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  • Open Access

    ARTICLE

    Multi-cohort comprehensive analysis unveiling the clinical value and therapeutic effect of GNAL in glioma

    ZHEN LIU1,#, LIANGWANG YANG2,#, ZHENGXING XIE1, HUI YU3, TIANYI GU3, DAOMING SHI4, NING CAI1,*, SHENGHUA ZHUO2,*

    Oncology Research, Vol.32, No.5, pp. 965-981, 2024, DOI:10.32604/or.2024.045769

    Abstract Clinical data indicates that glioma patients have poor treatment outcomes and clinical prognosis. The role of olfactory signaling pathway-related genes (OSPRGs) in glioma has not been fully elucidated. In this study, we aimed to investigate the role and relationship between OSPRGs and glioma. Univariate and multivariate Cox regression analyses were performed to assess the relationship between OSPRGs and the overall survival of glioma based on public cohorts, and the target gene (G Protein Subunit Alpha L, GNAL) was screened. The association of GNAL expression with clinicopathological characteristics, gene mutation landscape, tumor immune microenvironment (TIME), deoxyribonucleic acid (DNA) methylation, and naris-occlusion… More >

  • Open Access

    ARTICLE

    Multi-Objective Optimization of Aluminum Alloy Electric Bus Frame Connectors for Enhanced Durability

    Wenjun Zhou1,2, Mingzhi Yang1, Qian Peng2, Yong Peng1,*, Kui Wang1, Qiang Xiao1

    CMES-Computer Modeling in Engineering & Sciences, Vol.140, No.1, pp. 735-755, 2024, DOI:10.32604/cmes.2024.047258

    Abstract The widespread adoption of aluminum alloy electric buses, known for their energy efficiency and eco-friendliness, faces a challenge due to the aluminum frame’s susceptibility to deformation compared to steel. This issue is further exacerbated by the stringent requirements imposed by the flammability and explosiveness of batteries, necessitating robust frame protection. Our study aims to optimize the connectors of aluminum alloy bus frames, emphasizing durability, energy efficiency, and safety. This research delves into Multi-Objective Coordinated Optimization (MCO) techniques for lightweight design in aluminum alloy bus body connectors. Our goal is to enhance lightweighting, reinforce energy absorption, and improve deformation resistance in… More >

  • Open Access

    ARTICLE

    Synthesis and Characterization of Epoxy methacrylate of (2E, 6E)-Bis(4-hydroxybenzylidene)-4- methylcyclohexanone

    JALPA V. CHOPDA, DHARMESH B. SANKHAVARA, JIGNESH P. PATEL, P. H. PARSANIA*

    Journal of Polymer Materials, Vol.36, No.4, pp. 391-399, 2019, DOI:10.32381/JPM.2019.36.04.8

    Abstract The epoxymethcrylate resin (EMBHBCMA) of (2E, 6E)-bis(4-hydroxybenzylidene)-4- methylcyclohexanone(EMBHBC) was synthesized by condensing EMBHBC and methacrylic acid (1:2 mole ratio) by using 1,4-dioxane as a solvent and triethylamine as a catalyst at reflux temperature for 1-5 h to get acid value < 10. The structure of EMBHBCMA was supported by UV-Vis, FTIR, 1 HNMR and 13CNMR spectroscopic techniques. Molecular weights and molecular weight distribution of EMBHBCMA were determined by gel permeation chromatography. EMBHBCMA is thermally stable up to about 300°C and followed two step degradation reactions. Kinetic parameters such as n, Ea, A and ΔS* were determined according to Anderson-Freeman method… More >

  • Open Access

    ARTICLE

    Synthesis and Physico-Chemical Analysis of Epoxy Methacrylate of (2E, 6E)-2,6-Bis(4- hydroxybenzylidene)cyclohexanone

    DHARMESH B. SANKHAVARA, JALPA V. CHOPDA, JIGNESH P. PATEL, PARSOTAM H. PARSANIA*

    Journal of Polymer Materials, Vol.36, No.4, pp. 371-379, 2019, DOI:10.32381/JPM.2019.36.04.6

    Abstract The epoxy methacrylate of (2E,6E)-2, 6-bis(4-hydroxybenzylidene)cyclohexanone (EBHBCMA) was synthesized by condensing 0.02 equi. EBHBC, 0.04 equi. methacrylic acid, 50 mL THF as a solvent and 0.2 mL triethylamine as a catalyst at reflux temperature for 1-5 h to get acid value < 10. EBHBCMA showed good solubility in common solvents. The structure of EBHBCMA was supported by UV-Vis., FTIR, 1 H NMR, and 13C NMR spectroscopic techniques. DSC thermogram of EBHBCMA exhibited two endothermic peaks (86.4 and 117.1 °C) and one exothermic peak (142.6°C) due to moisture release, melting and curing of the resin, respectively. EBHBCMA is thermally stable up… More >

  • Open Access

    ARTICLE

    An Experimental Study and Analysis of Different Dielectrics in Electrical Discharge Machining of Al 6063 Alloy

    B. MOULIPRASANTHA, P. HARIHARANB

    Journal of Polymer Materials, Vol.36, No.4, pp. 351-369, 2019, DOI:10.32381/JPM.2019.36.04.5

    Abstract Electrical discharge machining is a non-traditional machining processes in which it is based upon thermal and electrical energy source as an interval energy pulse discharge in-between the work piece and tool electrode so as to remove the material. A systematical investigation of melting and vaporising of aluminium to find the output responses such as Material removal rate (MRR), Electrode wear rate (Ra), and Surface finish (EWR) in EDM using two different dielectrics was conducted as experimental work. The working fluids are Polyethylene glycol (PEG 600) and kerosene. It is the hour of need to get the maximum MRR and surface… More >

