostic biomarkers and therapeutic targets for lung adenocarcinoma (LUAD). Methods: We analyzed RNA and protein databases to assess the expression levels of cytochrome C oxidase 5B (COX5B) in LUAD. Several computational algorithms were employed to investigate the relationship between COX5B and immune infiltration in LUAD. To further elucidate the role of COX5B in LUAD, we utilized… More > Graphic Abstract

Xiangmei Ye^1,2,3, Baoyi Yang⁴, Xin Zhang⁵, Luyuan Yang¹, Likun Zhang⁵, Qin Ren¹, Xiaobing Li¹, Leiguang Feng¹, Lanlan Wei^3,6,7,*, Peng Song¹, Yuqing Ye⁸, Xin Lian⁹, Yujuan Gao⁹, Haidi Tang¹, Zhiyu Liu¹

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.068814 - 30 December 2025

Abstract Objectives: Philadelphia chromosome-positive B-cell acute lymphoblastic leukemia and Philadelphia-like B-cell acute lymphoblastic leukemia (Ph+/Ph-like ALL) constitute the majority of relapsed/refractory B-ALL (R/R B-ALL) cases, highlighting an urgent need to discover new therapeutic targets. This study aims to elucidate the mechanisms underlying poor prognosis in Ph+/Ph-like ALL through transcriptome sequencing and functional cytological assays, with the goal of informing new clinical treatment strategies. Results: Transcriptomic analysis of Ph+/Ph-like ALL patients revealed that low expression of P2X Purinoceptor 1 (P2RX1) was associated with unfavorable outcomes. Specifically, patients with poor prognosis and low P2RX1 expression exhibited downregulation of… More >

Ashok Kumar Sah^1,*, Ranjay Kumar Choudhary^1,2, Velilyaeva Alie Sabrievna³, Karomatov Inomdzhon Dzhuraevich⁴, Anass M. Abbas⁵, Manar G. Shalabi⁵, Nadeem Ahmad Siddique⁶, Raji Rubayyi Alshammari⁷, Navjyot Trivedi⁸, Rabab H. Elshaikh¹

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.068238 - 30 December 2025

Abstract Male breast cancer (MBC) is rare, representing 0.5%–1% of all breast cancers, but its incidence is increasing due to improved diagnostics and awareness. MBC typically presents in older men, is human epidermal growth factor receptor 2 (HER2)-negative and estrogen receptor (ER)-positive, and lacks routine screening, leading to delayed diagnosis and advanced disease. Major risk factors include hormonal imbalance, radiation exposure, obesity, alcohol use, and Breast Cancer Gene 1 and 2 (BRCA1/2) mutations. Clinically, it may resemble gynecomastia but usually appears as a unilateral, painless mass or nipple discharge. Advances in imaging and liquid biopsy have More >

Sk. A. Shezan^*

Energy Engineering, Vol.123, No.1, 2026, DOI:10.32604/ee.2025.073418 - 27 December 2025

Abstract Modern power systems increasingly depend on interconnected microgrids to enhance reliability and renewable energy utilization. However, the high penetration of intermittent renewable sources often causes frequency deviations, voltage fluctuations, and poor reactive power coordination, posing serious challenges to grid stability. Conventional Interconnection Flow Controllers (IFCs) primarily regulate active power flow and fail to effectively handle dynamic frequency variations or reactive power sharing in multi-microgrid networks. To overcome these limitations, this study proposes an enhanced Interconnection Flow Controller (e-IFC) that integrates frequency response balancing and an Interconnection Reactive Power Flow Controller (IRFC) within a unified adaptive… More >

Jingshuai Pang^1,2, Songcen Wang¹, Hongyin Chen^1,2,*, Xiaoqiang Jia¹, Yi Guo¹, Ling Cheng¹, Xinhe Zhang¹, Jianfeng Li¹

Energy Engineering, Vol.123, No.1, 2026, DOI:10.32604/ee.2025.070256 - 27 December 2025

Abstract To achieve the goals of sustainable development of the energy system and the construction of a low-carbon society, this study proposes a multi-energy storage collaborative optimization strategy for industrial park that integrates the laddered carbon trading mechanism with demand response. Firstly, a dual dimensional DR model is constructed based on the characteristics of load elasticity. The alternative DR enables flexible substitution of energy loads through complementary conversion of electricity/heat/cold multi-energy sources, while the price DR relies on time-of-use electricity price signals to guide load spatiotemporal migration; Secondly, the LCT mechanism is introduced to achieve optimal… More >

Tiankui Sun^*, Shuyi Zhuang, Yongling Lu, Wenqiang Xie, Ning Guo, Sudi Xu

Energy Engineering, Vol.123, No.1, 2026, DOI:10.32604/ee.2025.070213 - 27 December 2025

Abstract To ensure an uninterrupted power supply, mobile power sources (MPS) are widely deployed in power grids during emergencies. Comprising mobile emergency generators (MEGs) and mobile energy storage systems (MESS), MPS are capable of supplying power to critical loads and serving as backup sources during grid contingencies, offering advantages such as flexibility and high resilience through electricity delivery via transportation networks. This paper proposes a design method for a 400 V–10 kV Dual-Winding Induction Generator (DWIG) intended for MEG applications, employing an improved particle swarm optimization (PSO) algorithm based on a back-propagation neural network (BPNN). A… More >

Samira Rastbod¹, Mehdi Jahangiri^2,*, Behrang Moradi¹, Haleh Nazari¹

Energy Engineering, Vol.123, No.1, 2026, DOI:10.32604/ee.2025.070089 - 27 December 2025

Abstract Curtain wall systems have evolved from aesthetic façade elements into multifunctional building envelopes that actively contribute to energy efficiency and climate responsiveness. This review presents a comprehensive examination of curtain walls from an energy-engineering perspective, highlighting their structural typologies (Stick and Unitized), material configurations, and integration with smart technologies such as electrochromic glazing, parametric design algorithms, and Building Management Systems (BMS). The study explores the thermal, acoustic, and solar performance of curtain walls across various climatic zones, supported by comparative analyses and iconic case studies including Apple Park, Burj Khalifa, and Milad Tower. Key challenges—including… More > Graphic Abstract

Heping Qi, Wenyao Sun^*, Yi Zhao, Xiaoyi Qian, Xingyu Jiang

Energy Engineering, Vol.123, No.1, 2026, DOI:10.32604/ee.2025.069603 - 27 December 2025

Abstract Virtual power plant (VPP) integrates a variety of distributed renewable energy and energy storage to participate in electricity market transactions, promote the consumption of renewable energy, and improve economic efficiency. In this paper, aiming at the uncertainty of distributed wind power and photovoltaic output, considering the coupling relationship between power, carbon trading, and green card market, the optimal operation model and bidding scheme of VPP in spot market, carbon trading market, and green card market are established. On this basis, through the Shapley value and independent risk contribution theory in cooperative game theory, the quantitative… More > Graphic Abstract