Saleh Al-Maaqar1,2,3,*, Bassam Al-Johny1,*, Majed Al-Shaeri1,3, Lara Al-Johny4, Adel Qumusani1, Zakia Albalawy1, Djadjiti Namla1,3,5,*
Phyton-International Journal of Experimental Botany, Vol.95, No.4, 2026, DOI:10.32604/phyton.2026.077998
- 28 April 2026
Abstract Staphylococcal meningitis, a severe infection of the meninges, highlights the urgent need for new strategies to combat Staphylococcus aureus (S. aureus) infections. In this study, ethanolic leaf extracts of Coleus forskohlii were evaluated for their antibacterial potential against clinical S. aureus isolates associated with meningitis. Gas chromatography-mass spectrometry (GC-MS) analysis identified 15 phytochemical compounds, two of which—urs-12-en-28-ol (CID 22213452) and petroselaidic acid (CID 5282754) showed promising binding affinities (−7.5 and −5.9 kcal/mol, respectively) against S. aureus protein (30S ribosomal subunit) in molecular docking studies. In vitro assays confirmed the antibacterial activity of the crude extract, with a minimum inhibitory concentration (MIC) More >