  • Open Access

    ARTICLE

    Effect of Synthesis Parameters on Phosphoric Acid Doped Polybenzimidazole Membranes: A Parametric Evaluation from Microstructural Level to Fuel Cell Performance

    ÇAĞLA GÜL GÜLDİKEN, LEVENT AKYALÇIN, HASAN FERDİ GERÇEL*

    Journal of Polymer Materials, Vol.36, No.4, pp. 337-349, 2019, DOI:10.32381/JPM.2019.36.04.4

    Abstract In the present study, polybenzimidazole (PBI) polymer which has a great importance in polymer electrolyte membrane (PEM) research was synthesized via the solution polycondensation method, under various synthesis conditions to put forward the effect of the synthesis parameters on the properties of the synthesized polymer and consequently to the quality of the prepared polymer electrolyte membrane. The synthesized polymers were characterized in terms of their chemical structure, thermal degradation behaviour, and molecular weight by Fourier transform infrared spectroscopy (FTIR), nuclear magnetic resonance spectroscopy (1 H NMR), thermogravimetric analysis (TGA). The Mechanical properties, acid-doping level capacity, proton conductivity, and fuel cell… More >

  • Open Access

    ARTICLE

    Performance Evaluation of Nucleating Agents in Polypropylene Homopolymer

    RAVI KUMAR, VISHWA PRATAP SINGH, MADHUKAR PRAJAPATI, ASHWITH, PRIYANKA SINGH, SATYAJIT SAMANTA, SAIKAT BANERJEE*

    Journal of Polymer Materials, Vol.36, No.4, pp. 323-335, 2019, DOI:10.32381/JPM.2019.36.04.3

    Abstract Types of nucleating agents and their dosage level play an important role on the crystallinity of the polymer which controls the final properties like optical clarity, stiffness and reduced cycle time during molding. In this study, the efficiency of two different types of commercially available nucleating agents, phosphate ester and dicarboxylic acid based, have been studied. Both the nucleating agents were compounded with molding grade polypropylene homopolymer having melt flow index (MFI) of 12 g/10min at 2.16 Kg and 230°C, in a co-rotating twin screw extruder at two different dosage level, i.e. 300 ppm and 600 ppm. The effectiveness of… More >

  • Open Access

    ARTICLE

    Chitosan Modification by New Chromophore 4-(3-(4- nitrophenyl) thioureido) benzoic acid: Synthesis, Characterization and Evaluation

    KAZIM SHAMIM RIZVI, P. K. DUTTA

    Journal of Polymer Materials, Vol.36, No.3, pp. 217-228, 2019, DOI:10.32381/JPM.2019.36.03.2

    Abstract In this investigation we have shown the preparation of carboxylic acid containing new chromophore : 4-(3-(4-nitrophenyl) thioureido) benzoic acid and its use.The chemical modification of chitosan, e.g., chitosan- acid salt complexes is done under mild conditions. The synthesis of chromophore was carried out by conventional methods and the novel polymer complex was soluble in most of the organic solvents. The modified chitosan was analyzed by various techniques like optical properties by UV and SHG spectroscopy which showed red shift. The antibacterial activity showed obvious effect against food pathogenic bacteria. More >

  • Open Access

    ARTICLE

    Improved Corrosion Resistance of Carbon Reinforced Aluminium Laminates in Atmospheric Environment: Role of Environment Friendly Jute Fibre/ Alumina nano Coating

    M. VASUMATHI1,a,*, VELA MURALI2,b, S. RASHIA BEGUM1,c, N. RAJENDRAN2,d

    Journal of Polymer Materials, Vol.36, No.1, pp. 1-11, 2019, DOI:10.32381/JPM.2019.36.01.1

    Abstract In the Fibre Metal Laminate (FML), Carbon Reinforced Aluminium laminate (CARALL), aluminium is placed next to carbon fibres. The potential difference between the aluminium and carbon is larger, leads to galvanic corrosion, which tries to bring down the durability of the FML. To bring down the effect of corrosion, a material layer is introduced between fibres and aluminium so as to separate them thus lowering the possibility of occurrence of corrosion. Another approach is to coat the surfaces of aluminium with different proportions of aluminium oxide nano particles prior to fabrication of the FML. For both the cases, corrosion rates… More >

  • Open Access

    ARTICLE

    Swelling dynamics of Poly (N, N- Dimethylacrylamide - co- Crotonic acid) Hydrogel and Evaluation of its Potential for Controlled Release of Fertilizers

    FATMA LOUZRI, SADJIA BENNOUR

    Journal of Polymer Materials, Vol.37, No.1-2, pp. 55-76, 2020, DOI:10.32381/JPM.2020.37.1-2.5

    Abstract Poly(N,N-dimethymethylacrylamide -co-crotonic acid) (P(DMA-CAx)) hydrogels were prepared by free radical polymerization, using N,N- methylenebisacrylamide (NMBA) as cross-linking agent. The synthesized hydrogels were characterized by Fourier transform infrared spectroscopy (FTIR) and thermogravimetric analysis (TGA). The effects of comonomer composition and pH of the medium on the swelling behavior of hydrogels were investigated. The obtained results showed that the swelling capabilities of hydrogels increased as crotonic acid content and pH increased. In order to evaluate the controlled release potential of the polymeric matrix, it was loaded with potassium nitrate and ammonium nitrate as fertilizers and the release kinetics was studied as a… More >

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